Search Results - (Author, Cooperation:R. Adalbert)
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1Latest Papers from Table of Contents or Articles in PressJ. M. Osterloh ; J. Yang ; T. M. Rooney ; A. N. Fox ; R. Adalbert ; E. H. Powell ; A. E. Sheehan ; M. A. Avery ; R. Hackett ; M. A. Logan ; J. M. MacDonald ; J. S. Ziegenfuss ; S. Milde ; Y. J. Hou ; C. Nathan ; A. Ding ; R. H. Brown, Jr. ; L. Conforti ; M. Coleman ; M. Tessier-Lavigne ; S. Zuchner ; M. R. Freeman
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-06-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Animals, Genetically Modified ; Apoptosis ; Armadillo Domain Proteins/analysis/*genetics/*physiology ; Axons/*physiology/ultrastructure ; Axotomy ; Cell Survival ; Cells, Cultured ; Cytoskeletal Proteins/analysis/*genetics/*physiology ; Denervation ; Drosophila/embryology/genetics/physiology ; Drosophila Proteins/analysis/*genetics/*physiology ; Mice ; Mutation ; Neurons/*physiology ; Sciatic Nerve/injuries/physiology ; Signal Transduction ; Superior Cervical Ganglion/cytology ; Tissue Culture Techniques ; *Wallerian DegenerationPublished by: -
2Articles: DFG German National LicensesSiklós, L. ; Engelhardt, J. I. ; Reaume, A. G. ; Scott, R. W. ; Adalbert, R. ; Obál, I. ; Appel, S. H.
Springer
Published 2000Staff ViewISSN: 1432-0533Keywords: Key words Calcium ; SOD-1 ; Knockout mouse ; Motoneuron ; ParvalbuminSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract SOD-1-deficient mice demonstrate no loss of motoneurons but are still vulnerable to axotomy and ischemic insults. To investigate possible reasons for vulnerability of motoneuron populations, we studied changes in ultrastructural calcium distribution during maturation in spinal- and oculomotor neurons in SOD-1–/– mice. Between 3 and 11 months the cytoplasmic component of the intracellular calcium changed at a lower rate in spinal motoneurons and motor axon terminals in the interosseus muscle of SOD-1–/– animals compared to wild-type controls. No such dissimilarities were noted in the oculomotor system, or in mitochondrial calcium contents of either cell type. These data suggest that the lack of SOD-1 may be associated with vulnerability to insult by depletion of non-mitochondrial calcium stores selectively in motoneurons lacking parvalbumin and/or calbindin D28K.Type of Medium: Electronic ResourceURL: