Search Results - (Author, Cooperation:R. H. Medema)
-
1Latest Papers from Table of Contents or Articles in PressA. Janssen ; M. van der Burg ; K. Szuhai ; G. J. Kops ; R. H. Medema
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins/antagonists & inhibitors/metabolism ; Cell Line ; Cell Line, Tumor ; Checkpoint Kinase 2 ; *Chromosomal Instability ; *Chromosome Aberrations ; *Chromosome Segregation ; Cytokinesis ; *DNA Breaks, Double-Stranded ; DNA-Binding Proteins/metabolism ; Histones/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Neoplasms/*genetics ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism ; Protein-Tyrosine Kinases ; Pyrimidines/pharmacology ; Thiones/pharmacology ; *Translocation, Genetic ; Tumor Suppressor Protein p53/metabolism ; Tumor Suppressor Proteins/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. Tresini ; D. O. Warmerdam ; P. Kolovos ; L. Snijder ; M. G. Vrouwe ; J. A. Demmers ; I. W. F. van ; F. G. Grosveld ; R. H. Medema ; J. H. Hoeijmakers ; L. H. Mullenders ; W. Vermeulen ; J. A. Marteijn
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alternative Splicing/physiology ; Ataxia Telangiectasia Mutated Proteins/*metabolism ; Cell Line ; Chromatin/metabolism ; DNA Damage/*physiology ; DNA-Directed RNA Polymerases/metabolism ; Enzyme Activation ; Humans ; *Signal Transduction ; Spliceosomes/*metabolism ; Ultraviolet RaysPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-03-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Chromosomal Instability/*genetics ; Colorectal Neoplasms/*genetics ; DNA Replication/*genetics ; HumansPublished by: -
4Articles: DFG German National LicensesOijen, M. G. C. T. ; Tilanus, M. G. J. ; Medema, R. H. ; Slootweg, P. J.
Oxford, UK : Blackwell Publishing Ltd
Published 1998Staff ViewISSN: 1600-0714Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: p21 (Waf1/Cip1) is a critical downstream effector in the p53-dependent pathway of growth control and causes growth arrest through inhibition of cyclin-dependent kinases. In this study 67% of 43 head and neck squamous cell carcinoma (HNSCC) and 60% of 15 tumour-adjacent oral dysplasias overexpressed p21 by immunohistochemical staining. Overexpression of p21 in HNSCC was independent of the presence of functional p53, as assessed by analysis of mutations and loss of heterozygosity and by immunohistochemistry. Rather, the expression pattern of p21 was associated with differentiation. Furthermore, in most tumours, the p21 positive cells did not incorporate bromodeoxyuridine (BrdU), which indicates inhibition of proliferation by p21 in these cells. In some tumours, p21 was also expressed in proliferating cells. In these latter tumour cells, cyclin D1 was frequently expressed as well. Therefore, we suggest that expression of cyclin D1 might overcome the inhibitory effect of p21 in these cells.Type of Medium: Electronic ResourceURL: