Search Results - (Author, Cooperation:P. Rudge)

2015-09-17

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

2015-09-12

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Adult ; Alleles ; Alzheimer Disease/*etiology/genetics/metabolism/pathology ; Amyloid beta-Peptides/administration & dosage/analysis/*metabolism ; Autopsy ; Blood Vessels/metabolism/pathology ; Case-Control Studies ; Cerebral Amyloid Angiopathy/*etiology/metabolism/pathology ; Creutzfeldt-Jakob Syndrome/complications/*etiology/metabolism ; *Drug Contamination ; Endothelium, Vascular/metabolism/pathology ; Gray Matter/metabolism/pathology ; Human Growth Hormone/*administration & dosage ; Humans ; *Iatrogenic Disease ; Middle Aged ; Prions/administration & dosage/metabolism ; Risk Factors

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] The equipment comprised a photomultiplier type FW 130 ($20) feeding pulses to a bank of ten sealers which were activated in turn for one-tenth of the pulsar period. Although this gave only limited resolution of the pulse shape, it was adequate for the purpose and had advantages in detecting ...

Electronic Resource

1432-1920

Magnetic resonance imaging ; Systemic lupus erythematosus ; Behcet's disease

Springer Online Journal Archives 1860-2000

Medicine

Summary We performed MR (magnetic resonance) brain imaging on 24 patients with a systemic vasculitis. MRI proved to be a sensitive method for detecting brain lesions (clinically silent or manifest) in these patients. The most frequent abnormalities were periventricular lesions seen in 12 cases. Such changes are not specific for vascular disease, and are often seen in multiple sclerosis. However, additional changes were commonly seen which suggested the correct diagnosis.

Electronic Resource

1432-1920

Key words Gliomatosis cerebri ; oligodendroglial ; Magnetic resonance spectroscopy

Springer Online Journal Archives 1860-2000

Medicine

Abstract Oligodendroglial gliomatosis cerebri is very rare. We describe 42-year-old woman who had low-grade oligodendroglial gliomatosis cerebri confirmed on stereotactic biopsy. The diffuse nature of the tumour was apparent clinically, neurophysiologically, on MRI and on proton magnetic resonance spectroscopy (MRS). She also had an isolated, false-localising partial seventh nerve palsy. MRS, of which there are no previous reports, suggested elevated glycine/inositol levels. This might be explained by the cell lineage from which the tumour arose.

Electronic Resource

1432-1459

Tropical spastic paraparesis ; Cerebrospinal fluid ; Antigen blotting ; IgG ; IgM

Springer Online Journal Archives 1860-2000

Medicine

Summary The cerebrospinal fluid (CSF) from seven West Indian migrants to the United Kingdom with tropical spastic paraparesis were studied by antigen immunoblotting for specific anti-HTLV1 oligoclonal IgG and IgM. Eight CSFs from five patients were positive for specific IgG and negative for IgM; three CSFs from two patients were positive for IgM and negative for IgG. No patient had both IgG- and IgM-positive CSF. Those patients with IgM only had disease of the shortest duration. When looking for evidence that neurological damage is caused by HTLV1, both IgM and IgG should be examined.

Electronic Resource

1432-1459

Lupus ; Neurological disease ; Gadolinium ; Magnetic resonance imaging

Springer Online Journal Archives 1860-2000

Medicine

Summary Gadolinium (Gd)-DTPA enhanced magnetic resonance imaging (MRI) was performed in 15 systemic lupus. erythematosus patients with past (12) or present (3) features suggesting central nervous system (CNS) involvement. Symptomatic Gd-DTPA enhancing lesions were seen in 2 patients, and immunosuppressive treatment was associated with a rapid reversal of enhancement. The pattern of enhancement was different from that usually seen in multiple sclerosis. Gd-DTPA enhanced MRI may sometimes be useful in demonstrating the activity of CNS lupus.

Electronic Resource

1432-1459

Key words Vestibular failure ; Neurological disease ; Otological ; disorders ; Ototoxicity ; Autoimmine ; Oscillopsia

Springer Online Journal Archives 1860-2000

Medicine

Abstract The clinical presentations and aetiologies of a series of 53 cases of bilateral vestibular failure (BVF) seen by the authors over a decade were evaluated by retrospective review of the medical records. Thirty-nine per cent of patients had associated neurological disease; 13% had a progressive cerebellar syndrome with disabling gait ataxia, abnormal eye movements and cerebellar atrophy on neuro-imaging. BVF was usually unsuspected. Nine per cent had cranial or peripheral neuropathies and in this group there was no abnormality of brain stem/cerebellar oculomotor function, but hearing loss was common. Eleven per cent revealed BVF and hearing loss secondary to meningitis, and 6% had other neurological disorders. Idiopathic BVF was found in 21% of cases, characterised by paroxysmal vertigo and/or oscillopsia, but no abnormal clinical signs. Gentamicin ototoxicity accounted for a further 17%, while autoimmune disease was present in 9% of patients. Otological or neoplastic disease was diagnosed in the remaining 13% of patients. It was concluded that neurological, audiological and ocular motor assessments allow the probable cause of BVF to be defined in approximately 80% of cases. A group of BVF related to autoimmune pathologies is reported for the first time, indicating the need for immunological screening. Idiopathic BVF may present with only minor visual or vestibular symptoms, while in patients with cerebellar degeneration, BVF may be unsuspected and, thus, underdiagnosed.

Electronic Resource

1573-6679

Springer Online Journal Archives 1860-2000

Theology and Religious Studies

Electronic Resource