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1Latest Papers from Table of Contents or Articles in PressA. J. Ragauskas ; G. T. Beckham ; M. J. Biddy ; R. Chandra ; F. Chen ; M. F. Davis ; B. H. Davison ; R. A. Dixon ; P. Gilna ; M. Keller ; P. Langan ; A. K. Naskar ; J. N. Saddler ; T. J. Tschaplinski ; G. A. Tuskan ; C. E. Wyman
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-05-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Bioengineering/*methods ; Biofuels ; Carbon ; Cellulose/*chemistry ; Crops, Agricultural/chemistry/genetics/metabolism ; Elastomers ; Lignin/*biosynthesis/chemistry/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressN. D. Young ; F. Debelle ; G. E. Oldroyd ; R. Geurts ; S. B. Cannon ; M. K. Udvardi ; V. A. Benedito ; K. F. Mayer ; J. Gouzy ; H. Schoof ; Y. Van de Peer ; S. Proost ; D. R. Cook ; B. C. Meyers ; M. Spannagl ; F. Cheung ; S. De Mita ; V. Krishnakumar ; H. Gundlach ; S. Zhou ; J. Mudge ; A. K. Bharti ; J. D. Murray ; M. A. Naoumkina ; B. Rosen ; K. A. Silverstein ; H. Tang ; S. Rombauts ; P. X. Zhao ; P. Zhou ; V. Barbe ; P. Bardou ; M. Bechner ; A. Bellec ; A. Berger ; H. Berges ; S. Bidwell ; T. Bisseling ; N. Choisne ; A. Couloux ; R. Denny ; S. Deshpande ; X. Dai ; J. J. Doyle ; A. M. Dudez ; A. D. Farmer ; S. Fouteau ; C. Franken ; C. Gibelin ; J. Gish ; S. Goldstein ; A. J. Gonzalez ; P. J. Green ; A. Hallab ; M. Hartog ; A. Hua ; S. J. Humphray ; D. H. Jeong ; Y. Jing ; A. Jocker ; S. M. Kenton ; D. J. Kim ; K. Klee ; H. Lai ; C. Lang ; S. Lin ; S. L. Macmil ; G. Magdelenat ; L. Matthews ; J. McCorrison ; E. L. Monaghan ; J. H. Mun ; F. Z. Najar ; C. Nicholson ; C. Noirot ; M. O'Bleness ; C. R. Paule ; J. Poulain ; F. Prion ; B. Qin ; C. Qu ; E. F. Retzel ; C. Riddle ; E. Sallet ; S. Samain ; N. Samson ; I. Sanders ; O. Saurat ; C. Scarpelli ; T. Schiex ; B. Segurens ; A. J. Severin ; D. J. Sherrier ; R. Shi ; S. Sims ; S. R. Singer ; S. Sinharoy ; L. Sterck ; A. Viollet ; B. B. Wang ; K. Wang ; M. Wang ; X. Wang ; J. Warfsmann ; J. Weissenbach ; D. D. White ; J. D. White ; G. B. Wiley ; P. Wincker ; Y. Xing ; L. Yang ; Z. Yao ; F. Ying ; J. Zhai ; L. Zhou ; A. Zuber ; J. Denarie ; R. A. Dixon ; G. D. May ; D. C. Schwartz ; J. Rogers ; F. Quetier ; C. D. Town ; B. A. Roe
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-11-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: *Biological Evolution ; *Genome, Plant ; Medicago truncatula/*genetics/*microbiology ; Molecular Sequence Data ; Nitrogen Fixation/genetics ; Rhizobium/*physiology ; Soybeans/genetics ; *Symbiosis ; Synteny ; Vitis/geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-01-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Bacteria/*enzymology ; Biofuels/microbiology ; Biomass ; Cell Wall/*chemistry/*metabolism ; Fungi/*enzymology ; Plant Cells/chemistry/*metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressLi, Y., Shuai, L., Kim, H., Motagamwala, A. H., Mobley, J. K., Yue, F., Tobimatsu, Y., Havkin-Frenkel, D., Chen, F., Dixon, R. A., Luterbacher, J. S., Dumesic, J. A., Ralph, J.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-09-29Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
5Articles: DFG German National LicensesDixon, R. A. ; KENYON, C. ; MARSH, D. R. G. ; THORNTON, J. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: In a double-blind trial, 50 patients were randomly allocated to receive up to 0.29 mg/kg diazepam (Valium 5 mg/ml) or 0.14 mg/kg of midazolam (midazolam hydrochloride 5 mg/ml) intravenously at a first session of conservative dentistry, the alternative being administered at the second session. Good operating conditions were reported under each sedative and no important physiological differences were observed. Most patients failed to return to ‘street fitness’ 30 minutes after either session of treatment. Previous reports of reduced incidence of venous thrombophlebitis with midazolam were not convincingly confirmed in this trial, but data quality was poor. For about half the patients, the amnesic effect was stronger following midazolam.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesMann, P. E. ; Hatt, S. D. ; Dixon, R. A. ; Griffin, K. D. ; Perks, E. R. ; Thornton, J. A.
Oxford, UK : Blackwell Publishing Ltd
Published 1971Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1365-2958Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: The regulatory region spanning the divergently transcribed nif F and nifLA promoters contains a NIFA-specific upstream activator sequence (UAS) located around +59, and two NTRC binding sites centred at −142 and −163 with respect to the nifLA transcription start site. We have constructed mutations in each of these binding sites and examined their role in transcriptional activation of the divergently transcribed promoters. Analysis of a mutation at +60 confirms that the UAS is required for efficient NIFA-mediated activation of nifF transcription. This sequence is also required for maximal activation of the nifLA promoter. Mutations at −169 and −148, within the two NTRC binding sites, reduce activation of the nifLA promoter by NTRC in vivo and lower the affinity of the activator for these sites in vitro. Phosphorylation of NTRC by NTRB is required for efficient binding of NTRC to these sites.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] nifV mutants were originally isolated by their inability to grow anaerobically (anaerobic conditions are required because oxygen represses nitrogenase production) on nitrogen-free medium, but all nifV mutants were shown to give a leaky phenotype when assayed for C2H2 reduction5'6, a test normally ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-1106Keywords: Lateral geniculate nucleus ; Perigeniculate nucleus ; Extraretinal proprioceptive signal ; Extrinsic ocular musclesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary In cats, anaesthetized with chloralose and paralysed, the responses of units in the right lateral thalamus were recorded while the extrinsic ocular muscles (EOM) of the right eye were stretched in the dark. Phasic responses were found in all layers of the dorsal lateral geniculate nucleus (LGNd) and in the perigeniculate nucleus (PGN). A given unit usually responded to stretch of more than one EOM and thus to more than one direction of rotation of the eye in the orbit. LGNd. Of a sample of 76 units in LGNd, 55 (72%) gave visual but no muscle responses and 21 (28%) responded to EOM stretch. In all, 40 units with EOM responses were examined and 25 of the 27 tested (93%) also had visual responses. Of the 40 units, 32 could be allocated to layers, thus: layer A, 8 (25%); layer A1, 20 (63%); layer B, 3 (9%); central interlaminar nucleus, 1 (3%). It is interesting that most of the EOM responses were found in layer A1 which receives the excitatory visual input from the eye whose EOM were stretched. Muscle responsive units occurred with ON- and OFF-centre visual responses of sustained and transient types. PGN. In PGN, 21 units gave EOM responses and most of them were also excited by visual input. The conclusion is that the LGNd and PGN recieve an extraretinal proprioceptive signal which should be present during at least large saccadic eye movements. The anatomical pathways which may be involved and the significance of the signal are discussed briefly.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesDixon, R. A. F. ; Diehl, R. E. ; Opas, E. ; Rands, E. ; Vickers, P. J. ; Evans, J. F. ; Gillard, J. W. ; Miller, D. K.
[s.l.] : Nature Publishing Group
Published 1990Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] On the basis of the partial amino-acid sequence of purified rat FLAP4, we isolated cDNA clones 1 kilobase (kb) long from rat RBL-1 and human HL-60 cell-line cDNA libraries (Fig. 1). Both the rat and human cDNA clones encode proteins of 161 amino acids, which are 92% identical and ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The donor strain of K. pneumoniae M5al was prototrophic and carried a derepressed mutant I-like R factor, R144drd3 (Km coli)3. A derivative of M5al (R144drd3) was isolated following ultraviolet irradiation and subsequent selection for high frequency transfer of his, a marker known to be close to ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The species Klebsiella pneumoniae includes strains which fix nitrogen if the environment is anaerobic. Matsumoto and Tazaki4 have described fertile strains of K. pneumoniae which bring about gene transfer by conjugation and they have constructed a genetic linkage map of K. pneumoniae5 which is ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-2048Keywords: Cell culture ; Phaseolus (enzyme turnover) ; Phenylalanine ammonia-lyase ; Phenylpropanoid biosynthesisSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract The extractable activity ofl-phenylalanine ammonia-lyase (PAL; EC 4.3.1.5) in cell suspension cultures of bean (Phaseolus vulgaris) is greatly induced following exposure to an elicitor preparation from the cell walls of the phytopathogenic fungusColletotrichum lindemuthianum. Following exogenous application oftrans-cinnamic acid (the product of the PAL reaction) to elicitor-induced cells, the activity of the enzyme rapidly declines. Loss of enzyme activity is accompanied by inhibition of the rate of synthesis of PAL subunits, as determined by [35S]methionine pulse-labelling followed by specific immunoprecipitation; this is insufficient to account for the rapid loss of PAL enzyme activity. Pulse-chase and immune blotting experiments indicate that cinnamic acid does not affect the rate of degradation of enzyme subunits, but rather mediates inactivation of the enzyme. A non-dialysable factor from cinnamicacid-treated bean cells stimulates removal of PAL activity from enzyme extracts in vitro; this effect is dependent on the presence of cinnamic acid. Such loss of enzyme activity in vitro is accompanied by an apparent loss or reduction of the dehydroalanine residue of the enzyme's active site, as detected by active-site-specific tritiation, although levels of immunoprecipitable enzyme subunits do not decrease. Furthermore, cinnamic-acid-mediated loss of enzyme activity in vivo is accompanied, in pulse-chase experiments, by a greater relative loss of35S-labelled enzyme subunits precipitated by an immobilised active-site affinity ligand than of subunits precipitated with anti-immunoglobulin G. It is therefore suggested that a possible mechanism for cinnamic-acid-mediated removal of PAL activity may involve modification of the dehydroalanine residue of the enzyme's active site.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-2048Keywords: Cell suspension culture ; Phaseolus ; Phenylalanine ammonia-lyase ; Phenylpropanoid biosynthesisSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract The increase in extractable phenylalanine ammonia-lyase (PAL;EC 4.3.1.5.) activity induced in French bean cell suspension cultures in response to treatment with autoclaved ribonuclease A was inhibited by addition of the phenylpropanoid pathway intermediates cinnamic acid, 4-coumaric acid or ferulic acid. The effectiveness of inhibition was in the order cinnamic acid〉4-coumaric acid〉ferulic acid. Cinnamic acid also inhibited the PAL activity increase induced by dilution of the suspensions into an excess of fresh culture medium. Addition of low concentrations (〈10-5M) of the pathway intermediates to cultures at the time of application of ribonuclease gave variable responses ranging from inhibition to 30–40% stimulation of the PAL activity measured at 8 h. Following addition of pathway intermediates to cultures 4–5 h after ribonuclease treatment, rapid increases followed by equally rapid declines in PAL activity were observed. The cinnamic acid-stimulated increase in enzyme activity was unaffected by treatment with cycloheximide at a concentration which gave complete inhibition of the ribonuclease-induced response. However, cycloheximide completely abolished the subsequent decline in enzyme activity. Treatment of induced cultures with α-aminooxy-β-phenylpropionic acid (AOPPA) resulted in increased but delayed rates of enzyme appearance when compared to controls not treated with the phenylalanine analogue. The results are discussed in relation to current views on the regulation of enzyme levels in higher plants.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-2048Keywords: Cell suspension culture ; Colletotrichum ; Elicitor ; Flavanone synthase ; Phaseolus ; Phenylalanine ammonia-lyase ; PhytoalexinSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract The induction of L-phenylalanine ammonialyase (PAL, EC 4.3.1.5) and flavanone synthase in French bean cell suspension cultures in response to heat-released elicitor from cell walls of the phytopathogenic fungus Colletotrichum lindemuthianum is highly dependent upon elicitor concentration. The elicitor dose-response curve for PAL induction shows two maxima at around 17.5 and 50 μg elicitor carbohydrate per ml culture, whereas the flavanone synthase response shows one maximum at around 100 μg ml-1. The PAL response is independent of the elicitor concentration present during the lag phase of enzyme induction; if the initial elicitor concentration is increased after 2 h by addition of extra elicitor, or decreased by dilution of the cultures, the dose response curves obtained reflect the concentration of elicitor present at the time of harvest. PAL induction is not prevented by addition of methyl sugar derivatives to the cultures; α-methyl-D-glucoside, itself a weak elicitor of PAL activity, elicits a multiphasic PAL response when increasing concentrations are added in the presence of Colletotrichum elicitor. Eight fractions with different monosaccharide compositions, obtained from the crude elicitor by gel-filtration, each elicit different dose-responses for PAL induction; the response to unfractionated elicitor is not the sum of the response to the isolated fractions. There is no correlation between the ability of the fractions to induce PAL in the cultures and their ability to act as elicitors of isoflavonoid phytoalexin accumulation in bean hypocotyls.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesBasal activity of the hypothalamic-pituitary-adrenal axis and cognitive function in anorexia nervosaStaff View
ISSN: 1433-8491Keywords: Key Words Anorexia nervosa ; Cortisol ; Cognition ; NeuroendocrineSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Anorexia nervosa is associated with abnormalities in neuroendocrine function including sustained hypercortisolism, which has been shown elsewhere to be associated with impairment of function in learning, memory and attention. Cognitive impairment has also been observed in anorexia nervosa. These effects may be mediated in part through cortisol effects on the hippocampus, which is dense with glucocorticoid receptors. We investigated the association between cortisol levels and cognitive function in anorexia nervosa by measuring both 24-hour urinary cortisol counts and performance on tasks of learning, memory and attention in patients suffering from the disorder. Cortisol secretion was shown to be significantly higher in the patient group than in a matched control group and patients were also shown to be impaired in memory and attention. However, no correlations were found between the cognitive deficits and cortisol measures. It is suggested that more sensitive profiling of cortisol levels throughout the circadian cycle may be useful in future studies of cognitive function in anorexia nervosa.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-5028Keywords: Phaseolus vulgaris ; cell culture ; chalcone isomerase ; elicitorSource: Springer Online Journal Archives 1860-2000Topics: BiologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Keywords: Nitrogen fixation ; nifL ; Repression ; Metal ionsSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary The ability of the Klebsiella pneumoniae nifL gene product to antagonise NIFA mediated transcriptional activation from the nifH promoter in vivo was inhibited either by metal deprivation, or by the presence of the iron chelators EDDA or Desferal in the growth medium. This inhibition of the repressive activity of NIFL was reversed by the addition of ferrous or manganous ions to the medium but was unaffected by other transition metals. The dependence on metal ions for NIFL activity was observed when NIFL was overexpressed and when cultures were exposed to oxygen or high levels of fixed nitrogen. Immunochemical evidence suggests that NIFL and NIFA associate to form a functional protein complex. Metal ions are apparently not required for the formation of this complex.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary The enzymes involved in ammonia assimilation by Rhizobium meliloti 4l and their role in the regulation of nitrogen metabolism were studied. Glutamine synthetase (GS) and glutamate synthase (GOGAT) were present at relatively high levels in cells grown in media containing either low or high concentrations of ammonia. NADP-linked glutamate dehydrogenase could not be detected. GOGAT and GS mutants were isolated and characterised. A mutant lacking GOGAT activity did not grow even on high concentrations of ammonia, it was a glutamate auxotroph and was effective in symbiotic nitrogen fixation. The GS and assimilatory nitrate reductase activities of this mutant were not repressible by ammonia but still repressible by casamino acids. A mutant with low GS activity required glutamine for optimal growth. It was ineffective and its nitrate reductase was not inducible. These findings indicate that ammonia is assimilated via the GS/GOGAT pathway in free-living R. meliloti and bacterial GOGAT is not important in symbiosis. Furthermore, GS is suggested to be a controlling element in the nitrogen metabolism of R. meliloti.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesFujii, T. ; Huang, Yi-De ; Higashitani, A. ; Nishimura, Y. ; Iyama, S. ; Hirota, Y. ; Yoneyama, T. ; Dixon, R. A.
Springer
Published 1987Staff ViewISSN: 1573-5036Keywords: Associative dinitrogen fixation ; bacteria inoculation ; N2 fixer ; Oryza sativa L ; RhizosphereSource: Springer Online Journal Archives 1860-2000Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Abstract The influence ofKlebsiella oxytoca andEnterobacter cloacae inoculation on dinitrogen fixation by the rice-bacteria association was examined in pots in a greenhouse. For inoculation,K. oxytoca NG13 isolated from a Japan paddy soil,E. cloacae E26 isolated from a China soil and following three strains were employed.K. oxytoca NG1389 is a mutant from NG13 and has no nitrogenase activity (nif). K. oxytoca NG13/pMC71A andE. cloacae E26/pMC71A were produced by inserting anif A containingK. pneumoniae plasmid (pMC71A) to NG13 and E26, respectively. These two strains were able to fix dinitrogen fixation in the presence of ammonium, whereas nitrogenase activity of wild strains (NG13 and E26) were repressed under this condition. Inoculation effects were tested on two rice (Oryza sativa L.) varieties, a Indica type C5444 and a Japonica type T65. Rice seedlings were planted to nonsterilized potted soil, and grown under flooded conditions. Upon inoculation with NG13 and E26, growth and N increment of plants particularly in T65 were stimulated above NG1389 inoculated plants. Assay by15N dilution and acetylene reduction techniques indicated that this N increment may be due to fixed N. Inoculation with NG13/pMC71A and E26/pMC71A resulted in more dry weight and fixed N than those of NG13 and E26 inoculated plants.Type of Medium: Electronic ResourceURL: