Search Results - (Author, Cooperation:P. Morais)
-
1
Latest Papers from Table of Contents or Articles in PressStaff ViewPublication Date: 2018-06-02Publisher: Institute of Physics (IOP)Print ISSN: 1674-1137Topics: PhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. Barretina ; G. Caponigro ; N. Stransky ; K. Venkatesan ; A. A. Margolin ; S. Kim ; C. J. Wilson ; J. Lehar ; G. V. Kryukov ; D. Sonkin ; A. Reddy ; M. Liu ; L. Murray ; M. F. Berger ; J. E. Monahan ; P. Morais ; J. Meltzer ; A. Korejwa ; J. Jane-Valbuena ; F. A. Mapa ; J. Thibault ; E. Bric-Furlong ; P. Raman ; A. Shipway ; I. H. Engels ; J. Cheng ; G. K. Yu ; J. Yu ; P. Aspesi, Jr. ; M. de Silva ; K. Jagtap ; M. D. Jones ; L. Wang ; C. Hatton ; E. Palescandolo ; S. Gupta ; S. Mahan ; C. Sougnez ; R. C. Onofrio ; T. Liefeld ; L. MacConaill ; W. Winckler ; M. Reich ; N. Li ; J. P. Mesirov ; S. B. Gabriel ; G. Getz ; K. Ardlie ; V. Chan ; V. E. Myer ; B. L. Weber ; J. Porter ; M. Warmuth ; P. Finan ; J. L. Harris ; M. Meyerson ; T. R. Golub ; M. P. Morrissey ; W. R. Sellers ; R. Schlegel ; L. A. Garraway
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Lineage ; Chromosomes, Human/genetics ; Clinical Trials as Topic/methods ; *Databases, Factual ; Drug Screening Assays, Antitumor/*methods ; *Encyclopedias as Topic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, ras/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; *Models, Biological ; Neoplasms/*drug therapy/genetics/metabolism/*pathology ; Pharmacogenetics ; Plasma Cells/cytology/drug effects/metabolism ; Precision Medicine/methods ; Receptor, IGF Type 1/antagonists & inhibitors/metabolism ; Receptors, Aryl Hydrocarbon/genetics/metabolism ; Sequence Analysis, DNA ; Topoisomerase Inhibitors/pharmacologyPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1600-0536Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesBakuzis, A. F. ; Da Silva, M. F. ; Morais, P. C.
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The temperature, particle size, and particle concentration dependence of the zero-field birefringence were investigated using γ-Fe2O3 and MnFe2O4 ionic magnetic fluids in the range of 290–350 K. Upon heating a sample from below its characteristic temperature Tc, which depends upon the particle size and particle concentration, the zero-field birefringence goes critically down to zero. The experimental data are successfully explained when the following two points are considered in the model describing magnetic birefringence in magnetic fluids. First, dimers rather than monomers are responsible for the zero-field birefringence. Second, thermal disruption of the dimer structure follows a critical behavior. A theory for the zero-field birefringence is developed using classical statistics to evaluate the orientational order tensor component Szz. Finally, the zero birefringence signal at zero field, as found in magnetic fluids containing surfactant on the particle surface, is discussed within the dimer model. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesMonte, A. F. G. ; Cruz, J. M. R. ; Morais, P. C.
[S.l.] : American Institute of Physics (AIP)
Published 1997Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: The description of a new experimental design for microluminescence is presented in this article. The design is based on the optical analysis of a magnified luminescent region and has been proven to be useful for studying the photon transport mechanism in a solid luminescent material. Lock-in detection and a liquid-nitrogen-cooled detector are used to obtain signal-to-noise ratio as good as 102. The performance of the system is discussed by using the measurements taken from a natural ruby crystal. Using transport theory to fit our data, we found the photon diffusion length in the ruby crystal to be on the order of 46 μm. © 1997 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesMorais, P. C. ; Lara, M. C. F. L. ; Tronconi, A. L. ; Tourinho, F. A. ; Pereira, A. R. ; Pelegrini, F.
[S.l.] : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Magnetic resonance is used to study magnetic dipole particle–particle interaction in ionic water-based iron-manganese magnetic fluids. A set of six samples having particle concentration running from 1.2×1016 to 6.3×1016 particles/cm3 were frozen below room temperature and analyzed in the range of 100–250 K. Average values of magnetic particle–particle interaction energy were obtained from the temperature dependence of the resonance linewidth broadening. At 1.2×1016 particles/cm3 magnetic particle–particle interaction energy is found to be of the order of 1.2 meV. However, at 6.3×1016 particles/cm3 magnetic particle–particle interaction energy goes to 32 meV. The enhancement of the magnetic particle–particle interaction energy far beyond the linearity is associated to cluster structuration. A one-dimensional model for cluster structuration is presented. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesCox, H. M. ; Aspnes, D. E. ; Allen, S. J. ; Bastos, P. ; Hwang, D. M. ; Mahajan, S. ; Shahid, M. A. ; Morais, P. C.
Woodbury, NY : American Institute of Physics (AIP)
Published 1990Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We investigate a morphological instability that causes an InGaAs/InP multiquantum well structure grown on a vicinal (001) InP surface to spontaneously evolve into an array of InGaAs quasi-one-dimensional filaments buried in an InP matrix. To explain this behavior, we propose a step-flow growth model involving different lateral growth velocities for heteroepitaxy and homoepitaxy. A computer simulation based on the model agrees closely with the experiment.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesMorais, P. C. ; Cox, H. M. ; Bastos, P. L. ; Hwang, D. M. ; Worlock, J. M. ; Yablonovitch, E. ; Nahory, R. E.
Woodbury, NY : American Institute of Physics (AIP)
Published 1989Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Ultrathin InGaAs/InP single quantum well structures, grown by chloride transport vapor levitation epitaxy, have been investigated by low-temperature photoluminescence (PL). Well-resolved multiple peaks are observed in the PL spectra, instead of an expected single peak. We attribute this to monolayer (a0/2=2.93 A(ring)) variations in quantum well (QW) thickness. Separate peak positions for QW thicknesses corresponding to 2–6 monolayers have been determined, providing an unambiguous thickness calibration for spectral shifts due to quantum confinement. The PL peak corresponding to two monolayers occurs at 1.314 eV, corresponding to an energy shift of 524 meV. Experimental data agree very well with a simple effective mass theory.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesBakuzis, A. F. ; Da Silva, M. F. ; Morais, P. C. ; Neto, K. Skeff
[S.l.] : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The temperature dependence of the zero-field birefringence was investigated using acid and basic MnFe2O4 ionic magnetic fluids, in the range of 290–350 K. Approaching a characteristic temperature (Tc) from below, which depends upon the sample characteristics, the zero-field birefringence goes critically down to zero. Furthermore, the birefringence shows an irreversible path upon heating and cooling the samples above Tc. The experimental data are successfully explained as long as dimers are included in the model calculation and the thermal disruption of them follows a critical behavior. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: A connection between the temperature behavior of the internal magnetic field and Mössbauer linewidth broadening for a system which exhibits superparamagnetism is proposed.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Magnetization data obtained by a microvibrating sample magnetometer are presented. These data are obtained at different values of an external field applied to a sample which shows a bimodal particle-size distribution. The bendings in the M3×T plot are taken as an evidence of magnetic reorderings. These magnetic reorderings are discussed extensively.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesMorais, P. C. ; Köche, N. M. L. ; Tronconi, A. L. ; Skeff Neto, K.
[S.l.] : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7623Source: AIP Digital ArchiveTopics: PhysicsElectrical Engineering, Measurement and Control TechnologyNotes: A simple microvibrating sample magnetometer (MVSM), particularly inexpensive, sensitive, and versatile has been developed. An alternating magnetic field superposed to a steady uniform magnetic field is applied to the sample. The sample undergoes a periodic motion around an equilibrium position, causing a pressure fluctuation within a closed gas cell which is detected as an acoustic signal by a microphone.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesCardoso, A. J. C. ; Morais, P. C. ; Cox, H. M.
Woodbury, NY : American Institute of Physics (AIP)
Published 1996Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: A one-side modulation-doped quantum well of InGaAs lattice matched to InP has been used to investigate many-body effects in a quasi-two-dimensional (2D) electron gas. The sample was grown by vapor levitation epitaxy (VLE). Low-temperature photoluminescence (PL) measurements were carried out under different optical excitation intensities using 5145 A(ring) line from an argon ion laser. By increasing the laser intensity over five orders of magnitude a 13.2 meV blue shift in the PL line was observed to occur for a single asymmetric quantum well having a 2D electron gas density as low as 0.9×1011 cm−2. The observed blue shift is explained in terms of the reduction of both band bending (of the order of 1.8 meV) and many-body effects (of the order of 11.4 meV) due to the reduction of the 2D electron gas density in the quantum well. © 1996 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMorais, P. C. ; Tronconi, A. L. ; Neto, K. Skeff
[S.l.] : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The Mössbauer linewidth broadening of superparamagnetic particles of ferric hydroxysulfate, near the point where the paramagnetic lines begin to appear, has been investigated as a function of temperature. This behavior is explained by a geometric picture of an assembly of magnetically ordered single-domain particles whose magnetic moments move within an asymmetric double-well potential. A relaxation model is presented which combines the conventional theory of superparamagnetism with an exponential distribution of energy barriers.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Angular measurements of magnetic resonance are used to investigate the surface anisotropy field as well as the exchange anisotropy field in spherical MnFe2O4 magnetic nanoparticles as a function of temperature and particle diameter (D). The resonance field is a combination of angular dependent and angular independent fields, both affected by the surface anisotropy field, which in turn follows a D−α power law, with α very close to unity. The angular dependent component probes the surface anisotropy field while the angular independent component probes the exchange anisotropy field. In the temperature range from 100 to 250 K a negative surface anisotropy field is found, which increases as the particle size is reduced, indicating a radial orientation of the spins at the MnFe2O4 nanoparticle surface. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesMonte, A. F. G. ; da Silva, S. W. ; Cruz, J. M. R. ; Morais, P. C.
[S.l.] : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: The microluminescence surface scan technique has been used to investigate ambipolar carrier diffusion, photon diffusion, and photocarrier recombination in a nominally undoped InGaAs bulk layer lattice matched to InP grown by vapor levitation epitaxy. Measurements taken at different temperatures between 75 and 300 K are discussed in terms of the relative contribution of the two distinct mechanisms to the spectrally integrated luminescence intensity, namely, photon diffusion and photocarrier diffusion. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesMoreno, R. ; Amado, L. ; Estrada, H. ; Ferrão, M. ; Matos, R. ; Miranda, I. ; Morais, P. ; Pereira, E. ; Timóteo, T. ; Massa, L.
Springer
Published 1996Staff ViewISSN: 1432-1238Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Conclusions In this population of severely ill patients, SOFA score decrease over time, both in survivors and in non-survivors; it's discriminative power increases, but remains lower than general severity scores. At admission, best discrimination was achieved by cardiovascular failure, but after 5 days in the ICU, respiratory failure was superior. The impact on prognosis of organ failure was analysed, with cardiovascular failure at admission, and respiratory, renal, and hematological on 5th day having the greatest impact on prognosis. The relationships among the six organic systems analysed can be described in terms of a two dimensional structure; this point needs further research, since it can reveal new insights in the sequence and patterns of evolution of multiple organ disfunction/failure syndrome.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Keywords: Key words Severity of illness ; index ; Intensive care ; Critical care ; Mortality prediction ; Simplified Acute Physiology Score (SAPS II) ; Acute Physiology and Chronic Health Evaluation (APACHE II)Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Objective: To compare the performance of the New Simplified Acute Physiology Score (SAPS II) and Acute Physiology and Chronic Health Evaluation (APACHE) II in an independent database, using formal statistical assessment. Design: Analysis of the database of a multicentre, prospective study. Setting: 19 intensive care units (ICUs) in Portugal. Patients: Data for 1094 patients consecutively admitted to the ICUs were collected over a period of 4 months. Following the original SAPS II and APACHE II criteria, the analysis excluded patients younger than 18 years of age, readmissions, acute myocardial infarction, burns, patients in the post-operative period after coronary artery bypass surgery, and patients with a length of stay in the ICU of less than 24 h. The group analysed comprised 982 patients. Interventions: Collection of the first 24 h admission data necessary for the calculation of SAPS II, APACHE II, Therapeutic Intervention Scoring System (TISS), Simplified TISS, organ system failure and basic demographic statistics. Vital status at discharge from the hospital was registered. Measurements and results: In this cohort, discrimination was better for SAPS II than for APACHE II (SAPS II: area under the receiver operating characteristic curve 0.817, standard error 0.015; APACHE II: 0.787, 0.015; p 〈 0.001); however, both models presented a poor calibration, with significant differences between observed and predicted mortality (Hosmer-Lemeshow goodness-of-fit tests H and C, p 〈 0.001). In a stratified analysis, this study was unable to demonstrate any definite pattern of association between the poor performance of the models and specific subgroups of patients except for the most severely ill patients, where both models overestimated mortality. Conclusions: SAPS II performed better than APACHE II in this independent database, but the results do not allow its use, at least without being customised, to analyse quality of care or performance among ICUs in the target population.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1432-1238Keywords: Key words Therapeutic Intervention Scoring System ; Simplified Therapeutic Intervention Scoring System ; TISS-28 ; Intensive care unit ; Nursing workloadSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Objective: To evaluate the performance of the Simplified Therapeutic Intervention Scoring System on an independent database and determine its relation with the Therapeutic Intervention Scoring System in the quantification of nursing workload in intensive care. Design: Analysis of the database of a multicenter prospective Portuguese study. Setting: 19 intensive care units (ICUs) in Portugal. Patients: Data on 1094 patients consecutively admitted to the ICUs were collected during a period of 3 months. Methods: Collection of the data necessary for the calculation of the Therapeutic Intervention Scoring System (TISS-76) and the Simplified Therapeutic Intervention Scoring System (TISS-28) during the first 24 h in the ICU. Basic demographic statistics and all the variables necessary for the computation of the Simplified Acute Physiology Score II were also collected. Vital status at discharge from the hospital was registered. Regression techniques, Pearson's correlation and paired sample t-test were used. Results are presented as mean ± standard deviation except when stated otherwise. Reliability was evaluated by the use of intraclass correlation coefficients in a 5 % random sample. Measurements and results: After exclusion of all the patients with missing data, 1080 patients were analysed. The overall mean TISS-28 (29.82 ± 10.64) was significantly lower than the mean TISS-76 (31.14 ± 11.95). Both systems showed very significant differences between ICUs (p 〈 0.001). The correlation between the two was good, with TISS-28 explaining 72 % of the variation of TISS-76 (r = 0.85, r 2 = 0.72). The relation between the two systems was TISS-28 = 6.22 + 0.85 TISS-76. In this cohort, reliability of data collection was very high, with intraclass correlation coefficients greater than 0.90 for both systems. Conclusions: TISS-28 was validated on this independent population. The results indicate that TISS-28 can replace TISS-76 for the measurement of the nursing workload in Portuguese ICUsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1432-1939Keywords: Yeast communities ; Cactophilic yeasts ; Drosophila fasciola subgroupSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Yeast communities associated with four species of the Drosophila fasciola subgroup (repleta group) in tropical rain forests were surveyed in an abandoned orchard, and rain forest sites of Rio de Janeiro and Ilha Grande, State of Rio de Janeiro, Brazil. Adult flies of Drosophila carolinae, Drosophila coroica, Drosophila fascioloides and Drosophila onca frequently carried Candida colliculosa, Geotrichum sp, Kloeckera apiculata and a Pichia membranaefaciens-like species. The most frequent yeasts in the crop of flies included Candida collicullosa, C. krusei, Pichia kluyveri and a P. membranaefaciens-like species. The physiological abilities and species composition of these yeast communities differed from those of other forest-inhabiting Drosophila. The narrow feeding niches of the fasciola subgroup suggested the use of only part of the substrates available to the flies as food in the forest environment, as noted previously for cactophilic Drosophila serido (mulleri subgroup of the repleta group) in a sand dune ecosystem. The cactophilic yeasts that were isolated have not been previously found in forests. The fasciola subgroup probably used epiphytic cactus substrates as breeding and feeding sites in the forest. The physiological profile of yeasts associated with the fasciola flies was broader than that of yeasts associated with the cactophilic Drosophila serido, suggesting that the fasciola subgroup represents an older lineage from which the South American repleta species evolved.Type of Medium: Electronic ResourceURL: