Search Results - (Author, Cooperation:R. Sasisekharan)
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1Latest Papers from Table of Contents or Articles in PressS. S. Lakdawala ; A. Jayaraman ; R. A. Halpin ; E. W. Lamirande ; A. R. Shih ; T. B. Stockwell ; X. Lin ; A. Simenauer ; C. T. Hanson ; L. Vogel ; M. Paskel ; M. Minai ; I. Moore ; M. Orandle ; S. R. Das ; D. E. Wentworth ; R. Sasisekharan ; K. Subbarao
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Adaptation, Physiological/genetics ; Animals ; Epithelial Cells/metabolism/virology ; Female ; Ferrets/virology ; Hemagglutinin Glycoproteins, Influenza Virus/genetics/metabolism ; Humans ; Influenza A Virus, H1N1 Subtype/chemistry/genetics/*physiology ; Male ; Molecular Sequence Data ; Orthomyxoviridae Infections/transmission/virology ; Palate, Soft/chemistry/*metabolism/*virology ; Receptors, Virus/*metabolism ; Respiratory System/cytology/metabolism/virology ; *Selection, Genetic/genetics ; Sialic Acids/chemistry/metabolism ; Swine/virologyPublished by: -
2Articles: DFG German National LicensesUeda, Toshihiko ; Ueda, Takako ; Fukuda, Shohei ; Browne, Richard ; Jenis, Edwin ; Spengler, Robert ; Chou, Richard ; Buch, Peter ; Aljada, Ahmad ; Dandona, Paresh ; Sasisekharan, R. ; Dorey, C. Kathleen ; Armstrong, Donald
Springer
Published 1998Staff ViewISSN: 1573-7209Keywords: Cornea ; lipid hydroperoxide ; neovascularization ; rabbit ; tumor necrosis factor-α ; vascular endothelial growth factor.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Lipid hydroperoxides (LHP) at high concentrations are cytotoxic, but at sublethal concentration, they induce synthesis of cytokine vascular growth factors. Intracorneal injections of 30 μg LHP placed 5 mm from the superior limbus stimulated early vasodilation of limbal vasculature and a rapidly developing, sustained neovascularization. Under these conditions, vessels grew at the rate of 0.3 mm/day to a total length of 7.5 mm, 25 days after injection. Cholesterol peroxides were less effective. Developing vessels were oriented towards the stimulus. Around the developing vessel there was dissolution of the stromal extracellular matrix. The most distal endothelial cells displayed prominent endoplasmic reticulum, a lack of basement membrane or tight junction complexes and leakage of fluorescein dye. Both the injection site and superior quadrant showed increased levels of tumor necrosis factor (TNF)-α and vascular endothelial growth factor after exposure to LHP. The neovascular response was inhibited by simultaneous administration of TNF-α antibody or pentoxifylline, an inhibitor of TNF-α synthesis. This corneal model of peroxide-induced neovascularization should prove useful for temporal studies of events in the initiation and propagation of signals leading to neovascularization, and for evaluating effects of treatment on neovascular growth.Type of Medium: Electronic ResourceURL: