Search Results - (Author, Cooperation:R. Kaji)

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  1. 1
    Staff View
    Publication Date:
    2011-10-08
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    3' Untranslated Regions/genetics ; Alternative Splicing/drug effects/*genetics ; Animals ; Disease Models, Animal ; Dystroglycans/metabolism ; Exons/*genetics ; Gene Knock-In Techniques ; Glycosylation ; Humans ; Introns/genetics ; Japan ; Laminin/metabolism ; Membrane Proteins/genetics/metabolism ; Mice ; Molecular Sequence Data ; Mutagenesis, Insertional/drug effects/genetics ; Oligonucleotides, Antisense/genetics/pharmacology/therapeutic use ; RNA Isoforms/genetics ; RNA Splice Sites/genetics ; Retroelements/*genetics ; Walker-Warburg Syndrome/*genetics/*pathology/therapy
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    S. Yamamoto, R. Matsusaki, R. Kaji, and S. Adachi
    American Physical Society (APS)
    Published 2018
    Staff View
    Publication Date:
    2018-02-27
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Published by:
    http://www.aps.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Nerve conduction study, reproducibility, F-wave latency, diabetic polyneuropathy, serial study, drug trial, intraclass correlation coefficient (ICC), intertrial variation, nerve conduction velocity, sensory nerve action potential, motor conduction velocity.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Aims/hypothesis. For use in future drug development for diabetic polyneuropathy, we conducted multicentre trials to assess the reproducibility of nerve conduction studies.¶Methods. All measurements were repeated twice at a time interval of 1–4 weeks in 132 healthy subjects (63 men) and 172 patients (99 men) with diabetic polyneuropathy. Using a standardised method, 32 centres participated in the study of control subjects and 65, in patients with diabetic polyneuropathy. Motor nerve conduction studies consisted of stimulating the left median and tibial nerves and recording the compound action potential from abductor policis and adductor hallucis for measuring amplitude, terminal latency and minimal F-wave latency. For sensory conduction studies, sensory nerve action potentials were recorded antidromically from the second digit and the posterior aspect of the lateral malleous after distal stimulation of the left median and sural nerves. We also calculated motor conduction velocity, F-wave conduction velocity and sensory conduction velocity. The relative intertrial variation and intraclass correlation coefficient were used as an index of reproducibility.¶Results. Of all the measurements, F-wave latency yielded the highest intraclass correlation coefficient with the smallest relative intertrial variation for both median and tibial nerves in both groups.¶Conclusion/interpretation. Median and tibial F-wave latency provide the most reproducible measures for a nerve conduction study, serving as one of the best measures in multicentre drug trials for diabetic polyneuropathies. [Diabetologia (2000) 43: 915–921]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250051469

    Articles: DFG German National Licenses