Search Results - (Author, Cooperation:R. Saxena)
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1P. K. Joshi ; T. Esko ; H. Mattsson ; N. Eklund ; I. Gandin ; T. Nutile ; A. U. Jackson ; C. Schurmann ; A. V. Smith ; W. Zhang ; Y. Okada ; A. Stancakova ; J. D. Faul ; W. Zhao ; T. M. Bartz ; M. P. Concas ; N. Franceschini ; S. Enroth ; V. Vitart ; S. Trompet ; X. Guo ; D. I. Chasman ; J. R. O'Connel ; T. Corre ; S. S. Nongmaithem ; Y. Chen ; M. Mangino ; D. Ruggiero ; M. Traglia ; A. E. Farmaki ; T. Kacprowski ; A. Bjonnes ; A. van der Spek ; Y. Wu ; A. K. Giri ; L. R. Yanek ; L. Wang ; E. Hofer ; C. A. Rietveld ; O. McLeod ; M. C. Cornelis ; C. Pattaro ; N. Verweij ; C. Baumbach ; A. Abdellaoui ; H. R. Warren ; D. Vuckovic ; H. Mei ; C. Bouchard ; J. R. Perry ; S. Cappellani ; S. S. Mirza ; M. C. Benton ; U. Broeckel ; S. E. Medland ; P. A. Lind ; G. Malerba ; A. Drong ; L. Yengo ; L. F. Bielak ; D. Zhi ; P. J. van der Most ; D. Shriner ; R. Magi ; G. Hemani ; T. Karaderi ; Z. Wang ; T. Liu ; I. Demuth ; J. H. Zhao ; W. Meng ; L. Lataniotis ; S. W. van der Laan ; J. P. 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Kanoni ; S. M. Kerr ; N. M. Khan ; P. Koellinger ; H. A. Koistinen ; M. K. Kooner ; M. Kubo ; J. Kuusisto ; J. Lahti ; L. J. Launer ; R. A. Lea ; B. Lehne ; T. Lehtimaki ; D. C. Liewald ; L. Lind ; M. Loh ; M. L. Lokki ; S. J. London ; S. J. Loomis ; A. Loukola ; Y. Lu ; T. Lumley ; A. Lundqvist ; S. Mannisto ; P. Marques-Vidal ; C. Masciullo ; A. Matchan ; R. A. Mathias ; K. Matsuda ; J. B. Meigs ; C. Meisinger ; T. Meitinger ; C. Menni ; F. D. Mentch ; E. Mihailov ; L. Milani ; M. E. Montasser ; G. W. Montgomery ; A. Morrison ; R. H. Myers ; R. Nadukuru ; P. Navarro ; M. Nelis ; M. S. Nieminen ; I. M. Nolte ; G. T. O'Connor ; A. Ogunniyi ; S. Padmanabhan ; W. R. Palmas ; J. S. Pankow ; I. Patarcic ; F. Pavani ; P. A. Peyser ; K. Pietilainen ; N. Poulter ; I. Prokopenko ; S. Ralhan ; P. Redmond ; S. S. Rich ; H. Rissanen ; A. Robino ; L. M. Rose ; R. Rose ; C. Sala ; B. Salako ; V. Salomaa ; A. P. Sarin ; R. Saxena ; H. Schmidt ; L. J. Scott ; W. R. Scott ; B. Sennblad ; S. Seshadri ; P. Sever ; S. Shrestha ; B. H. Smith ; J. A. Smith ; N. Soranzo ; N. Sotoodehnia ; L. Southam ; A. V. Stanton ; M. G. Stathopoulou ; K. Strauch ; R. J. Strawbridge ; M. J. Suderman ; N. Tandon ; S. T. Tang ; K. D. Taylor ; B. O. Tayo ; A. M. Toglhofer ; M. Tomaszewski ; N. Tsernikova ; J. Tuomilehto ; A. G. Uitterlinden ; D. Vaidya ; A. van Hylckama Vlieg ; J. van Setten ; T. Vasankari ; S. Vedantam ; E. Vlachopoulou ; D. Vozzi ; E. Vuoksimaa ; M. Waldenberger ; E. B. Ware ; W. Wentworth-Shields ; J. B. Whitfield ; S. Wild ; G. Willemsen ; C. S. Yajnik ; J. Yao ; G. Zaza ; X. Zhu ; R. M. Salem ; M. Melbye ; H. Bisgaard ; N. J. Samani ; D. Cusi ; D. A. Mackey ; R. S. Cooper ; P. Froguel ; G. Pasterkamp ; S. F. Grant ; H. Hakonarson ; L. Ferrucci ; R. A. Scott ; A. D. Morris ; C. N. Palmer ; G. Dedoussis ; P. Deloukas ; L. Bertram ; U. Lindenberger ; S. I. Berndt ; C. M. Lindgren ; N. J. Timpson ; A. Tonjes ; P. B. Munroe ; T. I. Sorensen ; C. N. Rotimi ; D. K. Arnett ; A. J. 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Chambers ; J. S. Kooner ; D. P. Strachan ; H. Campbell ; J. N. Hirschhorn ; M. Perola ; O. Polasek ; J. F. Wilson
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biological Evolution ; Blood Pressure/genetics ; Body Height/*genetics ; Cholesterol, LDL/genetics ; *Cognition ; Cohort Studies ; Educational Status ; Female ; Forced Expiratory Volume/genetics ; Genome, Human/genetics ; *Homozygote ; Humans ; Lung Volume Measurements ; Male ; PhenotypePublished by: -
2Staff View
Publication Date: 2018-05-10Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
3Saxena, R. R. ; Fouquet, J. E. ; Sardi, V. M. ; Moon, R. L.
Woodbury, NY : American Institute of Physics (AIP)
Published 1988Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: A systematic study compares the quality of InP epitaxial layers grown by low-pressure organometallic vapor phase epitaxy (OMVPE) using triethylindium, phosphine, and tertiarybutylphosphine (TBP) sources. High quality InP layers are obtained with either phosphorus source for growth at a high V/III ratio. The full widths at half-maximum (FWHM) of the main 4 K photoluminescence peak from InP layers grown with phosphine and TBP sources are 1.1 and 1.3 meV, respectively. This 1.3 meV FWHM is the narrowest reported for InP grown by OMVPE with a nonhydride phosphorus source. High quality InP layers can be grown at a lower V/III ratio with the TBP source than with the phosphine source.Type of Medium: Electronic ResourceURL: -
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ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The paper aims at the detailed analytical investigation of Raman instability in a magnetoactive n-type cubic piezoelectric semiconducting crystal belonging to class 4¯3m under a geometrical configuration which can also be employed in analyzing the phenomenon under either Voigt or Faraday orientation. The electric vector E0 of the spatially uniform pump electromagnetic wave (applied along the y axis) is normal to the magnetostatic field B0 (along the z axis) as well as to the plane of propagation (x-z plane) of the scattered waves (Ω,k) and (Ω1,k1). The propagation vectors k, k1 (antiparallel to each other) are in the x-z plane making an angle θ with the x axis. The dispersion relation has been obtained by using a hydrodynamic model of the homogeneous, piezoelectric, one-component (electron) semiconducting plasma; and the threshold value of the pump electric field (necessary to achieve physically reasonable growth of the unstable mode) and the growth rate of the unstable Raman mode well above the threshold field have been obtained for isotropic (B0=0) and magnetoactive (B0≠0) plasmas. We have applied our analysis to a specific semiconductor, n-InSb at 77 K, duly irradiated by a pulsed 10.6-μm CO2 laser for numerical estimation. The phase velocity of the growing unstable mode is found to be constant over the whole range of system parameters and equal to the electromagnetic wave velocity in the crystal. The magnitude of threshold electric field decreases with increasing magnetostatic field and decreasing wave vector. The growth rate increases and attains a maximum value at a certain value of the pump intensity, magnetostatic field, and θ; and if these are raised further, growth rate starts decreasing. When the analysis is extended to Voigt and Faraday configurations, the results are not very encouraging.Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 1467-8691Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: The processes of individual conceptual discovery and its conversion into a new product or artifact are modelled in the form of a classical syllogism. The processes are represented as cycles of interaction of three mental processes of professionalism, generalism, and philosophy, within a communication domain ‘journalism’ (‘PGP-J’). The system is illustrated with examples including the multiple cycles of innovativeness required within the development of new generations of soil infiltrometers.Type of Medium: Electronic ResourceURL: -
6Saxena, R. K. ; Rickards, Tudor
Oxford, UK and Boston, USA : Blackwell Publishers Ltd
Published 1997Staff ViewISSN: 1467-8691Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: A regional irrigation project in India has been studied as a focus for economic growth through innovation over the period 1983–1993. The classical theory of Schumpeter is considered in terms of the irrigation potential of a dam as a primary environmental jolt or deviant. Subsequent secondary innovations are traced as new crops (‘products’) and processes. The main active ‘drivers’ were noted as technical influence agents and entrepreneurial end-users (farmers). Multiple tertiary innovations were also noted as emerging from the secondary innovations. It is suggested that the dynamics of economic growth through environmental jolts requires a combination of entrepreneurial and active processes as well as more passive diffusion processes. Thus early models of entrepreneurial and diffusional aspects of innovation may require adapting to a more integrated theory for explaining the economic consequences of regional development initiatives.Type of Medium: Electronic ResourceURL: -
7SAXENA, R. P. ; CHAND, LAXMI ; GARG, G. K. ; SINGH, B. P. N.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: Soaking pigeon pea seeds in 6% sodium bicarbonate solution for 1 h, followed by oven-drying to 10% moisture improved dehusking efficiency from 66% in untreated seeds, or 71% in water-soaked seeds similarly dried, to 94% yield of dhal. Treatment reduced gum and pectin content, increased enzyme activity, but caused losses in protein and starch content of the dhal.Type of Medium: Electronic ResourceURL: -
8Mojica, W D ; Saxena, R ; Starostik, P ; Cheney, R T
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Aims : To determine the frequency of point mutation in c-kit in CD117+ small cell lung cancer (SCLC). A significant proportion of SCLCs have been documented to be CD117+, thereby signifying they express the c-kit gene product. This finding suggests this tumour may be a potential target for tyrosine kinase inhibitor (TKI) agents directed at c-kit. A point mutation in exon 17 of the c-kit gene, however, can abrogate the binding of TKIs. This being the case, immunohistochemistry is necessary to identify potential candidates for treatment with TKIs, but DNA sequence analysis may need to be performed to determine if these tumours will respond.Methods and results : Tumour cells of 23 cases of SCLC showing immunoreactivity for CD117 were laser capture microdissected from archived formalin-fixed paraffin-embedded tissue and the DNA isolated. PCR on exon 17 of the c-kit gene was performed and the amplified product sequenced. No point mutations were detected.Conclusions : The absence of mutations in exon 17 of CD117+ SCLC suggests this tumour may respond to therapy with TKI.Type of Medium: Electronic ResourceURL: -
9SAXENA, R. ; HUMPHREYS, S. ; WILLIAMS, R. ; PORTMANN, B.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report a case of acetaminophen-induced liver necrosis in a 14-year-old girl. At autopsy, a 9 cm subcapsular nodule was present in the right lobe of the liver which showed distinct zonation: a central greyish white area of fibrolamellar carcinoma with a peripheral fleshy, tan-coloured rim ranging from 1 to 2 cm in thickness. This peripheral zone consisted of nodular, hyperplastic parenchyma resembling the changes seen in focal nodular hyperplasia, and stood out from the adjacent necrotic parenchyma. The sparing of this zone from the deleterious effects of acetaminophen provides indirect evidence of a predominantly arterial rather than portal blood supply to this region. The arterial supply was most probably derived from the tumour vasculature and may explain the parenchymal hyperplasia sometimes reported adjacent to a fibrolamellar carcinoma. Awareness of this phenomenon is essential when evaluating a needle biopsy, as sampling of this region may lead to a false negative diagnosis.Type of Medium: Electronic ResourceURL: -
10Kashyap, R. ; Choudhry, V. P. ; Mahapatra, M. ; Chumber, S. ; Saxena, R. ; Kaul, H. L.
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Postpartum acquired haemophilia is a rare but serious complication of an otherwise normal pregnancy. Patients usually present with postpartum haemorrhage (PPH) or uncontrolled bleeding following surgical interventions, which fail to respond to conservative treatment. A high index of clinical suspicion along with early laboratory diagnosis and prompt institution of appropriate therapy is essential for the management of acute bleeding episodes. Our patient, a 32-year-old female, presented with severe PPH and shock. She had undergone dilation and curettage three times, with subsequent total abdominal hysterectomy and internal iliac artery ligation, before she was diagnosed with acquired haemophilia (factor VIII autoantibodies) and an inhibitor level of 8 Bethesda units (BU). The patient underwent an abdominal laprotomy for removal of the abdominal packing used in the previous operation, and blood and blood clots, and was given FEIBA® therapy. The patient responded to these measure and the factor VIII inhibitor level decreased to 2 BU at the time of discharge 10 weeks later.Type of Medium: Electronic ResourceURL: -
11Mukhopadhyay, S. ; Saxena, R. ; Kashyap, R. ; Choudhry, V. P.
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Factor X (FX) deficiency is a rare coagulation disorder that usually presents with bleeding manifestations and is treated with fresh frozen plasma or prothrombin complex concentrates. We report a case of FX deficiency in which the patient presented with bleeding as well as thrombosis. The patient responded to Danazol and relapsed when the drug was stopped. The occurrence of thrombosis in FX deficiency and the role of Danazol in coagulopathies are reviewed.Type of Medium: Electronic ResourceURL: -
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ISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Haemophilia A and B remain the most common hereditary bleeding disorders in India, with 58% of the patients being below 10 years of age. CNS haemorrhage was observed in 5.8% and HIV infection was present in 8.7% of the patients. The main source of factor replacement therapy was fresh frozen plasma and cryoprecipitate. Only 48% of the patients with mild to moderate bleeding episodes received adequate factor therapy (more than 80% of the required factor level). Inadequate availability of fresh frozen plasma and cryoprecipitate and the prohibitive cost of commercial concentrate preparation are the chief limiting factors for adequate factor replacement therapy in India.Type of Medium: Electronic ResourceURL: -
13Saxena, R. ; Gupta, M. ; Gupta, P. K. ; Kashyap, R. ; Choudhry, V. P. ; Bhargava, M.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. In order to define the prevalence of haemostatic defects in women presenting with menorrhagia in our region, the coagulation data on women bleeders investigated in the Department of Haematology, AIIMS, were analysed. A total of 337 of the 2200 menorrhagic women investigated were characterized to have an inherited bleeding disorder; 221 of these 337 women presented with menorrhagia alone while 116 also had other associated bleeding manifestations as prolonged bleeding from injury site, ecchymotic patches in the skin, epistaxis, haematomas, haemarthroses and major bleeds like intracerebral bleeding. The tests performed included bleeding time (BT), platelet count, prothrombin time (PT), prothrombin consumption index (PCI), activated partial thromboplastin time (APTT), PF3 release with adenosine diphosphate (ADP) at 0 and 20 min, total PF3 assay and platelet Aggregation studies with collagen, ADP, adrenaline, arachidonic acid and ristocetin. Coagulation factor assays, von Willebrand antigen estimation, ristocetin cofactor assay and electron microscopy were performed wherever necessary.Inherited platelet dysfunction was seen in 283 (83.9%) of the patients. Amongst these, isolated PF3 availability defect was seen in 163 (48.4%) cases. Glanzman's thrombasthenia was seen in 30 (8.9%) patients, Storage pool disease in eight (2.4%) patients, arachidonic acid pathway defect in five (1.5%) patients and Bernard–Soulier Syndrome in six (1.8%) patients. In 71 (21.1%) patients, the platelet function defect could not be classified into any specific subtypes. Inherited defects of coagulation were observed in 54 (16%) of the cases. Amongst these, von Willebrand disease (vWD) was the most frequent being seen in 40 (11.9%) of the cases. Factor XIII deficiency was seen in one (0.3%), factor X deficiency in four (1.2%), factor VII deficiency in one (0.3%) and factor XII deficiency in one (0.3%) of the patients.It is concluded that although hereditary platelet function defects constitute a large majority of women bleeders in India but among the coagulation defects, vWD is the commonest as reported from the caucasian population. It is thus suggested that in women presenting with menorrhagia, screening tests for haemostasis especially for vWD and inherited platelet function defects must be performed.Type of Medium: Electronic ResourceURL: -
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ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Figure 1 shows that the addition of the anterior pituitary extract (APE) to the isolated thymocytes resulted in a notable stimulation of the incorporation of 3H-thymidine into cold trichloroacetic acid (TCA)-precipitable pellet. A stimulation with APE was consistently obtained but the extent varied ...Type of Medium: Electronic ResourceURL: -
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ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1. Cooling curves for mercury and water with and without the magnetic field. Curves AI and BI refer to mercury, whiJe A and B* are for water. Curve B corresponds to the cooling in a magnetic field of ~ 23,000 oersteds and A refers to field free cooling. Abscissa denotes time in minutes and ...Type of Medium: Electronic ResourceURL: -
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ISSN: 0003-2670Keywords: Atomic absorption spectrometry ; Cadmium ; Chelating resin ; Lead ; Nickel ; Preconcentration ; Waters ; ZincSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Saxena, R. ; Sardi, V. ; Oberstar, J. ; Hodge, L. ; Keever, M. ; Trott, G. ; Chen, K.L. ; Moon, R.
Amsterdam : ElsevierStaff ViewISSN: 0022-0248Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyGeosciencesPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 0039-9140Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Durani, S. ; Agarwal, A.K. ; Saxena, R. ; Setty, B.S. ; Gupta, R.C. ; Kole, P.L. ; Ray, S. ; Anand, N.
Amsterdam : ElsevierStaff ViewISSN: 0022-4731Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: