Search Results - (Author, Cooperation:R. E. Vance)

2011-08-30

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antigens, Bacterial/*immunology ; Apoptosis Regulatory Proteins/immunology ; Bacteria/*immunology ; Calcium-Binding Proteins/immunology ; Caspase 1/metabolism ; Cells, Cultured ; Flagellin/immunology ; HEK293 Cells ; Humans ; Immunity, Innate/*immunology ; Inflammasomes/*immunology ; Ligands ; Macrophages/immunology/metabolism ; Mice ; Mice, Inbred C57BL ; Neuronal Apoptosis-Inhibitory Protein/deficiency/*immunology/metabolism ; Salmonella typhimurium/immunology ; Substrate Specificity

2011-09-29

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adjuvants, Immunologic ; Amino Acid Sequence ; Animals ; Cyclic GMP/*analogs & derivatives/immunology ; DNA/immunology ; HEK293 Cells ; Humans ; Immunity, Innate/*immunology ; Interferons/immunology ; Macrophages/immunology/metabolism ; Membrane Proteins/genetics/*immunology/*metabolism ; Mice ; Molecular Sequence Data

2012-08-21

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antigens, Bacterial/chemistry/genetics/metabolism ; Apoptosis Regulatory Proteins/deficiency/metabolism ; Bacterial Toxins/chemistry/genetics/metabolism ; Body Fluids/metabolism ; Body Temperature ; Calcium Signaling ; Calcium-Binding Proteins/deficiency/metabolism ; Capillary Permeability ; Caspase 1/deficiency/metabolism ; Cyclooxygenase 1/deficiency ; Cytosol/metabolism ; Death ; Eicosanoids/*biosynthesis/metabolism ; Female ; Flagellin/genetics/immunology/metabolism ; Fluid Shifts ; Hematocrit ; Immunity, Innate/immunology ; Inflammasomes/*metabolism ; Inflammation/immunology/metabolism/pathology ; Interleukin-18 ; Interleukin-1beta ; Intestines/metabolism ; Legionella pneumophila ; Macrophages, Peritoneal/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Neuronal Apoptosis-Inhibitory Protein/deficiency/metabolism ; Peritoneal Cavity ; Peritoneal Lavage ; Recombinant Fusion Proteins/genetics/metabolism ; Salmonella Infections/immunology ; Salmonella typhimurium/immunology ; Time Factors

2013-01-26

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Burkholderia/pathogenicity/physiology ; Burkholderia Infections/enzymology/immunology/metabolism ; Burkholderia pseudomallei/pathogenicity/physiology ; Caspases/*metabolism ; *Cell Death ; Cytosol/*microbiology ; Gram-Negative Bacterial Infections/enzymology/*immunology/microbiology ; Immunity, Innate ; Inflammasomes/metabolism ; Macrophages/immunology/*microbiology ; Mice ; Mice, Inbred C57BL ; Phagosomes/microbiology ; Salmonella Infections, Animal/enzymology/immunology/microbiology ; Salmonella typhimurium/pathogenicity/physiology ; Vacuoles/*microbiology

2018-03-06

Rockefeller University Press

0022-1007

1540-9538

Medicine

1573-0417

Great Plains ; mineralogy ; ostracodes ; paleohydrology ; plant macrofossils ; stable isotopes

Springer Online Journal Archives 1860-2000

Biology

Geosciences

Abstract Sediment lithology and mineralogy, as well as ostracode, plant macrofossil and stable isotope stratigraphies of lake sediment cores, are used to reconstruct late Holocene hydrologic changes at Kenosee Lake, a relatively large, hyposaline lake in southeastern Saskatchewan. Chronological control is provided by AMS radiocarbon ages of upland and shoreline plant macrofossils. All indicators outline an early, low-water, saline phase of lake history (4100–3000 BP), when the basin was occupied by a series of small, interconnected, sulfate-rich brine pools, as opposed to the single, topographically-closed lake that exists today. A rapid rise in lake-level (3000–2300 BP) led to the establishment of carbonate-rich, hyposaline lake conditions like those today. Lithostratigraphic data and ostracode assemblages indicate peak salinities were attained early in this period of lake infilling, suggesting that the lake-level rise was initially driven by an influx of saline groundwater. Lake-level and water chemistry have remained relatively stable over the last 2000 years, compared to earlier events. Because of a lack of datable organic material in sediments deposited during the last 2000 years, the chronology of recent events is not well resolved. Plant macrofossil, lithostratigraphic and ostracode evidence suggests that lake draw-down, accompanied by slightly higher than present salinites, occurred sometime prior to 600 BP, followed by peak lake-level and freshwater conditions. This most recent high lake stand, indicative of a high water table on the surrounding upland, may also have led to the establishment of an extensive cover of Betula in the watershed, possibly in response to paludification. Ostracode assemblages indicate that peak freshwater conditions occurred within the last 100 years. Since historically documented lake-level fluctuations correlate with decadal scale climatic fluctuations in the meteorological record, and late-Holocene hydrologic dynamics correspond to well documented climatic excursions of the Neoglacial and Little Ice Age, Kenosee Lake dynamics offer insight into the susceptibility of the region's water resources to climate change.

Electronic Resource

1573-0417

Lake Winnipeg ; plant macrofossils ; entomology ; AMS ; radiocarbon ; ‘hard-water’ effect

Springer Online Journal Archives 1860-2000

Biology

Geosciences

Abstract Conventional radiocarbon dating of Lake Winnipeg core samples has produced erroneously old ages due to the incorporation of pre-Quaternary carbon derived from carbonaceous rocks, soils and sediments in the watershed, as well as a ‘hard-water’ effect resulting from leaching of calcareous rocks and soils. To circumvent these problems and develop a reliable chronology for the Lake Winnipeg core series, a total of 64 samples from the Lake Winnipeg core series were processed to isolate well preserved macrofossils suitable for Accelerator Mass Spectrometry (AMS) radiocarbon dating. Here we report six radiocarbon ages derived from plant macrofossils and ostracodes, and reconstruct aspects of the depositional environment of each sample based on the associated macrofossil assemblage.

Electronic Resource

1573-0417

pollen analysis ; paleobotany ; mineralogy ; Great Plains ; drought ; paleosalinity ; paleoclimatology

Springer Online Journal Archives 1860-2000

Biology

Geosciences

Abstract Analyses of pollen, plant macrofossils, sediment mineralogy, geochemistry, and lithology of cores from Chappice Lake, southeastern Alberta, provide an outline of paleohydrological changes spanning the last 7300 radiocarbon years. Situated near the northern margin of the Great Plains, Chappice Lake is currently a small (1.5 km2), shallow (〈1 m), hypersaline lake. Results of this study suggest that the lake has experienced significant changes in water level and chemistry during the Holocene. From 7300 to 6000 BP the lake oscillated between relatively high stands and desiccation. From 6000 to 4400 BP it was smaller than present and ponded highly saline water. Although extreme water level variations of the preceding period had ceased, pronounced seasonal fluctuations persisted. Between 4400 and 2600 BP, lake level was more stable but gradually rising. Carbonates were a major component of the sediments deposited during this interval. A large, relatively fresh lake existed from 2600 to 1000 BP. Illite was the dominant mineral deposited during this period, but since then has been a minor constituent in a mineral suite dominated by detrital silicates. A series of low-water, high-salinity stands occurred between 1000 and 600 BP, although these low stands were not as pronounced as low-water intervals in the middle Holocene. Relatively high water levels were sustained from 600 BP until the late 1800s. The lake declined significantly in the last one hundred years, notably during the historically documented droughts of the late 1800s, 1920s, 1930s, and 1980s. The timing of paleohydrological events at Chappice Lake corresponds closely with well documented Holocene climatic intervals, such as the Hypsithermal, Neoglaciation, Medieval Warm Period, and Little Ice Age. In addition, historic lake-level fluctuations can be related directly to climate. As a result, the Chappice Lake sedimentary succession offers a rare opportunity to obtain a high-resolution, surrogate record of Holocene climate on the northern Great Plains, and to observe the response of lake chemistry and biota to significant environmental change.

Electronic Resource