Search Results - (Author, Cooperation:R. Desai)
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1Latest Papers from Table of Contents or Articles in PressApparao B. Kummarapurugu, Daniel K. Afosah, Nehru Viji Sankaranarayanan, Rahaman Navaz Gangji, Shuo Zheng, Thomas Kennedy, Bruce K. Rubin, Judith A. Voynow, Umesh R. Desai
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-08-11Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressM. Yu ; A. Bardia ; N. Aceto ; F. Bersani ; M. W. Madden ; M. C. Donaldson ; R. Desai ; H. Zhu ; V. Comaills ; Z. Zheng ; B. S. Wittner ; P. Stojanov ; E. Brachtel ; D. Sgroi ; R. Kapur ; T. Shioda ; D. T. Ting ; S. Ramaswamy ; G. Getz ; A. J. Iafrate ; C. Benes ; M. Toner ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/*pharmacology/therapeutic use ; Breast Neoplasms/*drug therapy/genetics ; Cell Culture Techniques ; Cell Separation ; Culture ; Drug Resistance, Neoplasm/*genetics ; Drug Screening Assays, Antitumor/methods ; Estrogen Receptor alpha/genetics ; Female ; Gene Frequency ; Humans ; Mice ; Microfluidics/methods ; *Molecular Targeted Therapy ; Mutation ; Neoplastic Cells, Circulating/*drug effects/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Sequence Analysis, DNA ; Tumor Cells, Cultured ; Xenograft Model Antitumor AssaysPublished by: -
3Latest Papers from Table of Contents or Articles in PressD. T. Miyamoto ; Y. Zheng ; B. S. Wittner ; R. J. Lee ; H. Zhu ; K. T. Broderick ; R. Desai ; D. B. Fox ; B. W. Brannigan ; J. Trautwein ; K. S. Arora ; N. Desai ; D. M. Dahl ; L. V. Sequist ; M. R. Smith ; R. Kapur ; C. L. Wu ; T. Shioda ; S. Ramaswamy ; D. T. Ting ; M. Toner ; S. Maheswaran ; D. A. Haber
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Androgen Antagonists/pharmacology/*therapeutic use ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/*genetics ; Humans ; Male ; Mice ; Neoplastic Cells, Circulating/drug effects/*metabolism ; Phenylthiohydantoin/*analogs & derivatives/pharmacology/therapeutic use ; Prostate/drug effects/metabolism/pathology ; Prostatic Neoplasms/*drug therapy/*pathology ; Proto-Oncogene Proteins/genetics/metabolism ; RNA Splicing ; Receptors, Androgen/*genetics ; Sequence Analysis, RNA/methods ; Signal Transduction ; Single-Cell Analysis/methods ; Transcriptome ; Wnt Proteins/genetics/*metabolism ; Xenograft Model Antitumor AssaysPublished by: -
4Latest Papers from Table of Contents or Articles in PressKrishna Mohan Sepuru, Balaji Nagarajan, Umesh R. Desai, Krishna Rajarathnam
The American Society for Biochemistry and Molecular Biology (ASBMB)
Published 2018Staff ViewPublication Date: 2018-11-17Publisher: The American Society for Biochemistry and Molecular Biology (ASBMB)Print ISSN: 0021-9258Electronic ISSN: 1083-351XTopics: BiologyChemistry and PharmacologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-12-08Publisher: Institute of Physics (IOP)Print ISSN: 1748-9318Electronic ISSN: 1748-9326Topics: BiologyEnergy, Environment Protection, Nuclear Power EngineeringPublished by: -
6Latest Papers from Table of Contents or Articles in PressS. A. Taylor, A. J. Coates, G. H. Jones, A. Wellbrock, A. N. Fazakerley, R. T. Desai, R. Caro-Carretero, M. W. Morooka, P. Schippers, J. H. Waite
Wiley-Blackwell
Published 2018Staff ViewPublication Date: 2018-01-04Publisher: Wiley-BlackwellPrint ISSN: 0148-0227Topics: GeosciencesPhysicsPublished by: -
7Latest Papers from Table of Contents or Articles in PressWithey, S. L., Doyle, M. R., Bergman, J., Desai, R. I.
The American Society for Pharmacology and Experimental Therapeutics
Published 2018Staff ViewPublication Date: 2018-07-19Publisher: The American Society for Pharmacology and Experimental TherapeuticsPrint ISSN: 0022-3565Electronic ISSN: 1521-0103Topics: MedicinePublished by: -
8Articles: DFG German National LicensesBalaji, J. ; Desai, R. ; Kaushalya, S. K. ; Eaton, M. J. ; Maiti, S.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Synthesis and subsequent sequestration into vesicles are essential steps that precede neurotransmitter exocytosis, but neither the total neurotransmitter content nor the fraction sequestered into vesicles have been measured in individual live neurons. We use multiphoton microscopy to directly observe intracellular and intravesicular serotonin in the serotonergic neuronal cell line RN46A. We focus on how the relationship between synthesis and sequestration changes as synthesis is up-regulated by differentiation or down-regulated by chemical inhibition. Temperature-induced differentiation causes an increase of about 60% in the total serotonin content of individual cells, which goes up to about 10 fmol. However, the number of vesicles per cell increases by a factor of four and the proportion of serotonin sequestered inside the vesicles increases by a factor of five. When serotonin synthesis is inhibited in differentiated cells and the serotonin content goes down to the level present in undifferentiated cells, the sequestered proportion still remains at this high level. The total neurotransmitter content of a cell is, thus, an unreliable indicator of the sequestered amount.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesKNOX, R. B. ; SUPHIOGLU, C. ; TAYLOR, P. ; DESAI, R. ; WATSON, H. C. ; PENG, J. L. ; BURSILL, L. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Grass pollen allergens are known to be present in the atmosphere in a range of particle sizes from whole pollen grains (approx. 20 to 55 μim in diameter) to smaller size fractions 〈 2.5 μ (fine particles, PM2.5). These latter particles are within the respirable range and include allergen-containing starch granules released from within the grains into the atmosphere when grass pollen ruptures in rainfall and are associated with epidemics of thunderstorm asthma during the grass pollen season. The question arises whether grass pollen allergens can interact with other sources of fine particles, particularly those present during episodes of air pollution.Objective We propose the hypothesis that free grass pollen allergen molecules, derived from dead or burst grains and dispersed in microdroplets of water in aerosols, can bind to fine particles in polluted air.Methods We used diesel exhaust carbon particles (DECP) derived from the exhaust of a stationary diesel engine, natural highly purified Lol p 1, immunogold labelling with specific monoclonal antibodies and a high voltage transmission electron -microscopic imaging techniqueResults DECP are visualized as small carbon spheres, each 30–60 nm in diameter, forming fractal aggregates about 1–2μ in diameter. Here we test our hypothesis and show by in vitro experiments that the major grass pollen allergen, Lol p I. binds to one defined class of fine particles, DECP.Conclusion DECP are in the respirable size range, can bind to the major grass pollen allergen Lol p I under in vitro conditions and represent a possible mechanism by which allergens can become concentrated in polluted air and thus trigger attacks of asthma.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The geographical co-ordinates of the station are 36-82° E., 1-32° S., the latitude being approximately 10-5° S. of the magnetic dip equator, which in East Africa passes close to Addis Ababa. The measured dip of 26-9° S. compares with the 26-7° S. found by Whitham and Hoge1 in ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesCatalytic and regulatory properties of two forms of bovine heart cyclic nucleotide phosphodiesteraseStaff View
ISSN: 0005-2744Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] ON bromination, the isomeric forms of 1-carboxy-4-methylcyclohexane-1-acetic acid (m.p. 173° and 137°)1 furnished monobromo acids, which gave the corresponding hydroxy acids on being heated with aqueous sodium carbonate. Oxidation of the hydroxy acids with alkaline permanganate ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] BOTH 4-methylcyclohexane-l-carboxy-l-succinic acid and 3-methylcyclohexane-l-carboxy-l-succinic acid, synthesized by condensation of ethyl bromoacetate with the sodio derivatives of the dicyano esters prepared by Higson and Thorpe's method1, have been isolated in two forms ; ...Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE work done by us, so far, has shown that it is possible to isolate only two forms of 4-methyl-, 3-methyl- and 2-methyleyclohexane-1-carboxy-1-acetic acids1 and one form of 3:3-dimethylcyclohexane-1-carboxy-1-acetic acid2. In order to get more evidence on the ...Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE claim of Dr. Qudrat-i-Khuda1 to the isolation of the four stereoisomeric forms of l-carboxy-4-methyleycloZohexane-1-acetic acid required by the Sasche-Mohr hypothesis which it has not been possible to substantiate in this laboratory2 led us to search for ...Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] THE synthesis of 1-carboxy-3-methylcyclohexane-l-acetic acid by Higson and Thorpe's method1 gave rise to a small amount of the acid, m.p. 163°, originally obtained by oxidation of α-keto-3-methylcyclo-hexane-1 : 1-diacetic acid2, accompanied by a low melting point ...Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: