Search Results - (Author, Cooperation:R. J. Lefkowitz)
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1Latest Papers from Table of Contents or Articles in PressA. K. Shukla ; A. Manglik ; A. C. Kruse ; K. Xiao ; R. I. Reis ; W. C. Tseng ; D. P. Staus ; D. Hilger ; S. Uysal ; L. Y. Huang ; M. Paduch ; P. Tripathi-Shukla ; A. Koide ; S. Koide ; W. I. Weis ; A. A. Kossiakoff ; B. K. Kobilka ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/*chemistry/immunology/*metabolism ; Crystallography, X-Ray ; Humans ; Immunoglobulin Fab Fragments/chemistry/immunology/metabolism ; Models, Molecular ; Phosphopeptides/*chemistry/*metabolism ; Phosphorylation ; Protein Binding ; Protein Conformation ; Protein Stability ; Rats ; Receptors, Vasopressin/*chemistry ; RotationPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. K. Shukla ; G. H. Westfield ; K. Xiao ; R. I. Reis ; L. Y. Huang ; P. Tripathi-Shukla ; J. Qian ; S. Li ; A. Blanc ; A. N. Oleskie ; A. M. Dosey ; M. Su ; C. R. Liang ; L. L. Gu ; J. M. Shan ; X. Chen ; R. Hanna ; M. Choi ; X. J. Yao ; B. U. Klink ; A. W. Kahsai ; S. S. Sidhu ; S. Koide ; P. A. Penczek ; A. A. Kossiakoff ; V. L. Woods, Jr. ; B. K. Kobilka ; G. Skiniotis ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/*chemistry/*metabolism ; GTP-Binding Proteins/chemistry/metabolism ; *Models, Molecular ; Protein Structure, Quaternary ; Receptors, Adrenergic, beta-2/chemistry/metabolism ; Receptors, G-Protein-Coupled/*chemistry/*metabolism ; Sf9 CellsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2016-01-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressM. R. Hara ; J. J. Kovacs ; E. J. Whalen ; S. Rajagopal ; R. T. Strachan ; W. Grant ; A. J. Towers ; B. Williams ; C. M. Lam ; K. Xiao ; S. K. Shenoy ; S. G. Gregory ; S. Ahn ; D. R. Duckett ; R. J. Lefkowitz
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Arrestins/deficiency/genetics/*metabolism ; Catecholamines/pharmacology ; Cell Line ; Cell Nucleus/enzymology/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; *DNA Damage ; Fibroblasts ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Protein Processing, Post-Translational/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-mdm2/metabolism ; Receptors, Adrenergic, beta-2/*metabolism ; Signal Transduction/drug effects ; Stress, Physiological/*physiology ; Testis/metabolism ; Thymus Gland/metabolism ; Tumor Suppressor Protein p53/chemistry/metabolismPublished by: -
5Latest Papers from Table of Contents or Articles in PressAhn, S., Pani, B., Kahsai, A. W., Olsen, E. K., Husemoen, G., Vestergaard, M., Jin, L., Zhao, S., Wingler, L. M., Rambarat, P. K., Simhal, R. K., Xu, T. T., Sun, L. D., Shim, P. J., Staus, D. P., Huang, L.-Y., Franch, T., Chen, X., Lefkowitz, R. J.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018Staff ViewPublication Date: 2018-06-27Publisher: The American Society for Pharmacology and Experimental Therapeutics (ASPET)Print ISSN: 0026-895XElectronic ISSN: 1521-0111Topics: Chemistry and PharmacologyMedicinePublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: β-Adrenergic receptor ; β-Adrenergic receptor kinase ; G protein-coupled receptor kinase ; Transgenic mice ; Myocardial contractilitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the §-adrenergic receptor (§ AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial contraction is closely regulated by G protein coupled β-adrenergic receptors through the action of the second messenger cAMP. The β-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G protein-coupled receptor kinases. The study of this complex system in vivo has recently been advanced by the development of transgenic and gene targeted (“knock out”) mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful strategy to study the regulation of myocardial contractility in the normal and failing heart.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Keywords: Key words β-Adrenergic receptor ; β-Adrenergic receptor kinase ; G protein-coupled receptor kinase ; Transgenic mice ; Myocardial contractilitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Heart failure is a problem of increasing importance in cardiovascular medicine. An important characteristic of heart failure is reduced agonist-stimulated adenylyl cyclase activity (receptor desensitization) due to both diminished receptor number (receptor downregulation) and impaired receptor function (receptor uncoupling). These changes in the §-adrenergic receptor (§-AR) system may in part account for some of the abnormalities of contractile function in this disease. Myocardial contraction is closely regulated by G protein coupled β-adrenergic receptors through the action of the second messenger cAMP. The β-adrenergic receptors themselves are regulated by a set of specific kinases, termed the G-protein-coupled receptor kinases. The study of this complex system in vivo has recently been advanced by the development of transgenic and gene targeted (”knockout”) mouse models. Combining transgenic technology with sophisticated physiological measurements of cardiac hemodynamics is an extremely powerful strategy to study the regulation of myocardial contractility in the normal and failing heart.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE heterotrimeric G proteins1, mol-ecules that have a central role in signal transduction across the cell membrane, are composed of a, ft and y subunits. For several years it was the a subunit which held the limelight, with a great deal of attention being paid to its mediation of the activation of ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesKingsmore, S. F. ; Peppel, K. ; Suh, D. ; Caron, M. G. ; Lefkowitz, R. J. ; Seldin, M. F.
Springer
Published 1995Staff ViewISSN: 1432-1777Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineType of Medium: Electronic ResourceURL: