Search Results - (Author, Cooperation:R. A. Depinho)
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1H. Inuzuka ; S. Shaik ; I. Onoyama ; D. Gao ; A. Tseng ; R. S. Maser ; B. Zhai ; L. Wan ; A. Gutierrez ; A. W. Lau ; Y. Xiao ; A. L. Christie ; J. Aster ; J. Settleman ; S. P. Gygi ; A. L. Kung ; T. Look ; K. I. Nakayama ; R. A. DePinho ; W. Wei
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; *Apoptosis/drug effects ; Benzenesulfonates/pharmacology ; Biphenyl Compounds/pharmacology ; Cell Cycle Proteins/genetics/*metabolism ; Cell Line, Tumor ; F-Box Proteins/genetics/*metabolism ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Mice ; Molecular Sequence Data ; Myeloid Cell Leukemia Sequence 1 Protein ; Niacinamide/analogs & derivatives ; Nitrophenols/pharmacology ; Phenylurea Compounds ; Phosphorylation ; Piperazines/pharmacology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Protein Binding/drug effects ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors/*chemistry/*metabolism ; Pyridines/pharmacology ; SKP Cullin F-Box Protein Ligases/*chemistry/*metabolism ; Sulfonamides/pharmacology ; Tumor Suppressor Proteins/deficiency/genetics/metabolism ; Ubiquitin-Protein Ligases/deficiency/genetics/*metabolism ; *Ubiquitination/drug effectsPublished by: -
2J. Son ; C. A. Lyssiotis ; H. Ying ; X. Wang ; S. Hua ; M. Ligorio ; R. M. Perera ; C. R. Ferrone ; E. Mullarky ; N. Shyh-Chang ; Y. Kang ; J. B. Fleming ; N. Bardeesy ; J. M. Asara ; M. C. Haigis ; R. A. DePinho ; L. C. Cantley ; A. C. Kimmelman
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenocarcinoma/genetics/metabolism/pathology ; Aspartate Aminotransferases/deficiency/genetics/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Citric Acid Cycle ; Glutamate Dehydrogenase/metabolism ; Glutamine/*metabolism ; Homeostasis ; Humans ; Ketoglutaric Acids/metabolism ; *Metabolic Networks and Pathways ; Oncogene Protein p21(ras)/genetics/*metabolism ; Oncogenes/genetics ; Oxidation-Reduction ; Pancreatic Neoplasms/genetics/*metabolism/*pathology ; Proto-Oncogene Proteins/genetics/*metabolism ; Reactive Oxygen Species/metabolism ; ras Proteins/genetics/*metabolismPublished by: -
3F. Muller ; S. Colla ; E. Aquilanti ; V. E. Manzo ; G. Genovese ; J. Lee ; D. Eisenson ; R. Narurkar ; P. Deng ; L. Nezi ; M. Lee ; B. Hu ; J. Hu ; E. Sahin ; D. Ong ; E. Fletcher-Sananikone ; D. Ho ; L. Kwong ; C. Brennan ; Y. A. Wang ; L. Chin ; R. A. DePinho
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-07-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
4A. Viale ; P. Pettazzoni ; C. A. Lyssiotis ; H. Ying ; N. Sanchez ; M. Marchesini ; A. Carugo ; T. Green ; S. Seth ; V. Giuliani ; M. Kost-Alimova ; F. Muller ; S. Colla ; L. Nezi ; G. Genovese ; A. K. Deem ; A. Kapoor ; W. Yao ; E. Brunetto ; Y. Kang ; M. Yuan ; J. M. Asara ; Y. A. Wang ; T. P. Heffernan ; A. C. Kimmelman ; H. Wang ; J. B. Fleming ; L. C. Cantley ; R. A. DePinho ; G. F. Draetta
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Autophagy ; Carcinoma, Pancreatic Ductal/drug therapy/genetics/*metabolism/*pathology ; Cell Respiration/drug effects ; Cell Survival/drug effects ; Disease Models, Animal ; Female ; Gene Expression Regulation, Neoplastic ; Genes, p53/genetics ; Glycolysis ; Lysosomes/metabolism ; Mice ; Mitochondria/drug effects/*metabolism ; Mutation/genetics ; Neoplasm Recurrence, Local/prevention & control ; Neoplastic Stem Cells/drug effects/metabolism/pathology ; Oxidative Phosphorylation/drug effects ; Pancreatic Neoplasms/drug therapy/genetics/*metabolism/*pathology ; Proto-Oncogene Proteins p21(ras)/*genetics/metabolism ; Recurrence ; Signal TransductionPublished by: -
5M. Jaskelioff ; F. L. Muller ; J. H. Paik ; E. Thomas ; S. Jiang ; A. C. Adams ; E. Sahin ; M. Kost-Alimova ; A. Protopopov ; J. Cadinanos ; J. W. Horner ; E. Maratos-Flier ; R. A. Depinho
Nature Publishing Group (NPG)
Published 2010Staff ViewPublication Date: 2010-11-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/drug effects/*metabolism/*pathology ; Animals ; Avoidance Learning/drug effects ; Brain/anatomy & histology/cytology/drug effects/pathology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; DNA Damage/drug effects ; Enzyme Activation/drug effects ; Enzyme Reactivators/pharmacology ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Myelin Sheath/metabolism ; Neural Stem Cells/cytology/drug effects/enzymology/pathology ; Organ Size/drug effects ; Phenotype ; Receptors, Estrogen/genetics/metabolism ; Recombinant Fusion Proteins/genetics/metabolism ; Regenerative Medicine ; Smell/drug effects/physiology ; Tamoxifen/analogs & derivatives/pharmacology ; Telomerase/*deficiency/genetics/*metabolism ; Telomere/drug effects/metabolism/pathologyPublished by: -
6Z. Ding ; C. J. Wu ; G. C. Chu ; Y. Xiao ; D. Ho ; J. Zhang ; S. R. Perry ; E. S. Labrot ; X. Wu ; R. Lis ; Y. Hoshida ; D. Hiller ; B. Hu ; S. Jiang ; H. Zheng ; A. H. Stegh ; K. L. Scott ; S. Signoretti ; N. Bardeesy ; Y. A. Wang ; D. E. Hill ; T. R. Golub ; M. J. Stampfer ; W. H. Wong ; M. Loda ; L. Mucci ; L. Chin ; R. A. DePinho
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone Morphogenetic Proteins/metabolism ; Cell Proliferation ; Cyclin D1/genetics/metabolism ; *Disease Progression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor/physiology ; Humans ; Lung Neoplasms/secondary ; Lymphatic Metastasis ; Male ; Mice ; Mice, Transgenic ; Models, Biological ; Neoplasm Invasiveness/genetics/pathology ; Neoplasm Metastasis/genetics/*pathology ; Osteopontin/genetics/metabolism ; PTEN Phosphohydrolase/deficiency/genetics ; Penetrance ; Prognosis ; Prostate/metabolism ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/diagnosis/genetics/*pathology ; Smad4 Protein/deficiency/genetics/*metabolism ; Transforming Growth Factor betaPublished by: -
7E. Sahin ; S. Colla ; M. Liesa ; J. Moslehi ; F. L. Muller ; M. Guo ; M. Cooper ; D. Kotton ; A. J. Fabian ; C. Walkey ; R. S. Maser ; G. Tonon ; F. Foerster ; R. Xiong ; Y. A. Wang ; S. A. Shukla ; M. Jaskelioff ; E. S. Martin ; T. P. Heffernan ; A. Protopopov ; E. Ivanova ; J. E. Mahoney ; M. Kost-Alimova ; S. R. Perry ; R. Bronson ; R. Liao ; R. Mulligan ; O. S. Shirihai ; L. Chin ; R. A. DePinho
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-02-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenosine Triphosphate/biosynthesis ; Aging/metabolism/pathology ; Animals ; Cardiomyopathies/chemically induced/metabolism/pathology/physiopathology ; Cell Proliferation ; DNA, Mitochondrial/analysis ; Doxorubicin/toxicity ; Gluconeogenesis ; Hematopoietic Stem Cells/metabolism/pathology ; Liver/cytology/metabolism ; Mice ; Mitochondria/*metabolism/*pathology ; Myocardium/cytology/metabolism ; RNA/genetics ; Reactive Oxygen Species/metabolism ; Telomerase/deficiency/genetics ; Telomere/enzymology/genetics/*metabolism/*pathology ; Transcription Factors/antagonists & inhibitors/metabolism ; Tumor Suppressor Protein p53/deficiency/genetics/metabolismPublished by: -
8F. L. Muller ; S. Colla ; E. Aquilanti ; V. E. Manzo ; G. Genovese ; J. Lee ; D. Eisenson ; R. Narurkar ; P. Deng ; L. Nezi ; M. A. Lee ; B. Hu ; J. Hu ; E. Sahin ; D. Ong ; E. Fletcher-Sananikone ; D. Ho ; L. Kwong ; C. Brennan ; Y. A. Wang ; L. Chin ; R. A. DePinho
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-08-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antineoplastic Agents/pharmacology/therapeutic use ; Biomarkers, Tumor/deficiency/genetics ; Brain Neoplasms/*drug therapy/*genetics/pathology ; Cell Line, Tumor ; Cell Proliferation ; Chromosomes, Human, Pair 1/genetics ; DNA-Binding Proteins/deficiency/genetics ; Enzyme Inhibitors ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Genes, Essential/*genetics ; Genes, Tumor Suppressor ; Glioblastoma/*drug therapy/*genetics/pathology ; Homozygote ; Humans ; Hydroxamic Acids/pharmacology/therapeutic use ; Mice ; Molecular Targeted Therapy/*methods ; Neoplasm Transplantation ; Phosphonoacetic Acid/analogs & derivatives/pharmacology/therapeutic use ; Phosphopyruvate Hydratase/antagonists & inhibitors/deficiency/genetics/metabolism ; RNA, Small Interfering/genetics ; Sequence Deletion/*genetics ; Tumor Suppressor Proteins/deficiency/geneticsPublished by: