Search Results - (Author, Cooperation:P. J. Talmud)

Showing 1 - 6 results of 6, query time: 0.20s Refine Results
  1. 1
    G. B. Ehret ; P. B. Munroe ; K. M. Rice ; M. Bochud ; A. D. Johnson ; D. I. Chasman ; A. V. Smith ; M. D. Tobin ; G. C. Verwoert ; S. J. Hwang ; V. Pihur ; P. Vollenweider ; P. F. O'Reilly ; N. Amin ; J. L. Bragg-Gresham ; A. Teumer ; N. L. Glazer ; L. Launer ; J. H. Zhao ; Y. Aulchenko ; S. Heath ; S. Sober ; A. Parsa ; J. Luan ; P. Arora ; A. Dehghan ; F. Zhang ; G. Lucas ; A. A. Hicks ; A. U. Jackson ; J. F. Peden ; T. Tanaka ; S. H. Wild ; I. Rudan ; W. Igl ; Y. Milaneschi ; A. N. Parker ; C. Fava ; J. C. Chambers ; E. R. Fox ; M. Kumari ; M. J. Go ; P. van der Harst ; W. H. Kao ; M. Sjogren ; D. G. Vinay ; M. Alexander ; Y. Tabara ; S. Shaw-Hawkins ; P. H. Whincup ; Y. Liu ; G. Shi ; J. Kuusisto ; B. Tayo ; M. Seielstad ; X. Sim ; K. D. Nguyen ; T. Lehtimaki ; G. Matullo ; Y. Wu ; T. R. Gaunt ; N. C. Onland-Moret ; M. N. Cooper ; C. G. Platou ; E. Org ; R. Hardy ; S. Dahgam ; J. Palmen ; V. Vitart ; P. S. Braund ; T. Kuznetsova ; C. S. Uiterwaal ; A. Adeyemo ; W. Palmas ; H. Campbell ; B. Ludwig ; M. Tomaszewski ; I. Tzoulaki ; N. D. Palmer ; T. Aspelund ; M. Garcia ; Y. P. Chang ; J. R. O'Connell ; N. I. Steinle ; D. E. Grobbee ; D. E. Arking ; S. L. Kardia ; A. C. Morrison ; D. Hernandez ; S. Najjar ; W. L. McArdle ; D. Hadley ; M. J. Brown ; J. M. Connell ; A. D. Hingorani ; I. N. Day ; D. A. Lawlor ; J. P. Beilby ; R. W. Lawrence ; R. Clarke ; J. C. Hopewell ; H. Ongen ; A. W. Dreisbach ; Y. Li ; J. H. Young ; J. C. Bis ; M. Kahonen ; J. Viikari ; L. S. Adair ; N. R. Lee ; M. H. Chen ; M. Olden ; C. Pattaro ; J. A. Bolton ; A. Kottgen ; S. Bergmann ; V. Mooser ; N. Chaturvedi ; T. M. Frayling ; M. Islam ; T. H. Jafar ; J. Erdmann ; S. R. Kulkarni ; S. R. Bornstein ; J. Grassler ; L. Groop ; B. F. Voight ; J. Kettunen ; P. Howard ; A. Taylor ; S. Guarrera ; F. Ricceri ; V. Emilsson ; A. Plump ; I. Barroso ; K. T. Khaw ; A. B. Weder ; S. C. Hunt ; Y. V. Sun ; R. N. Bergman ; F. S. Collins ; L. L. Bonnycastle ; L. J. Scott ; H. M. Stringham ; L. Peltonen ; M. Perola ; E. Vartiainen ; S. M. Brand ; J. A. Staessen ; T. J. Wang ; P. R. Burton ; M. Soler Artigas ; Y. Dong ; H. Snieder ; X. Wang ; H. Zhu ; K. K. Lohman ; M. E. Rudock ; S. R. Heckbert ; N. L. Smith ; K. L. Wiggins ; A. Doumatey ; D. Shriner ; G. Veldre ; M. Viigimaa ; S. Kinra ; D. Prabhakaran ; V. Tripathy ; C. D. Langefeld ; A. Rosengren ; D. S. Thelle ; A. M. Corsi ; A. Singleton ; T. Forrester ; G. Hilton ; C. A. McKenzie ; T. Salako ; N. Iwai ; Y. Kita ; T. Ogihara ; T. Ohkubo ; T. Okamura ; H. Ueshima ; S. Umemura ; S. Eyheramendy ; T. Meitinger ; H. E. Wichmann ; Y. S. Cho ; H. L. Kim ; J. Y. Lee ; J. Scott ; J. S. Sehmi ; W. Zhang ; B. Hedblad ; P. Nilsson ; G. D. Smith ; A. Wong ; N. Narisu ; A. Stancakova ; L. J. Raffel ; J. Yao ; S. Kathiresan ; C. J. O'Donnell ; S. M. Schwartz ; M. A. Ikram ; W. T. Longstreth, Jr. ; T. H. Mosley ; S. Seshadri ; N. R. Shrine ; L. V. Wain ; M. A. Morken ; A. J. Swift ; J. Laitinen ; I. Prokopenko ; P. Zitting ; J. A. Cooper ; S. E. Humphries ; J. Danesh ; A. Rasheed ; A. Goel ; A. Hamsten ; H. Watkins ; S. J. Bakker ; W. H. van Gilst ; C. S. Janipalli ; K. R. Mani ; C. S. Yajnik ; A. Hofman ; F. U. Mattace-Raso ; B. A. Oostra ; A. Demirkan ; A. Isaacs ; F. Rivadeneira ; E. G. Lakatta ; M. Orru ; A. Scuteri ; M. Ala-Korpela ; A. J. Kangas ; L. P. Lyytikainen ; P. Soininen ; T. Tukiainen ; P. Wurtz ; R. T. Ong ; M. Dorr ; H. K. Kroemer ; U. Volker ; H. Volzke ; P. Galan ; S. Hercberg ; M. Lathrop ; D. Zelenika ; P. Deloukas ; M. Mangino ; T. D. Spector ; G. Zhai ; J. F. Meschia ; M. A. Nalls ; P. Sharma ; J. Terzic ; M. V. Kumar ; M. Denniff ; E. Zukowska-Szczechowska ; L. E. Wagenknecht ; F. G. Fowkes ; F. J. Charchar ; P. E. Schwarz ; C. Hayward ; X. Guo ; C. Rotimi ; M. L. Bots ; E. Brand ; N. J. Samani ; O. Polasek ; P. J. Talmud ; F. Nyberg ; D. Kuh ; M. Laan ; K. Hveem ; L. J. Palmer ; Y. T. van der Schouw ; J. P. Casas ; K. L. Mohlke ; P. Vineis ; O. Raitakari ; S. K. Ganesh ; T. Y. Wong ; E. S. Tai ; R. S. Cooper ; M. Laakso ; D. C. Rao ; T. B. Harris ; R. W. Morris ; A. F. Dominiczak ; M. Kivimaki ; M. G. Marmot ; T. Miki ; D. Saleheen ; G. R. Chandak ; J. Coresh ; G. Navis ; V. Salomaa ; B. G. Han ; X. Zhu ; J. S. Kooner ; O. Melander ; P. M. Ridker ; S. Bandinelli ; U. B. Gyllensten ; A. F. Wright ; J. F. Wilson ; L. Ferrucci ; M. Farrall ; J. Tuomilehto ; P. P. Pramstaller ; R. Elosua ; N. Soranzo ; E. J. Sijbrands ; D. Altshuler ; R. J. Loos ; A. R. Shuldiner ; C. Gieger ; P. Meneton ; A. G. Uitterlinden ; N. J. Wareham ; V. Gudnason ; J. I. Rotter ; R. Rettig ; M. Uda ; D. P. Strachan ; J. C. Witteman ; A. L. Hartikainen ; J. S. Beckmann ; E. Boerwinkle ; R. S. Vasan ; M. Boehnke ; M. G. Larson ; M. R. Jarvelin ; B. M. Psaty ; G. R. Abecasis ; A. Chakravarti ; P. Elliott ; C. M. van Duijn ; C. Newton-Cheh ; D. Levy ; M. J. Caulfield ; T. Johnson
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-09-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa/ethnology ; Asia/ethnology ; Blood Pressure/*genetics/physiology ; Cardiovascular Diseases/*genetics ; Coronary Artery Disease/genetics ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Humans ; Hypertension/genetics ; Kidney Diseases/genetics ; Polymorphism, Single Nucleotide/*genetics ; Stroke/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-02-14
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    1942-325X
    Electronic ISSN:
    1942-3268
    Topics:
    Medicine
    Keywords:
    Arrhythmias, Electrophysiology, Functional Genomics
    Published by:
    http://www.americanheart.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] A specific genetic factor that strongly influences human physical performance has not so far been reported, but here we show that a polymorphism in the gene encoding angiotensin-converting enzyme does just that. An ‘insertion’ allele of the gene is associated with elite endurance ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/30374

    Articles: DFG German National Licenses
  4. 4
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Keywords Polymorphism ; Type II diabetes ; nuclear receptors ; PPARα ; dyslipidaemia.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Aims/hypothesis. Peroxisome proliferator activated receptor alpha (PPARα) regulates genes involved in lipid metabolism, haemostasis and inflammation, in response to fatty acids and fibrates, making it a candidate gene for risk of dyslipidaemia, atherosclerosis and coronary artery disease. Plasma non-esterified fatty acids are increased in subjects with Type II (non-insulin-dependent) diabetes mellitus, suggesting that PPARα could link Type II diabetes and dyslipidaemia, and affect response to fibrates. This has been investigated in association studies in healthy and diabetic subjects and in vitro studies. Methods. The human PPARα gene was isolated and screened for variation by single strand conformation polymorphism analysis. Genotypes were determined for 129 Type II diabetic subjects and 2508 healthy men. The association with plasma lipid concentrations was examined. The function of the V162 variant was examined in co-transfection assays. Results. We identified two polymorphisms, one in intron 3 and a missense mutation, leucine 162 to valine, in the DNA binding domain. In Type II diabetic patients, V162 allele carriers had higher total cholesterol, HDL cholesterol and apoAI whereas intron 3 rare allele carriers had higher apoAI concentrations. By contrast, no effect was observed in healthy rare allele carriers. In vitro, the V162 variant showed greater transactivation of a reporter gene construct. Conclusion/interpretation. Naturally occurring variation alters PPARα function, influencing plasma lipid concentrations in Type II diabetic patients but not healthy people. This demonstrates that PPARα is a link between diabetes and dyslipidaemia, and so could influence the risk of coronary artery disease, the greatest cause of morbidity and mortality in Type II diabetes. [Diabetologia (2000) 43: 673–680]
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s001250051357

    Articles: DFG German National Licenses
  5. 5
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary We have used four independently isolated cDNA probes for human apolipoprotein B (apo B), to isolate overlapping genomic recombinants for the 3′ portion of the apo B gene. The cDNA clones and a unique fragment from the genomic recombinant have been used to identify the human apo B gene in DNA from a series of roden x human somatic cell hybrids. Our results provide evidence for the assignment of this gene to the short arm of human chromosome 2 (p23-pter). We have used the cDNA probes to identify three common DNA polymorphisms. The first, detected with the restriction enzyme XbaI and our probe pAB4, has a rare allele frequency of 0.48. The other two polymorphisms are detected with the probe pAB3. The enzyme MspI detects at least three alleles, with frequencies of 0.67, 0.16 and 0.15, while that detected with the enzyme EcoRI has a rare allele frequency of 0.12. The relative position of these polymorphisms has been mapped using the genomic recombinants.Investigation of a small number of haplotypes indicares that there is linkage equilibrium between the polymorphisms, which have a total polymorphism information content (PIC) value of more than 0.8. These polymorphisms will provide useful markers for genetic studies on chromosome 2 and for the analysis of the involvement of variants of the apo B gene in the development of hyperlipidaemia.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00279093

    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Summary We report a common DNA polymorphism of the apolipoprotein E (apo E) gene detected with the enzyme HpaI. In an individual who is heterozygous for the polymorphism, two hybridising fragments of DNA, one of 50 kb (the H1 allele) and one of 20 kb (the H2 allele) are detected. In 54 controls the frequency of the rare allele is 0.38 (PIC value 0.36). We have also studied the frequency of the polymorphism in normolipidaemic and hyperlipidaemic individuals whose apo E protein typing is known. In 39 individuals with type III hyperlipidaemia and the apo E phenotype E2E2, the frequency of the H2 allele is 0.97. In contrast, the frequency of the H2 allele in normolipidaemic individuals with the E2E2 phenotype is closer to that found in the general population. Possible explanations for this are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00281067

    Articles: DFG German National Licenses