ILSE | Search Results - (Author, Cooperation:R. H. Hruban)

1

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

Y. Jiao ; C. Shi ; B. H. Edil ; R. F. de Wilde ; D. S. Klimstra ; A. Maitra ; R. D. Schulick ; L. H. Tang ; C. L. Wolfgang ; M. A. Choti ; V. E. Velculescu ; L. A. Diaz, Jr. ; B. Vogelstein ; K. W. Kinzler ; R. H. Hruban ; N. Papadopoulos
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-01-22
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Adaptor Proteins, Signal Transducing/genetics ; Carcinoma, Pancreatic Ductal/genetics ; Chromatin Assembly and Disassembly/genetics ; DNA Helicases/genetics ; Genes, Tumor Suppressor ; Humans ; Mutation ; Neuroendocrine Tumors/genetics/metabolism ; Nuclear Proteins/genetics ; PTEN Phosphohydrolase/genetics ; Pancreatic Neoplasms/genetics/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Prognosis ; Proto-Oncogene Proteins/genetics ; Sequence Analysis, DNA ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/genetics/metabolism ; Tumor Suppressor Proteins/genetics
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

2

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

N. Agrawal ; M. J. Frederick ; C. R. Pickering ; C. Bettegowda ; K. Chang ; R. J. Li ; C. Fakhry ; T. X. Xie ; J. Zhang ; J. Wang ; N. Zhang ; A. K. El-Naggar ; S. A. Jasser ; J. N. Weinstein ; L. Trevino ; J. A. Drummond ; D. M. Muzny ; Y. Wu ; L. D. Wood ; R. H. Hruban ; W. H. Westra ; W. M. Koch ; J. A. Califano ; R. A. Gibbs ; D. Sidransky ; B. Vogelstein ; V. E. Velculescu ; N. Papadopoulos ; D. A. Wheeler ; K. W. Kinzler ; J. N. Myers
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-07-30
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Carcinoma/drug therapy/genetics/virology ; Carcinoma, Squamous Cell ; Cell Cycle Proteins/genetics ; Codon, Nonsense ; Exons ; F-Box Proteins/genetics ; Gene Dosage ; Genes, Tumor Suppressor ; Genes, p53 ; Head and Neck Neoplasms/drug therapy/genetics/virology ; Humans ; INDEL Mutation ; Mutation ; Mutation, Missense ; Neoplasms, Squamous Cell/drug therapy/genetics/virology ; Oligonucleotide Array Sequence Analysis ; Oncogenes ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/virology ; Receptor, Notch1/chemistry/genetics ; Sequence Analysis, DNA ; Smoking ; Tobacco ; Ubiquitin-Protein Ligases/*genetics
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

3

Mutations in CIC and FUBP1 contribute to human oligodendroglioma

C. Bettegowda ; N. Agrawal ; Y. Jiao ; M. Sausen ; L. D. Wood ; R. H. Hruban ; F. J. Rodriguez ; D. P. Cahill ; R. McLendon ; G. Riggins ; V. E. Velculescu ; S. M. Oba-Shinjo ; S. K. Marie ; B. Vogelstein ; D. Bigner ; H. Yan ; N. Papadopoulos ; K. W. Kinzler
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-08-06
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Brain Neoplasms/genetics ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 19/genetics ; DNA Helicases/chemistry/genetics/metabolism ; DNA-Binding Proteins/chemistry/genetics/metabolism ; Exons ; Female ; Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Humans ; Loss of Heterozygosity ; Male ; Mutation ; Mutation, Missense ; Oligodendroglioma/genetics ; Receptor, Notch2/genetics ; Repressor Proteins/chemistry/genetics/metabolism ; Sequence Analysis, DNA
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

4

Altered telomeres in tumors with ATRX and DAXX mutations

C. M. Heaphy ; R. F. de Wilde ; Y. Jiao ; A. P. Klein ; B. H. Edil ; C. Shi ; C. Bettegowda ; F. J. Rodriguez ; C. G. Eberhart ; S. Hebbar ; G. J. Offerhaus ; R. McLendon ; B. A. Rasheed ; Y. He ; H. Yan ; D. D. Bigner ; S. M. Oba-Shinjo ; S. K. Marie ; G. J. Riggins ; K. W. Kinzler ; B. Vogelstein ; R. H. Hruban ; A. Maitra ; N. Papadopoulos ; A. K. Meeker
American Association for the Advancement of Science (AAAS)
Published 2011

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Publication Date:	2011-07-02
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Adaptor Proteins, Signal Transducing/genetics/metabolism ; Carcinoma, Neuroendocrine/genetics/pathology/physiopathology ; Cell Nucleus/metabolism ; Central Nervous System Neoplasms/genetics/pathology/physiopathology ; Chromatin Assembly and Disassembly ; DNA Helicases/genetics/metabolism ; Humans ; In Situ Hybridization, Fluorescence ; Mutant Proteins/genetics/metabolism ; Mutation ; Nuclear Proteins/genetics/metabolism ; Pancreatic Neoplasms/genetics/pathology/physiopathology ; Phenotype ; Telomere/*physiology/ultrastructure
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

5

Whole genomes redefine the mutational landscape of pancreatic cancer

N. Waddell ; M. Pajic ; A. M. Patch ; D. K. Chang ; K. S. Kassahn ; P. Bailey ; A. L. Johns ; D. Miller ; K. Nones ; K. Quek ; M. C. Quinn ; A. J. Robertson ; M. Z. Fadlullah ; T. J. Bruxner ; A. N. Christ ; I. Harliwong ; S. Idrisoglu ; S. Manning ; C. Nourse ; E. Nourbakhsh ; S. Wani ; P. J. Wilson ; E. Markham ; N. Cloonan ; M. J. Anderson ; J. L. Fink ; O. Holmes ; S. H. Kazakoff ; C. Leonard ; F. Newell ; B. Poudel ; S. Song ; D. Taylor ; S. Wood ; Q. Xu ; J. Wu ; M. Pinese ; M. J. Cowley ; H. C. Lee ; M. D. Jones ; A. M. Nagrial ; J. Humphris ; L. A. Chantrill ; V. Chin ; A. M. Steinmann ; A. Mawson ; E. S. Humphrey ; E. K. Colvin ; A. Chou ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Pettitt ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. B. Jamieson ; J. S. Graham ; S. P. Niclou ; R. Bjerkvig ; R. Grutzmann ; D. Aust ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; M. Falconi ; G. Zamboni ; G. Tortora ; M. A. Tempero ; A. J. Gill ; J. R. Eshleman ; C. Pilarsky ; A. Scarpa ; E. A. Musgrove ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
Nature Publishing Group (NPG)
Published 2015

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Publication Date:	2015-02-27
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Adenocarcinoma/drug therapy/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy/genetics ; DNA Mutational Analysis ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genome, Human/genetics ; Genomic Instability/genetics ; Genomics ; Genotype ; Humans ; Mice ; Mutation/genetics ; Pancreatic Neoplasms/classification/drug therapy/*genetics ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor Assays
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

6

Genomic analyses identify molecular subtypes of pancreatic cancer

P. Bailey ; D. K. Chang ; K. Nones ; A. L. Johns ; A. M. Patch ; M. C. Gingras ; D. K. Miller ; A. N. Christ ; T. J. Bruxner ; M. C. Quinn ; C. Nourse ; L. C. Murtaugh ; I. Harliwong ; S. Idrisoglu ; S. Manning ; E. Nourbakhsh ; S. Wani ; L. Fink ; O. Holmes ; V. Chin ; M. J. Anderson ; S. Kazakoff ; C. Leonard ; F. Newell ; N. Waddell ; S. Wood ; Q. Xu ; P. J. Wilson ; N. Cloonan ; K. S. Kassahn ; D. Taylor ; K. Quek ; A. Robertson ; L. Pantano ; L. Mincarelli ; L. N. Sanchez ; L. Evers ; J. Wu ; M. Pinese ; M. J. Cowley ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; L. A. Chantrill ; A. Mawson ; J. Humphris ; A. Chou ; M. Pajic ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; N. D. Merrett ; C. W. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; K. Moran-Jones ; N. B. Jamieson ; J. S. Graham ; F. Duthie ; K. Oien ; J. Hair ; R. Grutzmann ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; B. Rusev ; P. Capelli ; R. Salvia ; G. Tortora ; D. Mukhopadhyay ; G. M. Petersen ; D. M. Munzy ; W. E. Fisher ; S. A. Karim ; J. R. Eshleman ; R. H. Hruban ; C. Pilarsky ; J. P. Morton ; O. J. Sansom ; A. Scarpa ; E. A. Musgrove ; U. M. Bailey ; O. Hofmann ; R. L. Sutherland ; D. A. Wheeler ; A. J. Gill ; R. A. Gibbs ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
Nature Publishing Group (NPG)
Published 2016

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Publication Date:	2016-02-26
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinoma, Pancreatic ; Ductal/classification/genetics/immunology/metabolism/pathology ; Cell Line, Tumor ; DNA Methylation ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Genes, Neoplasm/genetics ; Genome, Human/genetics ; Genomics ; Hepatocyte Nuclear Factor 3-beta/genetics ; Hepatocyte Nuclear Factor 3-gamma/genetics ; Histone Demethylases/genetics ; Homeodomain Proteins/genetics ; Humans ; Mice ; Mutation/genetics ; Nuclear Proteins/genetics ; Pancreatic Neoplasms/classification/genetics/immunology/metabolism/pathology ; Prognosis ; Receptors, Cytoplasmic and Nuclear/genetics ; Survival Analysis ; Trans-Activators/genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transcriptome ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/genetics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

7

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

G. M. DeNicola ; F. A. Karreth ; T. J. Humpton ; A. Gopinathan ; C. Wei ; K. Frese ; D. Mangal ; K. H. Yu ; C. J. Yeo ; E. S. Calhoun ; F. Scrimieri ; J. M. Winter ; R. H. Hruban ; C. Iacobuzio-Donahue ; S. E. Kern ; I. A. Blair ; D. A. Tuveson
Nature Publishing Group (NPG)
Published 2011

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Publication Date:	2011-07-08
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Adaptor Proteins, Signal Transducing/genetics/metabolism ; Alleles ; Animals ; Antioxidants/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics/metabolism/pathology ; Cells, Cultured ; Cytoskeletal Proteins/genetics/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibroblasts/metabolism ; Genes, myc/genetics ; Humans ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Signaling System ; Mice ; Mitogen-Activated Protein Kinase Kinases/metabolism ; NF-E2-Related Factor 2/deficiency/genetics/metabolism ; NIH 3T3 Cells ; Oncogenes/genetics ; Oxidation-Reduction ; Pancreatic Neoplasms/genetics/metabolism/pathology ; Proto-Oncogene Proteins B-raf/genetics/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics/metabolism ; Reactive Oxygen Species/*metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

8

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

A. V. Biankin ; N. Waddell ; K. S. Kassahn ; M. C. Gingras ; L. B. Muthuswamy ; A. L. Johns ; D. K. Miller ; P. J. Wilson ; A. M. Patch ; J. Wu ; D. K. Chang ; M. J. Cowley ; B. B. Gardiner ; S. Song ; I. Harliwong ; S. Idrisoglu ; C. Nourse ; E. Nourbakhsh ; S. Manning ; S. Wani ; M. Gongora ; M. Pajic ; C. J. Scarlett ; A. J. Gill ; A. V. Pinho ; I. Rooman ; M. Anderson ; O. Holmes ; C. Leonard ; D. Taylor ; S. Wood ; Q. Xu ; K. Nones ; J. L. Fink ; A. Christ ; T. Bruxner ; N. Cloonan ; G. Kolle ; F. Newell ; M. Pinese ; R. S. Mead ; J. L. Humphris ; W. Kaplan ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; A. Chou ; V. T. Chin ; L. A. Chantrill ; A. Mawson ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; R. J. Daly ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. Kakkar ; F. Zhao ; Y. Q. Wu ; M. Wang ; D. M. Muzny ; W. E. Fisher ; F. C. Brunicardi ; S. E. Hodges ; J. G. Reid ; J. Drummond ; K. Chang ; Y. Han ; L. R. Lewis ; H. Dinh ; C. J. Buhay ; T. Beck ; L. Timms ; M. Sam ; K. Begley ; A. Brown ; D. Pai ; A. Panchal ; N. Buchner ; R. De Borja ; R. E. Denroche ; C. K. Yung ; S. Serra ; N. Onetto ; D. Mukhopadhyay ; M. S. Tsao ; P. A. Shaw ; G. M. Petersen ; S. Gallinger ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; R. D. Schulick ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; P. Capelli ; V. Corbo ; M. Scardoni ; G. Tortora ; M. A. Tempero ; K. M. Mann ; N. A. Jenkins ; P. A. Perez-Mancera ; D. J. Adams ; D. A. Largaespada ; L. F. Wessels ; A. G. Rust ; L. D. Stein ; D. A. Tuveson ; N. G. Copeland ; E. A. Musgrove ; A. Scarpa ; J. R. Eshleman ; T. J. Hudson ; R. L. Sutherland ; D. A. Wheeler ; J. V. Pearson ; J. D. McPherson ; R. A. Gibbs ; S. M. Grimmond
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-10-30
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Axons/metabolism ; Carcinoma, Pancreatic Ductal/genetics/pathology ; Gene Dosage ; Gene Expression Regulation, Neoplastic ; Genome/genetics ; Humans ; Kaplan-Meier Estimate ; Mice ; Mutation ; Pancreatic Neoplasms/genetics/pathology ; Proteins/genetics ; Signal Transduction
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

9

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

B. Waclaw ; I. Bozic ; M. E. Pittman ; R. H. Hruban ; B. Vogelstein ; M. A. Nowak
Nature Publishing Group (NPG)
Published 2015

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Publication Date:	2015-08-27
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Cell Division ; Cell Movement ; Drug Resistance, Neoplasm/genetics ; Evolution, Molecular ; Genetic Variation/genetics ; Humans ; Models, Biological ; Mutation/genetics ; Neoplasms/genetics/metabolism/pathology ; Selection, Genetic ; Time Factors
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

10

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

P. A. Perez-Mancera ; A. G. Rust ; L. van der Weyden ; G. Kristiansen ; A. Li ; A. L. Sarver ; K. A. Silverstein ; R. Grutzmann ; D. Aust ; P. Rummele ; T. Knosel ; C. Herd ; D. L. Stemple ; R. Kettleborough ; J. A. Brosnan ; R. Morgan ; S. Knight ; J. Yu ; S. Stegeman ; L. S. Collier ; J. J. ten Hoeve ; J. de Ridder ; A. P. Klein ; M. Goggins ; R. H. Hruban ; D. K. Chang ; A. V. Biankin ; S. M. Grimmond ; L. F. Wessels ; S. A. Wood ; C. A. Iacobuzio-Donahue ; C. Pilarsky ; D. A. Largaespada ; D. J. Adams ; D. A. Tuveson
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-06-16
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Anoikis/genetics ; Carcinoma, Pancreatic Ductal/enzymology/genetics/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Endopeptidases ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Humans ; Mice ; Mice, Inbred C57BL ; Pancreatic Neoplasms/enzymology/genetics/pathology ; U937 Cells ; Ubiquitin Thiolesterase/genetics/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

11

A draft map of the human proteome

M. S. Kim ; S. M. Pinto ; D. Getnet ; R. S. Nirujogi ; S. S. Manda ; R. Chaerkady ; A. K. Madugundu ; D. S. Kelkar ; R. Isserlin ; S. Jain ; J. K. Thomas ; B. Muthusamy ; P. Leal-Rojas ; P. Kumar ; N. A. Sahasrabuddhe ; L. Balakrishnan ; J. Advani ; B. George ; S. Renuse ; L. D. Selvan ; A. H. Patil ; V. Nanjappa ; A. Radhakrishnan ; S. Prasad ; T. Subbannayya ; R. Raju ; M. Kumar ; S. K. Sreenivasamurthy ; A. Marimuthu ; G. J. Sathe ; S. Chavan ; K. K. Datta ; Y. Subbannayya ; A. Sahu ; S. D. Yelamanchi ; S. Jayaram ; P. Rajagopalan ; J. Sharma ; K. R. Murthy ; N. Syed ; R. Goel ; A. A. Khan ; S. Ahmad ; G. Dey ; K. Mudgal ; A. Chatterjee ; T. C. Huang ; J. Zhong ; X. Wu ; P. G. Shaw ; D. Freed ; M. S. Zahari ; K. K. Mukherjee ; S. Shankar ; A. Mahadevan ; H. Lam ; C. J. Mitchell ; S. K. Shankar ; P. Satishchandra ; J. T. Schroeder ; R. Sirdeshmukh ; A. Maitra ; S. D. Leach ; C. G. Drake ; M. K. Halushka ; T. S. Prasad ; R. H. Hruban ; C. L. Kerr ; G. D. Bader ; C. A. Iacobuzio-Donahue ; H. Gowda ; A. Pandey
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-05-30
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Adult ; Cells, Cultured ; Databases, Protein ; Fetus/metabolism ; Fourier Analysis ; Gene Expression Profiling ; Genome, Human/genetics ; Hematopoietic Stem Cells/cytology/metabolism ; Humans ; Internet ; Mass Spectrometry ; Molecular Sequence Annotation ; Open Reading Frames/genetics ; Organ Specificity ; Protein Biosynthesis ; Protein Isoforms/analysis/genetics/metabolism ; Protein Sorting Signals ; Protein Transport ; Proteome/analysis/chemistry/genetics/metabolism ; Proteomics ; Pseudogenes/genetics ; RNA, Untranslated/genetics ; Reproducibility of Results ; Untranslated Regions/genetics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

12

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C. L., Goggins, M. G., Dal Molin, M., Wang, T.-L., Roden, R., Klein, A. P., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H.-L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M., Papadopoulos, N.
American Association for the Advancement of Science (AAAS)
Published 2018

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Publication Date:	2018-02-23
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Geosciences Computer Science Medicine Natural Sciences in General Physics
Keywords:	Medicine, Diseases
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

13

Hepatocellular carcinoma: Findings on spiral CT during arterial portography

Soyer, P. ; Bluemke, D. A. ; Sitzmann, J. V. ; Hruban, R. H. ; Fishman, E. K.
Springer
Published 1995

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ISSN:	1432-0509
Keywords:	Computed tomography (CT), helical technology ; Liver neoplasms, diagnosis ; Portography ; Liver neoplasms, CT ; Hepatocellular carcinoma ; Portal hypertension
Source:	Springer Online Journal Archives 1860-2000
Topics:	Medicine
Notes:	Abstract Background To determine characteristic imaging features of hepatocellular carcinoma (HCC) on spiral CT during arterial portography (SCTAP) and to correlate the presence or absence of spontaneous portosystemic shunts with the degree of hepatic parenchymal enhancement during SCTAP in patients with HCC. Methods SCTAP scans of 20 patients with HCC were retrospectively analyzed for tumor features, degree of hepatic parenchymal enhancement, and presence or absence of spontaneous portosystemic shunts. Results Nineteen tumors (95%) were hypoattenuating masses and one (5%) was isoattenuating compared with the liver on SCTAP. In seven patients (35%), the tumor was homogeneous in attenuation. Tumor margins were smooth and regular in 12 patients (60%). Vascular invasion and encapsulation were depicted in 10 patients (50%). A high degree of hepatic parenchymal enhancement was observed in 14 patients; one of them (7%) had spontaneous portosystemic shunts. Poor or moderate enhancement was observed in six patients; five of them (83%) had spontaneous portosystemic shunts (p 〈.001). Conclusion The presence of a low attenuated homogeneous intrahepatic mass with associated vascular invasion on SCTAP scans should raise the possibility of HCC. The presence of spontaneous portosystemic shunts is associated with poor or moderate parenchymal enhancement.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1007/BF01256708

Articles: DFG German National Licenses

14

Globular changes in cytomegaloviral inclusions after Ganciclovir treatment

Hruban, Z. ; Kuzo, R. ; Heimann, P. ; Weisenberg, E. ; Hruban, R. H.
Springer
Published 1989

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ISSN:	1432-8798
Source:	Springer Online Journal Archives 1860-2000
Topics:	Medicine
Notes:	Summary Ganciclovir treatment induced eosinophilic intranuclear globules and loss of DNA staining in pulmonary CMV-infected cells. Nuclear capsids contained ring-shaped cores. Cytoplasmic vacuoles contained altered, enveloped, mostly coreless viral particles.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1007/BF01310941

Articles: DFG German National Licenses

15

Familial Pancreatic Cancer

Hruban, R. H. ; Petersen, G. M. ; Goggins, M. ; Tersmette, A. C. ; Offerhaus, G. J. A. ; Falatko, F. ; Yeo, C. J. ; Kern, S.E.
Springer
Published 1999

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ISSN:	1569-8041
Keywords:	familial ; families ; inheritance ; pancreas ; pancreatic cancer ; tumor suppressor genes
Source:	Springer Online Journal Archives 1860-2000
Topics:	Medicine
Notes:	Abstract Background: For many years anecdotal case reports have suggested that pancreatic cancer aggregates in some families. Methods: Two recent advances have established that this is in fact the case. First, large registries, such as the National Familial Pancreas Tumor Registry (NFPTR) at Johns Hopkins, have identified a number of families in which multiple family members have been diagnosed with pancreatic cancer. As a result, the patterns of inheritance of pancreatic cancer can now be studied on a scale not possible before. Second, advances in molecular genetic techniques make it possible to test members of these families for germline mutations in known candidate cancer causing genes. As a result, some of the genetic alterations responsible for the familial aggregation of pancreatic cancer have been identified in some families. Results: The NFPTR has enrolled 362 families in which at least one family member has been diagnosed with pancreatic cancer. These include 151 families in which at least two first-degree relatives have been diagnosed with pancreatic cancer. Analysis of these families has revealed that even second-degree relatives of patients from these families are at increased risk of developing pancreatic cancer. In addition, a number of kindreds which exhibit aggregation of cancer have been tested for germline mutations in known cancer causing genes. Germline mutations in BRCA2 have been shown to predispose to both breast and pancreatic cancer, germline mutations in p16 to melanoma and pancreatic cancer (the FAMMM syndrome), and genetic mutations in STK11/LKB1 to pancreatic cancer in patients with the Peutz-Jeghers Syndrome (PJS). Conclusions: Pancreatic cancer aggregates in some families, and relatives of patients with pancreatic cancer have an increased risk of developing pancreatic cancer themselves. The genetic basis for the familial aggregation of pancreatic cancer has been shown to be germline mutations in known cancer causing genes in some of these families.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1023/A:1008345021197

Articles: DFG German National Licenses

16

Pathology of Incipient Pancreatic Cancer

Hruban, R. H. ; Wilentz, R.E. ; Goggins, M. ; Offerhaus, G.J.A. ; Yeo, C.J. ; Kern, S.E.
Springer
Published 1999

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ISSN:	1569-8041
Keywords:	duct lesions ; hyperplasia ; K-ras ; p16 ; p53 ; pancreas ; pancreas cancer
Source:	Springer Online Journal Archives 1860-2000
Topics:	Medicine
Notes:	Abstract Background: An understanding of incipient pancreatic neoplasia is an essential foundation for the future development of effective screening tests for pancreatic cancer. Only when we understand early pancreatic neoplasms will be able to detect tumors that are curable with surgical resection. Method: Two approaches have helped define incipient pancreatic neoplasia. First, the histologic examination of pancreata has helped identify the most common histologic lesions in pancreatic tissues adjacent to infiltrating carcinomas. The assumption is that some of these lesions represent the precursors to the infiltrating cancers. Second, advances in molecular genetics now make it possible to define the genetic alterations present in small lesions. The demonstration that a suspected precursor lesion and an infiltrating pancreatic carcinoma share the same genetic alterations would help establish that the lesion is indeed a precursor to infiltrating pancreatic carcinoma. Results: A spectrum of intraductal proliferations in the pancreas has been found associated with infiltrating adenocarcinoma of the pancreas. These lesions, called "duct lesions," have even been identified in pancreas years before patients develop infiltrating carcinoma. Molecular genetic analysis of these lesions has revealed that they frequently harbor many of the same alterations present in infiltrating carcinoma of the pancreas. These alterations include activation of K-ras and inactivation of p16, p53 and, rarely BRCA2. Conclusions: From these morphologic and molecular observations, we can now develop a progression model for the development of infiltrating carcinoma of the pancreas. Infiltrating carcinomas of the pancreas may arise from pancreatic duct lesions, and the progression of duct lesions to infiltrating cancer is associated with the accumulation of generalized and specific genetic alterations.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1023/A:1008359929858

Articles: DFG German National Licenses

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