Search Results - (Author, Cooperation:P. Mieczkowski)

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  1. 1
    P. Mieczkowski and B. Budziński
    Institute of Physics (IOP)
    Published 2018
    Staff View
    Publication Date:
    2018-05-16
    Publisher:
    Institute of Physics (IOP)
    Print ISSN:
    1757-8981
    Electronic ISSN:
    1757-899X
    Topics:
    Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2014-08-01
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Calcineurin/genetics/metabolism ; Calcineurin Inhibitors ; Drug Resistance, Fungal/*genetics ; Epigenesis, Genetic/*genetics ; Humans ; Hyphae/drug effects/genetics/growth & development ; Molecular Sequence Data ; Mucor/*drug effects/*genetics/growth & development ; Mucormycosis/drug therapy/microbiology ; Mutation/*genetics ; Phenotype ; *RNA Interference ; Tacrolimus/metabolism/*pharmacology ; Tacrolimus Binding Protein 1A/deficiency/genetics/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-11-07
    Publisher:
    Genetics Society of America (GSA)
    Electronic ISSN:
    2160-1836
    Topics:
    Biology
    Published by:
    http://www.genetics-gsa.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Mieczkowski, P. A. ; Fikus, M. U. ; Ciesla, Z.
    Springer
    Published 1997
    Staff View
    ISSN:
    1617-4623
    Keywords:
    Key words DNA damage  ;  DIN genes  ;  DIN7 homologs ;  Regulation  ;  Saccharomyces cerevisiae
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract A number of DNA damage-inducible genes (DIN) have been identified in Saccharomyces cerevisiae. In the present study we describe isolation of a novel gene, Din7, the expression of which is induced by exposure of cells to UV light, MMS (methyl methanesulfonate) or HU (hydoxyurea). The DNA sequence of DIN7 was determined. By comparison of the predicted Din7 amino acid sequence with those in databases we found that it belongs to a family of proteins which includes S. cerevisiae Rad2 and its Schizosaccharomyces pombe and human homologs Rad13 and XPGC; S. cerevisiae Rad27 and its S. pombe homolog Rad2, and S. pombe Exo I. All these proteins are endowed with DNA nuclease activity and are known to play an important function in DNA repair. The strongest homology to Din7 was found with the Dhs1 protein of S.␣cerevisiae, the function of which is essentially unknown. The expression of the DIN7 gene was studied in detail using a DIN7-lacZ fusion integrated into a chromosome. We show that the expression level of DIN7 rises during meiosis at a time nearly coincident with commitment to recombination. No inducibility of DIN7 was found after treatment with DNA-damaging agents of cells bearing the rad53-21 mutation. Surprisingly, a high basal level of DIN7 expression was found in strains in which the DUN1 gene was inactivated by transposon insertion. We suggest that a form of Dun1 may be a negative regulator of the DIN7 gene expression.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004380050369

    Articles: DFG German National Licenses