Search Results - (Author, Cooperation:P. Puccetti)
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1Latest Papers from Table of Contents or Articles in PressA. Bessede ; M. Gargaro ; M. T. Pallotta ; D. Matino ; G. Servillo ; C. Brunacci ; S. Bicciato ; E. M. Mazza ; A. Macchiarulo ; C. Vacca ; R. Iannitti ; L. Tissi ; C. Volpi ; M. L. Belladonna ; C. Orabona ; R. Bianchi ; T. V. Lanz ; M. Platten ; M. A. Della Fazia ; D. Piobbico ; T. Zelante ; H. Funakoshi ; T. Nakamura ; D. Gilot ; M. S. Denison ; G. J. Guillemin ; J. B. DuHadaway ; G. C. Prendergast ; R. Metz ; M. Geffard ; L. Boon ; M. Pirro ; A. Iorio ; B. Veyret ; L. Romani ; U. Grohmann ; F. Fallarino ; P. Puccetti
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-06-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacterial Infections/immunology/metabolism ; Disease Resistance/drug effects/*genetics/*immunology ; Endotoxemia/genetics/immunology/metabolism ; Enzyme Activation/drug effects ; Gene Expression Regulation/drug effects ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Inflammation/enzymology/genetics/metabolism ; Kynurenine/metabolism ; Lipopolysaccharides/pharmacology ; Mice ; Phosphorylation ; Receptors, Aryl Hydrocarbon/genetics/*metabolism ; Signal Transduction ; Tryptophan Oxygenase/metabolism ; src-Family Kinases/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2014-10-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Granulomatous Disease, Chronic/*metabolism/*pathology ; Inflammation/*metabolism ; Kynurenine/*metabolism ; Tryptophan/*metabolismPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 0305-0491Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesNardelli, B. ; Puccetti, P. ; Romani, L. ; Sava, G. ; Bonmassar, E. ; Fioretti, M. C.
Springer
Published 1984Staff ViewISSN: 1432-0851Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Equitoxic doses of 5-(3-3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) and aryl-triazene derivatives (compounds all capable of inducing a marked increase in murine tumor cell immunogenicity) were studied for their effects on the host immune system. At different times after drug exposure the animals were tested for allograft responses, competence in producing lymphocytes active in lethal graft-versus-host disease, delayed-type hypersensitivity, humoral antibody production, and mitogen responsiveness. While some of the aryl-triazenes tested (DM-COOK DM-NO2) showed a pattern of immunodepression similar to that of DTIC, others were less (MIC, MM-COOK, MM-Cl) or far less (DM-Cl, MM-NO2) active than DTIC in impairing host immunocompetence, although all retained or even augmented their ability to induce chemical xenogenization.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary 2 primary immune responses (anti-SRBC antibody response and allograft rejection) have been tested in mice at various time intervals after single doses of either DTIC or cyclophosphamide. The DTIC-induced immunodepression proved to be extremely long-lasting, being still detectable after 2 months.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesAllegrucci, M. ; Fuschiotti, P. ; Puccetti, P. ; Romani, L. ; Fioretti, M. C.
Springer
Published 1989Staff ViewISSN: 1573-7276Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Treatment of B16/BL6 murine melanoma cellsin vitro with the ‘xenogenizing’ agent potassiump-(3-methyl-1-triazeno)benzoate (MM-COOK) had a profound impact on the tumorigenic and metastatic properties of the tumor, an effect that was only detectable in immunologically intact hosts. The treated tumor cells gave rise to a considerably smaller number of experimental and spontaneous pulmonary metastases and displayed an impaired growth ratein vivo, but were highly tumorigenic and metastatic in irradiated recipients. Moreover, the drug-treated cells retained thein vitro growth pattern and plating efficiency of the parent line, and were able actively to immunize intact hosts. Studies aimed at clarifying the mechanisms responsible for the decreased metastatic potential of the cells treated with MM-COOK indicated the involvement of host immune responses largely mediated by cells in the T-dependent compartment with no major contribution of natural immunity effector mechanisms.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesRomani, L. ; Mocci, S. ; Cenci, E. ; Mencacci, A. ; Sbaraglia, G. ; Puccetti, P. ; Bistoni, F.
Springer
Published 1992Staff ViewISSN: 1573-7284Keywords: C. albicans ; Yeast-reactive CTL ; Infection and cytolysisSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Immune L3T4+ and Lyt-2+ lymphocytes play an important role in the acquired resistance of mice to challenge with virulent Candida albicans, and release macrophage-activating cytokines in response to yeast cells in vitro. To determine whether antigen (Ag)-specific cytotoxic T lymphocytes are generated during fungal infection, purified L3T4+ and Lyt-2+ lymphocytes from immunized mice were cultured in the presence of syngeneic accessory cells, Candida Ag, and IL-2. Yeast-infected bone marrow macrophages and peritoneal exudate neutrophils were used as target cells in a standard 51Cr release assay. Ag-specific, MHC-unrestricted lysis of infected macrophages was evident with immune Lyt-2+ cells after 5–10 days in culture. Under the same experimental conditions, the cytotoxic activity of L3T4+ cells was negligible, but its expression could be induced by the addition of anti-CD3 antibody. Culturing immune Lyt-2+ cells for shorter periods of time (1–2 days) resulted in preferential lysis of infected neutrophils. In addition, at limiting effector cell numbers, Ag-specific MHC-restricted lymphocytes with cytotoxic activity to infected macrophages could be identified. We suggest that C. albicans infection stimulates multiple cytotoxic T-cell precursors with varying recognition stringency, wich may have an important role in antifungal resistance in vivo.Type of Medium: Electronic ResourceURL: