Search Results - (Author, Cooperation:P. Siegel)
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1Latest Papers from Table of Contents or Articles in PressJ. Schwartzentruber ; A. Korshunov ; X. Y. Liu ; D. T. Jones ; E. Pfaff ; K. Jacob ; D. Sturm ; A. M. Fontebasso ; D. A. Quang ; M. Tonjes ; V. Hovestadt ; S. Albrecht ; M. Kool ; A. Nantel ; C. Konermann ; A. Lindroth ; N. Jager ; T. Rausch ; M. Ryzhova ; J. O. Korbel ; T. Hielscher ; P. Hauser ; M. Garami ; A. Klekner ; L. Bognar ; M. Ebinger ; M. U. Schuhmann ; W. Scheurlen ; A. Pekrun ; M. C. Fruhwald ; W. Roggendorf ; C. Kramm ; M. Durken ; J. Atkinson ; P. Lepage ; A. Montpetit ; M. Zakrzewska ; K. Zakrzewski ; P. P. Liberski ; Z. Dong ; P. Siegel ; A. E. Kulozik ; M. Zapatka ; A. Guha ; D. Malkin ; J. Felsberg ; G. Reifenberger ; A. von Deimling ; K. Ichimura ; V. P. Collins ; H. Witt ; T. Milde ; O. Witt ; C. Zhang ; P. Castelo-Branco ; P. Lichter ; D. Faury ; U. Tabori ; C. Plass ; J. Majewski ; S. M. Pfister ; N. Jabado
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-01-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/genetics ; Base Sequence ; Child ; Chromatin/*genetics/metabolism ; Chromatin Assembly and Disassembly/*genetics ; DNA Helicases/genetics ; DNA Mutational Analysis ; Exome/genetics ; Gene Expression Profiling ; Glioblastoma/*genetics ; Histones/*genetics/metabolism ; Humans ; Molecular Sequence Data ; Mutation/*genetics ; Nuclear Proteins/genetics ; Telomere/genetics ; Tumor Suppressor Protein p53/geneticsPublished by: -
2FIS Bildung LiteraturdatenbankStaff View
Type of Medium: articlePublication Date: 2001Keywords: Unterrichtsmethode ; Linse (Phys) ; OptikIn: The Physics teacher, Bd. 39 (2001) H. 6, S. 342, 0031-921XLanguage: English -
3Latest Papers from Table of Contents or Articles in PressPoffenberger, M. C., Metcalfe-Roach, A., Aguilar, E., Chen, J., Hsu, B. E., Wong, A. H., Johnson, R. M., Flynn, B., Samborska, B., Ma, E. H., Gravel, S.- P., Tonelli, L., Devorkin, L., Kim, P., Hall, A., Izreig, S., Loginicheva, E., Beauchemin, N., Siegel, P. M., Artyomov, M. N., Lum, J. J., Zogopoulos, G., Blagih, J., Jones, R. G.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Immunology, Medicine, DiseasesPublished by: -
4Latest Papers from Table of Contents or Articles in PressDankner, M., Lajoie, M., Moldoveanu, D., Nguyen, T.-T., Savage, P., Rajkumar, S., Huang, X., Lvova, M., Protopopov, A., Vuzman, D., Hogg, D., Park, M., Guiot, M.-C., Petrecca, K., Mihalcioiu, C., Watson, I. R., Siegel, P. M., Rose, A. A. N.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-12-15Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
5Articles: DFG German National LicensesDepree, G. J. ; Bledsoe, T. A. ; Siegel, P. D.
Oxford, UK; Malden, USA : Munksgaard International Publishers
Published 2005Staff ViewISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: 2-Mercaptobenzothiazole and zinc dialkyldithiocarbamates are commonly used sulfur-containing rubber vulcanization accelerators known to cause allergic contact dermatitis. Exposure to these agents occurs through clothing such as undergarments and shoes, latex medical devices and latex and nitrile gloves. A simple, inexpensive screening method for total sulfur accelerator and a high performance liquid chromatographic speciation method were developed in the present study. These methods were applied to screen and quantify the sulfur accelerator content from 38 brands of ‘off-the-shelf’ latex and nitrile gloves obtained from commercial vendors. It was found that accelerator levels ranged from not detectable to 7.35 mg/g in the gloves analysed. Brands were found to contain single and multiple accelerator species within the glove. Powdered gloves had significantly higher accelerator levels than powder-free gloves from the same manufacturer; however, these chemical accelerators do not preferentially partition to the powder. The present analytical methodology is suitable for both manufacturing quality validation purposes, as well as for accelerator allergy research.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesZhang, X. D. ; Murray, D. K. ; Lewis, D. M. ; Siegel, P. D.
Oxford, UK : Munksgaard International Publishers
Published 2002Staff ViewISSN: 1398-9995Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background: Trimellitic anhydride (TMA)-induced occupational asthma is thought to be associated with its ability to acylate proteins and to induce production of TMA-specific immunoglobulin (Ig)E. Though the respiratory tract is considered to be a major exposure route leading to airway sensitization, the potential role of dermal exposure producing asthmatic sensitization is not known. The present study examines the ability of dry TMA powder to sensitize Brown Norway rats when applied, topically, to the skin.Methods: A patch of hair was carefully clipped with scissors on the rat's back. Dry TMA powder (0.3, 1.25, 5 and 20 mg) was administered on days 0, 7, 14 and 21, and the area occluded with surgical tape overnight after each application. Residual powder recovered from the occluded skin was analyzed by proton nuclear magnetic resonance and was still predominantly TMA. Circulating anti-TMA IgE and IgG were measured by ELISA.Results: TMA elicited dose-dependent production of specific IgE and IgG. Specific antibodies were detectable 2 weeks after the first TMA exposure and peaked between 3 and 4 weeks.Conclusion: The data suggest that topical skin exposure to dry TMA powder can induce allergic/immunological sensitization as demonstrated by the production of specific antibodies.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0375-9474Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-1793Source: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Female sand crabs (Emerita analoga) were sampled from 12 beaches along a 350 km stretch of Southern California coastline during the reproductive season in July, 1982. The percentage of mature females with egg masses and the condition of those egg masses were examined at each site. The proportion of mature females with egg masses varied only slightly between beaches. However, at sites within about 20 km of the San Onofre Nuclear Generating Station, a high percentage of females carried egg masses consisting of empty egg shells. A transplant experiment was conducted. Females with empty egg masses were taken from the 6.5 km N study site, where only 5% of the mature females carried normal egg masses, and transferred to running unfiltered seawater in Santa Barbara. After 2 wk, about a third of the transplanted females carried normal egg masses, while at the same time the proportion of mature females with normal egg masses remained at 5% on the beach of origin. Heated water discharged from the nuclear generating station is probably not the cause of the abnormal reproduction of sand crabs along the nearby coast. More likely causes are: (1) runoff of agricultural pesticides from a creek 3 km north of the nuclear generating plant; (2) release of metals from corroding cooling pipes, and/or (3) increased turbidity of the nearshore waters.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung An 23 Toxikoseplacenten wird die Ausdehnung der eklamptischen Placentarveränderungen untersucht und mit der Schwere der Erkrankung, der Ausdehnung der Augenhintergrundsveränderungen und dem Reifegrad der Kinder in Zusammenhang gebracht. Dabei ergibt sich, daß bei den schwersten Toxikosen die Verödungen der Placenta sowie die Augenhintergrundsveränderungen am ausgedehntesten sind und die Kinder immer intrauterin absterben. Verläuft die Erkrankung nicht so schwer, sind auch die Ausdehnung der Placentarverödungen und die Augenhintergrundsveränderungen geringer. Die Kinder werden teils als Frühgeburt, bei leichteren Fällen sogar mit normalem Reifegrad geboren.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Zusammenfassung Die Reaktion des Endometriums auf cyclische Gaben von verschiedenen Oestrogen-Gestagengemischen, sog. Ovulationshemmern, ist ziemlich einheitlich. Im Beginn kommt es zu einer Hemmung der bereits einsetzenden Proliferation mit unregelmäßiger Verteilung der Drüsen und unregelmäßiger Oberfläche der Schleimhaut. Schon wenige Tage nach Behandlungsbeginn tritt zu einem Zeitpunkt, zu dem im normalen Ablauf des Cyclus noch kein Glykogen gefunden wird, massenhaft Glykogen in den Drüsen auf. Sonstige Zeichen von Funktion fehlen. Schon ab 12. Behandlungstag erkennt man bei allen Präparaten Regressionserscheinungen, die je nach Höhe des Gestagenanteils mit einer mehr oder weniger ausgeprägten decidualen Stromareaktion einhergehen. Diese kann bei langdauernder, ununterbrochener Verabfolgung, wie sie zur Erzielung einer Pseudogravidität notwendig ist, bis zur Bildung einer „Pseudodecidua“ gehen.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-0711Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-1440Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyNotes: APPARATUSURL: -
17Articles: DFG German National LicensesLacey, O. L. ; Siegel, P. S. ; Siegel, H. S.
Urbana, etc. : Periodicals Archive Online (PAO)
Published 1949Staff ViewISSN: 0002-9556Topics: PsychologyNotes: NOTES AND DISCUSSIONSURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0002-9556Topics: PsychologyURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Zusammenfassung Vergleichend-histologische Untersuchung der Darmbeingefässe bei Wildhühnern und der White-Rock-Rasse zeigen eine stärkere Entwicklung der Wildhuhngefässe. Es scheint, dass das gesamte Gefäß-system bei den Wildhühnern, in Anpassung an die erhöhte Herzfrequenz und den gesteigerten Blutdruck bei besondern Erregungszuständen, über Schutzmechanismen in der Gefässwand verfügt.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesSchachter, E. N. ; Zuskin, E. ; Rienzi, N. ; Goswami, S. ; Maayani, S. ; Wan, A. E. ; Castranova, V. ; Siegel, P. ; Whitmer, M. ; Mustajbegovic, J.
Springer
Published 1998Staff ViewISSN: 1432-1750Keywords: Key words: Isolated guinea pig trachea—Paper dust extract—Airway reactivity.Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. The effect of paper dust collected at two different locations in a paper recycling plant (PD1 and PD2) on isolated nonsensitized guinea pig tracheal smooth muscle was studied in vitro. Dust extracts were prepared as a 1:10 w/v aqueous solution. Dose-related contractions of guinea pig tracheal rings were elicited with both PD1 and PD2. Pharmacologic studies were performed with atropine (10−6 M), indometacin (10−6 M), pyrilamine (10−6 M), LY171883 (10−5 M), nordihydroguaiaretic acid (10−5 M), and TMB8 (10−5 M). The possible role of endogenous neuropeptides in this constrictor process was studied by depleting neural mediators with capsaicin (5 × 10−6 M) before challenge with dust extracts. Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 concsistent with the well established role of intracellular calcium in smooth muscle constriction. Pretreatment with capsaicin significantly increased the contractile activity of paper dust extracts but only at the higher doses of these extracts. This suggests that the effect of paper dust is not initiated by the release of mediators stored in sensory nerves but that the prerelease of these mediators may enhance the constrictor effects of these dusts. We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. The constrictor effect does not require tissue presensitization or the release of neuropeptides from sensory nerves.Type of Medium: Electronic ResourceURL: