Search Results - (Author, Cooperation:R. Houlston)

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  1. 1
    E. Ruark ; K. Snape ; P. Humburg ; C. Loveday ; I. Bajrami ; R. Brough ; D. N. Rodrigues ; A. Renwick ; S. Seal ; E. Ramsay ; V. Duarte Sdel ; M. A. Rivas ; M. Warren-Perry ; A. Zachariou ; A. Campion-Flora ; S. Hanks ; A. Murray ; N. Ansari Pour ; J. Douglas ; L. Gregory ; A. Rimmer ; N. M. Walker ; T. P. Yang ; J. W. Adlard ; J. Barwell ; J. Berg ; A. F. Brady ; C. Brewer ; G. Brice ; C. Chapman ; J. Cook ; R. Davidson ; A. Donaldson ; F. Douglas ; D. Eccles ; D. G. Evans ; L. Greenhalgh ; A. Henderson ; L. Izatt ; A. Kumar ; F. Lalloo ; Z. Miedzybrodzka ; P. J. Morrison ; J. Paterson ; M. Porteous ; M. T. Rogers ; S. Shanley ; L. Walker ; M. Gore ; R. Houlston ; M. A. Brown ; M. J. Caufield ; P. Deloukas ; M. I. McCarthy ; J. A. Todd ; C. Turnbull ; J. S. Reis-Filho ; A. Ashworth ; A. C. Antoniou ; C. J. Lord ; P. Donnelly ; N. Rahman
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-12-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Breast Neoplasms/*genetics ; Cluster Analysis ; Exons ; Female ; Genetic Predisposition to Disease/*genetics ; Humans ; Isoenzymes/genetics ; Lymphocytes/metabolism ; *Mosaicism ; *Mutation ; Ovarian Neoplasms/*genetics ; Phosphoprotein Phosphatases/*genetics ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-08-31
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Myeloid Neoplasia, Clinical Trials and Observations
    Published by:
    http://www.hematology.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-11-09
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Immunobiology and Immunotherapy, Lymphoid Neoplasia
    Published by:
    http://www.hematology.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2018-12-07
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Multiple Myeloma, Lymphoid Neoplasia, Brief Reports, Clinical Trials and Observations
    Published by:
    http://www.hematology.org/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Patel, H. ; Nardelli, M. ; Fenn, T. ; Houlston, R. ; Coonar, A. ; Patton, M.A. ; Crosby, A.H.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2133
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background The inherited palmoplantar keratodermas (PPKs) are a clinically heterogeneous group of disorders characterized by thickening of the skin of the palms and the soles. These diseases also exhibit genetic heterogeneity and many autosomal dominant and recessive forms have been described. Mal de Meleda (Meleda disease, MD) is an autosomal recessive form of PPK first described on the Dalmatian island of Meleda. A gene for MD has recently been assigned to the most telomeric portion of chromosome 8q using two large Algerian families. Objectives To determine whether the same gene underlies the skin disease in Meleda islanders. Methods We have examined five affected individuals originating from the Dalmatian island itself for 8qter homozygosity. Results This region was found to be homozygous in all five affected individuals but in none of the 20 other unaffected family members examined. Conclusions The current study confirms the localization of a gene for MD to 8qter using samples from the island of Meleda, highlighting the clinical and genetic homogeneity of this condition.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2133.2001.04127.x

    Articles: DFG German National Licenses
  6. 6
    BUCKLEY, C. ; THOMAS, V. ; CROW, J. ; HOULSTON, R. ; SLACK, J. ; RUSTIN, M.H.A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1365-2133
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A 64-year-old female with the cancer family syndrome suffered from multiple malignant melanomas and a malignant fibrous histiocytoma. She has shown unusually long survival which is a feature of these patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2133.1992.tb08410.x

    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    0925-4439
    Keywords:
    (Human fibroblast) ; Apoliprotein B ; Gene mutation ; Hypercholesterolemia ; LDL receptor ; Receptor binding domain
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0925-4439(91)90010-7

    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract. Autosomal recessive Robinow syndrome is a form of mesomelic dwarfism with multiple rib and vertebral anomalies. Using autozygosity mapping we have identified a genetic locus (RBNW1) for this syndrome at chromosome 9q22 in seven consanguineous families from Oman. Our results indicate that the gene lies within a 4 cM region between markers D9S1836 and D9S1803 (maximum multipoint LOD score 12.3). In addition, we have analysed two non-Omani families with autosomal recessive Robinow and found no genetic heterogeneity.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004390000242

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary Allelic sequence variation in the apolipoprotein (apo) E gene has been analysed by means of synthetic oligonucleotide probes that detect single base pair substitutions in the codons for amino acid positions 112 and 158, substitutions that are responsible for the common isoforms. Use of the polymerase chain reaction procedure to amplify a sequence of 330 base pairs of the human apo E gene has permitted the development of a robust method for apo E genotyping. This technique has been used to determine the apo E genotype in 95 individuals in whom the genotype for an apo CII TaqI restriction fragment length polymorphism has also been determined. No strong linkage disequilibrium between the two gene loci was detected. This suggests that the metabolic effects of variation, in the apo E and apo CII genes, as detected by the polymorphisms used here, would operate in a statistically independent manner.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00291382

    Articles: DFG German National Licenses
  10. 10
    Vickers, G. W. ; Houlston, R.
    Springer
    Published 1983
    Staff View
    ISSN:
    1573-1987
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes:
    Abstract A model is presented of the erosion damage and cleaning efficiency of cavitation and conventional cleaning jets. The effect of supply pressure, jet velocity, standoff distance, nozzle diameter and type of fluid are considered and assessed in relation to experimental findings.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00383042

    Articles: DFG German National Licenses
  11. 11
    Houlston, R. ; Vickers, G. W. ; Anderson, D. L.

    Chichester [u.a.] : Wiley-Blackwell
    Published 1986
    Staff View
    ISSN:
    0029-5981
    Keywords:
    Engineering ; Engineering General
    Source:
    Wiley InterScience Backfile Collection 1832-2000
    Topics:
    Mathematics
    Technology
    Notes:
    This paper is concerned with the effect of material properties, boundary friction, and inertia on the flow and strain patterns in material undergoing large plane strain compression. Experimental results are presented for both the rapid compression of Plasticine and the quasi-static compression of aluminium. In addition, a finite element code for rigid-plastic material behaviour is discussed, and approximate procedures are described for both in-plane and platen friction. Provision in the code was also made for strain hardening and strain rate sensitive material properties, and inertia effects. Comparison of the finite element and experimental results showed good agreement. Finite element calculations revealed that in-plane friction had a very significant effect on the strain patterns observed in the Plasticine experiments. Finite element calculations also showed that strain hardening was of fundamental importance in determining the strain patterns that were observed to occur in the quasi-static compression of aluminium.
    Additional Material:
    14 Ill.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1002/nme.1620230803

    Articles: DFG German National Licenses