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1Latest Papers from Table of Contents or Articles in PressS. Heilmann ; D. Drichel ; J. Clarimon ; V. Fernandez ; A. Lacour ; H. Wagner ; M. Thelen ; I. Hernandez ; J. Fortea ; M. Alegret ; R. Blesa ; A. Mauleon ; M. R. Roca ; J. Kornhuber ; O. Peters ; R. Heun ; L. Frolich ; M. Hull ; M. T. Heneka ; E. Ruther ; S. Riedel-Heller ; M. Scherer ; J. Wiltfang ; F. Jessen ; T. Becker ; L. Tarraga ; M. Boada ; W. Maier ; A. Lleo ; A. Ruiz ; M. M. Nothen ; A. Ramirez
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alzheimer Disease/*genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Phospholipase D/*geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressC. Cruchaga ; C. M. Karch ; S. C. Jin ; B. A. Benitez ; Y. Cai ; R. Guerreiro ; O. Harari ; J. Norton ; J. Budde ; S. Bertelsen ; A. T. Jeng ; B. Cooper ; T. Skorupa ; D. Carrell ; D. Levitch ; S. Hsu ; J. Choi ; M. Ryten ; J. Hardy ; D. Trabzuni ; M. E. Weale ; A. Ramasamy ; C. Smith ; C. Sassi ; J. Bras ; J. R. Gibbs ; D. G. Hernandez ; M. K. Lupton ; J. Powell ; P. Forabosco ; P. G. Ridge ; C. D. Corcoran ; J. T. Tschanz ; M. C. Norton ; R. G. Munger ; C. Schmutz ; M. Leary ; F. Y. Demirci ; M. N. Bamne ; X. Wang ; O. L. Lopez ; M. Ganguli ; C. Medway ; J. Turton ; J. Lord ; A. Braae ; I. Barber ; K. Brown ; P. Passmore ; D. Craig ; J. Johnston ; B. McGuinness ; S. Todd ; R. Heun ; H. Kolsch ; P. G. Kehoe ; N. M. Hooper ; E. R. Vardy ; D. M. Mann ; S. Pickering-Brown ; N. Kalsheker ; J. Lowe ; K. Morgan ; A. David Smith ; G. Wilcock ; D. Warden ; C. Holmes ; P. Pastor ; O. Lorenzo-Betancor ; Z. Brkanac ; E. Scott ; E. Topol ; E. Rogaeva ; A. B. Singleton ; M. I. Kamboh ; P. St George-Hyslop ; N. Cairns ; J. C. Morris ; J. S. Kauwe ; A. M. Goate
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-12-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/*genetics/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Brain/metabolism ; Case-Control Studies ; Europe/ethnology ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Peptide Fragments/metabolism ; Phospholipase D/deficiency/*genetics/metabolism ; Protein Processing, Post-Translational/genetics ; ProteolysisPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0165-0327Keywords: Borderline personality disorder ; Family studies ; Personality disorders ; Unipolar depressionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesMaier, W. ; Lichtermann, D. ; Minges, J. ; Heun, R. ; Hallmayer, J. ; Klingler, T.
Amsterdam : ElsevierStaff ViewISSN: 0165-0327Keywords: Age at onset ; Family study ; Geriatric depression ; Recurrent depression ; Unipolar depressionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0165-0327Keywords: Family study ; Neuroticism ; Premorbid personality ; Unipolar depressionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesMaier, W. ; Lichtermann, D. ; Minges, J. ; Franke, P. ; Heun, R. ; Hallmayer, J.
Amsterdam : ElsevierStaff ViewISSN: 0920-9964Keywords: Affected sib pair ; Family study ; Sex effectSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0920-9964Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0920-9964Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0920-9964Keywords: Family study ; Introversion ; Neuroticism ; Personality assessment ; Rigidity ; SchizoidiaSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0920-9964Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0165-1781Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1433-0407Keywords: Schlüsselwörter Demenz ; Screening ; Schweregradeinteilung ; ROC-Analyse ; Key words Dementia ; Staging ; ROC-analysisSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary Dementia-screening in clinical routine requires short, sensitive and specific tools. A number of standardized instruments are available for this purpose. The present study analysed the relationship between size of three examplary dementia-screening tests and their diagnostic accuracy. The Mini-Mental-State-Examination (MMSE), the Structured Interview for the Diagnosis of Dementia of the Alzheimer-type, Multiinfarct Dementia and Dementias of other Aetiologies according to ICD-10 and DSM-III-R (SIDAM) and the Alzheimer’s Disease Assessment Scale (ADAS) were applied to 71 patients with dementia of the Alzheimer-type and 73 non-demented controls. A ROC-analysis revealed that neighter SIDAM nor ADAS differentiated better between demented and non-demented probands than the MMSE. This was also true for patients with mild dementia. In dementia staging the more comprehensive instruments did not surpass the MMSE, too. Due to it’s brevity, the MMSE is the preferential screening-instrument for clinical routine.Notes: Zusammenfassung Für ein Demenzscreening im klinischen Alltag sind kurze, sensitive und spezifische Tests erforderlich. Hierfür stehen einige standardisierter Verfahren zur Verfügung. In der vorliegenden Arbeit wurde der Zusammenhang von Testumfang und diagnostischer Güte an 3 beispielhaften Demenzscreeninginstrumenten untersucht. Die Mini-Mental-State-Untersuchung (MMSE), das Strukturierte Interview für die Diagnose einer Demenz vom Alzheimer-Typ, der Multiinfarktdemenz und Demenzen anderer Ätiologie nach ICD-10 und DSM-III-R (SIDAM) und die Alzheimer’s Disease Assessment Scale (ADAS) wurden bei 71 Patienten mit Demenz vom Alzheimer-Typ und 73 nichtdementen Kontrollprobanden durchgeführt. Eine ROC-Analyse zeigte, daß weder SIDAM noch ADAS besser zwischen dementen Patienten und nichtdementen Kontrollprobanden unterschieden, als der MMSE-Testwert. Dies galt auch für Patienten mit leichter Demenz. Auch bei der Abgrenzung verschiedener Schweregrade der Demenz waren die umfangreicheren Instrumente dem Kurztest MMSE nicht überlegen. Für den klinischen Alltag stellt die MMSE wegen ihrer Kürze das geeignetste Screeninginstrument dar.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1433-9285Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract There is no study indicating that informant-derived information on dementia and depression (i.e. family history information) is equivalently valid for first-degree relatives and for index subjects (i.e. patients and control subjects). However, this unproven assumption is the basis for the frequent, possibly inappropriate, use of instruments validated for patients and control subjects in family studies which focus on frequencies of psychiatric disorders in first-degree relatives. Consequently, there is a need to compare the validity of family history information for both disorders in index subjects and their first-degree relatives. Validity was assessed by comparison of family history information for dementia and depression with interview-derived diagnoses in 75 index subjects and 195 age-matched first-degree relatives. The validity of informant-derived information varied for different disorders, i.e. dementia and depression, and different samples, i.e. index subjects and first-degree relatives. In agreement with the study hypothesis, the sensitivity of surrogate information on dementia was significantly reduced in first-degree relatives in comparison with index subjects. In contrast, the sensitivity to detect depression was equivalent in subjects and in relatives. The results indicate the necessity to assess the validity of the psychiatric diagnoses of interest in the sample of interest, e.g. dementia or depression in first-degree relatives of patients and of control subjects. Observations in selected samples, i.e. subjects treated, hospitalised and/or autopsied, cannot be generalised to first-degree relatives in family studies.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1433-9285Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The aim of the present study was to evaluate the combined test-retest and interrater reliability of different psychiatric lifetime diagnoses yielded in the course of a family study in elderly patients and controls. The following interviews and questionnaires were used in combination: the Composite International Diagnostic Interview (CIDI), the Structured Interview for the Diagnosis of Dementia of the Alzheimer Type, Multi-infarct Dementia and Dementias of Other Aetiology (SIDAM), the General Health Questionnaire (GHQ-12) and questionnaires for neurasthenia and recurrent brief depression (RBD). Depressive and dementia disorders can be diagnosed with good reliability in a family study setting with the use of these instruments. The diagnoses of phobic disorders, neurasthenia, RBD, subthreshold RBD and psychiatric caseness as indicated by GHQ-12 scores were less reliable in this setting and are therefore less suitable for use in family studies.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1433-8491Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Some recent family studies have shown that the familial risk for schizophrenia is higher in female than in male schizophrenics. It is debated whether the risks for the other disorders, such as schizotypal personality disorder or affective disorders in families of schizophrenics are similarly influenced by the proband's gender. Also, the reason for the effect of proband's gender on the recurrence risk for schizophrenia has not been clarified. This family study (159 probands, 589 first degree relatives) confirms that schizophrenia, but also schizophrenia spectrum disorders were more frequent in families of female compared with male schizophrenics. Neither age at onset in probands nor the interaction between gender and age at onset in probands had a relevant impact on the risk figures in relatives. Affective disorders occurred in families independently of the probands' gender. Aetiological heterogeneity or ascertainment bias may account for the modifying effect of proband's gender in schizophrenia.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1433-8491Keywords: Key words Interinformant reliability ; Family history information ; Dementia ; DepressionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Knowledge on the reliability of family history information is essential for every family study. However, systematic analyses of interinformant reliability of family history information on individual relatives have not yet been published. Consequently, family history information on 1306 first-degree relatives and spouses of patients and of control subjects was collected from at least two other family members using questionnaires. Interinformant reliability was acceptable for dementia [Kappa = 0.58, 95% confidence interval (CI) = 0.48–0.68], but less so for alcoholism (Kappa = 0.41, CI = 0.23–0.59), depression (Kappa = 0.26, CI = 0.14–0.38) and anxiety disorders (Kappa = 0.19, CI = 0.05–0.43). Demographic variables of subjects and informants and their familial relationship did not influence diagnostic agreement on the diagnosis of dementia. Diagnostic agreement on depression was significantly reduced when information from siblings of index subjects was compared with information from spouses of index subjects. The interinformant agreement for the diagnosis of depression was higher in younger than in older subjects (relative risk for disagreement 1.08/additional year, CI = 1.02–1.15). Siblings of index subjects seem to provide different, but not necessarily less relevant, family history information in comparison with other relatives. Researchers should be aware of the problem that depression in the elderly can be easily missed by family history. It seems more important for the diagnosis of depression than for a diagnosis of dementia to get information from multiple informants.Type of Medium: Electronic ResourceURL: