Search Results - (Author, Cooperation:R. Holle)

Showing 1 - 8 results of 8, query time: 0.19s Refine Results
  1. 1
    C. A. Rietveld ; S. E. Medland ; J. Derringer ; J. Yang ; T. Esko ; N. W. Martin ; H. J. Westra ; K. Shakhbazov ; A. Abdellaoui ; A. Agrawal ; E. Albrecht ; B. Z. Alizadeh ; N. Amin ; J. Barnard ; S. E. Baumeister ; K. S. Benke ; L. F. Bielak ; J. A. Boatman ; P. A. Boyle ; G. Davies ; C. de Leeuw ; N. Eklund ; D. S. Evans ; R. Ferhmann ; K. Fischer ; C. Gieger ; H. K. Gjessing ; S. Hagg ; J. R. Harris ; C. Hayward ; C. Holzapfel ; C. A. Ibrahim-Verbaas ; E. Ingelsson ; B. Jacobsson ; P. K. Joshi ; A. Jugessur ; M. Kaakinen ; S. Kanoni ; J. Karjalainen ; I. Kolcic ; K. Kristiansson ; Z. Kutalik ; J. Lahti ; S. H. Lee ; P. Lin ; P. A. Lind ; Y. Liu ; K. Lohman ; M. Loitfelder ; G. McMahon ; P. M. Vidal ; O. Meirelles ; L. Milani ; R. Myhre ; M. L. Nuotio ; C. J. Oldmeadow ; K. E. Petrovic ; W. J. Peyrot ; O. Polasek ; L. Quaye ; E. Reinmaa ; J. P. Rice ; T. S. Rizzi ; H. Schmidt ; R. Schmidt ; A. V. Smith ; J. A. Smith ; T. Tanaka ; A. Terracciano ; M. J. van der Loos ; V. Vitart ; H. Volzke ; J. Wellmann ; L. Yu ; W. Zhao ; J. Allik ; J. R. Attia ; S. Bandinelli ; F. Bastardot ; J. Beauchamp ; D. A. Bennett ; K. Berger ; L. J. Bierut ; D. I. Boomsma ; U. Bultmann ; H. Campbell ; C. F. Chabris ; L. Cherkas ; M. K. Chung ; F. Cucca ; M. de Andrade ; P. L. De Jager ; J. E. De Neve ; I. J. Deary ; G. V. Dedoussis ; P. Deloukas ; M. Dimitriou ; G. Eiriksdottir ; M. F. Elderson ; J. G. Eriksson ; D. M. Evans ; J. D. Faul ; L. Ferrucci ; M. E. Garcia ; H. Gronberg ; V. Guethnason ; P. Hall ; J. M. Harris ; T. B. Harris ; N. D. Hastie ; A. C. Heath ; D. G. Hernandez ; W. Hoffmann ; A. Hofman ; R. Holle ; E. G. Holliday ; J. J. Hottenga ; W. G. Iacono ; T. Illig ; M. R. Jarvelin ; M. Kahonen ; J. Kaprio ; R. M. Kirkpatrick ; M. Kowgier ; A. Latvala ; L. J. Launer ; D. A. Lawlor ; T. Lehtimaki ; J. Li ; P. Lichtenstein ; P. Lichtner ; D. C. Liewald ; P. A. Madden ; P. K. Magnusson ; T. E. Makinen ; M. Masala ; M. McGue ; A. Metspalu ; A. Mielck ; M. B. Miller ; G. W. Montgomery ; S. Mukherjee ; D. R. Nyholt ; B. A. Oostra ; L. J. Palmer ; A. Palotie ; B. W. Penninx ; M. Perola ; P. A. Peyser ; M. Preisig ; K. Raikkonen ; O. T. Raitakari ; A. Realo ; S. M. Ring ; S. Ripatti ; F. Rivadeneira ; I. Rudan ; A. Rustichini ; V. Salomaa ; A. P. Sarin ; D. Schlessinger ; R. J. Scott ; H. Snieder ; B. St Pourcain ; J. M. Starr ; J. H. Sul ; I. Surakka ; R. Svento ; A. Teumer ; H. Tiemeier ; F. J. van Rooij ; D. R. Van Wagoner ; E. Vartiainen ; J. Viikari ; P. Vollenweider ; J. M. Vonk ; G. Waeber ; D. R. Weir ; H. E. Wichmann ; E. Widen ; G. Willemsen ; J. F. Wilson ; A. F. Wright ; D. Conley ; G. Davey-Smith ; L. Franke ; P. J. Groenen ; M. Johannesson ; S. L. Kardia ; R. F. Krueger ; D. Laibson ; N. G. Martin ; M. N. Meyer ; D. Posthuma ; A. R. Thurik ; N. J. Timpson ; A. G. Uitterlinden ; C. M. van Duijn ; P. M. Visscher ; D. J. Benjamin ; D. Cesarini ; P. D. Koellinger
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-06-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cognition ; *Educational Status ; Endophenotypes ; Female ; Genetic Loci ; *Genome-Wide Association Study ; Humans ; Male ; Multifactorial Inheritance ; *Polymorphism, Single Nucleotide
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1398-9995
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background:  Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods:  We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels 〈50% percentile and 24 individuals with atopic eczema and serum IgE levels 〉90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results:  Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions:  Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x

    Articles: DFG German National Licenses
  3. 3
    Jaques, G. ; Bepler, G. ; Holle, R. ; Wolf, M. ; Havemann, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0022-4731
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91611-6

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1432-0843
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Patients with small cell carcinoma of the lung (SCCL) were treated in two multicenter trials with different cytostatic drug regimens including ifosfamide. In the first randomized study, including 306 patients, alternating chemotherapy with VP 16, ifosfamide, vindesine (VPIV), adriamycin, cisplatinum, vincristine (APO), and cyclophosphamide, methotrexate, CCNU (CMCC) was compared against standard treatment with ACO (adriamycin, cyclophosphamide, vincristine). It was shown that the alternating therapy resulted in a higher response rate (88% vs 78%) and a longer median survival time (11 months vs 10 months). Regarding toxicity, VPIV was similar to ACO, whereas APO and CMCC had more side-effects, leading to an increase in the number of drop-outs. In the second randomized study 144 patients were treated either with ifosfamide/VP 16 (IVP) or with cisplatinum/VP 16 (PVP). In the case of no further response, no change, or progression the induction therapy was changed to ACO. Interim analyses show that both regimens have similar therapeutic effects; but higher toxicity was observed in patients treated withcis-platinum/VP 16 than in patients treated with ifosfamide/VP 16. According to the response rate in patients treated with ACO after first-line therapy there was less cross-resistance of IVP than of PVP to ACO.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00647450

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    0340-1855
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s003930050101

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Non-insulin-dependent diabetes mellitus ; mortality ; macrovascular mortality ; von Willebrand-factor ; urine albumin excretion ; HbA1c ; blood pressure ; lipids.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The 10-year follow-up of the Munich General Practitioner Project was designed as a long-term prospective study to evaluate factors predicting macrovascular and overall mortality in a random cohort of non-insulin-dependent diabetic (NIDDM) patients. Of the original 290 patients (103 males, 187 females, median age 65 years) 92.5 % could be assessed, 103 subjects had died, 58 from macrovascular causes. In an univariate analysis of baseline data, deceased patients, and especially those who died from macrovascular causes had significantly higher fasting blood glucose, HbA1c, von Willebrand-factor protein, urine albumin excretion, and serum β 2-microglobulin, were significantly older, exhibited significantly more ischaemic heart disease (abnormal ECG Minnesota codes), carotid artery and peripheral vascular disease (both determined by ultrasound-Doppler), and had significantly inferior knowledge about diabetes and its treatment. No significant differences were seen for gender, blood pressure, smoking, total cholesterol, triglycerides, HDL-cholesterol, or the use of antidiabetic, antihypertensive or coronary drugs. In a multiple logistic regression analysis, the risk factors for macrovascular death were age, HbA1c and von Willebrand-factor protein. When baseline macrovascular disease was taken into account, carotid artery disease was also a determinant. The main variables from the metabolic syndrome (blood pressure, dyslipidaemia, body mass index) did not enter a multiple logistic regression analysis. The data suggest that age and haemoglobin A1c are major determinants, and that in addition von Willebrand-factor associated endothelial damage is a risk factor for macrovascular mortality in NIDDM patients. [Diabetologia (1996) 39: 1540–1545]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250050612

    Articles: DFG German National Licenses
  7. 7
    Windeler, J. ; Holle, R.
    Springer
    Published 1997
    Staff View
    ISSN:
    1432-1289
    Keywords:
    Schlüsselwörter Klinische Studien ; Auswertung ; Klinische Studien ; Planung ; Studiendesign
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Zum Thema Es gibt eine Reihe methodischer Kriterien, nach denen wissenschaftliche Studien in Hinblick auf ihre Qualität und Aussagefähigkeit bewertet werden können. Aber auch diejenigen, die keine Spezialisten für Studiendesign sind und ”nur” die Studienergebnisse zur Kenntnis nehmen und diese für mehr oder weniger glaubwürdig halten, kurzum: die weitaus überwiegende Zahl unserer Leser, sollte über Basiskenntnisse auf dem Gebiet der Validierung wissenschaftlicher Resultate verfügen. Für sie ist diese Übersichtsarbeit geschrieben, damit sie imstande sind, sich ein besseres Urteil zu bilden, und nicht nur nach vagen Gesichtspunkten subjektive Urteile fällen. So können, wie hier erläutert, an jede Studie auch von Nichtspezialisten gezielt Fragen gestellt werden. Gerade in einer Zeit (und leider auch in einem Land!), in der paramedizinische und sogenannte alternative medizinische, nicht wissenschaftlich validierte Lehren unverhältnismäßig ernstgenommen werden, erscheint es notwendig, den kritischen Lesern auch die Bewertungskriterien darzustellen, mit deren Hilfe sie selbst zu begründeten Urteilen kommen können.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001080050045

    Articles: DFG German National Licenses
  8. 8
    Buchkremer, G. ; Stricker, K. ; Holle, R. ; Kuhs, H.
    Springer
    Published 1991
    Staff View
    ISSN:
    1433-8491
    Keywords:
    Predictability ; Relapses ; Schizophrenics patients prognosis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The objective of this study was to identify clinically relevant predictors of short-term (2 years) outcome in schizophrenic patients and to gather these predictors into one simple prognosis model for the course of the disease. Ninety-nine schizophrenic outpatients classified according to DSM-III criteria were observed for 3 years with regard to their relapse (rehospitalization) frequency. Predictors of both a high and a low relapse risk permitting a prognostic assessment of the individual case were based on various sources: case history data, especially those relating to the previous course of the disease; cocial and therapeutic situation; psychopathological findings; emotional family atmosphere; and prognosis scales.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF02189543

    Articles: DFG German National Licenses