Search Results - (Author, Cooperation:P. Kolb)

2018-03-17

American Physical Society (APS)

1098-4402

Physics

Radio Frequency Calculations and Technology

2014-12-24

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Azepines/*chemistry/metabolism/*pharmacology ; Crystallography, X-Ray ; Humans ; Molecular Docking Simulation ; *Orexin Receptor Antagonists ; Orexin Receptors/*chemistry/metabolism ; Protein Conformation ; Receptors, G-Protein-Coupled/antagonists & inhibitors/chemistry/metabolism ; Recombinant Fusion Proteins/chemistry/metabolism ; Sleep Initiation and Maintenance Disorders/drug therapy ; Triazoles/*chemistry/metabolism/*pharmacology

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A compact sensor for measuring position in two dimensions has been developed. The device, operating on the principle that the capacitance of parallel plate electrodes depends on their mutual area of overlap, is compatible with high magnetic fields and cryogenic temperatures. A resolution of approximately 1.2 μm has been achieved and is limited by the electronics used. The position reproducibility, which is limited by drift of the positioner used to test the sensor, has been measured to be better than 3 μm. © 1998 American Institute of Physics.

Electronic Resource

1432-1440

Diarrhoea ; Colostrum-acquired immunodeficiency syndrome ; Human immunodeficiency virus ; Cryptosporidiosis

Springer Online Journal Archives 1860-2000

Medicine

Summary Diarrhoea and weight loss are found in more than 50% of patients with the acquired immunodeficiency syndrome (AIDS). In some patients the symptoms can be very severe, leading to death even in the absence of opportunistic infections. In 30% of these patients, enteric pathogens cannot be identified, and approximately only half of the identifiable aetiologic agents of diarrhoea in patients infected with the human immunodeficiency virus (HIV) were treatable with antibiotics. Immunoglobulins from bovine colostrum (Lactobin, Biotest, Dreieich, FRG) contain high titers of antibodies against a wide range of bacterial, viral and protozoal pathogens as well as against various bacterial toxins. Lactobin (LIG) is quite resistant to 24-h incubation with gastric juice. In a multi-center pilot study 37 immunodeficiency patients with chronic diarrhoea [29 HIV-infected patients, 2 patients with common variable immunodeficiency (CVID), one unidentified immunodeficiency, five patients with graft versus host disease (GvHD) following bone marrow transplantation] were treated with oral LIG (10 g/day for 10 days). Good therapeutic effects were observed. Out of 31 treatment periods in 29 HIV-infected patients 21 gave good results leading to transient (10 days) or long-lasting (more than 4 weeks) normalisation of the stool frequency. The mean daily stool frequency decreased from 7.4 to 2.2 at the end of the treatment. Eight HIV-infected patients showed no response. The diarrhoea recurred in 12 patients within 4 weeks (32.4%), while 19 patients were free of diarrhoea for at least 4 weeks (51.3%). In 5 patients intestinal cryptosporidiosis disappeared following oral LIG treatment. LIG treatment was also beneficial in 4 out of 5 GvHD patients. No serious side effects were recorded in any of the treated patients.

Electronic Resource