Search Results - (Author, Cooperation:R. Kapur)

2015-09-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Androgen Antagonists/pharmacology/*therapeutic use ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/*genetics ; Humans ; Male ; Mice ; Neoplastic Cells, Circulating/drug effects/*metabolism ; Phenylthiohydantoin/*analogs & derivatives/pharmacology/therapeutic use ; Prostate/drug effects/metabolism/pathology ; Prostatic Neoplasms/*drug therapy/*pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA Splicing ; Receptors, Androgen/*genetics ; Sequence Analysis, RNA/methods ; Signal Transduction ; Single-Cell Analysis/methods ; Transcriptome ; Wnt Proteins/genetics/*metabolism ; Xenograft Model Antitumor Assays

2014-07-12

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antineoplastic Agents/*pharmacology/therapeutic use ; Breast Neoplasms/*drug therapy/genetics ; Cell Culture Techniques ; Cell Separation ; Culture ; Drug Resistance, Neoplasm/*genetics ; Drug Screening Assays, Antitumor/methods ; Estrogen Receptor alpha/genetics ; Female ; Gene Frequency ; Humans ; Mice ; Microfluidics/methods ; *Molecular Targeted Therapy ; Mutation ; Neoplastic Cells, Circulating/*drug effects/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Sequence Analysis, DNA ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

2018-08-17

American Society of Hematology (ASH)

0006-4971

1528-0020

Biology

Medicine

Free Research Articles

1365-2303

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

During a recent discussion on classification of cervical cytology, the introduction of a ‘Borderline Nuclear Change – High Grade Dyskaryosis Not Excluded’ (BNCH) category was proposed. BNCH cases diagnosed prospectively were retrieved from laboratory records. Questionnaires were sent to referring practitioners regarding clinicopathological outcome. Cytopathological features resulting in the BNCH classification were recorded on slide review. A total of 103 reports on conventional cervical smears diagnosed as BNCH from 1999 to 2002 were retrieved, comprising 0.096% of 107 634 smears. Of 86/103 cases with clinical follow-up, CIN2 or worse was present in 30 (35%); 15 (17%) showed a borderline/low-grade abnormality and 41 (48%) were negative. No individual cytopathological feature was predictive of high-grade disease on follow-up. The yield of high-grade abnormalities on follow-up of BNCH supports the introduction of this terminology.

Electronic Resource

1365-3083

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Using a novel anti-natural killer (NK) cell monoclonal antibody (MoAb), we have recently identified an evolutionary conserved function-associated molecule (FAM) present on fish, rat and human NK cells. This molecule is involved in NK cell function as anti-FAM MoAbs inhibit cytotoxicity, stimulate lymphokine secretion and inhibit conjugate formation between effector cells and target cells. We now have examined murine NK cells for the presence of this structure. It was observed by two-colour flow cytometric analysis that the anti-FAM MoAb 5C6 specifically bound to a subpopulation of nylon wool non-adherent splenic lymphocytes (19–20%). The expression of the FAM molecule was restricted to NK cells that expressed the NK1.1 antigen. Neither T cells, B cells, nor macrophages reacted with the anti-FAM MoAb. Analysis of FAM expression in various lymphoid tissues revealed that splenocytes expressed the greatest numbers of MoAb(+) cells. Generation of lymphokine-activated killer (LAK) cells and adherent tymphokine-activated killer (ALAK) cells resulted in higher levels of FAM expression. The anti-FAM MoAb 5C6 also detected the presence of FAM on fresh SCID NK cells. It was demonstrated that the anti-FAM MoAb 5C6 inhibited the lysis of target cells by endogenous NK cells, activated NK cells, 5d LAK cells, ALAK cells and SCID NK cells. Moreover, conjugate assays demonstrated involvement of this molecule in recognition between NK cells and target cells.

Electronic Resource

1433-9285

Springer Online Journal Archives 1860-2000

Medicine

Summary The paper describes a study demonstrating that the screening of a few members of the population and asking them about the distribution of psychiatric symptoms in total population is a very inadequate way of discovering the real prevalence rates. The analysis shows that people report symptoms more amongst those who are socially and geographically close to them and amongst the members of their own sex. The characteristics of the ‘reporters’ are analysed and the results show that the young, the rich, the highly educated and those belonging to more advanced sections of the society are more prone to reporting symptoms in others. The most interesting finding is that those who have psychiatric symptoms themselves report symptoms in others more than those who are symptom-free.

Electronic Resource

1433-9285

Springer Online Journal Archives 1860-2000

Medicine

Summary The paper discusses the advantages of the structured interview in psychiatric research and goes on to describe the details of development of a structured interview Schedule (IPIS) suitable for an Indian setting. The Schedule is described, as well as the results of interinvestigator reliability tests. Possible uses of the instrument and the necessary further developments are outlined.

Electronic Resource

1433-9285

Springer Online Journal Archives 1860-2000

Medicine

Summary The paper describes the development of Indian Psychiatric Survey Schedule (IPSS) which is designed to inquire about the presence of 124 psychiatric symptoms and 10 items of historical information in the general population. The symptoms as well as the items of historical information are the same as those in IPIS (Kapur et al., 1974) but because of a multi-stage procedure adopted with IPSS, the inquiry takes much less time than that for IPIS. — A “preliminary interview schedule” which is meant for all members of the population can be used by a nonpsychiatrist after a short period of training. The other sections in IPSS, that is “detailed inquiry with the subject”, “detailed inquiry with an informant” and “observations during interview” are completed when necessary by a trained psychiatrist who also gives a physical examination when somatic symptoms are reported. — The paper describes the reasons why a multi-stage procedure was designed, a pilot study which helped reach certain decisions regarding the construction of the schedule and the results of a study carried out to test the level of agreement obtained when three non-psychiatrists (after a short period of training) and a psychiatrist used the preliminary interview schedule with 40 hospital patients and 40 members of the general population.

Electronic Resource

1573-7284

Pseudomonas aeruginosa ; Protease ; Elastase ; Aeruginocine typing

Springer Online Journal Archives 1860-2000

Medicine

Abstract Sixty six consecutive P. aeruginosa isolates from heterogeneous clinical specimens were subjected to aeruginocine (pyocine) typing and assayed for in vitro protease and elastase production by a simple and reproducible qualitative test. The 45.4% of the clinical isolates were found to be both protease and elastase (P + E +) producers; 40.9% were only protease producers (P + E −) and 13.6% were non producers (P− E t-). Aeruginocine code 7777 strains were found to be predominant among P + E + and P+ E− types, as 48.2% and 51.7% isolates belonged to the types, respectively, suggesting thereby the virulence of this aeruginocine type in P. aeruginosa infections and the possible association of protease and elastase production with aeruginocine production.

Electronic Resource

0165-005X

Springer Online Journal Archives 1860-2000

Ethnic Sciences

Medicine

Electronic Resource