Search Results - (Author, Cooperation:R. Ravindran)
-
1R. Ravindran ; N. Khan ; H. I. Nakaya ; S. Li ; J. Loebbermann ; M. S. Maddur ; Y. Park ; D. P. Jones ; P. Chappert ; J. Davoust ; D. S. Weiss ; H. W. Virgin ; D. Ron ; B. Pulendran
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-12-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Antigen Presentation ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; Cricetinae ; Dendritic Cells/enzymology/*immunology ; Enzyme Activation ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Microtubule-Associated Proteins/genetics ; Protein-Serine-Threonine Kinases/*biosynthesis/genetics ; Yellow Fever Vaccine/*immunologyPublished by: -
2S. P. Kasturi ; I. Skountzou ; R. A. Albrecht ; D. Koutsonanos ; T. Hua ; H. I. Nakaya ; R. Ravindran ; S. Stewart ; M. Alam ; M. Kwissa ; F. Villinger ; N. Murthy ; J. Steel ; J. Jacob ; R. J. Hogan ; A. Garcia-Sastre ; R. Compans ; B. Pulendran
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-26Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/biosynthesis/*immunology ; Antibodies, Viral/biosynthesis/*immunology ; Antibody Formation/*immunology ; Dendritic Cells/cytology/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Immunity, Innate/*immunology ; Immunologic Memory/*immunology ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H5N1 Subtype/immunology ; Influenza Vaccines/administration & dosage/*immunology ; Lactic Acid ; Ligands ; Lymph Nodes/cytology/immunology ; Lymphocyte Activation ; Macaca mulatta/immunology/virology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Nanoparticles/administration & dosage ; Plasma Cells/cytology/immunology/metabolism ; Polyglycolic Acid ; T-Lymphocytes/immunology ; Toll-Like Receptors/immunology/metabolismPublished by: -
3R. Ravindran ; J. Loebbermann ; H. I. Nakaya ; N. Khan ; H. Ma ; L. Gama ; D. K. Machiah ; B. Lawson ; P. Hakimpour ; Y. C. Wang ; S. Li ; P. Sharma ; R. J. Kaufman ; J. Martinez ; B. Pulendran
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acids/administration & dosage/deficiency/*metabolism/pharmacology ; Animals ; Antigen-Presenting Cells/immunology/metabolism ; Autophagy ; Colitis/etiology/*metabolism/pathology/prevention & control ; Disease Models, Animal ; Epithelial Cells/metabolism ; Female ; Humans ; Inflammasomes/*antagonists & inhibitors/metabolism ; Inflammation/etiology/*metabolism/pathology/prevention & control ; Interleukin-1beta/immunology ; Intestines/*metabolism/*pathology ; Male ; Mice ; Microtubule-Associated Proteins/deficiency/metabolism ; Protein-Serine-Threonine Kinases/deficiency/genetics/*metabolism ; Reactive Oxygen Species/metabolism ; Stress, Physiological ; Th17 Cells/immunology ; Ubiquitin-Activating Enzymes/deficiency/metabolismPublished by: -
4A. M. Keestra-Gounder ; M. X. Byndloss ; N. Seyffert ; B. M. Young ; A. Chavez-Arroyo ; A. Y. Tsai ; S. A. Cevallos ; M. G. Winter ; O. H. Pham ; C. R. Tiffany ; M. F. de Jong ; T. Kerrinnes ; R. Ravindran ; P. A. Luciw ; S. J. McSorley ; A. J. Baumler ; R. M. Tsolis
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-03-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacterial Outer Membrane Proteins/metabolism ; Brucella abortus/immunology/pathogenicity ; Cell Line ; Dithiothreitol/pharmacology ; Endoplasmic Reticulum/drug effects/pathology ; *Endoplasmic Reticulum Stress/drug effects ; Endoribonucleases/antagonists & inhibitors ; Female ; Humans ; Immunity, Innate ; Inflammation/chemically induced/*metabolism ; Interleukin-6/biosynthesis ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Nod1 Signaling Adaptor Protein/immunology/*metabolism ; Nod2 Signaling Adaptor Protein/immunology/*metabolism ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Receptors, Pattern Recognition/metabolism ; *Signal Transduction/drug effects ; TNF Receptor-Associated Factor 2/metabolism ; Taurochenodeoxycholic Acid/pharmacology ; Thapsigargin/pharmacology ; Unfolded Protein Response/drug effectsPublished by: -
5Staff View
ISSN: 0022-328XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1435-1528Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyPhysicsNotes: Summary In the present paper, we have undertaken a comparative study of the flow behaviour of two types of fluids —Eringen's mioropolar fluid andStokes' couple stress fluid — in a simple oscillatory flow. This study was undertaken with a view to see if the close resemblance of the flow behaviour of these two fluids in steady shearing flows was maintained even in time dependent flows. We find that the flow behaviour of these two fluids are widely different in oscillatory motion.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1435-1528Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyPhysicsNotes: Summary In the present paper we have made a study of simple shearing flows in three polar fluids — (i) the model ofCondiff andDahler, (ii) the model ofEringen, and (iii) the model ofStokes. We have investigated in detail the components of stress, equations governing the motion and boundary conditions in the above fluids in flows induced by motion of boundaries or a pressure gradient. By means of tables, we have studied the common features of these fluids and related the fluid parameters involved in each case.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1619-6937Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Summary The shock manifold equation is a first order nonlinear partial differential equation, which describes the kinematics of a shockfront in an ideal gas with constant specific heats. However, it was found that there was more than one of these shock manifold equations, and the shock surface could be embedded in a one parameter family of surfaces, obtained as a solution of any of these shock manifold equations. Associated with each shock manifold equation is a set of characteristic curves called ‘shock rays’. This paper investigates the nature of various associated shock ray equations.Type of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1619-6937Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsDescription / Table of Contents: Zusammenfassung In der vorliegenden Arbeit wird das Charakteristikenverfahren für zweidimensionale instationäre Strömungen auf ein Problem der Axialturbinen angewandt. Das System besteht aus zwei Gitterreihen, den feststehenden Leitschaufeln und den hierzu senkrecht bewegten Laufschaufeln. Die anfangs ungestörte konstante Strömung wird gestört, indem den Laufschaufeln eine geringe Normalgeschwindigkeit erteilt wird, um eine konstante Anstellung zu simulieren. Die gestörte Strömung ist periodisch nach den ersten drei Perioden. Berechnet wurde das gestörte Dichtefeld während einer Periode.Notes: Summary In this paper we have used the method of characteristics developed for two dimensional unsteady flow problems to study a simplified axial turbine problem. The system consists of two sets of blades —the guiding vanes which are fixed and the rotor blades which move perpendicular to these vanes. The initial undisturbed constant flow in the system is perturbed by introducing a small velocity normal to the rotor blades to simulate a slight constant inclination. The resulting perturbed flow is periodic after the first three cycles. We have studied the perturbed density distribution throughout the system during a period.Type of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 1619-6937Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Summary With the use of tensor analysis and the method of singular surfaces, an infinite system of equations can be derived to study the propagation of curved shocks of arbitrary strength in gas dynamics. The first three of these have been explicitly given here. This system is further reduced to one involving scalars only. The choice of dependent variables in the infinite system is quite important, it leads to coefficients free from singularities for all values of the shock strength.Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 1619-6937Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: Summary In this paper the kinematics of a weak shock front governed by a hyperbolic system of conservation laws is studied. This is used to develop a method for solving problems, involving the propagation of nonlinear unimodal waves. It consists of first solving the nonlinear wave problem by moving along the bicharacteristics of the system and then fitting the shock into this solution field, so that it satisfies the necessary jump conditions. The kinematics of the shock leads in a natural way to the definition of “shock-rays”, which play the same role as the “rays” in a continuous flow. A special case of a circular cylinder introduced suddenly in a constant streaming flow is studied in detail. The shock fitted in the upstream region propagates with a velocity which is the mean of the velocities of the linear and the nonlinear wave fronts. In the downstream the solution is given by an expansion wave.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1619-6937Source: Springer Online Journal Archives 1860-2000Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsDescription / Table of Contents: Zusammenfassung Die vorliegenden Untersuchungen beziehen sich auf die mathematische Behandlung des „Modalwellen”-Problems. Die achsensymmetrische Strömung einer nichtviskosen Flüssigkeit in einem dünnwandigen viskoelastischen Rohr, unter bestimmten vereinfachenden Annahmen, wird betrachtet. Zuerst werden die Gleichungen des Ausbreitungsraumes im Langwellenbereich abgeleitet und eine allgemeine Methode zur Herleitung dieser Gleichungen für beliebige Wellenlängen bei nichtrotierender Strömung angegeben. Eine Operatorenmethode mit multiplem Maßstab wird verwendet zur Herleitung der nichtlinearen Schrödinger-Gleichung für die Modulation der periodischen Wellen, und die „langmodulierten Wellen” sowie die „modulierten Langwellen” werden aufgezeigt. Weiters wird die Existenz und die Stabilität der Stokes-Wellen im System untersucht. Anschließend werden die progressiven Wellenlösungen der Langwellengleichungen diskutiert. Eines der wichtigsten Ergebnisse dieser Arbeit ist, daß die Gleichungen des Ausbreitungsraumes keine partiellen Differentialgleichungen mehr sind, sondern Ausdrücke von Pseudo-Differentialoperatoren.Notes: Summary Our investigations in this paper are centred around the mathematical analysis of a “modal wave” problem. We have considered the axisymmetric flow of an inviscid liquid in a thinwalled viscoelastic tube under certain simplifying assumptions. We have first derived the propagation space equations in the long wave limit and also given a general procedure to derive these equations for arbitrary wave length, when the flow is irrotational. We have used the method of operators of multiple scales to derive the nonlinear Schrödinger equation governing the modulation of periodic waves and we have elaborated on the “long modulated waves” and the “modulated long waves”. We have also examined the existence and stability of Stokes waves in this system. This is followed by a discussion of the progressive wave solutions of the long wave equations. One of the most important results of our paper is that the propagation space equations are no longer partial differential equations but they are in terms of pseudo-differential operators.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1435-1528Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyPhysicsDescription / Table of Contents: Zusammenfassung Das Fließen einzelner großer Flüssigkeitsblasen in geschlossenen Rohren unter dem Einfluß der Schwerkraft wird für den Fall untersucht, daß die Flüssigkeitsblase mikropolares Verhalten zeigt. Die Filmdicke, das Geschwindigkeitsprofil in der Blase und dem umgebenden Film sowie die nicht-newtonschen Wirkungen werden untersucht und mit den entsprechenden Größen für einenewtonsche Flüssigkeit verglichen. Die Untersuchung beschränkt sich auf den Spezialfall, daß die Länge der Blase viel größer als der Rohrradius ist.Notes: Summary The flow of single large liquid bubbles under gravity in closed tubes is studied here for the case when the liquid bubble exhibits micropolar behaviour. The film thickness, velocity profile in the bubble and film, and nonNewtonian effects are studied and compared with those for the correspondingNewtonian fluid. The investigation is restricted to the case where the bubble length is far greater than the tube radius.Type of Medium: Electronic ResourceURL: