Search Results - (Author, Cooperation:R. J. Carroll)
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1Latest Papers from Table of Contents or Articles in PressY. Okada ; D. Wu ; G. Trynka ; T. Raj ; C. Terao ; K. Ikari ; Y. Kochi ; K. Ohmura ; A. Suzuki ; S. Yoshida ; R. R. Graham ; A. Manoharan ; W. Ortmann ; T. Bhangale ; J. C. Denny ; R. J. Carroll ; A. E. Eyler ; J. D. Greenberg ; J. M. Kremer ; D. A. Pappas ; L. Jiang ; J. Yin ; L. Ye ; D. F. Su ; J. Yang ; G. Xie ; E. Keystone ; H. J. Westra ; T. Esko ; A. Metspalu ; X. Zhou ; N. Gupta ; D. Mirel ; E. A. Stahl ; D. Diogo ; J. Cui ; K. Liao ; M. H. Guo ; K. Myouzen ; T. Kawaguchi ; M. J. Coenen ; P. L. van Riel ; M. A. van de Laar ; H. J. Guchelaar ; T. W. Huizinga ; P. Dieude ; X. Mariette ; S. L. Bridges, Jr. ; A. Zhernakova ; R. E. Toes ; P. P. Tak ; C. Miceli-Richard ; S. Y. Bang ; H. S. Lee ; J. Martin ; M. A. Gonzalez-Gay ; L. Rodriguez-Rodriguez ; S. Rantapaa-Dahlqvist ; L. Arlestig ; H. K. Choi ; Y. Kamatani ; P. Galan ; M. Lathrop ; S. Eyre ; J. Bowes ; A. Barton ; N. de Vries ; L. W. Moreland ; L. A. Criswell ; E. W. Karlson ; A. Taniguchi ; R. Yamada ; M. Kubo ; J. S. Liu ; S. C. Bae ; J. Worthington ; L. Padyukov ; L. Klareskog ; P. K. Gregersen ; S. Raychaudhuri ; B. E. Stranger ; P. L. De Jager ; L. Franke ; P. M. Visscher ; M. A. Brown ; H. Yamanaka ; T. Mimori ; A. Takahashi ; H. Xu ; T. W. Behrens ; K. A. Siminovitch ; S. Momohara ; F. Matsuda ; K. Yamamoto ; R. M. Plenge
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Animals ; Arthritis, Rheumatoid/*drug therapy/*genetics/metabolism/pathology ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Computational Biology ; *Drug Discovery ; Drug Repositioning ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Hematologic Neoplasms/genetics/metabolism ; Humans ; Male ; Mice ; Mice, Knockout ; *Molecular Targeted Therapy ; Polymorphism, Single Nucleotide/geneticsPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1365-2478Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: GeosciencesPhysicsNotes: A depth migration method is presented that uses Radon-transformed common-source seismograms as input. It is shown that the Radon depth migration method can be extended to spatially varying velocity depth models by using asymptotic ray theory (ART) to construct wavefield continuation operators. These operators downward continue an incident receiver-array plane wave and an assumed point-source wavefield into the subsurface. The migration velocity model is constrained to have longer characteristic wavelengths than the dominant source wavelength such that the ART approximations for the continuation operators are valid.This method is used successfully to migrate two synthetic data examples:〈list xml:id="l1" style="custom"〉1a point diffractor, and2a dipping layer and syncline interface model.It is shown that the Radon migration method has a computational advantage over the standard Kirchhoff migration method in that fewer rays are computed in a main memory implementation.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesCARROLL, R. J. ; CAVANAUGH, J. R. ; RORER, F. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1981Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Scanning electron microscopy (SEM) studies were carried out on bovine semitendinosus samples that were subjected both to long-term frozen storage and to repeated freeze-thaw cycles. Samples frozen at –18°C and stored up to 26 wk showed essentially no change in muscle ultrastructure. Samples frozen at liquid nitrogen temperature and stored at 2–3°C did show ice crystal damage within the muscle fiber. Repeated freeze-thaw produced essentially no change in muscle ultrastructure.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesCARROLL, R. J. ; RORER, F. P. ; JONES, S. B. ; CAVANAUGH, J. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1978Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The changes in ultrastructure of bovine semitendinosus, both raw and heated (90°C) and subjected to tensile stress, were determined by scanning electron microscopy. Stress parallel to the fiber axis resulted in the initial rupture of the muscle fiberendomysium sheath. Perpendicular stress caused initial rupture at the endomysium-perimysium junction with the muscle fibers remaining undisturbed. Similar observations were made on the muscle tissue heated to 90°C and subjected to tensile stress. Heating to 90°C does not alter completely the fibrous nature of the perimysium connective tissue. Some native type collagen fibrils were observed, even after the severe heat treatment. The effect of applied stress on components of the muscle tissue is an important consideration in the development of a more reliable test method for evaluation of meat tenderness.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Meat emulsions were examined by light microscopy to determine the relationships between structure and emulsion stability. Beef-meat based emulsions were prepared either by varying chopping temperature or by adding soy plastic fats of different hardness. Formation of fat channels was observed in uncooked emulsions prepared either at a chopping temperature of 26°C or with soft plastic fat of 0.25cm−1 hardness index. Such fat channel formations caused discontinuity of protein matrix, leading to fat separation during cooking and weakening of textural strength of products. Changes in fat globule size and distribution as affected by melting properties or hardness of fats were clearly reflected by changes in emulsion stability. Results suggest that emulsion stability is determined largely by the physical properties of protein matrix and fat incorporated. Stable emulsions were obtained with fats of appropriate melting properties and hardness and relatively cohesive protein matrix under given comminution conditions which allowed uniform fat distribution.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesACKERMAN, S. A. ; SWIFT, C. E. ; CARROLL, R. J. ; TOWNSEND, W. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1971Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: — The effect of time, temperature and rpm of comminution of emulsions was determined on the dispersion of approximately 25% of beef fat, pork fat or cottonseed oil in frankfurters. The numbers of lipid particles 5 μ or less in diameter increased in frankfurters containing either beef or pork fat as comminution was continued to higher temperatures, with pork fat dispersed more thoroughly. Fat tended to separate from frankfurters containing beef fat in particles 200 μ or more in diameter. In contrast, no specific degree of dispersion of particles 5 μ or less in diameter consistently indicated emulsion stability, or its lack. Increased rpm during comminution produced an increased dispersion of beef or pork fat. Under the same conditions pork fat was dispersed more finely than beef fat. Dispersion of cottonseed oil produced finely dispersed particles beyond the resolution of light microscopy, as was confirmed by electron microscopy which showed a substantial number of particles to be less than 1 μ in diameter.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesFOX, JAY B. ; RORER, F. P. ; FIDDLER, R. N. ; CARROLL, R. J. ; WASSERMAN, A. E.
Oxford, UK : Blackwell Publishing Ltd
Published 1980Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Scanning electron microscopy of the ultrastructure of cured beef has shown that the combination of sodium chloride and nitrite effects changes in the interfiber spaces not caused by either salt alone. The effect is attributed to catalysis of the nitrosation reaction through the formation of the more powerful nitrosating species, NOCI.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesPatzelt, C. ; Tager, H. S. ; Carroll, R. J. ; Steiner, D. F.
[s.l.] : Nature Publishing Group
Published 1979Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Immunoprecipitation and tryptic peptide analysis of newly synthesised proteins from rat islets have identified an 18,000 molecular weight (MW) protein as proglucagon. Conversion of this precursor was kinetically similar to the conversion of proinsulin and resulted in the formation of both ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1572-9036Keywords: Primary 62G05 ; secondary 65J10 ; Ill-posed problem ; operator inversion ; deconvolution ; biased sampling ; Wicksell's problem ; regression ; errors-in-variables ; mixtures ; empirical Radon transformSource: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract Ill-posed problems arise in a wide variety of practical statistical situations, ranging from biased sampling and Wicksell's problem in stereology to regression, errors-in-variables and empirical Bayes models. The common mathematics behind many of these problems is operator inversion. When this inverse is not continuous a regularization of the inverse is needed to construct approximate solutions. In the statistical literature, however, ill-posed problems are rather often solved in an ad hoc manner which obccures these common features. It is our purpose to place the concept of regularization within a general and unifying framework and to illustrate its power in a number of interesting statistical examples. We will focus on regularization in Hilbert spaces, using spectral theory and reduction to multiplication operators. A partial extension to a Banach function space is briefly considered.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-2064Source: Springer Online Journal Archives 1860-2000Topics: MathematicsNotes: Abstract We consider the problem of sequential estimation of a density function f at a point x 0 which may be known or unknown. Let T n be a sequence of estimators of x 0 . For two classes of density estimators f n , namely the kernel estimates and a recursive modification of these, we show that if N(d) is a sequence of integer-valued random variables and n(d) a sequence of constants with N(d)/n(d)→ 1 in probability as d → 0, then f N(d) (T N(d) -f(x 0) is asymptotically normally distributed (when properly normed). We also propose two new classes of stopping rules based on the ideas of fixed-width interval estimation and show that for these rules, N(d)/n(d) → 1 almost surely and EN(d)/n(d) → 1 as d → 0. One of the stopping rules is itself asymptotically normally distributed when properly normed and yields a confidence interval for f(x 0) of fixed-width and prescribed coverage probability.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0006-3525Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: The infrared spectra of undenatured bovine tendon collagen were investigated at 25°C and relative humidities from 0 to 95%. Suitable samples were prepared by forcing frozen suspensions of the material in distilled water through a stainless steel capillary. The samples were investigated by electron microscopy before and after the spectra were obtained to ascertain that no denaturation had taken place while the sample was exposed to infrared radiation. Temperature controlled absorption cells were constructed which permitted the passing of air with a known water content over the sample film. Gradual changes were observed in the frequencies and intensities of characteristic amide bands over the relative humidity range of 0 to 75%. These changes are particularly pronounced for the amide II band, associated with bending motions of peptide NH bonds. They lead to the conclusion that water molecules are gradually attached to peptide NH bonds within the triple helix over a wide range of relative humidity. Changes in CH deformation bands suggest that CH to O hydrogen bonding does occur and that it is more pronounced in collagen exposed to high relative humidity.Additional Material: 4 Ill.Type of Medium: Electronic ResourceURL: