Search Results - (Author, Cooperation:R. A. Harris)

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  1. 1
    L. Carbone ; R. A. Harris ; S. Gnerre ; K. R. Veeramah ; B. Lorente-Galdos ; J. Huddleston ; T. J. Meyer ; J. Herrero ; C. Roos ; B. Aken ; F. Anaclerio ; N. Archidiacono ; C. Baker ; D. Barrell ; M. A. Batzer ; K. Beal ; A. Blancher ; C. L. Bohrson ; M. Brameier ; M. S. Campbell ; O. Capozzi ; C. Casola ; G. Chiatante ; A. Cree ; A. Damert ; P. J. de Jong ; L. Dumas ; M. Fernandez-Callejo ; P. Flicek ; N. V. Fuchs ; I. Gut ; M. Gut ; M. W. Hahn ; J. Hernandez-Rodriguez ; L. W. Hillier ; R. Hubley ; B. Ianc ; Z. Izsvak ; N. G. Jablonski ; L. M. Johnstone ; A. Karimpour-Fard ; M. K. Konkel ; D. Kostka ; N. H. Lazar ; S. L. Lee ; L. R. Lewis ; Y. Liu ; D. P. Locke ; S. Mallick ; F. L. Mendez ; M. Muffato ; L. V. Nazareth ; K. A. Nevonen ; M. O'Bleness ; C. Ochis ; D. T. Odom ; K. S. Pollard ; J. Quilez ; D. Reich ; M. Rocchi ; G. G. Schumann ; S. Searle ; J. M. Sikela ; G. Skollar ; A. Smit ; K. Sonmez ; B. ten Hallers ; E. Terhune ; G. W. Thomas ; B. Ullmer ; M. Ventura ; J. A. Walker ; J. D. Wall ; L. Walter ; M. C. Ward ; S. J. Wheelan ; C. W. Whelan ; S. White ; L. J. Wilhelm ; A. E. Woerner ; M. Yandell ; B. Zhu ; M. F. Hammer ; T. Marques-Bonet ; E. E. Eichler ; L. Fulton ; C. Fronick ; D. M. Muzny ; W. C. Warren ; K. C. Worley ; J. Rogers ; R. K. Wilson ; R. A. Gibbs
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-09-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Evolution, Molecular ; Genome/*genetics ; Hominidae/classification/genetics ; Humans ; Hylobates/*classification/*genetics ; *Karyotype ; Molecular Sequence Data ; *Phylogeny ; Retroelements/genetics ; Selection, Genetic ; Transcription Termination, Genetic
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    A. Kundaje ; W. Meuleman ; J. Ernst ; M. Bilenky ; A. Yen ; A. Heravi-Moussavi ; P. Kheradpour ; Z. Zhang ; J. Wang ; M. J. Ziller ; V. Amin ; J. W. Whitaker ; M. D. Schultz ; L. D. Ward ; A. Sarkar ; G. Quon ; R. S. Sandstrom ; M. L. Eaton ; Y. C. Wu ; A. R. Pfenning ; X. Wang ; M. Claussnitzer ; Y. Liu ; C. Coarfa ; R. A. Harris ; N. Shoresh ; C. B. Epstein ; E. Gjoneska ; D. Leung ; W. Xie ; R. D. Hawkins ; R. Lister ; C. Hong ; P. Gascard ; A. J. Mungall ; R. Moore ; E. Chuah ; A. Tam ; T. K. Canfield ; R. S. Hansen ; R. Kaul ; P. J. Sabo ; M. S. Bansal ; A. Carles ; J. R. Dixon ; K. H. Farh ; S. Feizi ; R. Karlic ; A. R. Kim ; A. Kulkarni ; D. Li ; R. Lowdon ; G. Elliott ; T. R. Mercer ; S. J. Neph ; V. Onuchic ; P. Polak ; N. Rajagopal ; P. Ray ; R. C. Sallari ; K. T. Siebenthall ; N. A. Sinnott-Armstrong ; M. Stevens ; R. E. Thurman ; J. Wu ; B. Zhang ; X. Zhou ; A. E. Beaudet ; L. A. Boyer ; P. L. De Jager ; P. J. Farnham ; S. J. Fisher ; D. Haussler ; S. J. Jones ; W. Li ; M. A. Marra ; M. T. McManus ; S. Sunyaev ; J. A. Thomson ; T. D. Tlsty ; L. H. Tsai ; W. Wang ; R. A. Waterland ; M. Q. Zhang ; L. H. Chadwick ; B. E. Bernstein ; J. F. Costello ; J. R. Ecker ; M. Hirst ; A. Meissner ; A. Milosavljevic ; B. Ren ; J. A. Stamatoyannopoulos ; T. Wang ; M. Kellis
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-20
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Base Sequence ; Cell Lineage/genetics ; Cells, Cultured ; Chromatin/chemistry/genetics/metabolism ; Chromosomes, Human/chemistry/genetics/metabolism ; DNA/chemistry/genetics/metabolism ; DNA Methylation ; Datasets as Topic ; Enhancer Elements, Genetic/genetics ; Epigenesis, Genetic/*genetics ; *Epigenomics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genome-Wide Association Study ; Histones/metabolism ; Humans ; Organ Specificity/genetics ; RNA/genetics ; Reference Values
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2012-09-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)/*administration & ; dosage/deficiency/*genetics ; Adolescent ; Amino Acids, Branched-Chain/administration & dosage/blood/deficiency ; Animals ; Arginine/genetics ; Autistic Disorder/*diet therapy/enzymology/*genetics ; Base Sequence ; Brain/metabolism ; Child ; Child, Preschool ; Diet ; Epilepsy/*diet therapy/enzymology/*genetics ; Female ; Homozygote ; Humans ; Intellectual Disability/diet therapy/enzymology/genetics ; Male ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Mutation ; Pedigree ; Phosphorylation ; Protein Folding ; Protein Structure, Tertiary ; RNA, Messenger/metabolism ; Young Adult
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
  5. 5
    Staff View
    Publication Date:
    2018-09-28
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Genetics, Online Only
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
  7. 7
    Harris, R. A. ; Grayce, C. J. ; Makri, N. ; Miller, W. H.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1991
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Harris, R. A. ; Shi, Yaoming ; McClain, W. M.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1992
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    We consider the scattering of light from a molecule or a cluster. The scattering may be elastic or inelastic, but we limit ourselves to the special case of transitions from initial states having total angular momentum number J=0 to final states also having J=0. In practice, this covers elastic scattering from clusters as the rotational temperature drops toward absolute zero. This hypothesis allows us to do the orientation average at the amplitude level, a method fundamentally incorrect in the general case. Without approximation, we are able to deduce the pattern of the observable Mueller matrix M of the scattering. We find a new symmetry that reflects the spherical nature of the J=0 states: M11+M33=M22+M44. This result includes all multipole orders of the scattered light, and is therefore valid for clusters large compared to wavelength, as well as for small clusters. In an Appendix, we discuss a new generating function for orientation averages, which allows one to make exact tensor averages weighted by two plane waves (for scattering, one incoming and one outgoing).
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Pratt, L. R. ; Hoffman, G. G. ; Harris, R. A.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1990
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Hunt, K. L. C. ; Liang, Y. Q. ; Nimalakirthi, R. ; Harris, R. A.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1989
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The nonlocal polarizability density α(r;r',ω) is a linear-response tensor that determines the electronic polarization induced at point r in a molecule, by an external electric field of frequency ω, acting at r'. This work focuses on the change in α(r;r',ω) when a nuclear position shifts infinitesimally. We prove directly that the electronic charge distribution responds to the change in Coulomb field due to the nucleus via the same hyperpolarizability density that describes its response to external fields. This generalizes a result found previously for the static (ω=0) polarizability density. The work also provides a new interpretation for the integrated intensities of vibrational Raman bands: it proves that the intensities depend on the hyperpolarizability densities and the dipole propagator.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Dildy-Mayfield, J. E. ; Harris, R. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: The effects of acute and extended ethanol exposure on N-methyl-d-aspartate- and kainate-induced currents were examined electrophysiologically in Xenopus oocytes expressing rat hippocampal mRNA. Ethanol inhibited responses stimulated by low and high concentrations of N-methyl-d-aspartate to a similar degree. However, responses produced by low or high concentrations of kainate were differentially inhibited by ethanol. Low kainate concentration responses were much more sensitive to ethanol than high kainate concentrations (e.g., 50 mM ethanol inhibited 12.5 μM kainate responses by 45% compared to 15% inhibition of 400 μM kainate responses). In oocytes cultured in 100 mM ethanol for 1–5 days, the ethanol inhibition of maximum N-methyl-d-aspartate and kainate responses was not different from that in non–ethanol-exposed oocytes. Ethanol treatment, however, selectively decreased the ethanol sensitivity of low kainate concentration responses. Currents stimulated by N-methyl-d-aspartate or kainate were not different between control and ethanol-treated oocytes, indicating that ethanol exposure did not interfere with channel expression. The selective actions of acute and extended ethanol exposure on low kainate responses may indicate selective actions of ethanol on subtypes of kainate receptors expressed in oocytes.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Dildy-Mayfield, J. E. ; Harris, R. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: The effect of protein kinase C (PKC) activation on maximal kainate (KA)-induced currents was studied in Xenopus oocytes expressing the glutamate receptor (GluR) subunits GluR3, GluR1+3, GluR2+3, and GluR6. The PKC activator phorbol 12- myristate 13-acetate (PMA) inhibited peak KA responses in a time-dependent manner. The magnitude of inhibition was greatest in GluR6-expressing oocytes. Desensitizing KA currents characterized by a peak, transient current followed by a slower, desensitizing current were observed in oocytes expressing GluR3 and GluR 1+3 receptors. PMA inhibited the desensitization, and this effect could be observed before PMA's inhibition of peak current amplitude. PMA-mediated inhibition of both desensitization and peak current amplitude was prevented by intracellular injection of the protein kinase C (PKC) inhibitor peptide. These results suggest that the function of GluRs is regulated by PKC-dependent phosphorylation
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Harris, R. A. ; Silbey, R.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1985
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    The dynamics of tunneling of an asymmetric double well interacting with a heat bath is reexamined in the binary collision dilute gas phase limit and investigated in the harmonic bath case. (a) In both cases dynamic and static asymmetries are additive. (b) In both cases, when the tunneling amplitude is not renormalized to a value of zero, the effect of asymmetry on the approach to equilibrium due to incoherent tunneling only quantitatively differs from the symmetric double well. (c) When the renormalized tunneling amplitude is zero, the asymmetric tunneling turns dephasing into population relaxation. (d) Variational methods again give results in agreement with renormalization group and instanton calculations.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Harris, R. A. ; Pratt, Lawrence R.

    College Park, Md. : American Institute of Physics (AIP)
    Published 1985
    Staff View
    ISSN:
    1089-7690
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Chemistry and Pharmacology
    Notes:
    This paper outlines a program for the systematic treatment of correlation effects within density functional approaches to many-electron systems. This strategy is motivated by the observation that the ground state energy of an inhomogeneous electron gas is a functional of the many-body Hartree electron density. This fact is proved, and it is outlined how the functional can be constructed at any order of perturbation theory. Second order correlation contributions to the energy are discussed as an explicit example.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    SUNNEMARK, D. ; ULFGREN, A.-K. ; ÖRN, A. ; HARRIS, R. A.

    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Published 1996
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The authors analysed cytokine production in hearts of Trypanosoma cruzi-infected CBA-J mice by in situ immunocytochemical staining. Cellular infiltrates were recorded in hearts from both acute and chronic stages, but were not apparent in control hearts. In the acute heart, CD8 cells predominated, with associated production of IL-4, IL-6 and TNF-α. Cytokine production was characterized by IL-4, IL-5, IL-6 and TNF-α in the chronic heart, and numbers of CD4 and CD8 cells were more equal. At this stage, calcified infarctions and associated fibrosis were apparent, mimicking chronic human Chagas' heart pathology. The authors consider the CBA mouse an appropriate model of chronic T. cruzi infection, and suggest that local cytokine production reflects establishment of heart pathology.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Abdul-Majid, K-B. ; Stefferl, A. ; Bourquin, C. ; Lassmann, H. ; Linington, C. ; Olsson, T. ; Kleinau, S. ; Harris, R. A.

    Oxford, UK : Blackwell Science Ltd
    Published 2002
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Multiple sclerosis (MS) is simulated by various forms of experimental autoimmune encephalomyelitis, in which T cells, antibodies, cytokines and complementary factors interact with the central nervous system (CNS) myelin proteins and lead to inflammatory damage. We investigated the role of Fc receptors (FcRs), which link the cellular and humoral branches of the immune system, in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), using two different FcRγ knockout DBA/1 mice. The first knockout were the FcRγ chain-deficient mice, which lack FcγRI, FcγRIII and FcεRI, while the second knockout mice lack only FcγRII. The lack of FcγRII enhanced the disease susceptibility with associated increased CNS demyelination. While FcRγ+/+ DBA/1 mice also developed pronounced CNS infiltration and myelin destruction, FcRγ−/− littermates were protected despite initial peripheral autoimmune responses to MOG. In vitro analyses revealed equivalent potentials of fluid phase phagocytosis of myelin and MOG in bone-marrow macrophages derived from both FcRγ+/+ and FcRγ−/− mice, while MOG-immunoglobulin (Ig)G immune complexes were only internalized by FcRγ+/+ macrophages. This was associated with cellular activation in FcRγ+/+ but not FcRγ−/− macrophages, as assessed by the activation of intracellular mitogen activated protein (MAP)-kinase signalling elements. We propose that protection from EAE in FcRγ-deficient mice is due to the inefficient antigen processing/presentation of myelin proteins during the induction of secondary immune responses locally in the CNS, which leads to demyelination. This demonstrates the importance of FcR in the promotion of autoimmune inflammation of the CNS and highlights the therapeutic possibility of treatment of MS with FcR-directed modalities.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    VÁSQUEZ, J. E. ; KRUSNELL, J. ; O¨RN, A. ; SOUSA, O. E. ; HARRIS, R. A.

    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Published 1997
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Venous blood from 65 Panamanian schoolchildren living in an area endemic for both Trypanosoma cruzi and T. rangeli were screened for the presence of these parasites. Trypanosoma rangeli were isolated and cultured from four individuals. Serological tests of all 65 sera were performed, including immunohaemagglutination (IHA), indirect immunofluorescence assay (IF) and ELISA using both T. rangeli and T. cruzi as antigens, as well as T. cruzi synthetic peptides in an ELISA assay. Results indicated a higher immunoreactivity to T. rangeli preparations than to T. cruzi within the studied population, which could be divided into four ‘serological responder’ groups. Interestingly, the panel of SAPA and other T. cruzi synthetic peptides were not useful in the discrimination of patients. Furthermore, patients from whom parasites had been isolated could not be distinguished from those of two other groups. Significant immunoreactivityto T. cruzi preparations was displayed in all responder sera, despite total lack of evidence of infection with this parasite. The immunobiological significance of T. rangeli infection is unclear, but these data indicate that it is a compounding problem in the accurate diagnosis of pathological T. cruzi infection by serological analysis. The relationship of these cohabiting species, in respect to infection outcome and immunological activation, is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Kokkola, R. ; Andersson, Å. ; Mullins, G. ; Östberg, T. ; Treutiger, C.-J. ; Arnold, B. ; Nawroth, P. ; Andersson, U. ; Harris, R. A. ; Harris, H. E.

    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    High-mobility group box chromosomal protein 1 (HMGB1) is a protein with both intranuclear functions and extracellular cytokine-like effects. In this report, we study possible candidate receptors for HMGB1 on macrophages (Mφ) and define pathways activated by HMGB1 binding. Bone marrow Mφ were prepared from Dark Agouti (DA) rats and stimulated in vitro with HMGB1. The kinetics of tumour necrosis factor (TNF) production, NO production, activation of p38 mitogen-activated protein kinase (MAPK), p44/42 MAPK- and SAPK/JNK-signalling pathways, nuclear translocation of nuclear factor kappa B (NF-κB) and HMGB1-induced upregulation of major histocompatibility complex (MHC) class II and CD86 were analysed. Mφ from interleukin (IL)-1 receptor type I–/–, Toll-like receptor 2 (TLR2–/–) and RAGE–/– mice were used to investigate the role of these receptors in HMGB1 signalling. HMGB1 induced TNF and NO production by Mφ, phosphorylation of all investigated MAP kinase pathways and NF-κB translocation, and expression of MHC class II was increased. Mφ from RAGE–/– mice produced significantly lower amounts of TNF, IL-1β and IL-6, while IL-1RI–/– and TLR2–/– Mφ produced cytokine levels comparable with wildtype controls in response to HMGB1 stimulation. We conclude that HMGB1 has the potential to induce a proinflammatory phenotype in Mφ, with RAGE as the major activation-inducing receptor.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Wefer, J. ; Harris, R. A. ; Lobell, A.

    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Published 2004
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    DNA vaccine coding for the encephalitogenic peptide MOG91-108 protects LEW.1AV1 from subsequent development of experimental autoimmune encephalomyelitis (EAE). Protection is associated with a type 1 immune response and is dependent on the presence of CpG DNA motifs. The mechanisms underlying the observed reduction of EAE development in protected rats have not been fully clarified. We investigated immunological characteristics of lymphocytes after DNA vaccinaton and subsequent EAE induction. We confirm that protection was not associated with suppression of T1 cells, as transcription of the novel molecule rat T-cell immunoglobulin- and mucin-domain-containing molecule (TIM-3), reported to be exclusively expressed on differentiated T1 cells, was not altered by DNA vaccination. We did not note any clonal deletion upon tolerization, but detected an antigen-specific lymphocyte population upregulating IFNγ upon recall stimulation 3 weeks after protective DNA vaccination. In protected rats, we observed (1) no alterations in antigen-specific Th2 or Th3 responses, (2) reduced MHC II expression on splenocytes early after EAE induction, (3) antigen-specific upregulation of IFNβ upon recall stimulation and (4) reduced IL-12Rβ2 on lymphocytes. We thus demonstrate an association of the protective effect of DNA vaccination with expression of IFNβ. We are currently investigating the cellular mechanisms behind this IFNβ-mediated protection.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Harris, R. A. ; Hogarth, P. M. ; Penington, D. G. ; McKenzie, I. F. C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1984
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses