Search Results - (Author, Cooperation:R. Gautam)
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1Latest Papers from Table of Contents or Articles in PressR. Gautam ; Y. Nishimura ; A. Pegu ; M. C. Nason ; F. Klein ; A. Gazumyan ; J. Golijanin ; A. Buckler-White ; R. Sadjadpour ; K. Wang ; Z. Mankoff ; S. D. Schmidt ; J. D. Lifson ; J. R. Mascola ; M. C. Nussenzweig ; M. A. Martin
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-04-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/administration & dosage/immunology ; Animals ; Antibodies, Monoclonal/administration & dosage/blood/genetics/immunology ; Antibodies, Neutralizing/administration & dosage/blood/genetics/immunology ; Female ; HIV Antibodies/*administration & dosage/blood/genetics/*immunology ; HIV Infections/immunology/prevention & control/transmission ; Half-Life ; Immunoglobulin Fc Fragments/chemistry/genetics/immunology ; Macaca mulatta/immunology/virology ; Male ; Mutation/genetics ; Protein Structure, Tertiary ; SAIDS Vaccines/administration & dosage/immunology ; Simian Acquired Immunodeficiency Syndrome/blood/*immunology/*prevention & control ; Simian Immunodeficiency Virus/*immunology ; Time FactorsPublished by: -
2Latest Papers from Table of Contents or Articles in PressSantanu Baruah, Sebastiano D’Amico, Sowrav Saikia, J L Gautam, R. K. Mrinalinee Devi, Goutam Kashyap Boruah, Antara Sharma, Mohamed F Abdelwahed
Istituto Nazionale di Geofisica e Vulcanologia (INGV)
Published 2018Staff ViewPublication Date: 2018-03-17Publisher: Istituto Nazionale di Geofisica e Vulcanologia (INGV)Print ISSN: 1593-5213Topics: GeosciencesPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-09Publisher: American Chemical Society (ACS)Print ISSN: 1528-7483Electronic ISSN: 1528-7505Topics: Chemistry and PharmacologyGeosciencesPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-12Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressMithun Paul, Shaunak Chakraborty and Gautam R. Desiraju
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-02-06Publisher: American Chemical Society (ACS)Print ISSN: 0002-7863Electronic ISSN: 1520-5126Topics: Chemistry and PharmacologyPublished by: -
6Latest Papers from Table of Contents or Articles in PressSubhankar Saha, Manish Kumar Mishra, C. Malla Reddy, Gautam R. Desiraju
American Chemical Society (ACS)
Published 2018Staff ViewPublication Date: 2018-10-24Publisher: American Chemical Society (ACS)Print ISSN: 0001-4842Electronic ISSN: 1520-4898Topics: Chemistry and PharmacologyPublished by: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-4632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: : The immunologic profile during erythema nodosum leprosum (ENL) revealed increased percentage and absolute count of B-lymphocytes, in addition to considerably lowered levels of complement component C3. Serum immunoglobulins—IgG, IgA, and IgM—were significantly raised after subsidence of ENL, whereas upgrading reaction showed an increase of absolute count of total T lymphocytes and percentage and count of B-lymphocytes. In addition, a raised serum IgM level was noted after regression of ENL. Downgrading reaction demonstrated a decreased percentage of early T-lymphocytes and raised the absolute count of B-lymphocytes. Serum IgA levels were found to be increased after amelioration of ENL.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesSHROFF, GAUTAM R ; BADVE, SUNIL V ; JOSHI, ANAND G ; DESAI, DEVENDRA C ; ABRAHAM, PHILIP ; SIRSAT, RASIKA A
Melbourne, Australia : Blackwell Science Pty
Published 2004Staff ViewISSN: 1440-1797Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY: Acute renal failure has rarely been reported in association with acute hepatitis A infection. The commonest form of renal injury in such patients has been found to be acute tubular necrosis. We report two cases of hepatitis A infection in which acute renal failure occurred very early in the course of the illness and had a clinical presentation and recovery pattern suggestive of acute tubular necrosis. In both patients, the clinical course of renal dysfunction was almost parallel to the course of hepatic dysfunction. Patient 1 needed dialysis, whereas patient 2 did not need dialysis and had a very rapid recovery from renal function in spite of having more severe azotaemia. Patient 2 was administered acetylcysteine in high doses for suspected fulminant hepatic failure. A potential benefit of a high dose of acetylcysteine in recovery of renal function from acute tubular necrosis is postulated.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] ...I have always regarded myself as unconventional, taking roads not taken by others. Therefore, in 1978, despite a green card and being armed with a PhD from the University of Illinois, I came home permanently to India. Everyone else I knew was travelling in the opposite direction. Of course, my ...Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] For a long time chemists tried to understand nature at a level that was purely molecular — they considered only structures and functions involving strong covalent bonds. But some of the most important biological phenomena do not involve making and breaking covalent bonds — the linkages ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] ...Concepts that are ancient and pervasive do not lend themselves easily to precise definition. A layperson might think of 'crystal' as referring to table glass of high quality. But to a scientist, 'crystal' denotes solid matter in a more or less ordered form, whereas glass is considerably less ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesSarma, J. A. R. P. ; Nangia, Ashwini ; Desiraju, Gautam R. ; Zass, Engelbert ; Dunitz, Jack D.
[s.l.] : Nature Publishing Group
Published 1997Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] In commenting on our recent observation that there are more organic compounds with an even number of carbon atoms than with an odd number (Nature 384, 320; 1996), P. G. Stanley (Nature 385, 782; 1997) suggests that "The pronounced excess of C-even compounds among those with large numbers of carbon ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract The fate of total lipids, proteins and carbohydrates in the trachea, lungs, and heart of the common ground squirrel,Funambulus pennanti, have been determined after separate exposure to three principal air pollutants, carbon monoxide (CO), sulphur dioxide (SO2), and nitrogen dioxide (NO2). Exposure to all of these gases produced edematous conditions; however, the moisture content of heart muscle was reduced. Carbon monoxide (CO) and NO2 are more toxic to pulmonary lipids than SO2. The lipid content of the heart decreased, least effects noted with SO2 treatment. Mechanical properties of the lungs were changed by alteration of the lung lipids causing changes in the surface tension. Changes in protein content were caused by altered membrane permeability. Comparative data on the carbohydrates indicated adverse effects by the pollutants.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesSarma, Jagarlapudi A. R. P. ; Nangia, Ashwini ; Desiraju, Gautam R. ; Zass, Engelbert ; Dunitz, Jack D.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] SIR — We have stumbled on a striking feature of the composition of organic compounds, which, we believe, has not been noticed previously, and for which we have no simple explanation. In the sample of almost seven million organic compounds whose atomic compositions are listed in the Beilstein ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesBasu, C. K. ; Gautam, R. K. ; Sharma, R. P. ; Kumar, H. ; Tomar, O. S. ; Sawhney, R. C. ; Selvamurthy, W.
Springer
Published 1996Staff ViewISSN: 1432-1254Keywords: High altitude ; Acclimatization ; Metabolic changesSource: Springer Online Journal Archives 1860-2000Topics: GeographyPhysicsNotes: Abstract The study was carried out on 16 men (aged 20–30 years) to evaluate daily metabolic responses during the early phase of altitude acclimatization at moderate altitudes between 3100 and 4200 m in the Eastern Himalayas. Resting (R) and submaximal exercise (E) oxygen consumption (|VO2) at 100 W at sea level (SL) were 3.25 (SEM 0.15) and 20.31 (SEM 0.77) ml/kg per min respectively. On day 1 at 3110 m both R and E |VO2 decreased (P〈0.001) and subsequently remained constant. At 3445 m these values tended to increase over the 3110 m values but were lower than the SL values. At 4177 m the decline in |VO2 was significantly greater (P〈0.01) than at the preceding altitudes. Pulmonary ventilation (|VE) increased consistently (P〈0.001) with increase in altitude. The arterial oxygen saturation (S a O2) at different altitudes was lower (P〈0.001) than SL values. The cardiac frequency (f C ) at R and E was higher (P〈0.001) at altitude; the values at 3110 and 3445 m were significantly lower (P〈0.001) than at 4177 m. Blood pressure (BP) increased (P〈0.001) on the first day at each altitude. The systolic BP tended to decline towards SL values but the diastolic BP remained high (P〈0.001) throughout. The resting blood lactic acid concentration, [la −] bl , showed a decline (P〈0.001) only at 4177 m. The [la −] bl at E was similar at 3110 and 3445 m but was higher (P〈0.01) at 4177 m. These observations suggest that acclimatization to a mid-altitude of 3445 m can be safely avoided where rapid ascent to higher altitude is required.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract A simple neural network model is proposed for kindling — the phenomenon of generating epilepsy by means of repeated electrical stimulation. The model satisfies Dale's hypothesis, incorporates a Hebb-like learning rule and has low periodic activity in absence of shocks. Many of the experimental observations are reproduced and some new experiments are suggested. It is proposed that the main reason for kindling is the formation of a large number of excitatory synaptic connections due to learning.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesHargittai, Istvan ; Desiraju, Gautam R. ; Martin, Ned H. ; Kauffman, George B. ; Hargittai, Magdolna
Springer
Published 1997Staff ViewISSN: 1572-9001Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-5036Keywords: Planting schemes ; Plant densities ; Zinc deficiency (Khaira)Source: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Summary Visual zinc deficiency symptoms were recorded under two planting schemes and at three plant densities of four different duration rice varieties. Increase in plant density resulted in significant reduction in zinc deficiency (Khaira) symptoms. However planting schemes did not show very abrupt differences for the appearance of deficiency symptoms.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Festkörperstrukturen ; Kristall-Engineering ; Supramolekulare Chemie ; Wasserstoffbrücken ; Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: Der Kristall einer organischen Verbindung ist die höchste Form eines Supramoleküls, und sein von chemischen und geometrischen Faktoren bestimmter Zusammenbau aus Molekülen ist das perfekte Beispiel für molekulare Erkennung im festen Zustand. Die supramolekulare Beschreibung einer Kristallstruktur beinhaltet, daß die Moleküle im Kristall durch nichtkovalente Wechselwirkungen zusammengehalten werden. Die Notwendigkeit für einen rationalen Zugang zu Festkörpern von grundlegender und praktischer Bedeutung hat zum Entstehen des Kristall-Engineering geführt, bei dem man versucht, die intermolekularen Wechselwirkungen und Erkennungsphänomene im Zusammenhang mit der Kristallpackung zu verstehen. Das Ziel des Kristall-Engineering ist es, auf der Grundlage der intermolekularen Wechselwirkungen zuverlässige Zusammenhänge zwischen der molekularen und der supramolekularen Struktur herzustellen, und idealerweise möchte man Substrukturen in einem Zielsupramolekül identifizieren, das aus logisch gewählten Vorläufermolekülen zusammengesetzt werden kann. In der Tat ist Kristall-Engineering eine neue Form der organischen Synthese, und es soll in diesem Beitrag gezeigt werden, daß Kristall-Engineering nicht nur von nomineller Bedeutung für die Organische Chemie ist, sondern im Kerngebiet der Organischen Chemie liegt und konzeptionell der traditionellen organischen Synthese überraschend ähnlich ist. Im Detail unterscheiden sich Kristall-Engineering und organischen Synthese allerdings: Beim Kristall-Engineering spielen intermolekulare Wechselwirkungen und weniger kovalente Bindungen eine Rolle. Im ersten Teil dieses Beitrags wird die Strategie behandelt: Die verwandten Konzepte des Kristall-Engineering und der organischen Synthese werden hervorgehoben und der Begriff supramolekulares Synthon eingeführt. Im zweiten Teil steht die Methode im Vordergrund, d. h. die chemischen und geometrischen Eigenschaften der spezifischen intermolekularen Wechselwirkungen.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0570-0833Keywords: crystal engineering ; hydrogen bonding ; molecular recognition ; organic synthesis ; supramolecular chemistry ; Crystal engineering ; Hydrogen bonds ; Molecular recognition ; Supramolecular chemistry ; Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyNotes: A crystal of an organic compound is the ultimate supermolecule, and its assembly, governed by chemical and geometrical factors, from individual molecules is the perfect example of solid-state molecular recognition. Implicit in the supramolecular description of a crystal structure is the fact that molecules in a crystal are held together by noncovalent interactions. The need for rational approaches towards solid-state structures of fundamental and practical importance has led to the emergence of crystal engineering, which seeks to understand intermolecular interactions and recognition phenomena in the context of crystal packing. The aim of crystal engineering is to establish reliable connections between molecular and supramolecular structure on the basis of intermolecular interactions. Ideally one would like to identify substructural units in a target supermolecule that can be assembled from logically chosen precursor molecules. Indeed, crystal engineering is a new organic synthesis, and the aim of this article is to show that rather than being only nominally relevant to organic chemistry, this subject is well within the mainstream, being surprisingly similar to traditional organic synthesis in concept. The details vary because one is dealing here with intermolecular interactions rather than with covalent bonds; so this article is divided into two parts. The first is concerned with strategy, highlighting the conceptual relationship between crystal engineering and organic synthesis and introduces the term supramolecular synthon. The second part emphasizes methodology, that is, the chemical and geometrical properties of specific intermolecular interactions.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: