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1Latest Papers from Table of Contents or Articles in PressD. P. Locke ; L. W. Hillier ; W. C. Warren ; K. C. Worley ; L. V. Nazareth ; D. M. Muzny ; S. P. Yang ; Z. Wang ; A. T. Chinwalla ; P. Minx ; M. Mitreva ; L. Cook ; K. D. Delehaunty ; C. Fronick ; H. Schmidt ; L. A. Fulton ; R. S. Fulton ; J. O. Nelson ; V. Magrini ; C. Pohl ; T. A. Graves ; C. Markovic ; A. Cree ; H. H. Dinh ; J. Hume ; C. L. Kovar ; G. R. Fowler ; G. Lunter ; S. Meader ; A. Heger ; C. P. Ponting ; T. Marques-Bonet ; C. Alkan ; L. Chen ; Z. Cheng ; J. M. Kidd ; E. E. Eichler ; S. White ; S. Searle ; A. J. Vilella ; Y. Chen ; P. Flicek ; J. Ma ; B. Raney ; B. Suh ; R. Burhans ; J. Herrero ; D. Haussler ; R. Faria ; O. Fernando ; F. Darre ; D. Farre ; E. Gazave ; M. Oliva ; A. Navarro ; R. Roberto ; O. Capozzi ; N. Archidiacono ; G. Della Valle ; S. Purgato ; M. Rocchi ; M. K. Konkel ; J. A. Walker ; B. Ullmer ; M. A. Batzer ; A. F. Smit ; R. Hubley ; C. Casola ; D. R. Schrider ; M. W. Hahn ; V. Quesada ; X. S. Puente ; G. R. Ordonez ; C. Lopez-Otin ; T. Vinar ; B. Brejova ; A. Ratan ; R. S. Harris ; W. Miller ; C. Kosiol ; H. A. Lawson ; V. Taliwal ; A. L. Martins ; A. Siepel ; A. Roychoudhury ; X. Ma ; J. Degenhardt ; C. D. Bustamante ; R. N. Gutenkunst ; T. Mailund ; J. Y. Dutheil ; A. Hobolth ; M. H. Schierup ; O. A. Ryder ; Y. Yoshinaga ; P. J. de Jong ; G. M. Weinstock ; J. Rogers ; E. R. Mardis ; R. A. Gibbs ; R. K. Wilson
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-01-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Centromere/genetics ; Cerebrosides/metabolism ; Chromosomes ; Evolution, Molecular ; Female ; Gene Rearrangement/genetics ; Genetic Speciation ; *Genetic Variation ; Genetics, Population ; Genome/*genetics ; Humans ; Male ; Phylogeny ; Pongo abelii/*genetics ; Pongo pygmaeus/*genetics ; Population Density ; Population Dynamics ; Species SpecificityPublished by: -
2FIS Bildung LiteraturdatenbankSchmid, Hermann [Verfasser] ; Schmid-Steinke, Gisela [Verfasser] ; Schmidt, Roberto R. [Verfasser]
Published 1994Staff ViewType of Medium: articlePublication Date: 1994Keywords: Methode ; Moderation ; Beispiel ; Unterrichtsmethode ; Visuelle Wahrnehmung ; ErfahrungsberichtIn: Pädagogik (Weinheim), Bd. 46 (1994) H. 10, S. 27-31, 0933-422XLanguage: German -
3FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 1995Keywords: Führungsstil ; Methode ; Moderation ; Gruppenarbeit ; Mitbestimmung ; DefinitionIn: Pädagogik (Weinheim), Bd. 47 (1995) H. 6, S. 7-8, 0933-422XLanguage: German -
4Latest Papers from Table of Contents or Articles in PressShivaji A. Thadke, J. Dinithi R. Perera, V. M. Hridya, Kirti Bhatt, Ashif Y. Shaikh, Wei-Che Hsieh, Mengshen Chen, Chakicherla Gayathri, Roberto R. Gil, Gordon S. Rule, Arnab Mukherjee, Charles A. Thornton, Danith H. Ly
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-03-28Publisher: American Chemical Society (ACS)Print ISSN: 0006-2960Electronic ISSN: 1520-4995Topics: BiologyChemistry and PharmacologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-05Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
6Articles: DFG German National LicensesCONRAD, GARY W. ; SCHANTZ, ALLEN R. ; PATRON, ROBERTO R.
Oxford, UK : Blackwell Publishing Ltd
Published 1990Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesArabolaza, Ana L. ; Nakamura, Akira ; Pedrido, María E. ; Martelotto, Luciano ; Orsaria, Lelia ; Grau, Roberto R.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: Compartmentalized gene expression during sporulation is initiated after asymmetric division by cell-specific activation of the transcription factors σF and σE. Synthesis of these σ factors, and their regulatory proteins, requires the activation (phosphorylation) of Spo0A by the phosphorelay signalling system. We report here a novel regulatory function of the anti-anti-σF SpoIIAA as inhibitor of Spo0A activation. This effect did not require σF activity, and it was abolished by expression of the phosphorelay-independent form Spo0A-Sad67 indicating that SpoIIAA directly interfered with Spo0A∼P generation. IPTG-directed synthesis of the SpoIIE phosphatase in a strain carrying a multicopy plasmid coding for SpoIIAA and its specific inhibitory kinase SpoIIAB blocked Spo0A activation suggesting that the active form of the inhibitor was SpoIIAA and not SpoIIAA-P. Furthermore, expression of the non-phosphorylatable mutant SpoIIAAS58A (SpoIIAA-like), but not SpoIIAAS58D (SpoIIAA-P-like), completely blocked Spo0A-dependent gene expression. Importantly, SpoIIAA expressed from the chromosome under the control of its normal spoIIA promoter showed the same negative effect regulated not only by SpoIIAB and SpoIIE but also by septum morphogenesis. These findings are discussed in relation to the potential contribution of this novel inhibitory feedback with the proper activation of σF and σE during development.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesHollenstein, Hans ; Marquardt, Roberto R. ; Quack, Martin ; Suhm, Martin A.
College Park, Md. : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The pure rotational spectrum in the far-infrared and its absolute intensity in the vibrational ground state of CHD3 and CH3D, and the integrated band strength of the N=5 CH-stretching overtone of CHD3 in the near infrared to visible were measured by high-resolution interferometric Fourier transform techniques. The far-infrared data result in permanent electric dipole moments (||μz0||=(5.69±0.14)×10−3 D for CHD3, ||μz0||=(5.57±0.10)×10−3 D for CH3D), consistent with previous experimental data. The integrated N=5 overtone cross section is found to be (0.828±0.068) fm2. The overtone data are used, together with previous data, to derive a new, nine-dimensional, isotopically invariant dipole moment function for CH4 within the chromophore model for the CH chromophore in CHD3. With this function, the experimental data can be reproduced to an averaged factor of 1.2, in the best case. In the vibrational ground state, a nine-dimensional calculation of expectation values on a new, fully anharmonic potential surface was performed using the solution of the rovibrational Schrödinger equation by diffusion quantum Monte Carlo methods. The results for the rotational constants of several isotopomers, which include significant contributions from rovibrational interactions, indicate that the equilibrium CH bond length of methane is re=108.6 pm. The calculated value for the vibrationally averaged permanent dipole moment from these nine-dimensional vibrational quantum calculations, using the dipole moment function consistent with the analysis of the overtone bands, is μz0=−(6.6±0.4)×10−3 D for CHD3 (with positive z coordinate for the H atom) and μz0=(6.8±0.5)×10−3 D for CH3D (with positive z coordinate for the D atom) in essential agreement with the far-infrared rotational intensities. The sign could be determined unambiguously by comparison with ab initio data. We predict the permanent dipole moment of several further methane isotopomers. The polarity of the CH bond in methane is C−–H+, within our simple bond dipole model, but is discussed to be a model dependent (not purely experimental) quantity.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGALIZIO, NESTOR O. ; PESCE, RICARDO ; VALERO, ELINA ; GONZALEZ, JOSE L. ; FAVALORO, ROBERTO R. ; FAVALORO, LILIANA ; PERRONE, SERGIO ; DAVILA, PABLO ; GODOY, MIGUEL
350 Main Street , Malden , MA 02148-5018 , USA . : Blackwell Futura Publishing, Inc.
Published 2003Staff ViewISSN: 1540-8159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: GALIZIO, N.O., et al.: Which Patients with Congestive Heart Failure May Benefit from Biventricular Pacing? Background: Biventricular pacing improves the clinical status and ventricular function in patients with congestive heart failure (CHF) and intraventricular conduction delay. However, patient selection criteria including NYHA functional class, rhythm, PR interval, QRS duration (QRSd), left ventricular ejection fraction (LVEF), left ventricular diastolic diameter (LVDD), and other variables are not clearly defined. Objective: To determine which and how many patients referred for an initial cardiac transplantation evaluation may be eligible for biventricular pacing (BP) according to the criteria of recently completed trials of cardiac resynchronization therapy (CRT). Methods: This was a retrospective review of 200 patients, whose mean age was 51 ± 13 years (173 men). Sinus rhythm was present in 88% of the patients, 107 had a QRSd 〉120 ms, and 38% had left bundle branch block. LVDD was 72.5 ± 12 mm and LVEF 21.7 ± 9.3% ; 54% had mitral regurgitation. Results: When NYHA class, electrocardiographic, and ventricular function criteria were considered separately, a high proportion of patients appeared to be candidates for CRT: 70.5% were in NYHA functional class III/IV, 34% had QRSd ≥150 ms, 60% had LVDD ≥60 mm and 53.5% LVEF ≤35%. However, the proportions of patients eligible for CRT were different according to the selection criteria of recently completed trials: 18% of the patients with InSync criteria, 13% of the patients with MUSTIC SR criteria, 0.5% with MUSTIC AF criteria, 27% of patients with MIRACLE criteria, and 35% of the patients with CONTAK CD criteria (without considering indications for implantable cardioverter defibrillator). Conclusion: In this population-based study, a wide range of patients (13% to 35%) would have been candidates for CRT, according to the selection criteria of different completed trials.(PACE 2003; 26[Pt. II]:158–161)Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesOdegaard, Justin I. ; Ricardo-Gonzalez, Roberto R. ; Goforth, Matthew H. ; Morel, Christine R. ; Subramanian, Vidya ; Mukundan, Lata ; Eagle, Alex Red ; Vats, Divya ; Brombacher, Frank ; Ferrante, Anthony W. ; Chawla, Ajay
[s.l.] : Nature Publishing Group
Published 2007Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose tissue chronic overnutrition leads to macrophage infiltration, resulting in local inflammation that potentiates insulin resistance. For ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesAlmeida, Vilson R. ; Barrios, Carlos A. ; Panepucci, Roberto R. ; Lipson, Michal
[s.l.] : Macmillian Magazines Ltd.
Published 2004Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Photonic circuits, in which beams of light redirect the flow of other beams of light, are a long-standing goal for developing highly integrated optical communication components. Furthermore, it is highly desirable to use silicon—the dominant material in the microelectronic ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesHuang, I-Hsiu ; Waters, Michael ; Grau, Roberto R ; Sarker, Mahfuzur R
Oxford, UK : Blackwell Publishing Ltd
Published 2004Staff ViewISSN: 1574-6968Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: This study identified a functional spo0A ORF in enterotoxigenic Clostridium perfringens type A. To evaluate the function of spo0A, an isogenic spo0A knock-out mutant was constructed. The spo0A mutant was unable to form endospores and produce enterotoxin, however, these defects could be restored by complementing the mutant with a recombinant plasmid carrying the wild-type spo0A gene. These results provide evidence that spo0A expression is essential for sporulation and enterotoxin production in C. perfringens.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1522-9602Source: Springer Online Journal Archives 1860-2000Topics: BiologyMathematicsNotes: Abstract The evolutionary selection circuits model of learning has been specified algorithmically. The basic structural components of the selection circuits model are enzymatic neurons, that is, neurons whose firing behavior is controlled by membrane-bound macromolecules called excitases. Learning involves changes in the excitase contents of neurons through a process of variation and selection. In this paper we report on the behavior of a basic version of the learning algorithm which has been developed through extensive interactive experiments with the model. This algorithm is effective in that it enables single neurons or networks of neurons to learn simple pattern classification tasks in a number of time steps which appears experimentally to be a linear function of problem size, as measured by the number of patterns of presynaptic input. The experimental behavior of the algorithm establishes that evolutionary mechanisms of learning are competent to serve as major mechanisms of neuronal adaptation. As an example, we show how the evolutionary learning algorithm can contribute to adaptive motor control processes in which the learning system develops the ability to reach a target in the presence of randomly imposed disturbances.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1522-9602Source: Springer Online Journal Archives 1860-2000Topics: BiologyMathematicsNotes: Abstract The cycle structure of enzymatic neural networks may be characterized in terms of number of cycles exhibited, size of cycle state sets and cycle lengths. Simulation experiments show that the stability properties of these networks have some unusual features which are not exhibited by networks of two-state switching elements or by randomly constructed ecosystem models. The behavioral and structural stability of these systems decreases with their structural complexity, as measured by the number of components. The behavioral and structural stability of enzymatic neural networks also decreases with structural complexity, as measured by the number of excitase types, but only up to the middle level of excitases per neuron. This is the point of highest potential responsiveness of the system to environmental stimuli. Beyond this point the behavioral and structural stability increase. This is due to the fact that the number of possible states increases up to this point and decreases beyond it. The number of possible states, not the number of components, serves as the useful measure of complexity in these types of systems. The selection circuits learning algorithm has been used to evolve networks whose cycle structures have desired features.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1572-9001Keywords: AIM ; Peroxides ; atomic properties ; bond properties ; internal rotationSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyNotes: Abstract The evolution of the atomic and bond properties of hydrogen peroxide during H–O–O–H internal rotation was studied by means of Atoms in Molecules Theory. Wave functions obtained at several calculation levels were employed to test the reliability of the results. These levels included HF, MP2, QCISD, and B3LYP carried out with several basis sets. All the calculations show that the bondpath connecting the two oxygen atoms is a bent line, whose shape and orientation display a large variation along the internal rotation. The different calculation levels predict a very similar evolution for each property. We observed that the calculation level does not introduce important changes in the absolute values of the properties studied here, but comparisons between results provided by wave functions obtained after a geometry optimization carried out at an electron correlated level and results obtained after a HF geometry optimization. It was found that electron correlation provides lower electron populations and higher kinetic energies for the oxygen fragments in every conformation.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract A simple model for the hadronic contribution to the photon vacuum polarization function ∏had(q 2), for spacelike momenta, is presented. For small momenta, the two loop contribution from the pseudoscalar meson octet is computed from the chiral Lagrangian. The light quark contribution (which at low momentum gives the $$\mathcal{O}(q^6 )$$ counterterm in the chiral Lagrangian) is calculated within a relativistic constituent quark model incorporating the momentum dependence of the quark mass. The perturbative gluons of QCD are included in a standard fashion. The total result is close to an estimate of ∏had(q 2) that is obtained directly frome + e→hadrons data. We further use our results for ∏had(q 2) to calculate the $$\mathcal{O}(e^4 )$$ hadronic contribution to lepton magnetic moments and to calculate αQED(M Z 2 ). A simpler model of constituent quarks with momentum independent masses gives less favourable results.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1434-6052Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The decay rates for the exclusiveB decaysB→Kη c andB→K*η c are calculated in the context of the heavy quark effective theory. We obtainΓ(B→Kη c )/Γ (B→Kψ)=1.6±0.2 andΓ(B→K*η c )/Γ→ (K*ψ)=0.39±0.04. These results lead to estimates BR(B→Kη c )=(0.11±0.02)% and BR(B→K*η c )=(0.05±0.01)% if we use the central current experimental values forB→(K, K *)ψ branching ratios.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1590-3478Keywords: H reflex ; disc herniation ; roots L4, L5Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Sommario Un riflesso segmentario monosinaptico può essere evocato facilitandone la risposta attraverso una contrazione volontaria muscolare. La risposta riflessa dal mscolo Tibiale Anteriore (T.A.) è risultata in un gruppo di 15 volontari sani, 31.08+/−2.48 msec. con una differenza di lato di 0.41+/−0.36 msec. Dal Peroneo Lungo (P.L.) 29.90+/−2.20 msec. con differenza di lato di 0.38+/−0.25 msec. In un gruppo di 21 soggetti affetti da ernia discale, radiologicamente provata, (in 5 della radice L4, in 16 della radice L5) abbiamo riscontrato un ritardo oltre le 2.5 SD della differenza di lato o una assenza di risposta in 16 casi su 21. Data la semplicità e la rapidità della metodica se ne auspica un utilizzo routinario come completamento di una indagine elettromiografica convenzionale.Notes: Abstract A segmental monosynaptic reflex that can be evoked by using voluntary muscle contraction to facilitate it is of use in diagnosis. In a group of 15 healthy volunteers the reflex response from tibialis anterior proved to be 31.08±2.48 msec with a side difference of 0.41±0.36 msec and from peroneus longus 29.90±2.20 msec with a side difference of 0.38±0.25 msec. Of 21 patients with radiologically proven disc herniation (of root L4 in 5 and of root L5 in 16) 16 showed a delay of more than 2.5 SD of the side difference or no response at all. It is hope that this simple and speedy method will be routinely adopted as complement to standard electromyography.Type of Medium: Electronic ResourceURL: