Search Results - (Author, Cooperation:R. Pickering)
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1Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao, Jing Wang, Mei Zhao, Nene N. Kalu, Faye M. Johnson, Lauren A. Byers, John Heymach, Walter N. Hittelman, Durga Udayakumar, Raj K. Pandita, Tej K. Pandita, Curtis R. Pickering, Abena B. Redwood, Helen Piwnica-Worms, Katharina Schlacher, Mitchell J. Frederick, Jeffrey N. Myers
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-02-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 0008-5472Electronic ISSN: 1538-7445Topics: MedicinePublished by: -
2N. Agrawal ; M. J. Frederick ; C. R. Pickering ; C. Bettegowda ; K. Chang ; R. J. Li ; C. Fakhry ; T. X. Xie ; J. Zhang ; J. Wang ; N. Zhang ; A. K. El-Naggar ; S. A. Jasser ; J. N. Weinstein ; L. Trevino ; J. A. Drummond ; D. M. Muzny ; Y. Wu ; L. D. Wood ; R. H. Hruban ; W. H. Westra ; W. M. Koch ; J. A. Califano ; R. A. Gibbs ; D. Sidransky ; B. Vogelstein ; V. E. Velculescu ; N. Papadopoulos ; D. A. Wheeler ; K. W. Kinzler ; J. N. Myers
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-07-30Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Carcinoma/drug therapy/*genetics/virology ; Carcinoma, Squamous Cell ; Cell Cycle Proteins/*genetics ; Codon, Nonsense ; Exons ; F-Box Proteins/*genetics ; Gene Dosage ; *Genes, Tumor Suppressor ; Genes, p53 ; Head and Neck Neoplasms/drug therapy/*genetics/virology ; Humans ; INDEL Mutation ; *Mutation ; Mutation, Missense ; Neoplasms, Squamous Cell/drug therapy/*genetics/virology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Receptor, Notch1/chemistry/*genetics ; Sequence Analysis, DNA ; Smoking ; Tobacco ; Ubiquitin-Protein Ligases/*geneticsPublished by: -
3Staff View
Publication Date: 2018-10-17Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
4R. Pickering ; P. H. Dirks ; Z. Jinnah ; D. J. de Ruiter ; S. E. Churchil ; A. I. Herries ; J. D. Woodhead ; J. C. Hellstrom ; L. R. Berger
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-09-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Fossils ; *Geologic Sediments ; Geology/methods ; *Hominidae/anatomy & histology/classification ; Magnetics ; Radiometric Dating ; South Africa ; Time ; UraniumPublished by: -
5Gould, L. J., Griffiths, P., Barker, H. R., Libberton, P., Mesa-Eguiagaray, I., Pickering, R. M., Shipway, L. J., Bridges, J.
BMJ Publishing
Published 2018Staff ViewPublication Date: 2018-02-23Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, Health services research, NursingPublished by: -
6Toubia-Rahme, H. ; Johnston, P. A. ; Pickering, R. A. ; Steffenson, B. J. ; Graner, A.
Oxford, UK : Blackwell Publishing Ltd
Published 2003Staff ViewISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Septoria speckled leaf blotch (SSLB), caused by Septoria passerinii, has become one of the most serious diseases of barley in the Upper Midwest region of the USA. The recombinant line 36L5 derived from a backcross of the susceptible barley cultivar ‘Emir’ and a resistant Hordeum bulbosum parent Cb2920/4/Colch was found to be resistant to S. passerinii. Two doubled haploids derived from 36L5 were backcrossed to cv.‘Emir’ to obtain two BCF2 populations for determining the inheritance of resistance to S. passerinii. BCF2 progeny and BCF2:3 families were evaluated at the seedling stage in the greenhouse for reaction to S. passerinii. BCF2 progeny and BCF2:3 families from both crosses segregated 3 : 1 (resistant : susceptible), and 1:2:1 (resistant : segregating : susceptible), respectively, indicating that the H. bulbosum-derived SSLB resistance is conferred by a single dominant gene. The H. bulbosum introgressions were positioned on chromosome 4HL by genomic and fluorescent in situ hybridizations (GISH and FISH, respectively) and by Southern hybridization with the rye repetitive sequence pSc119.2. These findings indicate that SSLB resistance in H. bulbosum has the potential to be transferred and utilized in barley breeding programs.Type of Medium: Electronic ResourceURL: -
7Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: A hybrid plant was regenerated from embryo-derived callus after crossing Hordeum vulgare with Psathyrostachys fragilis. A mciotic analysis of pollen mother cells revealed the frequent occurrence of one ring bivalent and twelve univalents. It appeared that eight H. vulgare and six P. fragilis chromosomes were present and an unknown duplicate H. vulgare chromosome had compensated for the loss of one P. fragilis chromosome. Although it remains unclear whether the anomaly was present in the original explain or had occurred during the callus phase, the technique could be used to investigate genome homology between the two species.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: A trisomic series was produced from a triploid plant of barley (Hordeum vulgare L. cv. ‘Golden Promise’) derived from tissue culture. Its characteristics are briefly described and compared with two trisomic series reported previously. Trisomic number 1 performed poorly under glasshouse conditions. Number 2 failed to set any seed after selfing and must be maintained by pollinating with ‘Golden Promise’. The series was subsequently used to locate a recessive chlorina gene on barley chromosome 3.Type of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Rod or ring bivalents at metaphase I (MI) reflect whether crossing-over has occurred on one or both pairs of chromosome arms, respectively, during meiotic prophase (pachytene). In cultivated barley (Hordeum vulgare) the highest frequencies of rod bivalents were found for satellite chromosomes (either 5H or 6H). To distinguish between chromosome 5H and 6H associations, a recombinant line derived from an H. vulgare × H. bulbosum hybrid with a hemizygous introgression from H. bulbosum on the short arm of chromosome 6H was probed with 45S rDNA and pSc119.2 using fluorescent in situ hybridization and compared with non-recombinant H. vulgare. The frequencies of rod bivalents, caused by failure of the short arms of 5H chromosomes (5HS) to associate during meiosis in the recombinant line, were similar to the frequencies of rod bivalents involving the satellite chromosomes in H. vulgare. Hence, rod bivalent formation in H. vulgare satellite chromosomes is probably based on reduced association of 5HS, corresponding to a low frequency of genetic recombination. 5HS is, therefore, more likely to show linkage disequilibrium than the other chromosome arms.Type of Medium: Electronic ResourceURL: -
10PICKERING, R. A. ; STEEFFENSON, B. J. ; HILL, A. M. ; BOROVKOVA, I.
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: While studying powdery mildew resistance in a recombinant line (code 81882) derived from a Hordeum vulgare (cv. ‘Vada’) ×Hordeum bulbosum hybrid, a low infection type of resistance to leaf rust was observed. To determine the mode of inheritance of the leaf rust resistance and whether there was linkage between the two resistances, F2 and F3 progenies from crosses between 81882 and ‘Vada’ were inoculated with the leaf rust and powdery mildew pathogens. Southern blots were prepared using restricted DNA extracted from leaves of 82 F2 plants and four chromosome 2HS sequences were hybridized with the blots to define the length of the introgression. The leaf rust resistance appears to be inherited as a single dominant gene on chromosome 2HS, which co-segregates with the powdery mildew resistance. There was an almost complete association between the resistances and the respective molecular markers, but it is likely that the strong linkage results from the frequent inheritance of the introgressed H. bulbosum DNA as an intact segment of chromatin with only low levels of recombination within the segment.Type of Medium: Electronic ResourceURL: -
11Gilpin, M. J. ; Pickering, R. A. ; Fautrier, A. G. ; Mcneil, D. L. ; Szigat, G. ; Hill, A. M. ; Kynast, R. G.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Anther culture (AC) was carried out on a fertile triploid hybrid between Hordeum vulgare L. (cultivated barley) and H. bulbosum L, (bulbous barley grass) to determine whether AC-derived regenerants differed from progeny obtained through selfing and backcrossing. Chromosome counts were carried out on all plants and DNA was extracted from them to prepare Southern blots for molecular analysis. To identify true recombinants, the blots were probed with rye repetitive sequence probes (pSc119.1 and pScl19.2). which hybridize strongly and specifically to H. bulbosum DNA. Twenty probes that detect single- or low-copy sequences were hybridized with Southern blots containing restricted DNA extracted from 25 AC-derived plants, 11 selfed and six backcrossed progeny that showed hybridizations with pScll9. Although restriction fragment length polymorphisms (RFLPs) were only observed using probes that map to four of the possible 14 chromosome arms, an introgression associated with chromosome 6HS was frequently observed among plants derived from AC. selfing and backcrossing. Plants from AC differed from selfed and backcrossed progeny in their chromosome number; unique RFLP bands that were occasionally observed may indicate chromosomal rearrangements.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Investigations were carried out to assess the suitability of the intergeneric cross Hordeum vulgare×Psathyrostachys fragilis for haploid barley production. H. vulgare cvs. ‘Emir’ and ‘Vada’ were each pollinated with P. fragilis P.I. 343192 and plants regenerated from embryos cultured on a modified B5 medium. Seed sets on ‘Vada’ were significantly lower than on ‘Emir’, and all the planes from ‘Vada’×P. fragile remained hybrid. Several of these flowered but there was little pairing between the parental chromosomes. Most of the plants from ‘Emir’×P. fragilis died, as seedlings but 3 plants developed into haploid barley. Because of the practical limitations of pollen availability from P. fragilis and the inconsistencies in haploid plant formation, it is unlikely that the cross will prove as valuable as that between H. vulgare×H. bulbosum for a doubled haploid barley programme.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Hordeum bulbosum has several desirable attributes, including disease resistance, which would be worthwhile transferring to H. vulgare. Despite homoeologous chromosome pairing in the interspecific hybrids, there have been few reports of successful gene introgression between the two species. A possible explanation for this is that recombinant male gametes are at a competitive disadvantage with normal balanced gametes during post-pollination events. To circumvent this problem, the possibility of obtaining plants directly from immature pollen grains was investigated. Anthers from diploid, triploid and tetraploid H. vulgare × H. bulbosum hybrids were cultured on defined media. Only hybrids with dehiscent anthers in vivo responded in culture, and after transfer of calli and embryoids to regeneration medium, 36 albino and 12 green plants were obtained. Seven of the green regenerants survived, one of which contained 15 H. vulgare chromosomes (including one acrocentric chromosome) and one H. bulbosum chromosome. Another regenerant (Ac166) resembled a diploid H. vulgare × H. bulbosum hybrid but had partial anther dehiscence and a slightly modified chromosome constitution. Mostly normal H. vulgare progeny were obtained from crosses between H. vulgare cv.‘Emir’ and Ac166, but three plants involved chromosome additions and substitutions.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Doubled haploid production from crosses between barley (Hordeum vulgare L.) and H. bulbosum L. is a well established technique for inducing homozygosity. One problem which occurs using certain barley cultivars is premature seed degeneration. In this paper, a post-pollination spray of gibberellic acid and 2,4-dichlorophenoxyacetic acid that delays the onset of senescence is described. The technique improved the number of high quality seeds to more than 75% of the seed set. This improvement should result in increased survival of embryos for culture and subsequent plant regeneration.Type of Medium: Electronic ResourceURL: -
15THOMPSON, C. ; WESTWELL, P. ; VINEY, D. ; WILSON, B. A. ; HILL, F. ; HARRINGTON, R. ; BRYANT, T. N. ; PICKERING, R.
Oxford, UK : Blackwell Publishing Ltd
Published 1996Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Sixty-four males with haemophilia were assessed with a series of neuropsychological tests and a structured interview for psychiatric symptoms. Thirty-one had been infected with human immunodeficiency virus (HIV) before the age of 18 and were in various stages of the disease at the time of testing and 33 were HIV negative. Sixteen male control subjects were recruited to match in age with the haemophilia group. The HIV-seropositive group were older than the HIV-negative group due to the cohort effect of the time of infection. Contrary to predictions from the known effects of HIV on the central nervous system the HIV-seropositive group performed better on many of the tests than the HIV-seronegative group. In some but not all of the tests this may have been an age effect. There was very little psychiatric morbidity, consistent with the view that high levels of psychological support provided by the haemophilia units can alleviate the effects of the illness on emotions and behaviour. These findings form a baseline for a 2-year follow-up study which is in progress.Type of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0307-4412Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0307-4412Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesURL: -
19Staff View
ISSN: 0026-7937Topics: Linguistics and Literary StudiesNotes: REVIEWSURL: -
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ISSN: 0026-7937Topics: Linguistics and Literary StudiesURL: