Search Results - (Author, Cooperation:P. Schmezer)
-
1Latest Papers from Table of Contents or Articles in PressD. Walter ; A. Lier ; A. Geiselhart ; F. B. Thalheimer ; S. Huntscha ; M. C. Sobotta ; B. Moehrle ; D. Brocks ; I. Bayindir ; P. Kaschutnig ; K. Muedder ; C. Klein ; A. Jauch ; T. Schroeder ; H. Geiger ; T. P. Dick ; T. Holland-Letz ; P. Schmezer ; S. W. Lane ; M. A. Rieger ; M. A. Essers ; D. A. Williams ; A. Trumpp ; M. D. Milsom
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-02-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bone Marrow/pathology ; *Cell Cycle ; Cell Death ; Cell Proliferation ; *DNA Damage ; Fanconi Anemia/metabolism ; Hematopoietic Stem Cells/*cytology/*metabolism ; Mice ; Reactive Oxygen Species/metabolism ; Stress, PhysiologicalPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0027-5107Keywords: LacI transgenic mice ; Microgel electrophoresis ; StreptozotocinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0027-5107Keywords: Antioxidants ; Apo-transferrin ; Bleomycin ; COMET assay ; DNA damage, oxygen-radical-generated ; Deferoxamine mesylate ; Ferrous chloride ; Hydrogen peroxide ; Lymphocytes, human ; Mannitol ; Oxygen-radical-generated DNA damage ; Silymarin ; Vitamin C ; Vitamin ESource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesThe non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidineAshby, J. ; Lefevre, P.A. ; Tinwell, H. ; Brunborg, G. ; Schmezer, P. ; Pool-Zobel, B. ; Shanu-Wilson, R. ; Holme, J.A. ; Gulati, D. ; Soderlund, E.J. ; Wojciechowski, J.P.
Amsterdam : ElsevierStaff ViewISSN: 0027-5107Keywords: 2,4-Dimethoxyaniline ; Bladder carcinogens ; o-Anisidine ; p-CresidineSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesMcKelvey-Martin, V.J. ; Green, M.H.L. ; Schmezer, P. ; Pool-Zobel, B.L. ; De Meo, M.P. ; Collins, A.
Amsterdam : ElsevierStaff ViewISSN: 0027-5107Keywords: Comet assay ; DNA breakage, measurement ; SCGE ; Single cell gel electrophoresis assaySource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesPool-Zobel, B. L. ; Klein, R. G. ; Liegibel, U. M. ; Kuchenmeister, F. ; Weber, S. ; Schmezer, P.
Springer
Published 1992Staff ViewISSN: 1432-1440Keywords: Tobacco-specific nitrosamines ; Toxicokinetics ; Genotoxicity ; Systemic effects ; Primary cells ; Detection of DNA damageSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary An ex vivo model to detect nonspecific DNA damage in different rat tissues has been developed and employed to study systemic properties of tobacco-specific N-nitrosamines. One hour after treatment of rats with the carcinogens, primary, intact cells were isolated from various organs. Viability of the cells was monitored by trypan blue exclusion. Genotoxicity was determined by alkaline elution, in situ nick translation or microgel electrophoresis. We found that oral application of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces genotoxic effects in the liver (3.125–50 mg/kg), whereas N-nitrosonornicotine (NNN) is only moderately active (50–100 mg/kg). Furthermore, oral administration of NNK, NNN, and of N-nitrosodimethylamine (NDMA), induces DNA damage in the nasal cavity. In peripheral blood lymphocytes genotoxicity of NDMA (〈 2 mg/kg), but not of NNK (50 mg/kg), was observed. NDMA and NNK are just as genotoxic in the liver when administered by inhalation as orally (effective doses: 0.1–1 and 50 mg/kg, respectively). For human cancer, these results indicate that in addition to the susceptibilities in local organs (oral cavity after snuff dipping and lung after tobacco smoke inhalation), these nitrosamines also pose a risk systemically for more remote organs.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesMonarca, S. ; Pool-Zobel, B.L. ; Rizzi, R. ; Klein, P. ; Schmezer, P. ; Piatti, E. ; Pasquini, R. ; De Fusco, R. ; Biscardi, D.
Amsterdam : ElsevierStaff ViewISSN: 0165-7992Keywords: Ames test ; Chromosome aberrations in human lymphocytes ; DNA damage ; Dimethyl terephthalate ; In vitro genotoxicity ; Selective DNA amplificationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesErdinger, L. ; Schmezer, P. ; Razdan, R. ; Kumar, R. ; Spiegelhalder, B. ; Preussmann, R. ; Siddiqi, M.
Amsterdam : ElsevierStaff ViewISSN: 0165-1161Keywords: Caffeine-derived N-nitroso compounds ; DNA single-strand breaks in rat hepatocytes ; Human esophageal and gastric cancers ; Salmonella mutagenicitySource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesPasquini, R. ; Monarca, S. ; Klein, R. ; Schmezer, P. ; Zeller, W.J. ; Hermann, R. ; Pool-Zobel, B.L. ; Moretti, U.
Amsterdam : ElsevierStaff ViewISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesScassellati Sforzolini, G. ; Pasquini, R. ; Savino, A. ; Moretti, M. ; Fatigoni, C. ; Angeli, G. ; Monarca, S. ; Lasagni, L. ; Vezzani, A. ; Pool-Zobel, B.L. ; Del Santo, P. ; Dolara, P. ; Schmezer, P.
Amsterdam : ElsevierStaff ViewISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0165-1161Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1335Keywords: N-nitroso-N-acetoxymethyl-N-methylamine ; Syrian golden hamster ; Inhalation ; Tumors of the nasal cavitiesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Male Syrian golden hamsters inhaled 0.5–1 ppm (=2.7–5.5 mg/m3) of N-nitroso-N-acetoxymethyl-N-methylamine 1 h/week, for 14 weeks. The total dose per animal was calculated as 150–400 μg or 1–3 mg/kg. Four squamous cell carcinomas and one mucoepidermoid carcinoma of the nasal mucosa were observed. No such tumors occurred in the control group.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesClement, B. ; Schmezer, P. ; Weber, H. ; Schlehofer, J. R. ; Schmitt, S. ; Pool, B. L.
Springer
Published 1988Staff ViewISSN: 1432-1335Keywords: Benzamidine ; Benzamidoxime ; Mutagenicity ; Salmonella typhimurium ; DNA single-strand breaks ; DNA amplification ; Metabolic conjugatesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The genotoxic potentials of benzamidine and benzamidoxime were determined to study the toxicological relevance of the metabolicN-oxygenation (N-hydroxylation) of benzamidines to benzamidoximes. Benzamidoxime induced DNA single-strand breaks (in rat hepatocytes) and DNA amplification in SV40-transformed hamster cells. In the experiments performed, benzamidine itself was only marginally positive in the hepatocyte/DNA single-strand break assay. Since these cells possess an intact metabolization apparatus, the biological activities may be attributed to toxic and genotoxic metabolites formed by biotransformation. In theSalmonella typhimurium mutagenicity test (TA 98 and TA 100) benzamidoxime alone exhibited a low mutagenicity in the TA 98 strain in the presence of rabbit liver S-9 fractions. These results permit recognition of the metabolicN-hydroxylation of benzamidines to benzamidoximes as a process to toxication. Indirect evidence for the formation of a glucuronide of benzamidoxime has been obtained from in vitro experiments, but it could not be established that this process was a decisive factor in the genotoxicity of benzamidoxime.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesFrei, E. ; Pool, B. L. ; Glatt, H. R. ; Gemperlein-Mertes, I. ; Oesch, F. ; Schlehofer, J. R. ; Schmezer, P. ; Weber, H. ; Wiessler, M.
Springer
Published 1986Staff ViewISSN: 1432-1335Keywords: Nitroalkylamines ; Hepatocytes ; Metabolizing enzymesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary N-nitrodimethylamine is metabolized oxidatively to N-nitrohydroxymethylmethylamine, which decomposes to yield formaldehyde and N-nitromethylamine. All four compounds and N-nitroethylamine were tested for their ability to induce DNA single strand breaks in hepatocytes and in SV 40-transformed Chinese hamster embryo cell lines. Only the two monoalkylnitramines were positive. They induced single strand breaks in hepatocytes, but were not effective in the other cells. Formaldehyde and N-nitrohydroxymethylmethylamine were toxic to the cells. None of the compounds tested was able to induce selective DNA amplification in the two transformed cell lines. Enzymes involved in drug metabolism were assayed in the hamster cell lines. The activity of UDP-glucuronosyltransferase and cytosolic epoxide hydrolase were not detectable. N-nitrodimethylamine demethylation was low. The content of reduced glutathione and the activities of glutathione transferase and membrane bound epoxide hydrolase were comparable to values obtained in the rat liver.Type of Medium: Electronic ResourceURL: