Search Results - (Author, Cooperation:R. Herbst)
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1Latest Papers from Table of Contents or Articles in PressT. Hanada ; S. Weitzer ; B. Mair ; C. Bernreuther ; B. J. Wainger ; J. Ichida ; R. Hanada ; M. Orthofer ; S. J. Cronin ; V. Komnenovic ; A. Minis ; F. Sato ; H. Mimata ; A. Yoshimura ; I. Tamir ; J. Rainer ; R. Kofler ; A. Yaron ; K. C. Eggan ; C. J. Woolf ; M. Glatzel ; R. Herbst ; J. Martinez ; J. M. Penninger
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-12Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amyotrophic Lateral Sclerosis ; Animals ; Animals, Newborn ; Axons/metabolism/pathology ; Cell Death ; Diaphragm/innervation ; Embryo Loss ; Embryo, Mammalian/metabolism/pathology ; Exons/genetics ; Female ; Fibroblasts ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Motor Neurons/*metabolism/*pathology ; Muscular Atrophy, Spinal ; Neuromuscular Diseases/metabolism/pathology ; Oxidative Stress ; RNA Processing, Post-Transcriptional ; RNA, Transfer, Tyr/genetics/*metabolism ; Respiration ; Spinal Nerves/cytology ; Transcription Factors/deficiency/*metabolism ; Tumor Suppressor Protein p53/metabolism ; Tyrosine/genetics/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Boutet ; L. Lomb ; G. J. Williams ; T. R. Barends ; A. Aquila ; R. B. Doak ; U. Weierstall ; D. P. DePonte ; J. Steinbrener ; R. L. Shoeman ; M. Messerschmidt ; A. Barty ; T. A. White ; S. Kassemeyer ; R. A. Kirian ; M. M. Seibert ; P. A. Montanez ; C. Kenney ; R. Herbst ; P. Hart ; J. Pines ; G. Haller ; S. M. Gruner ; H. T. Philipp ; M. W. Tate ; M. Hromalik ; L. J. Koerner ; N. van Bakel ; J. Morse ; W. Ghonsalves ; D. Arnlund ; M. J. Bogan ; C. Caleman ; R. Fromme ; C. Y. Hampton ; M. S. Hunter ; L. C. Johansson ; G. Katona ; C. Kupitz ; M. Liang ; A. V. Martin ; K. Nass ; L. Redecke ; F. Stellato ; N. Timneanu ; D. Wang ; N. A. Zatsepin ; D. Schafer ; J. Defever ; R. Neutze ; P. Fromme ; J. C. Spence ; H. N. Chapman ; I. Schlichting
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-06-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Crystallography, X-Ray/*methods ; Lasers ; Muramidase/chemistry/radiation effects ; *Protein ConformationPublished by: -
3Latest Papers from Table of Contents or Articles in PressVillarroel-Espindola, F., Yu, X., Datar, I., Mani, N., Sanmamed, M., Velcheti, V., Syrigos, K., Toki, M., Zhao, H., Chen, L., Herbst, R. S., Schalper, K. A.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-04-04Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressGoldberg, S. B., Narayan, A., Kole, A. J., Decker, R. H., Teysir, J., Carriero, N. J., Lee, A., Nemati, R., Nath, S. K., Mane, S. M., Deng, Y., Sukumar, N., Zelterman, D., Boffa, D. J., Politi, K., Gettinger, S. N., Wilson, L. D., Herbst, R. S., Patel, A. A.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-04-14Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
5Latest Papers from Table of Contents or Articles in PressBiton, J., Mansuet-Lupo, A., Pecuchet, N., Alifano, M., Ouakrim, H., Arrondeau, J., Boudou-Rouquette, P., Goldwasser, F., Leroy, K., Goc, J., Wislez, M., Germain, C., Laurent-Puig, P., Dieu-Nosjean, M.-C., Cremer, I., Herbst, R., Blons, H., Damotte, D.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-11-16Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
6Latest Papers from Table of Contents or Articles in PressKinneer, K., Meekin, J., Tiberghien, A. C., Tai, Y.-T., Phipps, S., Kiefer, C. M., Rebelatto, M. C., Dimasi, N., Moriarty, A., Papadopoulos, K. P., Sridhar, S., Gregson, S. J., Wick, M. J., Masterson, L., Anderson, K. C., Herbst, R., Howard, P. W., Tice, D. A.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-12-15Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
7Articles: DFG German National LicensesHerbst, R. A. ; Uter, W. ; Pirker, C. ; Geier, J. ; Frosch, P. J.
Oxford, UK; Malden, USA : Munksgaard International Publishers
Published 2004Staff ViewISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Periorbital dermatitis is common and can be due to the external use of ophthalmic drugs. We evaluated patch test results of the Information Network of the Departments of Dermatology. During a 5-year period (1995–99), of a total 49 256 patch-tested patients, 1053 (2.1%) were eventually diagnosed as allergic periorbital contact dermatitis (APD) and 588 (1.2%) as non-allergic periorbital dermatitis (NAPD). Patient characteristics between APD, NAPD and other cases (OCs) differed with respect to sex (19.7% male in both periorbital groups versus 36.3% in OCs), atopic dermatitis (10.4% in APD versus 60.2% in NAPD versus 16.9% in OCs) and age, APD being substantially more often (68.2%) aged 40 and above than NAPD (52.6%). Several of the top allergens in OCs [such as fragrance mix, Myroxylon pereirae resin (balsam of Peru), lanolin alcohol and potassium dichromate] caused significantly fewer positive test reactions in both periorbital groups. In contrast, thimerosal, phenylmercuric acetate, sodium disulfite, gentamicin sulfate, phenylephrine hydrochloride and benzalkonium chloride tested positively significantly more often in APD but not in NAPD, verifying them as true ophthalmic allergens. Finally, in 42 cases (4%) of APD patients, additional allergens were identified by testing of the patients' own substances (mostly β-blockers, oxybuprocaine and dexpanthenol), supporting the necessity of testing with ophthalmic drugs as is where individual substances are not readily available.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0034-5687Keywords: Alveolar-arterial ; Dinitrophenol ; Oxygen consumption ; Oxygen diffusing capacity ; P"O"2 difference ; Unequal distributionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0304-4165Keywords: Crystal structure ; Detergent ; X-ray diffraction ; ZwitterionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0649Keywords: 42.65.Cq ; 42.72. + hSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We describe a synchronously pumped LBO parametric oscillator pumped by a cw mode-locked Ti:Sapphire laser. We demonstrate the synchronization between the pump pulses and the signal pulses by measuring a 100 fs cross correlation. We then generate pulses tunable from 2.6 to 5.3 µm by mixing the signal and idler pulses in an AgGaS2 crystal and obtain as much as 400 µW of average power.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesHerbst, R. A. ; Mommert, Susanne ; Schubach, Joke ; Podewski, Edith K. ; Kapp, Alexander ; Weiss, Jürgen
Springer
Published 1999Staff ViewISSN: 1432-069XKeywords: Key words Loss of heterozygosity ; Melanoma ; p73 ; Tumor suppressor geneSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-069XKeywords: TP53 locus ; Cutaneous malignant melanoma ; Point mutations ; Allelic lossSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-069XKeywords: Key words Loss of heterozygosity ; Melanoma ; PTEN/MMAC ; MXI1 ; Tumor suppressor geneSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesHolloway, W. R. ; Collier, F. M. ; Herbst, R. E. ; Hodge, J. M. ; Nicholson, G. C.
Springer
Published 1997Staff ViewISSN: 1432-0827Keywords: Key words: Osteoclast — Calcitonin — Protein-kinase-C — Phorbol-ester — Forskolin — Signal transduction.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsNotes: Abstract. The cytoplasmic spreading of osteoclasts has been used to assess responsiveness to agents such as calcitonin and associated signal transduction mechanisms. Although cyclic AMP and intracellular calcium are known mediators of calcitonin effects in osteoclasts, the role of protein kinase C (PKC) is less clear. We have used time-lapse videomicroscopy of isolated rat osteoclasts to characterize shape changes induced by calcitonin, forskolin, and phorbol 12-myristate-13-acetate (PMA) in the absence and presence of PKC blockers. Treatment with calcitonin reduced cytoplasmic plan area but increased perimeter length, resulting in a characteristic ``stellate'' appearance, whereas forskolin produced ``nonstellate'' contraction. The response of osteoclasts to PMA was dose dependent. High concentrations (10−7–10−6 M) produced biphasic responses with transitory, calcitonin-like ``stellate'' contraction followed by sustained expansion, whereas low concentrations (10−11–10−9 M) produced expansion only. The effects of low-concentration PMA could be prevented by pretreatment with a PKC blocker, whereas the effects of high concentrations were only partially inhibited. The effects of forskolin were unchanged by pretreatment with the PKC blocker. Treatment with calcitonin in the presence of various PKC blockers resulted in paradoxical transient expansion followed by contraction. These results indicate that calcitonin-induced shape change in osteoclasts is a complex process involving protein kinase C in addition to cyclic AMP-dependent mechanisms and possibly other factors.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesSchnermann, J. ; Schubert, G. ; Hermle, M. ; Herbst, R. ; Stowe, N. T. ; Yarimizu, S. ; Weber, P. C.
Springer
Published 1979Staff ViewISSN: 1432-2013Keywords: Micropuncture ; Rat kidney ; Tubuloglomerular feedback ; Prostaglandin inhibitors ; Renal prostaglandinsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract To further clarify the mechanism mediating the reduction of nephron filtration rate in response to an increase of loop of Henle flow rate we have studied the effect of prostaglandin inhibition on tubuloglomerular feedback in rats. Following inravenous administration of 2 or 5 mg/kg indomethacin feedback responses expressed as the percent reduction of early proximal flow rate (EPFR) during flow elevation from 0–40 nl/min decreased from control values of −54.3±4.3% (mean ± S.E.) and −39.5±3.9% to −27.9±2.8% (P〈0.001) and −5.0±4.9% (P〈0.001) respectively. A significant reduction in the feedback response was also seen following intravenous administration of 2 or 5 mg/kg Ro 20-5720 (−28.8±5.8% and −7.8±3.8% respectively), 10 mg/kg meclofenamate (−15±4%), and 2 mg/kg eicosa-5,8,11,14-tetraynoic acid (−16.2±4.8%). In contrast to control animals injection of 5 mg/kg indomethacin had no effect on the feedback response in rats kept on a low salt diet. After applying a single dose of 5 mg/kg indomethacin or Ro 20-5720 feedback responses were reduced to −5.4±4.3% and −3.0±4.36% in the period 0–80 min, but were normal in the period 81–160 min after injection (−36.1±2.83% and −44.3±2.82% respectively). A dose dependent inhibition of the feedback response was also noted when indomethacin was applied intraluminally with full inhibition being established at a concentration of 0.5 mM. Urinary excretion rates of PGE2 and PGF2α fell from control values of 286.1±73.7 and 143.5±25.9 pg/min to 31.2±9.9 and 23.6±9 pg/min following 2 mg/kg indomethacin and to 36.8±4.4 and 8.9±1.9 pg/min following 5 mg/kg Ro 20-5720. Reduction of PG excretion was not reversible during the time of the experiment. Our results demonstrate a consistent decrease of tubuloglomerular feedback responses during inhibition of prostaglandin biosynthesis.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary In 176 cases artificially fed premature infants of all weight-classes were examined in an A-B-test as to whether feeding them with artificial and adapted milk whose fatty acids are exchanged is superior to bringing them up with normal condensed 2/3 milk. The result showed that there is no difference between the two test-groups as to their clinical development. The birth-weight, however, was regained more quickly and the daily increase of weight was bigger with those premature infants fed with adapted milk than with those who got normal condensed 2/3 milk. Weight-classes up to 1.750 grams of test-group A (adapted milk) gained a weight of 2.500 grams—i.e. weight of dismissal from hospital—9 to 11 days earlier than group B. This is statistically verified. In the weight classes from 1.750 grams onwards no significant differences could be found between group A and B. In consequence thereof especially premature infants should be fed with not acidificated milk whose fatty acids are exchanged, in case there is no breast-milk available. From 1.800 grams onwards, however, the ability of adaption is so good even with premature infants that no differences between the two test-groups as to the bringing up with sweetened condensed 2/3 milk can be pointed out.Notes: Zusammenfassung An 176 nur künstlich ernährten Frühgeborenen aller Gewichtsklassen wurde im A-B-Versuch geprüft, ob die Fütterung mit fettausgetauschter, adaptierter künstlicher Säuglingsnahrung der Fütterung mit normaler Kondens-Zweidrittelmilch überlegen sei. Dabei ergab sich im klinischen Gedeihen kein Unterschied zwischen beiden. Untersuchungsgruppen, aber das Geburtsgewicht wurde bei Fütterung mit adaptierter Milch schneller wieder erreicht, die tägliche Gewichtszunahme war im Durchschnitt größer, und in den Gewichtsklassen bis 1750 g wurde das Entlassungsgewicht von 2500 g 9–11 Tage früher erreicht als bei der Fütterung mit einer normalen Zweidrittelmilch. Diese Differenz ist statistisch gesichert. In den Gewichtsklassen über 1750 g waren keine signifikanten Unterschiede mehr festzustellen. Daraus geht hervor, daß besonders die unreifen Frühgeborenen bei fehlender Muttermilch besser mit fettausgetauschter Süßmilch ernährt werden sollten, während von einem Geburtsgewicht von 1800 g an die Adaptationsfähigkeit auch des Frühgeborenen so groß ist, daß keine Differenzen mehr gegenüber der Aufzucht mit gesüßter Kondens-Zweidrittelmilch mehr zu erkennen sind.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung 1. Anläßlich einer Grippeepidemie in der Universitäts-Kinderklinik Halle im Frühjahr 1927, die fast das gesamte Personal und zahlreiche Kinder befiel, wurden ausgibige bakteriologische Untersuchungen bei Erwachsenen und Kindern ausgeführt. 2. Hierbei wurde der Bacillus influenzae (Pfeiffer) aus dem Sputum der Erwachsenen fast regelmäßig, aus dem der Kinder und Säuglinge sehr häufig gezüchtet und deshalb in Anbetracht der äußeren Umstände als Erreger dieser Grippeepidemie angesprochen. 3. Für die durch diesen Bacillus hervorgerufenen Erkrankungen wird versucht, ein charakteristisches Krankheitsbild aufzustellen: Schwere Allgemeinsymptome, Fehlen wesentlicher Lokalsymptome außer circumscripter dunkler Rötung der Gaumenbögen, pertussisähnlicher Husten, keine Komplikationen von seiten der Harnwege, der Ohren und des Darmtraktus. 4. Das gesamte Pflegepersonal ist, ganz besonders im Zustand katarrhalischer Erkrankungen, ab und zu auf Pfeiffersche Influenzabacillen durchzuuntersuchen, die positiv Befundenen müssen Schnupfenschleier tragen und sind von schwächlichen Kindern möglichst ganz fern zu halten. Die positiv befundenen Kinder — mindestens hustende Kleinkinder — sind nach Möglichkeit zu isolieren. 5. Es wird aus prophylaktischen Gründen vorgeschlagen, unter Außerachtlassung epidemiologischer Gesichtspunkte die Bezeichnung “Influenza vera” nicht für die pandemische Grippe zu reservieren, sondern auf alle durch denInfluenzabacillus hervorgerufenen Erkrankungen anzuwenden.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Summary Records show 38 cases of infants with diabetic syndromes in the first six weeks of life. These cases are summarized and arranged as follows: 1. 10 certain and 4 probable cases of genuine, permanent diabetes mellitus. 2. 6 cases of secondary hyperglycaemia following a cerebral alteration or infection. 3. 11 cases of transient diabetes mellitus to which the case we observed is added as the twelfth one. 4. 6 infants who only developed transient diabetes under the stress of an infection. The “transient diabetes mellitus syndrome of the newborn” described as an independent aspect of disease, is a diabetic syndrome without ketosis occuring to prenatal dystrophic infants within the first six weeks of life, mostly without any diabetic heredity, and cured completely if treated with relatively small doses of insulin. Only by observing the course of disease may the limits to genuine diabetes mellitus be clearly defined. Aetiologically the syndrome is interpreted as an adaption disease of prenatal dystrophic infants whose blood glucose level in intrauterine life had probably always been too low owing to a placental dysfunction so that the islets of the pancreas acquires normal function only after birth with a then sufficient glucose stimulation.Notes: Zusammenfassung Es werden aus der Literatur 38 Säuglinge der ersten 6 Lebenswochen mit diabetischen Syndromen zusammengestellt und gegliedert in: 1. 10 sichere und 4 wahrscheinliche Fälle von echtem, bleibendem Diabetes mellitus. 2. 6 Fälle von sekundärer Hyperglykämie nach cerebraler Alteration oder Infektion. 3. 11 Fälle von transitorischem Diabetes mellitus, denen die eigene Beobachtung als 12. Fall hinzugefügt wird. 4. 6 Säuglinge, die erst unter der Belastung einer Infektion das Bild eines transitorischen Diabetes entwickelten. Das als eigenständiges Krankheitsbild herausgestellte “Transitorische Diabetes mellitus-Syndrom des Neugeborenen” ist ein bei pränatal dystrophen Säuglingen, fast immer ohne familiäre Diabetes mellitus-Belastung, innerhalb der ersten 6 Lebenswochen auftretendes diabetisches Syndrom ohne Ketose, das unter Therapie mit relativ kleinen Insulindosen endgültig ausheilt. Nur die Verlaufsbeobachtung ermöglicht eine sichere Abgrenzung zum echten Diabetes mellitus. Ätiologisch wird das Syndrom als Adaptationskrankheit pränatal dystropher Säuglinge gedeutet, deren Blutzucker auf Grund einer placentaren Dysfunktion intrauterin wahrscheinlich ständig zu niedrig war, so daß ihr Inselapparat erst nach der Geburt unter jetzt ausreichender Glucosestimulation zu normaler Funktion heranreift.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-1076Keywords: Renin-angiotensin-aldosterone system ; Antidiuretic hormone ; Urinary sodium excretionSource: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Bei Säuglingen zwischen der 1. und 25. Lebenswoche und bei Kindern zwischen dem 1. und 14. Lebensjahr wurden Renin im Plasma und Aldosteron im Urin in Abhängigkeit von der Natriumausscheidung des Endharns gemessen. Es fand sich eine reziproke Beziehung, die zeigt, daß die hohen Renin- und Aldosteronwerte der Säuglingszeit durch die niedrige Natriumaufnahme mit der Nahrung bedingt sind. Ein zusätzlicher Stimulus ist das Hypothalamus-Hypophysenhinterlappen-System, da durch antidiuretisches Hormon (ADH) Renin und Aldosteron gesenkt werden, was zu einer vermehrten Natriumausscheidung im Harn führt. Die Untersuchungen lassen eine Rückkoppelung zwischen dem Renin-Angiotensin-Aldosteron-System und der ADH-Sekretion erkennen, und diese Rückkoppelung scheint für den Wasser- und Elektrolythaushalt während der Säuglingszeit von Bedeutung zu sein.Notes: Abstract In babies ranging in age from 1 to 25 weeks and in children between 1 and 14 years, plasma renin activity and urinary aldosterone activity were determined in relation to urinary sodium excretion. A reciprocal correlation was found demonstrating that the hyperactivity of the renin-angiotensin-aldosterone system is stimulated in infants by a low sodium intake. A second stimulus was observed in the influence of the hypothalamo-neurohypophyseal system, when the plasma renin activity was suppressed by administration of antidiuretic hormone and sodium excretion increased due to a decreased aldosterone activity. Our study suggests that there exists a feedback between the renin-angiotensin-aldosterone system and ADH release and that this feedback plays an important role in the regulation of water and electrolyte balance in the young infant.Type of Medium: Electronic ResourceURL: