Search Results - (Author, Cooperation:P. Koopman)
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1Latest Papers from Table of Contents or Articles in PressS. Kuroki ; S. Matoba ; M. Akiyoshi ; Y. Matsumura ; H. Miyachi ; N. Mise ; K. Abe ; A. Ogura ; D. Wilhelm ; P. Koopman ; M. Nozaki ; Y. Kanai ; Y. Shinkai ; M. Tachibana
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-09-07Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Epididymis/abnormalities ; *Epigenesis, Genetic ; Female ; *Gene Expression Regulation, Developmental ; Histones/*metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics/*metabolism ; Male ; Methylation ; Mice ; Mice, Mutant Strains ; Mice, Transgenic ; Ovary/abnormalities/enzymology ; *Protein Processing, Post-Translational ; Sex Determination Processes/*genetics ; Testis/abnormalities/enzymology ; Uterus/abnormalitiesPublished by: -
2Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0958-1669Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0959-437XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Keywords: Key words.Sry; Sox9; sex determination; Sox genes; testis; mammalian; review.Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. Sry is the Y-chromosomal gene that acts as a trigger for male development in mammalian embryos. This gene encodes a high mobility group (HMG) box transcription factor that is known to bind to specific target sequences in DNA and to cause a bend in the chromatin. DNA bending appears to be part of the mechanism by which Sry influences transcription of genes downstream in a cascade of gene regulation leading to maleness, but the direct targets of Sry remain to be positively identified. One gene known to be downstream from Sry in this cascade is Sox9, which encodes a transcription factor related to Sry by the HMG box. Like Sry, mutations in Sox9 disrupt male development, but unlike Sry, the role of Sox9 is not limited to mammals. This review focuses on what is known about the two genes and their likely modes of action, and draws together recent data relating to how they might interconnect with the network of gene activity implicated in testis determination in mammals.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0168-9525Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0168-9525Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1435-1463Keywords: Antidepressants ; DMI ; electrocortical activity ; \-adrenergic receptors ; chronic treatmentSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The aim of this study was to investigate the effects of chronic administration of desimipramine (DMI) after 2, 7 or 20 mg/kg per day, administered by osmotic minipumps, on electrocortical activity and Β-adrenergic receptors in rat brain. Rats receiving DMI chronically show a dose- and time-dependent increase of electrocortical activity above 15 Hz as well as a dose- and time-dependent decrease below 15 Hz. Already after 3 days of treatment a clear effect on the electrocorticogram (ECoG) was seen. The maximal change in the ECoG was reached at the end of the study, after 24 days of treatment. After acute treatment (20 and 45 minutes after 2, 4 or 10 mg/kg i.p.) with DMI, a decrease of electrocortical activity is seen above 15 Hz. Thus the effect of acute DMI treatment on the ECoG is different from that of chronic treatment. In the same group of rats the effect of chronic DMI treatment on the Β-adrenergic receptor number was determined 24 hours after the last ECoG recording. The number of Β-adrenergic receptors was dose dependently reduced in the DMI-treated rats as determined by [3H]-dihydroalprenolol binding. There was no change in affinity (KD) of the ligand for the Β-receptor. This finding was corroborated by a decrease in the functional activity of the Β-adrenergic receptors, as determined by isoprenaline stimulated efflux of cyclic-AMP in cortex slices. These data indicate that chronic treatment with DMI, resulting in a down-regulation of the cortical Β-adrenergic system, is paralleled by pronounced effects on the ECoG of rats. The different ECoG profiles after chronic DMI treatment compared with acute treatment suggest that adaptive changes in the electrical brain activity continually develop during the chronic treatment with this antidepressant drug.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesUchida, K. ; Koopman, P. ; Mita, A. ; Wakana, S. ; Wright, E. ; Kikkawa, Y. ; Yonekawa, H. ; Moriwaki, K. ; Shiroishi, T.
Springer
Published 1996Staff ViewISSN: 1432-1777Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract. The Sry-related gene Sox9 has been proposed as the gene responsible for the mouse skeletal mutant Tail-short (Ts), on the basis of its expression in skeletogenic mesenchymal condensations in the mouse embryo and its chromosomal location in the region of Ts on distal Chromosome (Chr) 11. We present here detailed mapping of Ts locus relative to the Sox9, using an intersubspecific cross. Among 521 backcross progeny, 16 recombinants were detected between Sox9 and Ts, suggesting a separation of 3.5 ± 0.01 cM, and excluding Sox9 as a candidate for Ts. A further nine recombinants were detected between Ts and the polycomb-like gene M33, suggesting that these loci are separated by 1.8 ± 0.011 cM. Six microsatellite markers were co-localized to the Ts locus, providing reagents for positional cloning of Ts.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1588-2837Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyDescription / Table of Contents: Abstract Активация силикагеля, пропитанного RuCl3 обработкой при высоких температурах до 700°C азотом и водородом оказывается лучшим прокаливания материала до восстановления. Усадка почти не набдюдается. Измерения активности, основанные на жидкофазном гидрировании бензола, а также термогравиметрический анализ указывают на благоприятное (химическое) взаимодействие между рутением и силикагелем.Notes: Abstract Activation of RuCl3-impregnated silica by nitrogen-hydrogen tratment at high temperature, up to 700 °C, is superior to calcination of the material prior to reduction. Sintering hardly occurs. In addition, activity measurements, based on the liquid phase hydrogenation of benzene, and thermogravimetric analysis suggest a favorable (chemical) interaction between ruthenium and silica.Type of Medium: Electronic ResourceURL: