Search Results - (Author, Cooperation:R. Goetz)
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1Latest Papers from Table of Contents or Articles in PressJ. M. Suh ; J. W. Jonker ; M. Ahmadian ; R. Goetz ; D. Lackey ; O. Osborn ; Z. Huang ; W. Liu ; E. Yoshihara ; T. H. van Dijk ; R. Havinga ; W. Fan ; Y. Q. Yin ; R. T. Yu ; C. Liddle ; A. R. Atkins ; J. M. Olefsky ; M. Mohammadi ; M. Downes ; R. M. Evans
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; Diabetes Mellitus, Experimental/drug therapy/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat ; Dose-Response Relationship, Drug ; Fibroblast Growth Factor 1/administration & dosage/adverse effects/*pharmacology ; Glucose/*metabolism ; Glucose Tolerance Test ; Humans ; Insulin/*metabolism ; Insulin Resistance ; Liver/drug effects/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Mitogens/pharmacology ; Muscle, Skeletal/drug effects/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. M. Suh ; J. W. Jonker ; M. Ahmadian ; R. Goetz ; D. Lackey ; O. Osborn ; Z. Huang ; W. Liu ; E. Yoshihara ; T. H. van Dijk ; R. Havinga ; W. Fan ; Y. Q. Yin ; R. T. Yu ; C. Liddle ; A. R. Atkins ; J. M. Olefsky ; M. Mohammadi ; M. Downes ; R. M. Evans
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-03-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
3Articles: DFG German National LicensesPatterson, John L. ; Goetz, R. H. ; Doyle, J. T. ; Warren, J. V. ; Gauer, O. H. ; Detweiler, D. K. ; Said, S. I. ; Hoernicke, H. ; McGregor, M. ; Keen, E. N. ; Smith, M. H. ; Hardie, E. L. ; Reynolds, M. ; Flatt, W. P. ; Waldo, D. R.
Oxford, UK : Blackwell Publishing Ltd
Published 1965Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Barley yellow mosaic disease is caused by several viruses, i.e. barley yellow mosaic virus (BaYMV), barley mild mosaic virus (BaMMV) and BaYMV-2. The reaction of different barley germplasms to the barley mosaic viruses was studied in field and greenhouse experiments. The results show a complex situation; some varieties are resistant to all the viruses, while others are resistant to one or two of them only.Crosses between different barley germplasms were earned out in order to test whether genetic diversity of resistance against mosaic viruses does exist, particularly, BaMMV. A total of 45 foreign barley varieties were crossed to German cultivars carrying the resistance gene ym4. In F2 of 27 crosses, no segregation could be detected, leading to the conclusion that the resistance genes of the foreign parents are allelic with ym4 e.g. Ym1 (‘Mokusekko 3’) and Ym2 (‘Mihori Hadaka 3’). A total of 18 crosses segregated in F2 indicating that foreign parents, like ‘Chikurin Ibaraki 1’, ‘Iwate Omugi 1’, and “Anson Barley”, carry resistance genes different from the gene of German cultivars, e.g. ‘Asorbia’ or ‘Franka’. By means of statistical evaluation (Chi2-test), the observed segregation ratios were analyzed in order to obtain significant information on the heredity of resistance. All the resistance genes described here as being different from the gene ym4, act recessively. Most of the exotic varieties seem to carry only one resistance gene. In a few cases, more than one gene may be present.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesQuitkin, F.M. ; Rabkin, J.G. ; Stewart, J.W. ; McGrath, P.J. ; Harrison, W. ; Davies, M. ; Goetz, R. ; Puig-Antich, J.
Amsterdam : ElsevierStaff ViewISSN: 0165-0327Keywords: Atypical depression - Endogenous depression - REM abnormalities - SleepSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0013-4686Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0013-4686Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0013-4686Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0039-6028Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesHeidbreder, E. ; Bahner, U. ; Hess, M. ; Geiger, H. ; Götz, R. ; Kirsten, R. ; Rascher, W. ; Heidland, A.
Springer
Published 1990Staff ViewISSN: 1432-1440Keywords: Thirst regulation ; Vasopressin ; Renin-angiotensin-system ; Atrial natriuretic peptide ; Endstage renal diseaseSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary About 30% of hemodialyzed patients are suffering from chronic fluid overload despite advice to restrict the oral fluid intake. To investigate the cause of the abnormal drinking behaviour a clinical study was performed in 51 non-diabetic patients with endstage renal disease exhibiting lower interdialytic weight gain (〈3 kg,n=17) and increased interdialytic weight gain (〉3 kg,n=34). Blood pressure, body weight self-estimated thirst intensity before and after hemodialysis were analyzed. Biochemical and behavioral variables were measured including hormonal factors of water and sodium metabolism. Significant differences of dry weight, creatinine, urea nitrogen and thirst intensity were found between the two groups. Catecholamines, renin, angiotensin II, aldosterone, vasopressin and atrial natriuretic peptide exhibited a similar pattern in both groups. Atrial natriuretic peptide decreased during hemodialysis in both groups, angiotensin II, however, and norepinephrine showed an exaggerated response to ultrafiltration rate in polydipsic patients. These results suggest that changes in serum osmolality during hemodialysis did not contribute to thirst and drinking behaviour. It seems that postdialytic hypovolaemia together with higher plasma-angiotensin II-levels is responsible for increased oral intake of fluid and excessive weight gain.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0568Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0568Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-0568Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0568Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStöckli, K. A. ; Lottspeich, F. ; Sendtner, M. ; Masiakowski, P. ; Carroll, P. ; Götz, R. ; Lindholm, D. ; Thoenen, H.
[s.l.] : Nature Publishing Group
Published 1989Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] CNTF was purified from adult rat sciatic nerve as described previously5, using an additional HPLC purification step (for details see legend to Table 1). The amino-acid sequences of the various fragments determined by gas-phase microsequencing represented more than 50% of the protein. The peptide ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesPancer, Zeev ; Amemiya, Chris T. ; Ehrhardt, Götz R. A. ; Ceitlin, Jill ; Larry Gartland, G. ; Cooper, Max D.
[s.l.] : Macmillian Magazines Ltd.
Published 2004Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-2013Keywords: Uterus ; Placenta ; Arteries ; Vascular resistance ; Vasodilation ; Pregnancy ; Structural dilation ; OestrogenSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Pressure-diameter curves were determined on mesometrial (uterine radial) arteries obtained from guinea pigs during different stages of ovarian cycle and pregnancy. In order to investigate changes in arterial diameter that are not caused by the vascular musculature, we studied excised arteries that were relaxed by papaverine (40 mg/l). The pressure-diameter curves were found to be shifted toward wider diameters when the arteries studied were obtained from pregnant, oestrous or oestrogen treated animals (oestradiol benzoate, 10 μg s.c.): the external diameter at 60 mm Hg transmural pressure on the 14th day of pregnancy exceeded the one during dioestrus by 50%. At term, there was a 7-fold increase. During oestrus and 24 h after oestrogen treatment the diameter was 30–40% wider than during dioestrus. Moreover, we found that the diameter measured on excised vessels in the presence of papaverine is the same as the one observed in situ. We conclude that the mesometrial arteries of guinea pigs possess a muscle-independent mechanism of lumen regulation. The mechanism operates in non-pregnant and pregnant animals. It may be induced by oestrogen and seems to be qualified for long-term lumen regulation during pregnancy. In contrast, dilation by smooth muscle relaxation appears to be of minor importance in mesometrial arteries.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesGoetz, R. H. ; Doyle, J. ; Gauer, O. H. ; Keen, T. ; Patterson, J. L. ; Warren, J. V.
Springer
Published 1957Staff ViewISSN: 1432-2013Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-2013Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-0738Keywords: Pentachlorophenol ; 2,4,6-Trichlorophenol ; Sulfobromophthalein ; Isolated hepatocytes ; Energy metabolismSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effect of pentachlorophenol (PCP) and 2,4,6-trichlorophenol (2,4,6 T) on the disposition of the hepatodiagnostic dye, sulfobromophthalein (BSP) has been studied in isolated liver cells. PCP (4–6 μM) as well as 2,4,6-T (50–100 μM) interferes with the disposition of BSP. The main effect apparently occurs at the secretion step as both drugs severely impair the release of the glutathione conjugate of BSP into the medium. As a consequence, BSP and its conjugate accumulate in the cell. High doses of PCP did not increase the release of lactate dehydrogenase from the hepatocytes. Concentrations of the two phenols which interfere with the secretion of BSP also completely uncouple the oxidative phosphorylation of hepatocellular mitochondria. The dysfunction of liver cells described here may therefore be explained by the effect of PCP and 2,4,6-T on the energy production of the cells. The higher toxicity of PCP as compared to 2,4,6-T observed in our system corresponds well with the higher LD50 of the latter compound.Type of Medium: Electronic ResourceURL: