Search Results - (Author, Cooperation:R. Chowdhury)
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1FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 2004Keywords: Gift ; Arsen ; Schadstofferfassung ; Trinkwasser ; Projekt ; Gesundheitsschaden ; Medizin ; Schadstoff ; Umweltkatastrophe ; Umweltschutz ; Verminderung ; Bevölkerung ; BangladeschIn: Spektrum der Wissenschaft, (2004) H. 12, S. 74-79, 0170-2971Language: GermanNote: Literaturangaben -
2Latest Papers from Table of Contents or Articles in PressDebra J. Skene, Elena Skornyakov, Namrata R. Chowdhury, Rajendra P. Gajula, Benita Middleton, Brieann C. Satterfield, Kenneth I. Porter, Hans P. A. Van Dongen, Shobhan Gaddameedhi
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-07-25Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
3Latest Papers from Table of Contents or Articles in PressP. Zanoni ; S. A. Khetarpal ; D. B. Larach ; W. F. Hancock-Cerutti ; J. S. Millar ; M. Cuchel ; S. DerOhannessian ; A. Kontush ; P. Surendran ; D. Saleheen ; S. Trompet ; J. W. Jukema ; A. De Craen ; P. Deloukas ; N. Sattar ; I. Ford ; C. Packard ; A. Majumder ; D. S. Alam ; E. Di Angelantonio ; G. Abecasis ; R. Chowdhury ; J. Erdmann ; B. G. Nordestgaard ; S. F. Nielsen ; A. Tybjaerg-Hansen ; R. F. Schmidt ; K. Kuulasmaa ; D. J. Liu ; M. Perola ; S. Blankenberg ; V. Salomaa ; S. Mannisto ; P. Amouyel ; D. Arveiler ; J. Ferrieres ; M. Muller-Nurasyid ; M. Ferrario ; F. Kee ; C. J. Willer ; N. Samani ; H. Schunkert ; A. S. Butterworth ; J. M. Howson ; G. M. Peloso ; N. O. Stitziel ; J. Danesh ; S. Kathiresan ; D. J. Rader
American Association for the Advancement of Science (AAAS)
Published 2016Staff ViewPublication Date: 2016-03-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Aged ; Amino Acid Substitution ; Animals ; Cholesterol, HDL/*blood ; Coronary Disease/*blood/*genetics ; DNA Mutational Analysis ; Female ; Genetic Variation ; Heterozygote ; Homozygote ; Humans ; Leucine/genetics ; Male ; Mice ; Middle Aged ; Proline/genetics ; Protein Processing, Post-Translational ; Risk ; Scavenger Receptors, Class B/*genetics/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressN. K. Grady ; J. E. Heyes ; D. R. Chowdhury ; Y. Zeng ; M. T. Reiten ; A. K. Azad ; A. J. Taylor ; D. A. Dalvit ; H. T. Chen
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-05-21Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressD. H. Kim ; N. Lu ; R. Ma ; Y. S. Kim ; R. H. Kim ; S. Wang ; J. Wu ; S. M. Won ; H. Tao ; A. Islam ; K. J. Yu ; T. I. Kim ; R. Chowdhury ; M. Ying ; L. Xu ; M. Li ; H. J. Chung ; H. Keum ; M. McCormick ; P. Liu ; Y. W. Zhang ; F. G. Omenetto ; Y. Huang ; T. Coleman ; J. A. Rogers
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-13Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adhesiveness ; Dermis ; Elastic Modulus ; Elastomers ; Electric Power Supplies ; Electrocardiography/instrumentation/methods ; Electrodes ; Electrodiagnosis/*instrumentation/*methods ; Electroencephalography/instrumentation/methods ; Electromyography/instrumentation/methods ; *Epidermis ; Humans ; Mechanical Phenomena ; Monitoring, Physiologic/*instrumentation/*methods ; Nanostructures ; *SemiconductorsPublished by: -
6Latest Papers from Table of Contents or Articles in PressR. Chowdhury ; R. Sekirnik ; N. C. Brissett ; T. Krojer ; C. H. Ho ; S. S. Ng ; I. J. Clifton ; W. Ge ; N. J. Kershaw ; G. C. Fox ; J. R. Muniz ; M. Vollmar ; C. Phillips ; E. S. Pilka ; K. L. Kavanagh ; F. von Delft ; U. Oppermann ; M. A. McDonough ; A. J. Doherty ; C. J. Schofield
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Catalytic Domain ; Conserved Sequence ; Eukaryota/classification/*enzymology ; Humans ; *Models, Molecular ; Oxygenases/*chemistry/metabolism ; Phylogeny ; Prokaryotic Cells/classification/*enzymology ; Protein Folding ; Protein Structure, Tertiary ; Ribosomes/*enzymology ; Sequence AlignmentPublished by: -
7Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: Nitric oxide may regulate cellular respiration by competition with oxygen at mitochondrial cytochrome oxidase. Using an astrocyte-derived cell line, we have compared the mechanism of action of the nitric oxide-generating compound Roussin's black salt with that of sodium nitroprusside on cellular oxygen consumption. Intense light exposure induced the release of large quantities of nitric oxide from both of the donor compounds. However, in room light only Roussin's black salt generated low levels of the radical. Simultaneous measurement of oxygen consumption and of nitric oxide production demonstrated that sodium nitroprusside only had inhibitory actions when exposed to intense light (nitric oxide release), whereas Roussin's black salt had inhibitory actions in room light. Extracellular haemoglobin did not prevent the inhibition of respiration rate induced by Roussin's black salt even though stimulation of nitric oxide release on light exposure was markedly reduced. Preincubation of cells with Roussin's black salt and subsequent measurement of levels of light-liberated nitric oxide demonstrated that the compound was rapidly internalised. The uptake of sodium nitroprusside was minimal. These data suggest that, in contrast to sodium nitroprusside, the cellular internalisation of Roussin's black salt allows site-directed nitric oxide release and very effective inhibition of cellular respiration.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesNarayan, J. ; Raghunathan, R. ; Chowdhury, R. ; Jagannadham, K.
[S.l.] : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The mechanism of self-propagating high-temperature synthesis (SHS) or combustion synthesis of SiC has been investigated using pellets consisting of silicon and carbon powders. The combustion reaction was initiated by rapidly heating the pellet on a graphite strip. The reaction products were analyzed using scanning and transmission electron microscopy, x-ray diffraction, and Raman spectroscopy. The results show that it is possible to produce β-SiC without any residual silicon and carbon. Occasionally, a very small number density of α-SiC precipitates embedded in the β-SiC matrix was observed. Based upon the microstructural features, it is proposed that the formation of SiC involves the dissolution of carbon into liquid silicon, diffusion of C into liquid silicon, and subsequent precipitation of SiC. The size of the SiC crystallites is determined by the diffusion coefficient of carbon in liquid silicon and the time available for SiC precipitation. The activation enthalpy for the SHS process is estimated to be 59±3 kcal/mol.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesVispute, R. D. ; Chowdhury, R. ; Tiwari, P. ; Narayan, J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Three-dimensional epitaxial Cu/TiN/Si(100) heterostructures have been grown by pulsed laser deposition using a single chamber, in situ processing method. The epitaxial TiN layers on Si(100) were grown at 600 °C and epitaxial Cu layers on TiN/Si(100) in the temperature range 200–600 °C using optimized laser parameters. These structures were characterized using three-axis x-ray diffraction (aitch-theta, Φ, Ψ scans) technique and high-resolution transmission electron microscopy. The results clearly indicate cube-on-cube epitaxial alignment along the three axes, i.e., 〈100〉Cu(parallel)〈100〉TiN(parallel)〈100〉Si. The Cu/TiN and TiN/Si interfaces were found to be quite sharp without any indication of interfacial reaction. The growth mechanism of copper on TiN was found to be three dimensional, with the size of island varying from 0.3 to 1.5 μm. We discuss domain matching epitaxy as a mechanism of growth in these large lattice mismatch systems, where three lattice constants of Si(5.43 A(ring)) match with four of TiN(4.24 A(ring)) and seven units of Cu(3.62 A(ring)) match with six of the TiN. The implications of these results in the fabrication of advanced microelectronic devices are discussed. © 1994 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesChowdhury, R. ; Chen, X. ; Narayan, J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We have successfully deposited multilayer Si/TiN/Si(100) epitaxial heterostructures using pulsed laser deposition technique. This silicon-on-conductor device configuration has potential applications in three-dimensional integrated circuits and radiation hardened devices. The Si and TiN films were deposited by pulsed laser (KrF: λ=248 nm, τ =25 ns) physical vapor deposition technique at a substrate temperature of 600 °C in a chamber maintained at a vacuum of ∼10−7 Torr. The epitaxial nature of the films was characterized using x-ray diffraction, Rutherford backscattering, and high resolution transmission electron microscopy techniques. The two interfaces (100)TiN/Si(100)substrate and (100)Si/(100)TiN layers were quite sharp without any indication of interfacial reaction between them. The epitaxial relationship was found to be 〈100〉Si(parallel)〈100〉TiN(parallel)〈100〉Si. In the plane, four unit cells of TiN matched with three unit cells of silicon with less than 4.0% misfit. This domain matching epitaxy provides a mechanism of epitaxial growth in systems with large lattice mismatch. Modeling of the domain matching epitaxial growth in the high lattice mismatch (100)Si/(100)TiN/(100)Si system and possible device implications are discussed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesNarayan, J. ; Tiwari, P. ; Chen, X. ; Singh, J. ; Chowdhury, R. ; Zheleva, T.
Woodbury, NY : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We report epitaxial growth of TiN films having low resistivity on (100) silicon substrates using pulsed laser deposition method. The TiN films were characterized using x-ray diffraction, Rutherford backscattering, four-point-probe ac resistivity, high resolution transmission electron microscopy and scanning electron microscopy techniques and epitaxial relationship was found to be 〈100〉 TiN (parallel) 〈100〉 Si. TiN films showed 10%–20% channeling yield. In the plane, four unit cells of TiN match with three unit cells of silicon with less than 4.0% misfit. This domain matching epitaxy provides a new mechanism of epitaxial growth in systems with large lattice misfits. Four-point-probe measurements show characteristic metallic behavior of these films as a function of temperature with a typical resistivity of about 15 μΩ cm at room temperature. Implications of low-resistivity epitaxial TiN in silicon device fabrication are discussed.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesSangfelt, E. ; Chowdhury, R. Roy ; Weiner, B. ; O¨hrn, Y.
College Park, Md. : American Institute of Physics (AIP)
Published 1987Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: The theory for polarization propagator calculations based on a correlated reference state in the form of a spin singlet restricted antisymmetrized geminal power (AGP) is discussed. Particular attention is paid to the calculation of excitation energies and transition moments for the molecules over all internuclear separations, i.e., not just single point vertical energies, which is done in standard RPA or in higher-order treatments using perturbation methods. Simple applications to the Be atom, and the LiH and Li2 molecules are used to illustrate how this simple correlated state, which is completely determined by the choice of orbital basis (i.e., no choice of configurations is necessary), can cure the notorious consistency problems and the instabilities against the breaking of symmetry, which plague standard RPA based on a Hartree–Fock (HF) single determinantal reference state.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Pancreatic function tests are most commonly used to diagnose chronic pancreatitis. These tests include tests which document exocrine or endocrine gland insufficiency and tests which instead measure gradations of decreased secretory capacity. The tests in the former category generally become abnormal when advanced, longstanding chronic pancreatitis is present. Tests in the latter category, however, have the potential to detect chronic pancreatitis at an earlier stage than other available diagnostic tests, including commonly used imaging tests such as computed tomography and endoscopic retrograde cholangiopancreatography. This potential advantage of diagnostic sensitivity is, however, counterweighed by the fact that these tests which measure stimulated secretory capacity are only available at a very few referral centres. This article will review the variety of pancreatic function tests and describe their rationale, accuracy, cost, and clinical usefulness.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1435-9537Keywords: Keywords Landslides ; Hazard ; Risk Assessment ; Neural Networks ; G.I.S ; Mots clés glissement de terrain ; aléa ; évaluation du risque ; réseaux neuronaux ; S.I.G.Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesDescription / Table of Contents: Résumé Cet article traite de plusieurs aspects de l'évaluation de l'aléa et du risque de glissement de terrain. Ces dernières années, l'intérêt pour ce sujet a grandement augmenté et de nombreux articles techniques s'y référant ont été publiés. Cet article présente un bilan résumé et une classification des principales approches qui ont été développées de par le monde. La première étape consiste à distinguer les méthodes qualitatives et quantitatives. Le premier groupe est basé principalement sur l'expérience régionale d'experts, avec une notion de prédisposition aux glissements déterminée directement sur le terrain ou par combinaison de différentes cartes d'indices. Les approches du second groupe sont théoriquement plus rigoureuses. Il est possible de différencier des analyses statistiques (bivariées ou multivariées) et des méthodes déterministes qui font intervenir l'étude de pentes ou de sites particuliers, basée sur des modèles géomécaniques. De telles analyses peuvent être déterministes ou probabilistes. Parmi les méthodes quantitatives présentées, on trouve l'approche par les réseaux neuronaux qui n'a été que récemment appliquée à des problèmes de géologie de l'ingénieur. Enfin, plusieurs considérations relatives au concept de risque acceptable et de gestion du risque sont présentées.Notes: Abstract This paper deals with several aspects of the assessment of hazard and risk of landsliding. In recent years the interest in this topic has increased greatly and there are many technical papers dealing with this subject in the literature. This article presents a summary review and a classification of the main approaches that have been developed world-wide. The first step is the subdivision between qualitative and quantitative methods. The first group is mainly based on the site-specific experience of experts with the susceptibility/hazard determined directly in the field or by combining different index maps. The approaches of the second group are formally more rigorous. It is possible to distinguish between statistical analyses (bivariate or multivariate) and deterministic methods that involve the analysis of specific sites or slopes based on geo-engineering models. Such analyses can be deterministic or probabilistic. Among the quantitative methods discussed is the Neural Networks approach which has only recently been applied to engineering geology problems. Finally several considerations concerning the concept of acceptable risk and risk management are presented.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1436-5073Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Auf der Grundlage der Farbreaktion von Kobalt(II)thiocyanat mit HMPA wurde eine einfache, empfindliche und selektive Methode zur Bestimmung von Co(II) entwickelt. Das Farbmaximum erhält man in 0,15–0,75M salzsaurer Lösung bei 0,5–1,0M Thiocyanat-Konzentration. Die Färbung ist mit Chloroform vollständig extrahierbar, wenn 2—4 ml HMPA verwendet werden. Die maximale Absorption liegt bei 610 nm. Der optimale Konzentrationsbereich liegt zwischen 6 und 48μg Co/ml. Die molare Absorption beträgt 1,24 x l03l·mole−1·cm−1, die Empfindlichkeit 0,047μg Co/cm2. Die Methode wurde zur Bestimmung von Kobalt in Stahl verwendet.Notes: Summary Use of HMPA in Co(II) thiocyanate colour system gives a simple, sensitive and selective method for the determination of Co(II). Maximum colour intensity is attained in the acidity range of 0.15–0.75M HCl and thiocyanate concentration of 0.5–1.0M. The colour is completely extractable into chloroform, when 2 to 4 ml HMPA is used. The colour system shows maximum absorption at 610 nm. The Beer's law range is 2 to 52μg Co/ml with optimum concentration range of 6–48μg Co/ml. The molar absorptivity and sensitivity are 1.24 x 103 l·mole−1·cm−1 and 0.047μg Co/cm2 respectively. The method has been applied to the determination of cobalt in steel.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1436-5073Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Der Zusatz von Hexamethylphosphoramid (HMPA) zu Eisen(III)-Thiocyanat führt zu einer einfachen, empfindlichen und sehr selektiven Methode der spektrophotometrischen Bestimmung von Fe(III) in organischer Phase (CHCl3). Die Farbe bleibt in Chloroform mehr als 24 Stunden beständig. Das System entspricht dem Beerschen Gesetz unterhalb 7μg Fe/ml. Das Konzentrationsoptimum liegt zwischen 0,5 und 5μg/ml. Die molare Extinktion beträgt 1,33·104 l·Mol−1·cm−1, die Empfindlichkeit nach Sandell 0,0044μg/cm2 bei 460 nm. Das Verhältnis Fe(III): Rhodanid in CHCl3 ist 1∶3 in Gegenwart von HMPA. Die Methode wird von vielen Anionen und Kationen nicht gestört. Sie wurde zur Bestimmung von Eisen in Bauxit verwendet.Notes: Summary Application of hexamethylphosphoramide (HMPA) in the iron(III)-thiocyanate system gives a simple, sensitive and highly selective method for the spectrophotometric determination of Fe(III) in the organic phase (CHCl3). The color is stable for more than 24 hours in CHCl3. The system obeys Beer's law for ⩽7μg Fe/ml and the optimum concentration range is found to be 0.5–5μg/ml. The molar absorptivity of 1.33×104 l·mole−1·cm−1, and Sandell's sensitivity is 0.0044μ/cm2 at 460 nm The composition of Fe(III) to thiocyanate is found to be 1∶3 in the presence of HMPA in CHCl3. The method is free from interferences of many anions and cations. The method has been used to determine iron in bauxite ore.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1436-5073Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Zusammenfassung Ru(III)thiocyanat wurde mit Hexamethylphosphoramid (HMPA) in Methylisobutylketon (MIBK) extrahiert. Die Extrahierbarkeit, Empfindlichkeit und Selektivität wurden im Vergleich zum binären Ru(III)-thiocyanatsystem durch spektrophotometrische Bestimmung in der organischen Phase verbessert. Das Farbmaximum entwickelt sich auf dem Wasserbad in 1,5 bis 2,5M Salzsäure bei einer Ammoniumthiocyanat-Konzentration von 0,25–0,5 Mol/l. Mit 1,5–3,0 ml HMPA läßt sich die Färbung vollständig in MIBK extrahieren und zeigt ein Absorptionsmaximum bei 570 nm. Die gefärbte Lösung entspricht dem Beerschen Gesetz für 0,7–13 νg Ru/ml; das Konzentrationsoptimum liegt zwischen 2 und 13 νg/ml Die molare Absorptivität und Empfindlichkeit betragen 69401·mol−1·cm−1 bzw. 0,0145νg/cm2. Die Methode ist sehr empfindlich; Oxydation und nachfolgende Destillation sind überflüssig. Bei Anwesenheit von Osmium ist dieses vorher zu entfernen.Notes: Summary Ru(III)-thiocyanate has been extracted with hexamethylphosphoramide (HMPA) in methyl isobutyl ketone (MIBK). Thus the extractability, sensitivity and selectivity are improved over the simple binary Ru(III) thiocyanate system in spectrophotometric determination of ruthenium in the organic phase. The maximum colour develops on the steam bath, at the acidity range of 1.5–2.5M with HCl and ammonium thiocyanate concentration range of 0.25–0.5M. The colour is completely extractable in MIBK when 1.5–3.0 ml HMPA is used and show maximum absorbance at 570 nm. The colour system obeys Beer's law for 0.7–13 νg Ru/ml and the optimum concentration range is 2–13 νg/ml. The molar absorptivity and sensitivity are 69401-mole−1 cm−1 and 0.0145 νg/cm2 respectively. The percent relative error is 2.72%. The method is very simple and does not require oxidation and subsequent distillation. The method can be applied in the presence of osmium.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The 5′ untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explained by a deletion of approximately 100 bp DNA and show that alleles of this novel, highly polymorphic locus are as strongly associated with haemochromatosis as HLA-A3 or D6S105-8. The observed frequency of heterozygosity at HLA-RF is extremely high (95%) and this locus has been found to be informative in pedigrees that are non-informative at HLA-A and D6S105. We also show an example of replication slippage at HLA-F in one pedigree.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-1203Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The 5′ untranslated region of HLA-F contains a polypurine tract comprising repeats of tri- and hexa-nucleotide motifs. We have recently demonstrated that this polypurine tract is highly polymorphic by using the polymerase chain reaction. Here, we demonstrate that some of the alleles can be explained by a deletion of approximately 100 by DNA and show that alleles of this novel, highly polymorphic locus are as strongly associated with haemochromatosis as HLA-A3 or D6S105-8. The observed frequency of heterozygosity at HLA-RF is extremely high (95%) and this locus has been found to be informative in pedigrees that are non-informative at HLA-A and D6S105. We also show an example of replication slippage at HL,A-F in one pedigree.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1434-9949Keywords: Pregnacy Associated Alpha2-Glycoprotein ; Oestrogens ; Indomethacin ; Rheumatoid ArthritisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary A sensitive enzyme-linked immuno-assay has been developed which can measure the amounts of pregnancy-associated alpha2 glycoprotein (PAG) producted by human peripheral blood mononuclear cells (MNC) in culture. Ethinyl oestradiol, indomethacin and pokewee nitrogen (PWM) stimulated PAG production directly while indomethacin produced an additional increase in PAG production by PWM-stimulated MNC probably by inhibiting the production of prostaglandins with down-regulatory effects on the MNC. Oestrogen stimulation of MNC produced significant increases in PAG levels only by the MNC of women on oral contraceptives but not from the cells of males or of females of reproductive age not on oral contraceptives. Since PAG has immunosuppressive properties these observations may be of relevence in understanding the mechanisms involved in the significant decrease in the incidence of rheumatoid arthritis in women takin oral contraceptives.Type of Medium: Electronic ResourceURL: