Search Results - (Author, Cooperation:P. Khil)

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  1. 1
    F. Pratto ; K. Brick ; P. Khil ; F. Smagulova ; G. V. Petukhova ; R. D. Camerini-Otero
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-11-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; *Chromosome Mapping ; *DNA Breaks, Double-Stranded ; Genome, Human/*genetics ; *Genomic Instability ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; *Homologous Recombination ; Humans ; Male ; Meiosis/*genetics ; Protein Binding ; Spermatocytes ; Telomere/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2012-06-23
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Female ; Gene Expression Regulation ; Gene Silencing ; Mice ; Monodelphis/*genetics/*metabolism ; RNA/*genetics/*metabolism ; Transgenes ; X Chromosome/*genetics/*metabolism ; *X Chromosome Inactivation
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    F. Smagulova ; I. V. Gregoretti ; K. Brick ; P. Khil ; R. D. Camerini-Otero ; G. V. Petukhova
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-04-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Chromosome Mapping/*methods ; Chromosome Segregation ; Chromosomes, Mammalian/*genetics ; Consensus Sequence ; Crossing Over, Genetic/genetics ; *DNA Breaks, Double-Stranded ; Genetic Markers ; Genome/*genetics ; Genomics ; Histones/metabolism ; Lysine/metabolism ; Male ; Meiosis/*genetics ; Methylation ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Nucleosomes/genetics/metabolism ; Organ Specificity ; Recombination, Genetic/*genetics ; Sister Chromatid Exchange/genetics ; Testis/metabolism ; Transcription, Genetic/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    K. Brick ; F. Smagulova ; P. Khil ; R. D. Camerini-Otero ; G. V. Petukhova
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-06-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Alleles ; Amino Acid Sequence ; Animals ; Base Sequence ; *DNA Breaks, Double-Stranded ; Genome/*genetics ; Histone-Lysine N-Methyltransferase/deficiency/genetics/*metabolism ; Histones/chemistry/metabolism ; Meiosis/genetics ; Methylation ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Promoter Regions, Genetic/*genetics ; Recombination, Genetic/*genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract Sequences of 45 long terminal repeats (LTRs) of the human endogenous retroviruses HERV-K family, precisely mapped by us earlier on human chromosome 19, were determined and a nearest-neighbour dendrogram was constructed. No correlation was observed between the degree of identity of the LTR pairs and their relative positions on the chromosome. Thus, sequences of distantly located LTRs, even positioned on different chromosome arms, could be highly similar to each other, whereas those of closely located LTRs could differ significantly. We conclude that the LTRs have randomly transposed across the chromosome in the course of evolution. The alignment of the LTR sequences allowed us to assign most of the LTRs to two major subfamilies. The LTRs belonging to the first subfamily (LTR-I) are characterised by higher intrasubfamily sequence divergence than those of the second subfamily (LTR-II). The two subfamilies are easily distinguished by the presence of characteristic deletions/insertions in the LTR sequences. The higher divergence of the first subfamily members suggests that their propagation started at earlier stages of evolution, probably soon after the insertion of their ancestral sequence into the primate genome. In turn, each of the subfamilies includes several distinct branches with various degrees of intragroup divergence and with characteristic diagnostic features, suggesting that the members of the branches represent amplified copies of particular master genes which had appeared at different periods of evolution. The sequences of the LTRs demonstrate a characteristic distribution of conservative and variable regions, indicating that the LTRs might have some sequence-dependent functions in the primate genome.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s004390050662

    Articles: DFG German National Licenses