Search Results - (Author, Cooperation:P. Kuhn)
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1Latest Papers from Table of Contents or Articles in PressM. A. Hanson ; C. B. Roth ; E. Jo ; M. T. Griffith ; F. L. Scott ; G. Reinhart ; H. Desale ; B. Clemons ; S. M. Cahalan ; S. C. Schuerer ; M. G. Sanna ; G. W. Han ; P. Kuhn ; H. Rosen ; R. C. Stevens
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-02-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Anilides/chemistry ; Binding Sites ; Crystallography, X-Ray ; Models, Molecular ; Muramidase/chemistry ; Mutagenesis ; Organophosphonates/chemistry ; Protein Conformation ; Receptors, Lysosphingolipid/agonists/antagonists & inhibitors/*chemistry/genetics ; Recombinant Fusion Proteins/chemistry/geneticsPublished by: -
2Latest Papers from Table of Contents or Articles in PressDuernberger, Y., Liu, S., Riemschoss, K., Paulsen, L., Bester, R., Kuhn, P.-H., Schölling, M., Lichtenthaler, S. F., Vorberg, I.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-07-17Publisher: The American Society for Microbiology (ASM)Print ISSN: 0270-7306Electronic ISSN: 1098-5549Topics: BiologyMedicinePublished by: -
3Articles: DFG German National LicensesPandya, P. P. ; Kuhn, P. ; Brizot, M. ; Cardy, D. L. ; Nicolaides, K. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective Evaluation of fluorescence in situ hybridisation in the detection of numerical aberrations involving chromosomes X, Y, 13, 18 and 21.Setting Harris Birthright Research Centre for Fetal Medicine.Subjects and methods Chorionic villi (n= 45) or fetal blood (n= 34) were obtained from 79 pregnancies undergoing fetal karyotyping at 10 to 39 weeks of gestation because of ultrasonographic markers of fetal chromosomal abnormality. Karyotyping was performed by both traditional cytogenetics and fluorescence in situ hybridisation, using commercially available kits which utilise a heterochromatic Y probe and the alpha satellite repeat probes for chromosomes X, 18, and 13/21. The frequency distributions of the number of signals obtained by fluorescence in situ hybridisation in the chromosomally normal and abnormal fetuses were compared.Results Traditional cytogenetic analysis demonstrated that the fetal karyotype was normal in 47 cases and abnormal in 32 (including 24 with trisomies 21, 18 or 13, three with triploidy, one with Turners syndrome and four with translocations, deletions or mosaicism). With fluorescence in situ hybridisation it was possible to obtain accurate diagnosis of trisomy 18, Turners or triploidy within six hours of sampling; signal distributions with these chromosomal abnormalities were very different from those of normals. However, for trisomies 21 and 13 there was an overlap in values with those from normals.Conclusions In detection of fetal numerical chromosomal abnormalities the use of the combined 13/21 probe cannot provide sufficiently accurate results to justify abandonment of traditional cytogenetics in favour of fluorescence in situ hybridisation.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesBrizot, M. L. ; Kuhn, P. ; Bersinger, N. A. ; Snijders, R. J. M. ; Nicolaides, K. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Objective To evaluate the potential value of maternal serum alpha-fetoprotein concentration in the detection of fetal trisomy at 10 to 13 weeks gestation and to examine the possible association between maternal serum alpha-fetoprotein and fetal nuchal translucency thickness.Design Cross-sectional study.Setting Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London.Subjects and methods Maternal serum alpha-fetoprotein concentration was measured at 10 to 13 weeks gestation in samples from 57 pregnancies with fetal trisomies (trisomy 21 (n= 35), trisomy 18 (n= 16), and trisomy 13 (n= 6)) in 228 matched controls in whom the fetal nuchal translucency was 〈 3 mm and in 114 chromosomally normal fetuses with translucency ≥3 mm.Results In the control group maternal serum alpha-fetoprotein increased significantly with fetal crown-rump length (r= 0.451). In this group, the median maternal serum alpha-fetoprotein was not significantly different from that in the groups with trisomy 21 (median = 0.84 MOM), trisomy 18 (median = 0.86 MOM), or trisomy 13 (median = 0.94 MOM), respectively. Neither in the control group nor in the group with trisomic fetuses was maternal serum alpha-fetoprotein significantly associated with fetal nuchal translucency thickness (r= 0.01 and r= 0.03).Conclusion Measurement of maternal serum alpha-fetoprotein concentration in the first trimester of pregnancy is not likely to be useful in the prediction of fetal trisomies.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1365-2761Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: The salmon louse, Lepeophtheirus salmonis, is an ectoparasitic copepod that infests both wild and farmed salmonid fish. Salmon lice are a major disease problem in the farming of Atlantic salmon, Salmo salar L., and the possibility of salmon lice playing a role in the decline of wild anadromous stocks has also been raised. Lepeophtheirus salmonis can detect a range of stimuli (pressure/moving water, chemicals and light) in the external environment. However, the response thresholds to various stimuli, and the spatial and temporal scales over which they operate in the context of host location, are largely unknown. In this context, we attempted to determine whether salmon lice copepodids settle onto hosts more effectively, or at different locations on the fish's body, under different qualities of light. Lice settlement trials were conducted under three lighting conditions; L1: unpolarized under ultraviolet A (UVA)-through visible; L2: unpolarized without UVA (control); L3: 100% linearly polarized without UVA. A dark control was also conducted. No statistically significant difference in lice settlement was found. While changes in light intensity are involved in host detection at spatial scales on the order of metres, the results presented here suggest that it is not the primary sensory modality underlying host location at smaller spatial scales (cm to mm).Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0047-2727Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EconomicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0927-5371Keywords: Firm-specific training ; Job rationing by gender ; Personnel policy ; [JEL classification codes] J31 ; [JEL classification codes] J71Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EconomicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0022-2836Keywords: PNGase F ; amidase ; amidohydrolase ; crystallization ; peptide-N^4-(N-acetyl-β-d-glucosaminyl)asparagine amidaseSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0038-0121Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: SociologyEconomicsType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0022-1996Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: EconomicsType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0031-9163Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0038-0121Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: SociologyEconomicsType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0038-0121Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: SociologyEconomicsType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0167-2738Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0167-2738Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-1912Keywords: Arterial Blood Pressure ; Action Potentials ; Central Sympathetic Activity ; Central Respiratory Activity ; α-Methyl-dopa ; Arterieller Blutdruck ; Aktionspotentiale Zentrale SympathicusaktivitÄt ; AtemzentrumSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The centralnervous sympathetic inhibitory and hypotensive effects ofα-methyl-dopa were studied in anaesthetized rats and cats. Preganglionic action potentials of the cervical sympathetic nerve were recorded simultaneously with the arterial blood pressure and evaluated quantitatively. Student'st-test was applied for statistical analysis. The experiments show thatα-methyl-dopa produces no significant hypotensive or sympathetic inhibitory effects at a dosage of 400 mg/kg i. v. during a 2 hr period after administration. Only after pretreatment for 4 consecutive days with a total dosage of 400–2000 mg/kg i.p. was there an inhibition of the spontaneous sympathetic activity as well as of that induced by nikethamide or asphyxia. Therefore the blockade affected not only the reflex but also the primarily central nervous patterns of discharges in the sympathetic nerve. Although a depression of sympathetic activity was already observed with doses which failed to produce a significant fall in blood pressure, our results suggest that a central nervous mechanism of action participates in the hypotensive effect ofα-methyl-dopa.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1432-1912Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0168-9002Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0165-2370Keywords: Captafol ; Metolachlor ; pesticides ; pyrolysis ; thermal decomposition.Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0165-2370Keywords: Chloridazon ; Metoxuron ; herbicides ; pesticides ; pyrolysis ; thermal decomposition.Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: