Search Results - (Author, Cooperation:R. A. Levine)
-
1Latest Papers from Table of Contents or Articles in PressR. Durst ; K. Sauls ; D. S. Peal ; A. deVlaming ; K. Toomer ; M. Leyne ; M. Salani ; M. E. Talkowski ; H. Brand ; M. Perrocheau ; C. Simpson ; C. Jett ; M. R. Stone ; F. Charles ; C. Chiang ; S. N. Lynch ; N. Bouatia-Naji ; F. N. Delling ; L. A. Freed ; C. Tribouilloy ; T. Le Tourneau ; H. LeMarec ; L. Fernandez-Friera ; J. Solis ; D. Trujillano ; S. Ossowski ; X. Estivill ; C. Dina ; P. Bruneval ; A. Chester ; J. J. Schott ; K. D. Irvine ; Y. Mao ; A. Wessels ; T. Motiwala ; M. Puceat ; Y. Tsukasaki ; D. R. Menick ; H. Kasiganesan ; X. Nie ; A. M. Broome ; K. Williams ; A. Johnson ; R. R. Markwald ; X. Jeunemaitre ; A. Hagege ; R. A. Levine ; D. J. Milan ; R. A. Norris ; S. A. Slaugenhaupt
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-08-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Body Patterning/genetics ; Cadherins/deficiency/*genetics/*metabolism ; Cell Movement/genetics ; Chromosomes, Human, Pair 11/genetics ; Female ; Humans ; Male ; Mice ; Mitral Valve/abnormalities/embryology/pathology/surgery ; Mitral Valve Prolapse/*genetics/*pathology ; Mutation/*genetics ; Pedigree ; Phenotype ; Protein Stability ; RNA, Messenger/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics/metabolismPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 1573-2568Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The possibility that cyclic AMP in gastric juice is derived from plasma by simple clearance was evaluated. The effect of exogenous cyclic AMP administration (1 mg/min) on radioimmunoassayable cyclic AMP in plasma and gastric juice was studied in dog stomach during histamine (8–16 μg/kg/hr) infusion. Experiments were performed in vagally denervated fundic (Heidenhain) and in innervated gastric pouches. During infusion of cyclic AMP with histamine, plasma cyclic AMP concentration rapidly increased 500-fold. Simultaneously, gastric juice cyclic AMP levels decreased almost 50%. In contrast, dibutyryl cyclic AMP infusion increased gastric juice cAMP concentration 5-fold, suggesting that the gastric mucosa is more permeable to dibutyryl cyclic AMP. In Heidenhain pouch experiments the clearance of dibutyryl cyclic AMP into gastric juice was only 1.5% of the clearance of aminopyrine. It appears that plasma clearance of cyclic AMP fails to account for most of the cyclic AMP present in gastric juice.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 1573-2568Keywords: pepsinogen ; acid ; salicylates ; histamine ; ranitidine ; prostaglandin E2Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ibuprofen's (10 mg/kg) fourfold increase was not significant. Aspirin in conjunction with histamine (0.5 mg/kg subcutaneously) significantly increased ulcerogenesis by 2.7-fold compared to histamine alone. Basal acid secretion was increased significantly by 156% after indomethacin, but not by other nonsteroidal antiinflammatory drugs. In contrast, all nonsteroidal antiinflammatory drugs, except indomethacin, significantly decreased histamine-stimulated acid secretion. Nonsteroidal antiinflammatory drugs had no effect on pepsinogen secretion. Ranitidine pretreatment (25 mg/kg intraperitoneally) significantly decreased basal acid and pepsinogen secretion in all treatment groups by 〉85% and 〉40%, respectively, and ulcerations induced by salicylate, aspirin, and indomethacin were also inhibited by 90%, 60%, and 60%, respectively. The observed inhibition of prostaglandin E2 generation by nonsteroidal antiinflammatory drugs under basal secretory conditions appeared to correlate with the extent of ulcerogenesis. Our data support the concept that acid, in addition to inhibition of prostaglandin E2 synthesis, plays an important role in the pathogenesis of nonsteroidal antiinflammatory drug-induced gastropathy.Type of Medium: Electronic ResourceURL: