Search Results - (Author, Cooperation:P. Maher)
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1Latest Papers from Table of Contents or Articles in PressToni Lyn Morelli, Sean P. Maher, Marisa C. W. Lim, Christina Kastely, Lindsey M. Eastman, Lorraine E. Flint, Alan L. Flint, Steven R. Beissinger and Craig Moritz
BioMed Central
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: BioMed CentralElectronic ISSN: 2053-7565Topics: Energy, Environment Protection, Nuclear Power EngineeringPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-09Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-10Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
4Latest Papers from Table of Contents or Articles in PressC. R. Dean ; L. Wang ; P. Maher ; C. Forsythe ; F. Ghahari ; Y. Gao ; J. Katoch ; M. Ishigami ; P. Moon ; M. Koshino ; T. Taniguchi ; K. Watanabe ; K. L. Shepard ; J. Hone ; P. Kim
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-05-17Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
5Latest Papers from Table of Contents or Articles in PressP. Maher ; L. Wang ; Y. Gao ; C. Forsythe ; T. Taniguchi ; K. Watanabe ; D. Abanin ; Z. Papic ; P. Cadden-Zimansky ; J. Hone ; P. Kim ; C. R. Dean
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-07-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsPublished by: -
6Articles: DFG German National LicensesSouder, W. E. ; Maher, P. M. ; Shumway, C. R. ; Baker, N. R. ; Rubenstein, A. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1973Staff ViewISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: Although some studies and experiences have shown that R & D project selection models can be potentially useful decision aids, their adoption and routine use is not widespread. This lack of usage may be a consequence of the lack of attention which model builders have traditionally given to the prevailing adoption attitudes of R & D managers. A design methodology centering around the measurement of adoption attitudes has been developed and used by the authors. The methodology consists of procedures for analyzing the organizational climate relative to project selection model usage, developing an acceptable model form relative to the organizational climate, and inducing the adoption of this model form within the climate. Three case applications of the methodology are described in which negative-to-positive shifts in adoption attitudes occurred and project selection models were adopted for long-term use. These results indicate that the use of this general methodology may lead to increased formal adoption and widespread usage of project selection model forms in R & D.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesSouder, W. E. ; Maher, P. M. ; Shumway, C. R. ; Baker, N. R. ; Rubenstein, A. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1974Staff ViewISSN: 1467-9310Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: EconomicsNotes: Although some studies and experiences have shown that R & D project selection models can be potentially useful decision aids, their adoption and routine use is not widespread. This lack of usage may be a consequence of the lack of attention which model builders have traditionally given to the prevailing adoption attitudes of R & D managers. A design methodology centering around the measurement of adoption attitudes has been developed and used by the authors. The methodology consists of procedures for analyzing the organizational climate relative to project selection model usage, developing an acceptable model form relative to the organizational climate, and inducing the adoption of this model form within the climate. Three case applications of the methodology are described in which negative-to-positive shifts in adoption attitudes occurred and project selection models were adopted for long-term use. These results indicate that the use of this general methodology may lead to increased formal adoption and widespread usage of project selection model forms in R & D.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: (Neuroblastoma cell) ; Cell surface ; Glycoprotein ; Lectin binding siteSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0021-9614Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1065-9129Topics: Political ScienceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words. ROS; apoptosis; necrosis; glutathione; H2O2; transcription factors; tyrosine phosphatases; protein kinases.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. Free radicals and reactive oxygen species (ROS) are involved in a variety of different cellular processes ranging from apoptosis and necrosis to cell proliferation and carcinogenesis. Cells contain multiple sites for ROS production and a few mechanisms for their degradation. Which of these sites is activated by a given stimulus may play a role in dictating the subsequent downstream effects of the ROS generated on cellular function. Even when the ultimate outcome is similar, such as when ROS production leads to cell death, the specific cellular changes can be quite different depending on the initial stimulus and the type of cell involved. These data, along with the evidence that ROS can modify a number of intracellular signaling pathways including protein phosphatases, protein kinases and transcription factors, suggest that the majority of the effects of ROS on cells are through their actions on signaling pathways rather than via nonspecific damage of intracellular macromolecules.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0091-7419Keywords: lectins ; binding sites ; neuroblastoma cells ; receptor redistribution ; cell surface labeling ; cytochalasin B ; concanavalin A ; wheat germ agglutinin ; fluorescent microscopy ; scanning electron microscopy ; Life Sciences ; Molecular Cell BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyChemistry and PharmacologyMedicineNotes: Concanavalin A (Con A), wheat germ agglutinin (WGA), and Ricinus communis agglutinin (RCA) bound with either 125I, fluorescent dyes, or fluorescent polymeric microspheres were used to quantitate and visualize the distribution of lectin binding sites on mouse neuroblastoma cells. As viewed by fluorescent light and scanning electron microscopy, over 107 binding sites for Con A, WGA, and RCA appeared to be distributed randomly over the surface of differentiated and undifferentiated cells. An energy-dependent redistribution of labeled sites into a central spot occurred when the cells were labeled with a saturating dose of fluorescent lectin and maintained at 37°C for 60 min. Reversible labeling using appropriate saccharide inhibitors indicated that the labeled sites had undergone endocytosis by the cell. A difference in the mode of redistribution of WGA or RCA and Con A binding sites was observed in double labeling experiments. When less than 10% of the WGA or RCA lectin binding sites were labeled, only these labeled sites appeared to be removed from the cell surface. In contrast, when less than 10% of the Con A sites were labeled, both labeled and unlabeled Con A binding sites were removed from the cell surface. Cytochalasin B uncoupled the coordinate redistribution of labeled and unlabeled Con A sites, suggesting the involvement of microfilaments. Finally, double labeling experiments employing fluorescein-tagged Con A and rhodamine-tagged WGA indicate that most Con A and WGA binding sites reside on different membrane components and redistribute independenty of each other.Additional Material: 9 Ill.Type of Medium: Electronic ResourceURL: