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1Latest Papers from Table of Contents or Articles in PressS. Sawcer ; G. Hellenthal ; M. Pirinen ; C. C. Spencer ; N. A. Patsopoulos ; L. Moutsianas ; A. Dilthey ; Z. Su ; C. Freeman ; S. E. Hunt ; S. Edkins ; E. Gray ; D. R. Booth ; S. C. Potter ; A. Goris ; G. Band ; A. B. Oturai ; A. Strange ; J. Saarela ; C. Bellenguez ; B. Fontaine ; M. Gillman ; B. Hemmer ; R. Gwilliam ; F. Zipp ; A. Jayakumar ; R. Martin ; S. Leslie ; S. Hawkins ; E. Giannoulatou ; S. D'Alfonso ; H. Blackburn ; F. Martinelli Boneschi ; J. Liddle ; H. F. Harbo ; M. L. Perez ; A. Spurkland ; M. J. Waller ; M. P. Mycko ; M. Ricketts ; M. Comabella ; N. Hammond ; I. Kockum ; O. T. McCann ; M. Ban ; P. Whittaker ; A. Kemppinen ; P. Weston ; C. Hawkins ; S. Widaa ; J. Zajicek ; S. Dronov ; N. Robertson ; S. J. Bumpstead ; L. F. Barcellos ; R. Ravindrarajah ; R. Abraham ; L. Alfredsson ; K. Ardlie ; C. Aubin ; A. Baker ; K. Baker ; S. E. Baranzini ; L. Bergamaschi ; R. Bergamaschi ; A. Bernstein ; A. Berthele ; M. Boggild ; J. P. Bradfield ; D. Brassat ; S. A. Broadley ; D. Buck ; H. Butzkueven ; R. Capra ; W. M. Carroll ; P. Cavalla ; E. G. Celius ; S. Cepok ; R. Chiavacci ; F. Clerget-Darpoux ; K. Clysters ; G. Comi ; M. Cossburn ; I. Cournu-Rebeix ; M. B. Cox ; W. Cozen ; B. A. Cree ; A. H. Cross ; D. Cusi ; M. J. Daly ; E. Davis ; P. I. de Bakker ; M. Debouverie ; B. D'Hooghe M ; K. Dixon ; R. Dobosi ; B. Dubois ; D. Ellinghaus ; I. Elovaara ; F. Esposito ; C. Fontenille ; S. Foote ; A. Franke ; D. Galimberti ; A. Ghezzi ; J. Glessner ; R. Gomez ; O. Gout ; C. Graham ; S. F. Grant ; F. R. Guerini ; H. Hakonarson ; P. Hall ; A. Hamsten ; H. P. Hartung ; R. N. Heard ; S. Heath ; J. Hobart ; M. Hoshi ; C. Infante-Duarte ; G. Ingram ; W. Ingram ; T. Islam ; M. Jagodic ; M. Kabesch ; A. G. Kermode ; T. J. Kilpatrick ; C. Kim ; N. Klopp ; K. Koivisto ; M. Larsson ; M. Lathrop ; J. S. Lechner-Scott ; M. A. Leone ; V. Leppa ; U. Liljedahl ; I. L. Bomfim ; R. R. Lincoln ; J. Link ; J. Liu ; A. R. Lorentzen ; S. Lupoli ; F. Macciardi ; T. Mack ; M. Marriott ; V. Martinelli ; D. Mason ; J. L. McCauley ; F. Mentch ; I. L. Mero ; T. Mihalova ; X. Montalban ; J. Mottershead ; K. M. Myhr ; P. Naldi ; W. Ollier ; A. Page ; A. Palotie ; J. Pelletier ; L. Piccio ; T. Pickersgill ; F. Piehl ; S. Pobywajlo ; H. L. Quach ; P. P. Ramsay ; M. Reunanen ; R. Reynolds ; J. D. Rioux ; M. Rodegher ; S. Roesner ; J. P. Rubio ; I. M. Ruckert ; M. Salvetti ; E. Salvi ; A. Santaniello ; C. A. Schaefer ; S. Schreiber ; C. Schulze ; R. J. Scott ; F. Sellebjerg ; K. W. Selmaj ; D. Sexton ; L. Shen ; B. Simms-Acuna ; S. Skidmore ; P. M. Sleiman ; C. Smestad ; P. S. Sorensen ; H. B. Sondergaard ; J. Stankovich ; R. C. Strange ; A. M. Sulonen ; E. Sundqvist ; A. C. Syvanen ; F. Taddeo ; B. Taylor ; J. M. Blackwell ; P. Tienari ; E. Bramon ; A. Tourbah ; M. A. Brown ; E. Tronczynska ; J. P. Casas ; N. Tubridy ; A. Corvin ; J. Vickery ; J. Jankowski ; P. Villoslada ; H. S. Markus ; K. Wang ; C. G. Mathew ; J. Wason ; C. N. Palmer ; H. E. Wichmann ; R. Plomin ; E. Willoughby ; A. Rautanen ; J. Winkelmann ; M. Wittig ; R. C. Trembath ; J. Yaouanq ; A. C. Viswanathan ; H. Zhang ; N. W. Wood ; R. Zuvich ; P. Deloukas ; C. Langford ; A. Duncanson ; J. R. Oksenberg ; M. A. Pericak-Vance ; J. L. Haines ; T. Olsson ; J. Hillert ; A. J. Ivinson ; P. L. De Jager ; L. Peltonen ; G. J. Stewart ; D. A. Hafler ; S. L. Hauser ; G. McVean ; P. Donnelly ; A. Compston
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-13Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alleles ; Cell Differentiation/immunology ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome, Human/genetics ; Genome-Wide Association Study ; HLA-A Antigens/genetics ; HLA-DR Antigens/genetics ; HLA-DRB1 Chains ; Humans ; Immunity, Cellular/genetics/*immunology ; Major Histocompatibility Complex/genetics ; Multiple Sclerosis/*genetics/*immunology ; Polymorphism, Single Nucleotide/genetics ; Sample Size ; T-Lymphocytes, Helper-Inducer/cytology/immunologyPublished by: -
2Articles: DFG German National LicensesASPILLAGA, M. O. ; WHITTAKER, P. G. ; TAYLOR, A. ; LIND, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Serial measurements of serum progesterone, oestradiol, prolactin, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) have been determined in 32 healthy women at regular intervals throughout pregnancy. The data confirm previous reports that levels of these hormones vary widely between individuals at each stage of gestation, but further analyses have shown two other features: first there is a clear tendency for individuals to retain their rank in the spectrum of hormone values throughout pregnancy; second when the concentrations of the individual hormones (except hCG) are transformed to logarithmic values, the trends within individuals approximate well to straight lines during the second and third trimester of pregnancy. These findings provide a relatively simple method for describing the rates of change in the concentrations of these hormones and for examining possible relations between them. They also suggest that the quality of the maternal endocrine milieu may be determined at an early stage of gestation.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesWINTERS, ANA L. ; WHITTAKER, P. A. ; WILSON, R. K.
Oxford, UK : Blackwell Publishing Ltd
Published 1987Staff ViewISSN: 1365-2494Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: Although many aspects of grass silage have received intensive study, the changes that take place within the grass blades during ensilage have received little attention.In two factorial experiments Italian ryegrass (cv. Lemtal) and cocksfoot (indigenous) were ensiled in laboratory silos (capacity 0·2 kg) with the grass under pressure (700 Pa) and subjected to two treatments (with or without 3·31 t-1 85% formic acid) and two silos from each treatment opened on eight sampling dates(1,2,3,4,7,10,14 and 21 d).For each sampling date transverse sections of grass laminae were examined and changes in the cross sections of the protoplasts and of cells, as defined by the cell walls, were recorded. These data were used to calculate the ratios of protoplast to cell volumes at each sampling date.Each silage was analysed for dry matter, pH, lactic acid, VFA, ammonia and glucose. The distance settled by the silage (a measure of decrease in silage volume) and the silage conductivity were also recorded.Both of the untreated grasses yielded silages with typical lactic acid levels and pH values. In all of the silages there was a marked shrinkage of the plast within the space defined by the cell wall. The ratio of protoplast to cell volume eventually stabilized at 0·4. The formic acid-treated grasses reached this level by day 1 but a longer period was required by untreated grasses.It is suggested that the decrease in silage volume is related to the lactic acid content of the liquid phase due to their close relationship in silages produced from untreated grasses (r= 0·97***).Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesWHITTAKER, P. G. ; STEWART, M. O. ; TAYLOR, A. ; LIND, T.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Serial measurements of serum progesterone, oestradiol, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) have been determined in 33 women experiencing early pregnancy failure and compared with the values of the same hormones in 72 healthy women having uncomplicated pregnancies. Steroid production by the corpus luteum seemed similar in both groups up to 6 weeks gestation but thereafter placental steroidogenesis was not evident in those women in whom spontaneous pregnancy losses occurred. Placental production of the two protein hormones, hCG and hPL, did take place, and whereas the circulating levels were not as high as in normal pregnancies, levels did usually increase before clinical evidence of miscarriage occurred. hCG was not a sensitive discriminator of subsequent failure. In these women there were no significant hormone differences between those with evidence of a fetus and those without.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesSTEWART, M. O. ; WHITTAKER, P. G. ; LIND, T. ; PERSSON, B. ; HANSON, U.
Oxford, UK : Blackwell Publishing Ltd
Published 1989Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Serum progesterone, oestradiol, human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) were determined serially throughout 27 pregnancies in insulin-dependent diabetic patients from Newcastle (UK), 15 such patients from Stockholm (Sweden) and in 69 normal women having uncomplicated pregnancies. Mean progesterone, oestradiol and hCG concentrations were somewhat higher in the diabetic women during the third trimester but hPL values were not different from normal. The increased hormone concentrations did not relate to the increased birthweights or placental weights in the diabetic women. It is suggested that the usual physiological endocrine changes during normal pregnancy are relatively undisturbed by insulin-dependent diabetes or the degree of diabetes control achieved.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Summary. Human pregnancy may induce changes in the sensitivity of the cardiovascular system to endogenous catecholamines. This was investigated in multigravid women with little likelihood of unsuspected vascular disease. Txe responses of blood pressure, pulse rate, plasma noradrenaline and adrenaline to a change in posture from semi-decumbency to standing were assessed in six normotensive women at 36 weeks gestation and in six non-pregnant control subjects. Standing for 10 min caused a surge in blood pressure, pulse rate and plasma noradrenaline in non-pregnant women. The pregnant women, whose basal levels of noradrenaline were higher than those in non-pregnant women, showed a slower noradrenergic response to postural change, and this response had less effect upon the cardiovascular indices. Blood pressure dropped immediately on standing and pulse rate remained unaffected throughout. It is suggested that some women may maintain a non-pregnant level of pressor sensitivity during pregnancy and thereby become hypertensive.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0309-1651Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Key words Actins — collagen — fibroblasts — myocardial infarction — wound healingSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1438-1168Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesDescription / Table of Contents: Zusammenfassung Minerale der Platin-Gruppe, Silikate und andere feste und flüssige Einschlüsse kommen in disseminierten und massiven Chromiten in einer Vielzahl von Gesteinen in ophiolitischen und anderen mafisch-ultramafischen Komplexen vor. Die Einschlüsse sind klein (〈250 microns) und unregelmäßig im Chromit verteilt. Silikat-Einschlüsse sind modal weiter verbreitet als andere Arten von Einschlüssen. Minerale der Platin-Gruppe sind durch Ruthenium-reiche Sulfide und Osmium-reiche Legierungen vertreten. Mafische Silikate (Olivin, Pyroxen, pargasitische Amphibole, Glimmer) sind Magnesium-, Titan- und Alkali-reich; felsische Silikate sind Natrium-reich (Albit, Nephelin). Die ausgeprägte Assoziation dieser Einschlüsse mit Chromit weist darauf hin, daß ihre Herkunft im Zusammenhang mit einem Kristallisations-Modell für Chromit zu sehen ist. Ein genetisches Konzept wird vorgelegt, wobei die Platin-Gruppen-Minerale als gut ausgebildete, idiomorphe kristalline Phasen, und die Silikate als Silikatschmelze während des Ausfallens des Chromites eingeschlossen werden. Die Ähnlichkeit der physikalischen Eigenschaften, der modalen mineralogischen Zusammensetzung und der chemischen Zusammensetzung weisen darauf hin, daß dieses Modell auf alle mafisch-ultramafischen Komplexe anzuwenden ist.Notes: Summary Platinum-group mineral, silicate and other solid and fluid inclusions occur in disseminated and massive chromite in a variety of lithologies from ophiolitic and other mafic-ultramafic complex-types. The inclusions are small (〈250 microns) and randomly distributed throughout their host. Silicate inclusions are modally more abundant than the other inclusion types. Platinum-group mineral phases are ruthenium-rich sulphides and PGE alloys are osmium-rich. Mafic silicates (olivine, pyroxenes, pargasitic-amphiboles, micas) are magnesium-, titanium-, and alkali-rich and felsic silicates are sodium-rich (albite, nepheline). The intimate association of these inclusions with chromite suggests that their origin must be considered within a chromite crystallization model. A hypothesis of origin is suggested wherein the platinum-group minerals and silicates are trapped as discrete, crystalline euhedral phases and silicate liquid during the precipitation of chromite. The similarity of physical characteristics, modal mineralogy and chemical compositions indicates that this model may be applicable to all mafic-ultramafic complex-types.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0614Source: Springer Online Journal Archives 1860-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Abstract The Melle-Boinot process (cell-recycle batch fermentation) was applied to the fermentation of xylose by two strains of the yeast Pachysolen tannophilus for periods of 31 days. This resulted in a significant increase in the ethanol yield and productivity from xylose by P. tannophilus NCYC 614 but not by strain CBS 4045. Analysis of cells of strain NCYC 614 at the end of the process revealed an increased ability to tolerate exogenous ethanol, a characteristic that was lost in the absence of selection pressure. It is postulated that the increased yield of ethanol from xylose by P. tannophilus NCYC 614 is a product of enhanced ethanol tolerance together with increased efficiency of the fermentation process associated with the Melle-Boinot system.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0614Source: Springer Online Journal Archives 1860-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Abstract The Melle-Boinot process (cell-recycle batch fermentation) was applied to the fermentation of xylose by two strains of the yeast Pachysolen tannophilus for periods of 31 days. This resulted in a significant increase in the ethanol yield and productivity from xylose by P. tannophilus NCYC 614 but not by strain CBS 4045. Analysis of cells of strain NCYC 614 at the end of the process revealed an increased ability to tolerate exogenous ethanol, a characteristic that was lost in the absence of selection pressure. It is postulated that the increased yield of ethanol from xylose by P. tannophilus NCYC 614 is a product of enhanced ethanol tolerance together with increased efficiency of the fermentation process associated with the Melle-Boinot system.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0428Keywords: Insulin release ; insulin synthesis ; protein synthesis ; adenylate cyclase ; pancreatic islets ; tissue culture ; growth hormoneSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The effects of rat growth hormone (1 μg/ ml) on the synthesis and release of insulin by isolated rat islets of Langerhans were studied. There was no effect of growth hormone on the release of insulin from freshly isolated islets during 30 min incubation periods. By contrast, islets previously cultured for 16h with growth hormone exhibited a 40% increase in the release of insulin in response to glucose or to glucose and theophylline. These islets also showed specific increases in basal and glucose-stimulated insulin synthesis of 16% and 21% respectively, together with a 22% increase in the basal rate of total protein synthesis. The total insulin content of islets was not affected by culture with growth hormone. The adenylate cyclase activity of islet homogenates was unaffected by the presence of growth hormone during 30 min incubations. When homogenates from islets previously cultured with growth hormone were studied, basal adenylate cyclase activity was unchanged, while fluoride-stimulated adenylate cyclase activity was increased by 37%. It is concluded that growth hormone can directly affect the synthesis and release of insulin in islets of Langerhans, without relation to its metabolic activities in other target organs.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary Anti-equilin antisera titers were determined weekly in 4 rabbits over a 5-month immunisation period. Crossreactions to equilin sulphate, oestrone and equilenin were also measured. There appeared to be no relationship between antiserum titer and specificity.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-1866Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesNotes: Abstract Platinum-group minerals (PGM) have been identified as inclusions in chromite from the Bird River Sill, Manitoba. The inclusions are small (〈20 microns) and are commonly euhedral. The PGM inclusions are (Ru, Os, Ir) S2, laurite, and (Os, Ir, Ru alloy), rutheniridosmine: Laurites contain up to 2.99 wt. % palladium. Arsenic content is negligible and no platinum or rhodium has been detected. One platinum-group element alloy contains 0.96 wt. % rhodium but neither platinum nor palladium has been detected. Laurite inclusions in chromite from the ultramafic zone record two compositional trends; first increasing and then decreasing Ru/(Ru+Os+Ir) up section. PGM inclusions and other solid inclusions occur as discrete phases in chromite and are part of the chromite precipitation event. Increasing oxygen fugacity by wall rock assimilation or new magma injection initiates chromite precipitation, locally increasing the sulphur content of the magma to convert PGE alloys to sulphides.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary Ethidium bromide selectively inhibits growth of the petite negative yeast Kluyveromyces fragilis on a non-fermentable carbon source. In short term experiments, when growth in ethidium is continued for about 11 generations, this inhibition is accompanied by a loss of cyanide sensitive respiration and particulate cytochromes, an initial phase of microcolony production, and an inhibition of mitochondrial DNA synthesis. The loss of respiratory ability and mitochondrial DNA is reversible on removal of the drug. In long term experiments, when growth in ethidium is continued for more than 40 generations, microcolony formation can no longer be detected and mitochondrial DNA synthesis reappears, but the cells remain respiratory incompetent. These cells are not petite mutants, nor are they resistant to the effects of ethidium bromide as an inhibitor of mitochondrial biogenesis, because they retain the ability to resynthesise respiratory enzymes on removal of the drug.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1617-4623Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Summary Sodium nalidixate inhibited the cell growth and division of several respiratory competent strains of Saccharomyces cerevisiae. A number of cytoplasmic petite strains (both spontaneous and induced by ethidium bromide) were shown to be more resistant to sodium nalidixate than the wild-type strains from which they were derived. There was considerable variation in sensitivity of different petites derived from the same wild-type. Usually petite strains which were induced by ethidium bromide were more resistant than spontaneously arising petites. The susceptibility of a wild-type strain to nalidixate was found to be least when the mitochondrial respiratory system was maximally repressed. It was also noted that sodium nalidixate (100 μg/ml) induced petite mutants.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Gadolinium ; ischemia ; second messenger systems ; signal tranduction ; stretch receptorsSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Actins ; collagen ; fibroblasts ; myocardial infarction ; wound healingSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Diffusion ; ischemia ; ischemic preconditioning ; infarct size ; mathematical modelSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary We constructed a mathematical model of ischemic preconditioning based on experimental data obtained from rat hearts. In this animal model of low collateral blood flow, we found that infarct size in preconditioned hearts, expressed as a percentage of area at risk, increased as the size of the area at risk increased (r=0.76, p=0.0007). In contrast, infarct size in control hearts appeared independent of changes in area at risk. Similarly, the lateral distance between the edge of the area at risk and the edge of the area of necrosis did not vary with risk region in control hearts, but in preconditioned hearts, lateral distance decreased as the size of the area at risk increased (r=−0.67, p=0.0046). We used these findings to develop a simple model which provided mathematical relationships between lateral distance and area at risk and between infarct size and area at risk for both control and preconditioned hearts that were consistent with the experimental data. These relationships led us to propose that in preconditioned hearts 1) a protective substance may be produced or activated throughout the heart, and 2) that the protective substance may be transported by diffusion. If we assumed uniform production of protective substance in an amount proportional to the size of the ischemic and non-ischemic areas, we were able to derive, using a simple diffusion model, relationships between the above variables that were consistent with our mathematical model and with the experimental data. Although our model does not identify the protective substance, its implications provide ideas for additional crucial experiments that may enhance our understanding of ischemic preconditioning.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1435-1803Keywords: Collagen ; heart ; histology ; polarized light microscopy ; stains and stainingSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Collagen plays a major role in the structural organization of the heart and therefore direct visualization of collagen fibers is a crucial component of cardiac analysis. Although linearly polarized light has proven an effective tool for the examination of myocardial collagen in histologic sections, the use of circularly polarized light may offer advantages and additional possibilities. We examined the potential enhancement of collagen analysis using circularly polarized light in two ways. We first measured the brightness, and hence indirectly assessed the birefringence, of collagen fibers in scars examined at different times after myocardial infarction. Secondly, we measured collagen content in myocardial tissue and compared results obtained from brightfield analysis of trichrome stained sections with those obtained from circularly polarized light analysis of picrosirius red stained sections. We observed a progressive increase in the maximum brightness of collagen fibers in the scar with time, and a time-dependent shift in the relative distribution of collagen fiber brightness from lower to higher levels. We found consistently lower values of collagen content in trichrome stained versus picrosirius red stained tissue, and concluded that trichrome staining underestimated collagen content. The information provided by these studies could not be obtained by brightfield analysis and could be only partially obtained from linearly polarized light analysis. Thus, analysis using circularly polarized light has the ability to enhance histologic assessment of tissue and can provide additional insights into the composition and structure of myocardial collagen.Type of Medium: Electronic ResourceURL: