Search Results - (Author, Cooperation:R. M. Johnson)
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1Latest Papers from Table of Contents or Articles in PressK. M. Kapheim ; H. Pan ; C. Li ; S. L. Salzberg ; D. Puiu ; T. Magoc ; H. M. Robertson ; M. E. Hudson ; A. Venkat ; B. J. Fischman ; A. Hernandez ; M. Yandell ; D. Ence ; C. Holt ; G. D. Yocum ; W. P. Kemp ; J. Bosch ; R. M. Waterhouse ; E. M. Zdobnov ; E. Stolle ; F. B. Kraus ; S. Helbing ; R. F. Moritz ; K. M. Glastad ; B. G. Hunt ; M. A. Goodisman ; F. Hauser ; C. J. Grimmelikhuijzen ; D. G. Pinheiro ; F. M. Nunes ; M. P. Soares ; E. D. Tanaka ; Z. L. Simoes ; K. Hartfelder ; J. D. Evans ; S. M. Barribeau ; R. M. Johnson ; J. H. Massey ; B. R. Southey ; M. Hasselmann ; D. Hamacher ; M. Biewer ; C. F. Kent ; A. Zayed ; C. Blatti, 3rd ; S. Sinha ; J. S. Johnston ; S. J. Hanrahan ; S. D. Kocher ; J. Wang ; G. E. Robinson ; G. Zhang
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-05-16Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino-Acid N-Acetyltransferase ; Animals ; Bees/classification/*genetics ; DNA Transposable Elements ; *Evolution, Molecular ; Gene Expression Regulation ; Gene Regulatory Networks ; *Genetic Drift ; Genome, Insect/genetics ; Phylogeny ; Selection, Genetic ; *Social Behavior ; Transcription Factors/chemistry/genetics ; *TranscriptomePublished by: -
2Latest Papers from Table of Contents or Articles in PressA. S. Allen ; S. F. Berkovic ; P. Cossette ; N. Delanty ; D. Dlugos ; E. E. Eichler ; M. P. Epstein ; T. Glauser ; D. B. Goldstein ; Y. Han ; E. L. Heinzen ; Y. Hitomi ; K. B. Howell ; M. R. Johnson ; R. Kuzniecky ; D. H. Lowenstein ; Y. F. Lu ; M. R. Madou ; A. G. Marson ; H. C. Mefford ; S. Esmaeeli Nieh ; T. J. O'Brien ; R. Ottman ; S. Petrovski ; A. Poduri ; E. K. Ruzzo ; I. E. Scheffer ; E. H. Sherr ; C. J. Yuskaitis ; B. Abou-Khalil ; B. K. Alldredge ; J. F. Bautista ; A. Boro ; G. D. Cascino ; D. Consalvo ; P. Crumrine ; O. Devinsky ; M. Fiol ; N. B. Fountain ; J. French ; D. Friedman ; E. B. Geller ; S. Glynn ; S. R. Haut ; J. Hayward ; S. L. Helmers ; S. Joshi ; A. Kanner ; H. E. Kirsch ; R. C. Knowlton ; E. H. Kossoff ; R. Kuperman ; S. M. McGuire ; P. V. Motika ; E. J. Novotny ; J. M. Paolicchi ; J. M. Parent ; K. Park ; R. A. Shellhaas ; J. J. Shih ; R. Singh ; J. Sirven ; M. C. Smith ; J. Sullivan ; L. Lin Thio ; A. Venkat ; E. P. Vining ; G. K. Von Allmen ; J. L. Weisenberg ; P. Widdess-Walsh ; M. R. Winawer
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Child Development Disorders, Pervasive ; Cohort Studies ; Exome/genetics ; Female ; Fragile X Mental Retardation Protein/metabolism ; Genetic Predisposition to Disease/genetics ; Humans ; Infant ; Intellectual Disability/*genetics/physiopathology ; Lennox Gastaut Syndrome ; Male ; Mutation/*genetics ; Mutation Rate ; N-Acetylglucosaminyltransferases/genetics ; Probability ; Receptors, GABA-A/genetics ; Spasms, Infantile/*genetics/physiopathologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressJohnson, R. M., Yu, H., Strank, N. O., Karunakaran, K., Zhu, Y., Brunham, R. C.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-01-23Publisher: The American Society for Microbiology (ASM)Print ISSN: 0019-9567Electronic ISSN: 1098-5522Topics: MedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressPoffenberger, M. C., Metcalfe-Roach, A., Aguilar, E., Chen, J., Hsu, B. E., Wong, A. H., Johnson, R. M., Flynn, B., Samborska, B., Ma, E. H., Gravel, S.- P., Tonelli, L., Devorkin, L., Kim, P., Hall, A., Izreig, S., Loginicheva, E., Beauchemin, N., Siegel, P. M., Artyomov, M. N., Lum, J. J., Zogopoulos, G., Blagih, J., Jones, R. G.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Immunology, Medicine, DiseasesPublished by: -
5Articles: DFG German National LicensesVerity, A. Neil ; Wyatt, T. L. ; Hajos, B. ; Eglen, R. M. ; Baecker, P. A. ; Johnson, R. M.
Oxford, UK : Blackwell Science Ltd
Published 1998Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: We have monitored glial cell line-derived neurotrophic factor (GDNF) secretion from rat C6 glioblastoma cells by ELISA. Representative cytokines, neurotrophins, growth factors, neuropeptides, and pharmacological agents were tested for their ability to modulate GDNF release. Whereas most factors tested had minimal effect, a 24-h treatment with fibroblast growth factor-1, −2, or −9 elevated secreted GDNF protein levels five- to 10-fold. The proinflammatory cytokines interleukin-1β, interleukin-6, tumor necrosis factor-α, and lipopolysaccharide elevated GDNF release 1.5- to twofold. Parallel studies aimed at elucidating intracellular events that may regulate GDNF synthesis/release demonstrated the involvement of multiple signaling pathways. GDNF levels were increased by phorbol 12,13-didecanoate (10 nM) activation of protein kinase C, the Ca2+ ionophore A23187 (1 µM), okadaic acid (10 nM) inhibition of type-2A protein phosphatases, nitric oxide donors (1 mM), and H2O2 (1 mM)-induced oxidative stress. Elevation of cyclic AMP levels by either forskolin (10 µM) or dibutyryl cyclic AMP (1 mM) repressed GDNF secretion, as did treatment with the glucocorticoid dexamethasone (1 µM). Our results demonstrate that diverse biological factors are capable of modulating GDNF protein levels and that multiple signal transduction systems can regulate GDNF synthesis and/or release.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesAlvarez, R. A. ; Byrne, D. P. ; Johnson, R. M.
[S.l.] : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: It is possible to generate high-power microwave pulses with fast rise time by using resonant cavities to obtain power gain from pulse compression. In the usual case, especially when normal-conducting cavities are used, the principal output pulse from a pulse-compression device is preceded by a precursor signal that may be only 40 dB below the main pulse. For some applications this large a prepulse is unacceptable. We have developed a prototype normal-conducting, x-band, pulse-compression cavity in which the prepulse is suppressed by more than 70 dB. When this cavity is driven by a 20-kW source, output pulses with 200-kW peak power, 5-ns pulse width, and sub-nanosecond rise time can be obtained. We have also built an s-band cavity that has produced pulses of 5-ns width, 200-MW peak power, and under 3-ns rise time. The s-band cavity is typically driven at 5–10 MW and has a prepulse that can be more than 80 dB below the peak of the main pulse.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesRutkowski, H. L. ; Johnson, R. M. ; Greenway, W. G. ; Gross, M. A. ; Hewett, D. W. ; Humphries, S.
[S.l.] : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: Heavy ion fusion requires high current density, low-emittance ion sources that are reliable and long lived. We report experimental and simulation results on the performance of carbon arc ion sources intended for use in a scaled induction linac experiment. These sources use a planar electrostatic plasma switch to prevent plasma from entering the extraction gap before the extraction voltage pulse is applied. This provides good beam optics for short pulse extraction. Measurements of current density and emittance are presented. Both double-slit and channel plate-pepper pot techniques are used for emittance measurement. Data presented are from a compact three-arc source with plasma coupling of the cathodes. Data on lifetime and multiple arc triggering are also presented. The plasma switch performance has been modeled with a 2D explicit electrostatic particle-in-cell code. Results showing plasma shutoff phenomena and behavior during extraction are presented. A 2D steady-state ion flow model is also used to predict the optimum plasma switch geometry for producing minimum emittance generation at the switch surface.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: Samples of commercial casein were processed either in solution or dry at temperatures between 100° and 130° for up to 8 hr. Denaturation (loss of solubility) occurred mainly at 120° and 130° and was preceded by darkening and by changes in gel filtration pattern, which indicated that molecular association had taken place. In samples subjected to severe heat treatment there were significant losses of aspartic acid, threonine, serine, cystine, histidine and lysine but apparent increases in glycine and alanine. The relationships between the various changes are discussed.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2621Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: The Relative Nutritive Value (RNV), microbiologically available amino acids, Net Protein Utilization (NPU) and pepsin digestibility (used to predict NPU for fish protein concentrates limited by methionine) were determined for heated casein samples. The microbiological availabilities of seven amino acids fell uniformly and both available methionine and available isoleucine correlated with RNV. Microbiological availabilities were higher than chemically determined values reported previously and an explanation of this has been given. The pepsin digestibility method did not predict the NPU or RNV of severely heated casein and possible reasons for this have been discussed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesFung, M. C. ; Hapel, A. J. ; Ymer, S. ; Cohen, D. R. ; Johnson, R. M. ; Campbell, H. D. ; Young, I. G.
[s.l.] : Nature Publishing Group
Published 1984Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The cDNA sequence for murine interleukin-3, one of the colony stimulating factors that regulate haematopoiesis, codes for a polypeptide of 166 amino acids including a putative signal peptide. The predicted amino acid sequence indicates that formation of mature interleukin-3 involves proteolytic ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The freezing point of whey was determined at 3,5, 10,15, and 20% solids content in an automatic Osmometer, and effective molecular weight of the solute was determined to be 235 using freezing point depression equations. Differential Scanning Calorimetery was used to estimate the specific heat of whey in the temperature range -40 to 20°C. The frozen water fraction and refrigeration requirements are predicted as a function of temperature. Correlations of enthalpy and the freezing point of whey are presented. With these correlations, energy required for freezing whey can be computed. The application of therm odynamic data to whey freeze concentration is demonstrated.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1476-5535Keywords: Keywords: benzo[a]pyrene; bioaugmentation; polyaromatic hydrocarbons; Marasmiellus troyanusSource: Springer Online Journal Archives 1860-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Benzo[a]pyrene (B[a]P) is a carcinogenic polyaromatic hydrocarbon that enters the environment as an incomplete combustion production of fossil fuels. Several species of filamentous fungi are capable of biotransforming and/or mineralizing B[a]P in liquid cultures, however there has been less success in soil habitats. In this study, the litter rot fungus Marasmiellus troyanus was encapsulated in alginate and delivered to B[a]P-spiked soil microcosms (100 μg B[a]P/g soil) for 1, 2 and 6 weeks, with and without a fertilizer solution. After 2 weeks, 32.5% of B[a]P was recovered from soil microcosms treated with M. troyanus compared to 55–70% for controls. After 6 weeks, controls demonstrated an average percent recovery of B[a]P of 54% while M. troyanus-inoculated samples gave an average percent recovery of 11%. Similar bioaugmentation of contaminated habitats with appropriately formulated fungi has potential for practical bioremediation in soil environments. Journal of Industrial Microbiology & Biotechnology (2000) 25, 116–119.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0037-7996Topics: HistoryURL: -
15Articles: DFG German National LicensesGilbert, R. G. ; Nakayama, F. S. ; Bucks, D. A. ; French, O. F. ; Adamson, K. C. ; Johnson, R. M.
Springer
Published 1982Staff ViewISSN: 1432-1319Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Bacterial numbers and predominant bacterial types were determined in trickle irrigation systems receiving treated Colorado River water. Fourteen bacterial genera were isolated and identified from 86 water and sediment samples collected from trickle emitter systems receiving six water treatments. The bacteria identified were common aquatic and soil microbes and the genera in order of prevalence were Pseudomonas, Flavobacterium, Vibrio, Brevibacterium, Micrococcus, and Bacillus. A greater diversity of bacterial types was found in water that was sand filtered and received no chemical treatment. Regardless of the water treatment, Pseudomonas stutzeri was the predominant bacterium followed by Flavobacterium lutescens. The data indicated that pigmented bacteria, F. lutescens and ytophaga hutchinsonii caused the yellow color of the slime deposits in biologically clogged emitters; and, their growth was presumably supported by P. stutzeri., a nonpigmented bacterium. The occurrence of Bacillus sp. was enhanced by sand and screen filtration and markedly reduced by chemical conditioning the water with either chlorine and acid or acid alone. No strictly anaerobic bacteria, such as Clostridium sp., were detected in water treated with chlorine and acid. Iron bacteria, Sphaerotilus spp., were not detected in any water or sediment samples from trickle irrigation systems.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesWoodcock, R. J. ; Marx, W. F. ; Johnson, R. M. ; Lowe, J. M. ; Lipper, M. H. ; Kallmes, D. F.
Springer
Published 2000Staff ViewISSN: 1432-1920Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Telephone calls were made to 1251 consecutive patients one day following outpatient myelography. Data were available on 518 patients punctured with 22-gauge (g) (large-diameter) and 465 with 25-g (small-diameter) spinal needles. We surveyed 48 academic and private practice groups regarding needle diameter use in myelography; data were obtained from 34 private practice and 14 academic radiology departments. Patients reported adverse effects including mild and severe headache, back pain and nausea. The percentage of total adverse effects was significantly greater in the 22-g than in the 25-g needle group. The percentage of patients with headache was higher in the 22-g than in the 25-g group, but this difference was not statistically significant. Only 19 % of private practice groups and 17 % of academic centers use 25-g needles; the remainder use 20-g or 22-g needles.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesMcKellar, D. P. ; Johnson, R. M. ; Dutro, J. A. ; Mellinger, J. ; Bernie, W. A. ; Peoples, J. B.
Springer
Published 1995Staff ViewISSN: 1432-2218Keywords: Laparoscopic cholecystectomy ; Cholecystectomy ; Cost-effectivenessSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This study retrospectively evaluated the cost-effectiveness of laparoscopic cholecystectomy compared to open cholecystectomy in a single university-affiliated community hospital. The medical records of all patients that underwent laparoscopic cholecystectomy during 1990 and open cholecystectomy during 1989 in one hospital were reviewed. Hospital stay, hospital charges, surgeons' and anesthesiologists' fees were determined. Fifty patients from each group were contacted to determine recovery time to full activity after surgery. Those having common duct exploration and those converted to open cholecystectomy after an attempted laparoscopic cholecystectomy (n=8) were excluded. A summary of results is included below (Table 1). In our early experience with laparoscopic cholecystectomy we found that the total charges for laparoscopic cholecystectomy were more than for open cholecystectomy when one recognizes the 1-year difference in patient accrual between the two groups. Time to full recovery was markedly reduced in patients undergoing laparoscopic cholecystectomy compared to those having an open procedure. Despite the overall increased total charge with laparoscopic cholecystectomy, the shorter recovery period allowing the patients an earlier return to full preoperative activities contributes to its cost-effectiveness when compared to open cholecystectomy. Further experience with laparoscopic cholecystectomy and refinements in management of these patients should allow for further reductions in charges for this procedure.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0538-8066Keywords: Chemistry ; Physical ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: A comparative study of the kinetics of the N-nitrosation of sulfanilamide by cyclohexyl nitrite and by nitrous acid has been made, using an automated technique. The results indicate that a common nitrosating species is effective in analogous reactions involving cyclohexyl nitrite or nitrous acid. The N-nitrosation reaction has been followed spectrophotometrically by coupling the diazotized product with 1-naphthol. Under certain conditions a competitive reaction takes place in which coupling occurs with unreacted sulfanilamide.Additional Material: 4 Tab.Type of Medium: Electronic ResourceURL: