Search Results - (Author, Cooperation:R. L. Vessella)
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1Latest Papers from Table of Contents or Articles in PressK. Xu ; Z. J. Wu ; A. C. Groner ; H. H. He ; C. Cai ; R. T. Lis ; X. Wu ; E. C. Stack ; M. Loda ; T. Liu ; H. Xu ; L. Cato ; J. E. Thornton ; R. I. Gregory ; C. Morrissey ; R. L. Vessella ; R. Montironi ; C. Magi-Galluzzi ; P. W. Kantoff ; S. P. Balk ; X. S. Liu ; M. Brown
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-12-15Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Castration ; Cell Line, Tumor ; Cohort Studies ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; Jumonji Domain-Containing Histone Demethylases/metabolism ; Male ; Methyltransferases/chemistry/genetics/metabolism ; Mice ; Mice, Inbred ICR ; Mice, SCID ; Oncogene Proteins/genetics/*metabolism ; Polycomb Repressive Complex 2/genetics/*metabolism ; Prostatic Neoplasms/genetics/*metabolism/mortality ; Protein Structure, Tertiary ; Receptors, Androgen/metabolism ; Xenograft Model Antitumor AssaysPublished by: -
2Articles: DFG German National LicensesMOON, T. D. ; MORLEY, J. E. ; VESSELLA, R. L. ; LANGE, P. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Calcium is known to play an essential role in the lytic mechanism of natural killer cells (NK), which form a subset of large granular lymphocytes. Many of the intracellular effects of calcium are mediated through the calcium-binding protein calmodulin. In this study we have demonstrated that the specific calmodulin inhibitors (naphthalene-sulphonamides) inhibit NK activity in humans at IC50's of 6.9 μM for W7 and 5.2 μM for W13. Comparison of the potency of these compounds with their less active counterparts suggests that NK activity is calmodulin-dependent.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1433-8726Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The development of immunoassays for prostate-specific antigen (PSA) and their clinical utility are summarized. Because of the complexity of the PSA molecule and anti-PSA antibodies, there is currently no standard in PSA measurement [1, 2]. Evaluating various immunoassays requires the knowledge of the lower limit of detection as well as the biological and clinical thresholds of a given assay [1]. There have been recent reports demonstrating earlier detection of residual prostate cancer after radical prostatectomy by ultrasensitive assays for PSA [3, 4]. Because of the recent evidence for non-prostatic sources of PSA such as the male urethra [5–7], the possibility of their contaminating PSA levels must be evaluated when more sensitive assays for PSA are under consideration.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesLightner, D. J. ; Vessella, R. L. ; Chiou, R. K. ; Palme, D. F. ; Lange, P. H.
Springer
Published 1986Staff ViewISSN: 1433-8726Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Advanced renal cell carcinoma (RCC) is refractory to all traditional therapies and has been the subject of intense investigation using newer therapeutic modalities, including monoclonal antibodies, lymphokine-activated killer cells and vaccines. We review these newer immunotherapies and summarize our results with radioimmune imaging and radioimmunotherapy using mouse xenografts of human RCC and one of our RCC-preferential monoclonal antibodies (A6H). We have consistently been able to image RCC xenografts without background subtraction. Radioimmunotherapy caused tumor shrinkage, and dosimetry results were consistent with xenograft “cure.” Phase I clinical trials are now underway at this institution.Type of Medium: Electronic ResourceURL: