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1S. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
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Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/*genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/*genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor AssaysPublished by: -
2J. Schwartzentruber ; A. Korshunov ; X. Y. Liu ; D. T. Jones ; E. Pfaff ; K. Jacob ; D. Sturm ; A. M. Fontebasso ; D. A. Quang ; M. Tonjes ; V. Hovestadt ; S. Albrecht ; M. Kool ; A. Nantel ; C. Konermann ; A. Lindroth ; N. Jager ; T. Rausch ; M. Ryzhova ; J. O. Korbel ; T. Hielscher ; P. Hauser ; M. Garami ; A. Klekner ; L. Bognar ; M. Ebinger ; M. U. Schuhmann ; W. Scheurlen ; A. Pekrun ; M. C. Fruhwald ; W. Roggendorf ; C. Kramm ; M. Durken ; J. Atkinson ; P. Lepage ; A. Montpetit ; M. Zakrzewska ; K. Zakrzewski ; P. P. Liberski ; Z. Dong ; P. Siegel ; A. E. Kulozik ; M. Zapatka ; A. Guha ; D. Malkin ; J. Felsberg ; G. Reifenberger ; A. von Deimling ; K. Ichimura ; V. P. Collins ; H. Witt ; T. Milde ; O. Witt ; C. Zhang ; P. Castelo-Branco ; P. Lichter ; D. Faury ; U. Tabori ; C. Plass ; J. Majewski ; S. M. Pfister ; N. Jabado
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Published 2012Staff ViewPublication Date: 2012-01-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/genetics ; Base Sequence ; Child ; Chromatin/*genetics/metabolism ; Chromatin Assembly and Disassembly/*genetics ; DNA Helicases/genetics ; DNA Mutational Analysis ; Exome/genetics ; Gene Expression Profiling ; Glioblastoma/*genetics ; Histones/*genetics/metabolism ; Humans ; Molecular Sequence Data ; Mutation/*genetics ; Nuclear Proteins/genetics ; Telomere/genetics ; Tumor Suppressor Protein p53/geneticsPublished by: -
3D. T. Jones ; N. Jager ; M. Kool ; T. Zichner ; B. Hutter ; M. Sultan ; Y. J. Cho ; T. J. Pugh ; V. Hovestadt ; A. M. Stutz ; T. Rausch ; H. J. Warnatz ; M. Ryzhova ; S. Bender ; D. Sturm ; S. Pleier ; H. Cin ; E. Pfaff ; L. Sieber ; A. Wittmann ; M. Remke ; H. Witt ; S. Hutter ; T. Tzaridis ; J. Weischenfeldt ; B. Raeder ; M. Avci ; V. Amstislavskiy ; M. Zapatka ; U. D. Weber ; Q. Wang ; B. Lasitschka ; C. C. Bartholomae ; M. Schmidt ; C. von Kalle ; V. Ast ; C. Lawerenz ; J. Eils ; R. Kabbe ; V. Benes ; P. van Sluis ; J. Koster ; R. Volckmann ; D. Shih ; M. J. Betts ; R. B. Russell ; S. Coco ; G. P. Tonini ; U. Schuller ; V. Hans ; N. Graf ; Y. J. Kim ; C. Monoranu ; W. Roggendorf ; A. Unterberg ; C. Herold-Mende ; T. Milde ; A. E. Kulozik ; A. von Deimling ; O. Witt ; E. Maass ; J. Rossler ; M. Ebinger ; M. U. Schuhmann ; M. C. Fruhwald ; M. Hasselblatt ; N. Jabado ; S. Rutkowski ; A. O. von Bueren ; D. Williamson ; S. C. Clifford ; M. G. McCabe ; V. P. Collins ; S. Wolf ; S. Wiemann ; H. Lehrach ; B. Brors ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; P. A. Northcott ; M. D. Taylor ; M. Meyerson ; S. L. Pomeroy ; M. L. Yaspo ; J. O. Korbel ; A. Korshunov ; R. Eils ; S. M. Pfister ; P. Lichter
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Published 2012Staff ViewPublication Date: 2012-07-27Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/genetics ; Amino Acid Sequence ; Cell Transformation, Neoplastic ; Cerebellar Neoplasms/classification/diagnosis/*genetics/pathology ; Child ; Chromatin/metabolism ; Chromosomes, Human/genetics ; DEAD-box RNA Helicases/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Genome, Human/*genetics ; Genomics ; Hedgehog Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Histone Demethylases/genetics ; Humans ; Medulloblastoma/classification/diagnosis/*genetics/pathology ; Methylation ; Mutation/genetics ; Mutation Rate ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Phosphoprotein Phosphatases/genetics ; Polyploidy ; Receptors, Cell Surface/genetics ; Sequence Analysis, RNA ; Signal Transduction ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/geneticsPublished by: -
4V. Hovestadt ; D. T. Jones ; S. Picelli ; W. Wang ; M. Kool ; P. A. Northcott ; M. Sultan ; K. Stachurski ; M. Ryzhova ; H. J. Warnatz ; M. Ralser ; S. Brun ; J. Bunt ; N. Jager ; K. Kleinheinz ; S. Erkek ; U. D. Weber ; C. C. Bartholomae ; C. von Kalle ; C. Lawerenz ; J. Eils ; J. Koster ; R. Versteeg ; T. Milde ; O. Witt ; S. Schmidt ; S. Wolf ; T. Pietsch ; S. Rutkowski ; W. Scheurlen ; M. D. Taylor ; B. Brors ; J. Felsberg ; G. Reifenberger ; A. Borkhardt ; H. Lehrach ; R. J. Wechsler-Reya ; R. Eils ; M. L. Yaspo ; P. Landgraf ; A. Korshunov ; M. Zapatka ; B. Radlwimmer ; S. M. Pfister ; P. Lichter
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Published 2014Staff ViewPublication Date: 2014-05-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Binding Sites ; Cell Line, Tumor ; Chromatin/genetics/metabolism ; Chromatin Immunoprecipitation ; DNA Methylation/*genetics ; Female ; *Gene Expression Regulation, Neoplastic ; *Gene Silencing ; Genome/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/*genetics/pathology ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Binding Proteins/genetics ; Sequence Analysis, DNA/*methods ; Transcription Factors/metabolism ; Transcription, GeneticPublished by: -
5C. Y. Lin ; S. Erkek ; Y. Tong ; L. Yin ; A. J. Federation ; M. Zapatka ; P. Haldipur ; D. Kawauchi ; T. Risch ; H. J. Warnatz ; B. C. Worst ; B. Ju ; B. A. Orr ; R. Zeid ; D. R. Polaski ; M. Segura-Wang ; S. M. Waszak ; D. T. Jones ; M. Kool ; V. Hovestadt ; I. Buchhalter ; L. Sieber ; P. Johann ; L. Chavez ; S. Groschel ; M. Ryzhova ; A. Korshunov ; W. Chen ; V. V. Chizhikov ; K. J. Millen ; V. Amstislavskiy ; H. Lehrach ; M. L. Yaspo ; R. Eils ; P. Lichter ; J. O. Korbel ; S. M. Pfister ; J. E. Bradner ; P. A. Northcott
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Published 2016Staff ViewPublication Date: 2016-01-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cerebellar Neoplasms/classification/*genetics/*pathology ; Enhancer Elements, Genetic/*genetics ; Female ; Gene Expression Regulation, Neoplastic/*genetics ; Gene Regulatory Networks/genetics ; Genes, Neoplasm/genetics ; Genes, Reporter/genetics ; Humans ; Male ; Medulloblastoma/*classification/genetics/*pathology ; Mice ; Reproducibility of Results ; Transcription Factors/*metabolism ; Zebrafish/geneticsPublished by: -
6P. A. Northcott ; C. Lee ; T. Zichner ; A. M. Stutz ; S. Erkek ; D. Kawauchi ; D. J. Shih ; V. Hovestadt ; M. Zapatka ; D. Sturm ; D. T. Jones ; M. Kool ; M. Remke ; F. M. Cavalli ; S. Zuyderduyn ; G. D. Bader ; S. VandenBerg ; L. A. Esparza ; M. Ryzhova ; W. Wang ; A. Wittmann ; S. Stark ; L. Sieber ; H. Seker-Cin ; L. Linke ; F. Kratochwil ; N. Jager ; I. Buchhalter ; C. D. Imbusch ; G. Zipprich ; B. Raeder ; S. Schmidt ; N. Diessl ; S. Wolf ; S. Wiemann ; B. Brors ; C. Lawerenz ; J. Eils ; H. J. Warnatz ; T. Risch ; M. L. Yaspo ; U. D. Weber ; C. C. Bartholomae ; C. von Kalle ; E. Turanyi ; P. Hauser ; E. Sanden ; A. Darabi ; P. Siesjo ; J. Sterba ; K. Zitterbart ; D. Sumerauer ; P. van Sluis ; R. Versteeg ; R. Volckmann ; J. Koster ; M. U. Schuhmann ; M. Ebinger ; H. L. Grimes ; G. W. Robinson ; A. Gajjar ; M. Mynarek ; K. von Hoff ; S. Rutkowski ; T. Pietsch ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; A. E. Kulozik ; A. von Deimling ; O. Witt ; R. Eils ; R. J. Gilbertson ; A. Korshunov ; M. D. Taylor ; P. Lichter ; J. O. Korbel ; R. J. Wechsler-Reya ; S. M. Pfister
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Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Child ; Chromosomes, Human, Pair 9/genetics ; DNA-Binding Proteins/*genetics/metabolism ; Enhancer Elements, Genetic/*genetics ; Genomic Structural Variation/*genetics ; Humans ; Medulloblastoma/classification/*genetics/pathology ; Mice ; Oncogenes/*genetics ; Proto-Oncogene Proteins/*genetics/metabolism ; Repressor Proteins/*genetics/metabolism ; Transcription Factors/*genetics/metabolismPublished by: -
7T. J. Pugh ; S. D. Weeraratne ; T. C. Archer ; D. A. Pomeranz Krummel ; D. Auclair ; J. Bochicchio ; M. O. Carneiro ; S. L. Carter ; K. Cibulskis ; R. L. Erlich ; H. Greulich ; M. S. Lawrence ; N. J. Lennon ; A. McKenna ; J. Meldrim ; A. H. Ramos ; M. G. Ross ; C. Russ ; E. Shefler ; A. Sivachenko ; B. Sogoloff ; P. Stojanov ; P. Tamayo ; J. P. Mesirov ; V. Amani ; N. Teider ; S. Sengupta ; J. P. Francois ; P. A. Northcott ; M. D. Taylor ; F. Yu ; G. R. Crabtree ; A. G. Kautzman ; S. B. Gabriel ; G. Getz ; N. Jager ; D. T. Jones ; P. Lichter ; S. M. Pfister ; T. M. Roberts ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho
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Published 2012Staff ViewPublication Date: 2012-07-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Cerebellar Neoplasms/classification/*genetics ; Child ; DEAD-box RNA Helicases/chemistry/genetics/metabolism ; DNA Helicases/chemistry/genetics ; DNA-Binding Proteins/genetics ; Exome/*genetics ; Genome, Human/*genetics ; Hedgehog Proteins/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification/*genetics ; Models, Molecular ; Mutation/*genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics/metabolismPublished by: -
8L. B. Alexandrov ; S. Nik-Zainal ; D. C. Wedge ; S. A. Aparicio ; S. Behjati ; A. V. Biankin ; G. R. Bignell ; N. Bolli ; A. Borg ; A. L. Borresen-Dale ; S. Boyault ; B. Burkhardt ; A. P. Butler ; C. Caldas ; H. R. Davies ; C. Desmedt ; R. Eils ; J. E. Eyfjord ; J. A. Foekens ; M. Greaves ; F. Hosoda ; B. Hutter ; T. Ilicic ; S. Imbeaud ; M. Imielinski ; N. Jager ; D. T. Jones ; D. Jones ; S. Knappskog ; M. Kool ; S. R. Lakhani ; C. Lopez-Otin ; S. Martin ; N. C. Munshi ; H. Nakamura ; P. A. Northcott ; M. Pajic ; E. Papaemmanuil ; A. Paradiso ; J. V. Pearson ; X. S. Puente ; K. Raine ; M. Ramakrishna ; A. L. Richardson ; J. Richter ; P. Rosenstiel ; M. Schlesner ; T. N. Schumacher ; P. N. Span ; J. W. Teague ; Y. Totoki ; A. N. Tutt ; R. Valdes-Mas ; M. M. van Buuren ; L. van 't Veer ; A. Vincent-Salomon ; N. Waddell ; L. R. Yates ; J. Zucman-Rossi ; P. A. Futreal ; U. McDermott ; P. Lichter ; M. Meyerson ; S. M. Grimmond ; R. Siebert ; E. Campo ; T. Shibata ; S. M. Pfister ; P. J. Campbell ; M. R. Stratton
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Published 2013Staff ViewPublication Date: 2013-08-16Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/genetics ; Algorithms ; Cell Transformation, Neoplastic/*genetics/pathology ; Cytidine Deaminase/genetics ; DNA/genetics/metabolism ; DNA Mutational Analysis ; Humans ; Models, Genetic ; Mutagenesis/*genetics ; Mutagenesis, Insertional/genetics ; Mutagens/pharmacology ; Mutation/*genetics ; Neoplasms/enzymology/*genetics/pathology ; Organ Specificity ; Reproducibility of Results ; Sequence Deletion/genetics ; Transcription, Genetic/geneticsPublished by: -
9Lichter, P. ; Nessling, M. ; Soder, A. ; Bock, D. ; Göttel, D. ; Solinas-Toldo, S. ; Stilgenbauer, S. ; Döhner, H. ; Lampel, Stefan
[s.l.] : Nature America, Inc.
Published 1999Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Comparative genomic hybridization (CGH) has been used for a genome-wide screening of genetic imbalances in tumours. As CGH to chromosomes is technically difficult and yields only limited resolution, the chromosome targets were replaced by arrays of defined DNA fragments, an approach termed ...Type of Medium: Electronic ResourceURL: -
10Stratowa, C. ; Löffler, G. ; Stilgenbauer, S. ; Haberl, P. ; Schweifer, N. ; Lichter, P. ; Döhner, H. ; Wilgenbus, K.K.
[s.l.] : Nature America, Inc.
Published 1999Staff ViewISSN: 1546-1718Source: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Combining data obtained by gene expression profiling with other sample-related data (for example clinical data in the case of patient samples) should increase the amount of information that can be extracted from the raw data. We performed a feasibility study by systematically comparing large-scale ...Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 0167-4781Keywords: (Human) ; Casein kinase II subunit α ; Chromosome localization ; genomic DNA sequenceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
14Jaenicke, T. ; Diederich, K.W. ; Haas, W. ; Schleich, J. ; Lichter, P. ; Pfordt, M. ; Bach, A. ; Vosberg, H.-P.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
15Giuffra, L.A. ; Lichter, P. ; Wu, J. ; Kennedy, J.L. ; Pakstis, A.J. ; Rogers, J. ; Kidd, J.R. ; Harley, H. ; Ward, D.C. ; Kidd, K.K. ; Jenkins, T.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
17Giuffra, L.A. ; Lichter, P. ; Wu, J. ; Kennedy, J.L. ; Pakstis, A.J. ; Rogers, J. ; Kidd, J.R. ; Harley, H. ; Ward, D.C. ; Kidd, K.K. ; Jenkins, T.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
19Fink, T.M. ; Zimmer, M. ; Tschopp, J. ; Etienne, J. ; Jenne, D.E. ; Lichter, P.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: