Search Results - (Author, Cooperation:R. A. Lerner)
-
1Latest Papers from Table of Contents or Articles in PressD. C. Ekiert ; A. K. Kashyap ; J. Steel ; A. Rubrum ; G. Bhabha ; R. Khayat ; J. H. Lee ; M. A. Dillon ; R. E. O'Neil ; A. M. Faynboym ; M. Horowitz ; L. Horowitz ; A. B. Ward ; P. Palese ; R. Webby ; R. A. Lerner ; R. R. Bhatt ; I. A. Wilson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-09-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/*chemistry/genetics/*immunology ; Antibodies, Viral/*chemistry/genetics/*immunology ; Antibody Specificity/genetics/*immunology ; Antigens, Viral/chemistry/immunology ; Binding Sites ; Complementarity Determining Regions/chemistry/genetics/immunology ; Conserved Sequence ; Cross Reactions/genetics/immunology ; Crystallography, X-Ray ; Enzyme-Linked Immunosorbent Assay ; Epitopes/chemistry/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry/immunology ; Influenza A Virus, H1N1 Subtype/chemistry/immunology ; Influenza A Virus, H3N2 Subtype/chemistry/immunology ; Influenza A virus/chemistry/*classification/*immunology ; Influenza Vaccines/immunology ; Mice ; Models, Molecular ; Molecular Sequence Data ; Mutation/genetics ; Orthomyxoviridae Infections/immunology/prevention & control/virology ; Protein ConformationPublished by: -
2Latest Papers from Table of Contents or Articles in PressR. K. Grover ; X. Zhu ; T. Nieusma ; T. Jones ; I. Boero ; A. S. MacLeod ; A. Mark ; S. Niessen ; H. J. Kim ; L. Kong ; N. Assad-Garcia ; K. Kwon ; M. Chesi ; V. V. Smider ; D. R. Salomon ; D. F. Jelinek ; R. A. Kyle ; R. B. Pyles ; J. I. Glass ; A. B. Ward ; I. A. Wilson ; R. A. Lerner
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-02-08Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antigen-Antibody Reactions/genetics/*immunology ; Antigens/*immunology ; Bacterial Proteins/chemistry/genetics/*immunology ; Crystallography, X-Ray ; Humans ; Immunoglobulin G/*immunology ; Immunoglobulin Variable Region/*immunology ; Immunoglobulin kappa-Chains/immunology ; Immunoglobulin lambda-Chains/immunology ; Lymphokines/chemistry/genetics/*immunology ; Membrane Proteins/chemistry/genetics/*immunology ; Mycoplasma/*immunology ; Protein Structure, Tertiary ; Recombinant Proteins/chemistry/genetics/immunologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressStepanov, A. V., Markov, O. V., Chernikov, I. V., Gladkikh, D. V., Zhang, H., Jones, T., Senkova, A. V., Chernolovskaya, E. L., Zenkova, M. A., Kalinin, R. S., Rubtsova, M. P., Meleshko, A. N., Genkin, D. D., Belogurov, A. A., Xie, J., Gabibov, A. G., Lerner, R. A.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-11-15Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
4Articles: DFG German National LicensesRowlands, D. J. ; Clarke, B. E. ; Carroll, A. R. ; Brown, F. ; Nicholson, B. H. ; Bittle, J. L. ; Houghten, R. A. ; Lerner, R. A.
[s.l.] : Nature Publishing Group
Published 1983Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] There is considerable evidence that the major immunogen is situated on VP1, one of the four capsid proteins1-5. Furthermore, the position of the major immunogenic site on VP1 of virus of serotype 0 has been shown to lie within the amino acid tract 141-1606-8. The same region of VP1 from other ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesSutcliffe, J. G. ; Shinnick, T. M. ; Green, N. ; Liu, F.-T. ; Niman, H. L. ; Lerner, R. A.
[s.l.] : Nature Publishing Group
Published 1980Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We previously determined the nucleotide sequence of the 3′ end of Moloney leukaemia virus and discovered the potential coding region for an unknown protein, R. We now show that this region does encode a protein. A pentadecapeptide of R was chemically synthesized and antibodies raised against ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesElder, J. H. ; Jensen, F. C. ; Bryant, M. L. ; Lerner, R. A.
[s.l.] : Nature Publishing Group
Published 1977Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Structural comparison of the major envelope glycoproteins (gp70) from 35 different murine type C viruses and free gp70 expressed at various anatomical sites in the mouse showed that the gp70s are polymorphic products of a large multi-gene family encoding viral and differentiation antigens. ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Historically, immunochemistry has focused on understanding and exploiting the remarkable binding affinity and specificity of antibody molecules. With the advent of antibody catalysis, chemists could ask for the first time whether this sophisticated system of molecular diversity ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0021-9541Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: A concept has been suggested that the role of immunogen is to stimulate resting cells to enter a phase of the cell cycle in which the synthesis of immunoglobulin is obligatory. This process conceivably involves the initial union of cells with immunogen followed by a subsequent transition from resting to proliferating cell. Several aspects of an in vitro cellular transition have been investigated using cultured WIL2 lymphocytes which are shown to enter the G1 phase of the cell cycle upon release from rest. This transition is associated with phenotypic changes in the cells manifested by differences in density of individual cells and the amount and profile of polyribosomes. An increase in the rate of synthesis of total protein and specific immunoglobulin polypeptides accompanies the G0 to G1 transition. Agents useful in bacterial and other mammalian cell systems to probe translational versus transcriptional control mechanisms are active in these lymphocytes. This cellular model appears to offer unique opportunities to approach regulatory problems in cell biology because large numbers of synchronized cells are obtainable in which specific messenger-RNAs and their corresponding polypeptides can be isolated in relatively pure form.Additional Material: 7 Ill.Type of Medium: Electronic ResourceURL: