Search Results - (Author, Cooperation:R. I. Fisher)

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  1. 1
    Staff View
    Publication Date:
    2010-12-24
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Sequence ; Amino Acid Substitution ; Burkitt Lymphoma/genetics ; Cell Line, Tumor ; Cell Survival ; Cytokines/metabolism/secretion ; High-Throughput Nucleotide Sequencing ; Humans ; Hydrophobic and Hydrophilic Interactions ; Interleukin-1 Receptor-Associated Kinases/biosynthesis/genetics/metabolism ; Janus Kinases/metabolism ; Lymphoma, B-Cell, Marginal Zone/genetics ; Lymphoma, Large B-Cell, Diffuse/classification/*genetics/*pathology ; Molecular Sequence Data ; Mutant Proteins/chemistry/genetics/metabolism ; Mutation/*genetics ; Myeloid Differentiation Factor 88/chemistry/*genetics/*metabolism ; NF-kappa B/metabolism ; Oncogenes/*genetics ; Phosphorylation ; Protein Structure, Tertiary ; RNA Interference ; Receptors, Interleukin-1/metabolism ; STAT3 Transcription Factor/metabolism ; Sequence Analysis, RNA ; Signal Transduction ; Toll-Like Receptors/metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2012-08-14
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Basic Helix-Loop-Helix Transcription Factors/antagonists & ; inhibitors/genetics/metabolism ; Burkitt Lymphoma/*drug therapy/*genetics/metabolism/pathology ; Cell Cycle ; Cyclin D3/genetics/metabolism ; Cyclin-Dependent Kinase 6/metabolism ; Genes, myc/genetics ; *Genomics ; High-Throughput Nucleotide Sequencing ; Humans ; Inhibitor of Differentiation Proteins/genetics/metabolism ; *Molecular Targeted Therapy ; Neoplasm Proteins/genetics/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; RNA Interference ; Receptors, Antigen, B-Cell/metabolism ; Signal Transduction
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    W. Liu, R. Cong, A. P. Reyes, I. R. Fisher, and V. F. Mitrović
    American Physical Society (APS)
    Published 2018
    Staff View
    Publication Date:
    2018-06-15
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Structure, structural phase transitions, mechanical properties, defects
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2018-09-13
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Dynamics, dynamical systems, lattice effects
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2018-08-08
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Electronic structure and strongly correlated systems
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    J. H. Chu ; H. H. Kuo ; J. G. Analytis ; I. R. Fisher
    American Association for the Advancement of Science (AAAS)
    Published 2012
    Staff View
    Publication Date:
    2012-08-11
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  7. 7
    H. H. Kuo ; J. H. Chu ; J. C. Palmstrom ; S. A. Kivelson ; I. R. Fisher
    American Association for the Advancement of Science (AAAS)
    Published 2016
    Staff View
    Publication Date:
    2016-05-21
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2018-11-16
    Publisher:
    American Physical Society (APS)
    Print ISSN:
    1098-0121
    Electronic ISSN:
    1095-3795
    Topics:
    Physics
    Keywords:
    Superfluidity and superconductivity
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  10. 10
    Fisher, R. I.
    Springer
    Published 2000
    Staff View
    ISSN:
    1569-8041
    Keywords:
    autologous transplantation ; CHOP ; diffuse large B-cell lymphoma ; IPI ; NHL
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background:New treatments are desperately needed to improve theresults obtained using CHOP chemotherapy for patients with diffuse large celllymphoma. In order to develop successful new strategies we need to understandwhy prior promising therapies have failed and to develop new testablehypotheses based on our current knowledge. Patients and methods:The International Non-Hodgkin's LymphomaPrognostic Factors Index has provided us with a methodology to compare theexpected prognosis of patients on different clinical trials. Many prior,apparent improvements in treatment outcome can now be attributed to theinclusion of patients with better prognoses. Results:Current areas of investigation include: l) theidentification of new active drugs for the treatment of lymphoma, 2) the useof colony stimulating factors to allow dose escalation of the activemyelotoxic drugs, 3) the use of strategies which may overcome the problem ofresistance to chemotherapy, 4) the combination of monoclonal antibodies withcombination chemotherapy and 5) ablative chemotherapy with autologousstem-cell support. Conclusions:Based on all of the available data, the NorthAmerican Lymphoma Intergroup has developed the hypothesis thathigh-intermediate and high risk patients with aggressive lymphoma who receivefull course standard induction therapy will benefit form the addition of highdose therapy and has antedated a clinical trial testing that hypothesis.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Fisher, R. I.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-0843
    Keywords:
    Key words Diffuse large-cell lymphoma ; Non-Hodgkin’s lymphoma ; CHOP ; ProMACE ; CytaBOM ; m-BACOD ; MACOP-B
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  Therapy for aggressive non-Hodgkin’s lymphomas has undergone significant evolution in the past 25 years. First-generation combination chemotherapy studies produced complete response (CR) rates of 45 – 53% together with 30 – 37% rates of long-term survival. New treatment programs aimed at increasing CR rates were then developed on the assumption that the additional patients who achieved a CR would become long-term disease-free survivors. Initial reports of single-institution pilot studies with third-generation regimens suggested CR and survival rates of 68 – 86% and 58 – 69%, respectively; however, after longer follow-up periods, survival rates decreased. Furthermore, confirmatory national phase II trials using these newer regimens produced CR rates of only 49 – 65% and survival rates of 50 – 61%. Thus, ultimate conclusions concerning the efficacy of these new regimens awaited the results of prospective randomized trials. The Southwest Oncology Group (SWOG) conducted a randomized trial comparing standard therapy, CHOP, to the third-generation chemotherapy regimens m-BACOD, ProMACE-CytaBOM, and MACOP-B. After 6 years, no difference in the response rate, progression-free survival, or overall survival has been found between CHOP and the third-generation regimens. For example, the 6-year estimates of progression-free survival are CHOP 33%, m-BACOD 36%, ProMACE-CytaBOM 34%, and MACOP-B 32% (P = 0.41). The 6-year overall survival estimates are CHOP 42%, m-BACOD 40%, ProMACE-CytaBOM 46%, and MACOP-B 41% (P = 0.89). Furthermore, we have not identified any subset of patients who survive longer on treatment with the third-generation regimens, and the cost and toxicity of the new regimens are higher. On the basis that 〈50% of these patients are cured, the best approach for any patient is an experimental one designed to improve our ability to cure the disease. Examples of this include (l) increasing the dose intensity of drugs used in standard regimens and (2) autologous bone marrow transplantation and/or peripheral stem-cell support as rescue from marrow-ablative chemotherapy. If a patient is not eligible or does not wish to participate in a clinical trial, CHOP, as inadequate as it is, remains the gold standard.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Fisher, R. I.
    Springer
    Published 1998
    Staff View
    ISSN:
    1569-8041
    Keywords:
    grey zone lymphoma ; Hodgkin's disease ; non-Hodgkin's lymphoma
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The inability of distinguishing difficult cases of Hodgkin's disease from non-Hodgkin's lymphoma has been a long-standing problem. Initially, the controversy centered on lymphocyte-depleted Hodgkin's disease; now with improved diagnostic techniques, most controversy centers around the anaplastic large-cell lymphomas. These problematic cases may also represent a less frequent problem, although data on this point is difficult to obtain. The future controversy may well involve the separation of T-cell rich B-cell lymphoma and Hodgkin's disease, nodular paragranuloma type. Fortunately, to date the clinical data does not support that there is a major difference in therapeutic results depending on whether these cases are treated as Hodgkin's disease or non-Hodgkin's lymphoma.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses