Search Results - (Author, Cooperation:R. Sukernik)

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  1. 1
    I. Lazaridis ; N. Patterson ; A. Mittnik ; G. Renaud ; S. Mallick ; K. Kirsanow ; P. H. Sudmant ; J. G. Schraiber ; S. Castellano ; M. Lipson ; B. Berger ; C. Economou ; R. Bollongino ; Q. Fu ; K. I. Bos ; S. Nordenfelt ; H. Li ; C. de Filippo ; K. Prufer ; S. Sawyer ; C. Posth ; W. Haak ; F. Hallgren ; E. Fornander ; N. Rohland ; D. Delsate ; M. Francken ; J. M. Guinet ; J. Wahl ; G. Ayodo ; H. A. Babiker ; G. Bailliet ; E. Balanovska ; O. Balanovsky ; R. Barrantes ; G. Bedoya ; H. Ben-Ami ; J. Bene ; F. Berrada ; C. M. Bravi ; F. Brisighelli ; G. B. Busby ; F. Cali ; M. Churnosov ; D. E. Cole ; D. Corach ; L. Damba ; G. van Driem ; S. Dryomov ; J. M. Dugoujon ; S. A. Fedorova ; I. Gallego Romero ; M. Gubina ; M. Hammer ; B. M. Henn ; T. Hervig ; U. Hodoglugil ; A. R. Jha ; S. Karachanak-Yankova ; R. Khusainova ; E. Khusnutdinova ; R. Kittles ; T. Kivisild ; W. Klitz ; V. Kucinskas ; A. Kushniarevich ; L. Laredj ; S. Litvinov ; T. Loukidis ; R. W. Mahley ; B. Melegh ; E. Metspalu ; J. Molina ; J. Mountain ; K. Nakkalajarvi ; D. Nesheva ; T. Nyambo ; L. Osipova ; J. Parik ; F. Platonov ; O. Posukh ; V. Romano ; F. Rothhammer ; I. Rudan ; R. Ruizbakiev ; H. Sahakyan ; A. Sajantila ; A. Salas ; E. B. Starikovskaya ; A. Tarekegn ; D. Toncheva ; S. Turdikulova ; I. Uktveryte ; O. Utevska ; R. Vasquez ; M. Villena ; M. Voevoda ; C. A. Winkler ; L. Yepiskoposyan ; P. Zalloua ; T. Zemunik ; A. Cooper ; C. Capelli ; M. G. Thomas ; A. Ruiz-Linares ; S. A. Tishkoff ; L. Singh ; K. Thangaraj ; R. Villems ; D. Comas ; R. Sukernik ; M. Metspalu ; M. Meyer ; E. E. Eichler ; J. Burger ; M. Slatkin ; S. Paabo ; J. Kelso ; D. Reich ; J. Krause
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-09-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agriculture/history/manpower ; Asia/ethnology ; Europe ; European Continental Ancestry Group/*classification/*genetics ; Genome, Human/*genetics ; History, Ancient ; Humans ; Population Dynamics ; Principal Component Analysis
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    P. H. Sudmant ; S. Mallick ; B. J. Nelson ; F. Hormozdiari ; N. Krumm ; J. Huddleston ; B. P. Coe ; C. Baker ; S. Nordenfelt ; M. Bamshad ; L. B. Jorde ; O. L. Posukh ; H. Sahakyan ; W. S. Watkins ; L. Yepiskoposyan ; M. S. Abdullah ; C. M. Bravi ; C. Capelli ; T. Hervig ; J. T. Wee ; C. Tyler-Smith ; G. van Driem ; I. G. Romero ; A. R. Jha ; S. Karachanak-Yankova ; D. Toncheva ; D. Comas ; B. Henn ; T. Kivisild ; A. Ruiz-Linares ; A. Sajantila ; E. Metspalu ; J. Parik ; R. Villems ; E. B. Starikovskaya ; G. Ayodo ; C. M. Beall ; A. Di Rienzo ; M. F. Hammer ; R. Khusainova ; E. Khusnutdinova ; W. Klitz ; C. Winkler ; D. Labuda ; M. Metspalu ; S. A. Tishkoff ; S. Dryomov ; R. Sukernik ; N. Patterson ; D. Reich ; E. E. Eichler
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-08-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    African Continental Ancestry Group/classification/genetics ; Animals ; *DNA Copy Number Variations ; *Evolution, Molecular ; *Gene Duplication ; Genome, Human/*genetics ; Hominidae/genetics ; Humans ; Oceanic Ancestry Group/classification/genetics ; Phylogeny ; Polymorphism, Single Nucleotide ; Population/*genetics ; Selection, Genetic ; *Sequence Deletion
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Osipova,and, L. P. ; Sukernik, R. I.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1983
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Serum blood samples from 563 of the total 700 Nganasans, members of the isolate in the northern-most part of Siberia were tested for G1m, (z,a,x,f), G2m (n), G3m (g,b0,b1,b3,b5,s,t), and km (1) allotypic determinants. Additionally, 78 Yenisey Samoyeds (Entsi) who are the Nganasan's western neighbours were studied. Both populations are remarkable for high frequency of ‘Northern Oriental’Gm (za;.;b0b3b5st) which appears to be the most frequent haplotype in the Nganasans (0.486), and is the second frequent in Yenisey Samoyeds (0.276). The Gm (f;b) generalized haplotype which used to be considered as an indicator of Caucasian gene flow occurred in the Nganasans in the very low frequency of 0.008, versus 0.045 revealed in adjoining Yenisey Samoyeds. Both populations also differ in the frequency of Km1 which is two times lower in the Nganasans (0.048), than in Yenisey Samoyeds (0.103). When segregation ratios for the Gm locus were inspected in 67 Nganasan families, no apparent deviations from Mendelian expectations, and no recombinant phenotypes were observed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1983.tb01011.x

    Articles: DFG German National Licenses
  4. 4
    Loghem, Erna van ; Sukernik, R. I. ; Osipova, L. P. ; Zegers, B. J. M. ; Matsumoto, H. ; Lange and, Gerda de ; Lefrance, G.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1980
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Individuals with selective absence of IgG1 and IgG2 were discovered by testing for allotypes and isotypes of the respective sub-classes. These individuals were homozygous for sub-class deleted Gm-Am haplotypes, as shown by allotype studies in two families (Gm-;…;g;A2ml/Gm-;n;b;A2ml and Gm-;n;b;A2ml/Gm-;…;b;A2ml) and by a population study of New Guineans (Gm fa;-;b;A2m2). The individuals with IgGl sub-class deficiency showed elevation of IgG2, IgG4 and in particular of IgG3.Gene deletion can result from unequal crossing over which renders a complementary chromosome with a duplication of a sub-class gene. In one family, duplication of γ3 genes was observed to have happened in one of a twin pair. Quantitation of sub-classes in families with γ1- and with γ3-duplicated haplotypes did not show increased levels of the gene involved.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1980.tb00722.x

    Articles: DFG German National Licenses
  5. 5
    McComb, J. ; Blagitko, N. ; Comuzzie, A. G. ; Schanfield, M. S. ; Sukernik, R. I. ; Leonard, W. R. ; Crawford, M. H.

    Baltimore : Periodicals Archive Online (PAO)
    Published 1995
    Staff View
    ISSN:
    0018-7143
    Topics:
    Biology
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5243-1995-067-02-000002

    Articles: DFG German National Licenses
  6. 6
    Posukh, O. L. ; Wiebe, V. P. ; Sukernik, R. I. ; Osipova, L. P. ; Karaphet, T. M. ; Schangield, M. S.

    Baltimore : Periodicals Archive Online (PAO)
    Published 1990
    Staff View
    ISSN:
    0018-7143
    Topics:
    Biology
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:5243-1990-062-04-000001

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract We have initiated a study of ancient male migrations from Siberia to the Americas using Y chromosome polymorphisms. The first polymorphism examined, a C→T transition at nucleotide position 181 of the DYS199 locus, was previously reported only in Native American populations. To investigate the origin of this DYS199 polymorphism, we screened Y chromosomes from a number of Siberian, Asian, and Native American populations for this and other markers. This survey detected the T allele in all five Native American populations studied at an average frequency of 61%, and in two of nine native Siberian populations, the Siberian Eskimo (21%) and the Chukchi (17%). This finding suggested that the DYS199 T allele may have originated in Beringia and was then spread throughout the New World by the founding populations of the major subgroups of modern Native Americans. We further characterized Native American Y chromosome variation by analyzing two additional Y chromosome polymorphisms, the DYS287 Y Alu polymorphic (YAP) element insertion and a YAP-associated A→G transition at DYS271, both commonly found in Africans. We found neither African allele associated with the DYS199 T allele in any of the Native American or native Siberian populations. However, we did find DYS287 YAP+ individuals who harbored the DYS199 C allele in one Native American population, the Mixe, and in one Asian group, the Tibetans. A correlation of these Y chromosome alleles in Native Americans with those of the DYS1 locus, as detected by the p49a/p49f (p49a,f) probes on TaqI-digested genomic DNA, revealed a complete association of DYS1 alleles (p49a,f haplotypes) 13, 18, 66, 67 and 69 with the DYS199 T allele, while DYS1 alleles 8 and 63 were associated with both the DYS199 C and T allele.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004390050548

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary A Samoyed-speaking group of fishers, hunters, and deer breeders numbering 1500 in total has been investigated. Seven territorial subgroups were examined with respect to 15 genetic systems. The presence of A2, cde, CwDe, Kpa, AK2, pc, Gmfb, and Gmfnb genes or haplotypes in low or moderate frequencies was observed. An unexpected finding was a deleted Gm(-;n;gb) phenotype in three siblings. Significant local genetic heterogeneity was observed with regard to AB0, Rh, Tf, PGM1, 6-PGD, and Gm systems. The summed genic heterogeneity was found to be highly significant (χ 132 2 =663.70, P〈 0.001). Mean Fst was equal to 0.0228, reflecting variation among subpopulations dispersed in the forest-tundra area and living under conditions of partial isolation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00290224

    Articles: DFG German National Licenses
  9. 9
    Sukernik, R. I. ; Osipova, Ludmila P.
    Springer
    Published 1982
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Blood samples from 403 Reindeer Chukchi of inland Chukotka, and 100 samples from Chaplin Eskimos of the Chukot Peninsula were tested for G1m (z,a,x,f), G2m (n), G3m (g,b0,b1,b3,b5,s,t), and Km (1) allotypic determinants. An apparent affinity between the Chukchi and the Eskimos could be inferred from similar frequencies of the two common haplotypes, Gmza;g and Gmza;bst, and from very similar frequencies of the Km1 allele. However, none of the Eskimos had Gmzax;g, though it occurred at a low or moderate frequency in the five Chukchi populations studied. It is assumed that Chukchi can be distinguished from adjoining Eskimos by the same G1m (x) outlier, that has been considered as a taxonomic marker useful in differentiating between Eskimos and American Indians. Comparison of North Asian and North American populations with respect to the array and frequencies of Gm haplotypes and the Km1 allele, supports the hypothesis of a nonrandom distribution of the Gmza;bst and Km1 on both sides of the Bering Strait.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00274206

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent “forbidden” combinations of DQA1 and DQB1 alleles. We suggest that a set of “public” haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004390050650

    Articles: DFG German National Licenses
  11. 11
    Sukernik, R. I. ; Skorova, S. V. ; Kaznacheev, V. P.
    Springer
    Published 1970
    Staff View
    ISSN:
    1573-8221
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00798983

    Articles: DFG German National Licenses