Search Results - (Author, Cooperation:R. C. Kennedy)

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  1. 1
    D. E. Neafsey ; R. M. Waterhouse ; M. R. Abai ; S. S. Aganezov ; M. A. Alekseyev ; J. E. Allen ; J. Amon ; B. Arca ; P. Arensburger ; G. Artemov ; L. A. Assour ; H. Basseri ; A. Berlin ; B. W. Birren ; S. A. Blandin ; A. I. Brockman ; T. R. Burkot ; A. Burt ; C. S. Chan ; C. Chauve ; J. C. Chiu ; M. Christensen ; C. Costantini ; V. L. Davidson ; E. Deligianni ; T. Dottorini ; V. Dritsou ; S. B. Gabriel ; W. M. Guelbeogo ; A. B. Hall ; M. V. Han ; T. Hlaing ; D. S. Hughes ; A. M. Jenkins ; X. Jiang ; I. Jungreis ; E. G. Kakani ; M. Kamali ; P. Kemppainen ; R. C. Kennedy ; I. K. Kirmitzoglou ; L. L. Koekemoer ; N. Laban ; N. Langridge ; M. K. Lawniczak ; M. Lirakis ; N. F. Lobo ; E. Lowy ; R. M. MacCallum ; C. Mao ; G. Maslen ; C. Mbogo ; J. McCarthy ; K. Michel ; S. N. Mitchell ; W. Moore ; K. A. Murphy ; A. N. Naumenko ; T. Nolan ; E. M. Novoa ; S. O'Loughlin ; C. Oringanje ; M. A. Oshaghi ; N. Pakpour ; P. A. Papathanos ; A. N. Peery ; M. Povelones ; A. Prakash ; D. P. Price ; A. Rajaraman ; L. J. Reimer ; D. C. Rinker ; A. Rokas ; T. L. Russell ; N. Sagnon ; M. V. Sharakhova ; T. Shea ; F. A. Simao ; F. Simard ; M. A. Slotman ; P. Somboon ; V. Stegniy ; C. J. Struchiner ; G. W. Thomas ; M. Tojo ; P. Topalis ; J. M. Tubio ; M. F. Unger ; J. Vontas ; C. Walton ; C. S. Wilding ; J. H. Willis ; Y. C. Wu ; G. Yan ; E. M. Zdobnov ; X. Zhou ; F. Catteruccia ; G. K. Christophides ; F. H. Collins ; R. S. Cornman ; A. Crisanti ; M. J. Donnelly ; S. J. Emrich ; M. C. Fontaine ; W. Gelbart ; M. W. Hahn ; I. A. Hansen ; P. I. Howell ; F. C. Kafatos ; M. Kellis ; D. Lawson ; C. Louis ; S. Luckhart ; M. A. Muskavitch ; J. M. Ribeiro ; M. A. Riehle ; I. V. Sharakhov ; Z. Tu ; L. J. Zwiebel ; N. J. Besansky
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-01-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Anopheles/classification/*genetics ; Base Sequence ; Chromosomes, Insect/genetics ; Drosophila/genetics ; *Evolution, Molecular ; *Genome, Insect ; Humans ; Insect Vectors/classification/*genetics ; Malaria/*transmission ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    KENNEDY, R. C. ; HENKEL, R. D. ; DREESMAN, G. R.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1986
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The further characterization of internal image anti-idiotypic antibodies (anti-Id) that represent a potential alternative vaccine candidate for type B viral hepatitis is described. The anti-Id preparation contains an internal image component or related epitope that mimics hepatitis B surface antigen (HBsAg) and binds to murine hybridoma cells that secrete antibodies to HBsAg (anti-HBs). This binding to anti-HBs-secreting hybridomas was partially inhibited by intact HBsAg particles and was associated with the expression of an interspecies idiotype. Immunoprecipitation studies demonstrated that the anti-Id bound to immunoglobulin molecules expressed on the surface of the hybridoma cells. These data suggest that internal image anti-Id, which induces an in vivo antibody response by antigenic mimicry in the absence of HBsAg, binds to anti-HBs molecules on the surface of cells actively secreting anti-HBs. The possible mechanism for internal image anti-Id-based antibody vaccines that mimic the overall conformation of antigens associated with infectious agents is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1986.tb03080.x

    Articles: DFG German National Licenses
  3. 3
    SHEARER, M. H. ; BRIGHT, R. K ; KENNEDY, R. C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    In this report we compare the immunoglobulin variable (IgV) region function and structure relationships of murine monoclonal antibodies that recognize simian virus 40 (SV40) large tumour antigen (T ag). Comparison of monoclonal antibody V region function is based on SV40 T ag epitope recognition and idiotype (Id) expression. Structural comparisons are based on V region gene sequence determination. The data presented herein, suggests that a high degree of homology within both the Vk and VH regions, along with minor differences within Vk complementarity determining regions (CDR) may result in the detection of similar SV40 T ag epitopes by the monoclonal anti-SV40 T ag preparations. The expression of a cross-reactive Id also appears to be based on the high degree of homology within both VK and VH regions and depends on conformational interactions imparted by both regions.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-3083.1994.tb03483.x

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1573-2592
    Keywords:
    Anti-DNA antibodies ; systemic lupus erythematosus ; drug-induced lupus ; autoimmunity ; idiotypes ; procainamide ; antihistone antibodies
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R=0.56,P〈0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG,R=0.43; IgM,R=0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00917019

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1573-2592
    Keywords:
    Monoclonal gammopathies ; monoclonal antibodies ; autoantibodies ; autoimmune diseases ; anti-DNA antibodies ; multiple myeloma ; macroglobulinemia ; idiotypes
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract The sera of 265 patients with monoclonal gammopathies were examined for the presence of a dominant idiotype of the anti-DNA antibody [16/6 idiotype (Id)] and for anti-DNA activity. An enzyme-linked immunosorbent assay (ELISA) with a rabbit anti-16/6 antibody revealed 23 (8.7%) sera that contained increased concentrations of the idiotype. Seven of the patients had benign monoclonal gammopathy, three multiple myeloma, three Waldenström macroglobulinemia, five essential mixed cryoglobulinemia, and five monoclonal cryoglobulinema. In 5 of the 23 sera, antinuclear activity was also noted. In 11 of the 16/6 Id-positive sera the anti-nucleic acid antibody reactions were found to be polyspecific, reacting with polydeoxythymidilic acid and polyinosinic acid, in addition to single-stranded DNA and double-stranded DNA. Similar results were achieved with the purified serum monoclonal components. The specificity of the idiotype analysis was demonstrated with an unrelated dominant idiotype of anti-HBsAg antibody. In none of the patients, except one (with essential mixed cryoglobulinemia), was lupus symptomatology noted.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00918699

    Articles: DFG German National Licenses