Search Results - (Author, Cooperation:P. J. Conn)

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  1. 1
    H. Wu ; C. Wang ; K. J. Gregory ; G. W. Han ; H. P. Cho ; Y. Xia ; C. M. Niswender ; V. Katritch ; J. Meiler ; V. Cherezov ; P. J. Conn ; R. C. Stevens
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-03-08
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Allosteric Regulation ; Allosteric Site ; Amino Acid Sequence ; Benzamides/*chemistry/*metabolism ; Binding Sites ; Cholesterol ; Crystallography, X-Ray ; Humans ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Models, Molecular ; Molecular Sequence Data ; Mutation ; Protein Conformation ; Protein Multimerization ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, Metabotropic Glutamate/*chemistry/*metabolism ; Structure-Activity Relationship ; Thiazoles/*chemistry/*metabolism
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-04-11
    Publisher:
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Print ISSN:
    0026-895X
    Electronic ISSN:
    1521-0111
    Topics:
    Chemistry and Pharmacology
    Medicine
    Published by:
    http://www.aspet.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Gogliotti, R. G., Fisher, N. M., Stansley, B. J., Jones, C. K., Lindsley, C. W., Conn, P. J., Niswender, C. M.
    The American Society for Pharmacology and Experimental Therapeutics
    Published 2018
    Staff View
    Publication Date:
    2018-03-30
    Publisher:
    The American Society for Pharmacology and Experimental Therapeutics
    Print ISSN:
    0022-3565
    Electronic ISSN:
    1521-0103
    Topics:
    Medicine
    Published by:
    http://www.aspet.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Conn, P. J. ; Sanders-Bush, E.
    Springer
    Published 1987
    Staff View
    ISSN:
    1432-2072
    Keywords:
    Serotonin ; Serotonin receptors ; Serotonin binding sites ; Adenylate cyclase ; Phosphoinositide hydrolysis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Radioligand binding studies have revealed four distinct serotonin (5HT) binding sites in rat brain that are thought to function as 5HT receptors. These include the 5HT-1a, 5HT-1b, 5HT-1c, and 5HT-2 binding sites. Studies have shown that the 5HT-2 binding site mediates a number of effects of 5HT agonists and serves as a 5HT receptor in neuronal and non-neuronal tissues. The 5HT-2 site employs phosphoinositide hydrolysis for signal transduction. The 5HT-1c binding site is also a functional receptor that is linked to phosphoinositide hydrolysis. However, the physiological role of the 5HT-1c receptor is not yet known. Lack of appropriate pharmacological tools for probing the 5HT-1a and 5HT-1b binding sites has made it difficult to definitively determine whether these binding sites are coupled to biochemical effector systems or mediate any of the physiological responses to 5HT agonists. However, there is some evidence that the 5HT-1a site is coupled to adenylate cyclase, and a number of functional roles for the 5HT-1a and 5HT-1b sites have been proposed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00210830

    Articles: DFG German National Licenses