Search Results - (Author, Cooperation:P. J. Baker)

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  1. 1
    Staff View
    Publication Date:
    2011-11-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Motifs ; Animals ; Bacterial Proteins/*chemistry/genetics/metabolism/*toxicity ; Bacterial Toxins/*chemistry/genetics/metabolism/*toxicity ; Burkholderia pseudomallei/*chemistry/*pathogenicity ; Catalytic Domain ; Cell Line ; Crystallography, X-Ray ; Cytotoxins/chemistry/genetics/metabolism/toxicity ; Escherichia coli Proteins/chemistry ; Eukaryotic Initiation Factor-4A/*antagonists & inhibitors/metabolism ; Glutamine/metabolism ; Humans ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Mutant Proteins/toxicity ; Peptide Chain Initiation, Translational/drug effects ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-03-16
    Publisher:
    Institute of Physics (IOP)
    Print ISSN:
    1748-9318
    Electronic ISSN:
    1748-9326
    Topics:
    Biology
    Energy, Environment Protection, Nuclear Power Engineering
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-04-05
    Publisher:
    Royal Society
    Electronic ISSN:
    2054-5703
    Topics:
    Natural Sciences in General
    Keywords:
    medicinal chemistry, organic chemistry
    Published by:
    http://royalsocietypublishing.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2011-04-02
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2014-01-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Aging/metabolism ; Biomass ; *Body Size ; Carbon/*metabolism ; *Carbon Cycle ; Climate ; Geography ; Models, Biological ; Plant Leaves/growth & development/metabolism ; Sample Size ; Species Specificity ; Time Factors ; Trees/*anatomy & histology/classification/growth & development/*metabolism ; Tropical Climate
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Al-Fayez, M. ; Russell, D. ; Wayne Davies, R. ; Shiels, P. G. ; Baker, P. J. ; Payne, A. P.

    Oxford, UK : Blackwell Publishing Ltd
    Published 2005
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The AS/AGU rat carries a recessive mutation (agu) in the gene coding for the gamma isoform of protein kinase C. The rat is characterized by disordered locomotion and progressive dysfunction of the nigrostriatal dopaminergic (DA) system. This dysfunction begins with a failure to release DA within the striatum and culminates in cell loss within the substantia nigra pars compacta. The present study examines another midbrain aminergic system with input to the basal ganglia, the serotonergic (5-HT) raphe–striatal system originating in the dorsal raphe nucleus. By 3 months after birth, there is a very substantial reduction in the extracellular levels of 5-HT in the dorsal caudate-putamen of the mutants compared with controls (c. 70%). This is accompanied by a proportional increase in the levels of the 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA). At a later age, there are reductions in whole tissue 5-HT (and increases in 5-HIAA) in both the striatum and the region containing the dorsal raphe nucleus, as well as numbers of 5-HT-immunoreactive cells in the dorsal raphe nucleus. The median raphe appears to be unaffected. The results are seen in terms of an initial dysfunction in transmitter release leading to cell death, perhaps through the formation of free radicals or neurotoxins.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-9568.2005.04502.x

    Articles: DFG German National Licenses
  7. 7
    Baker, P. J. ; Coburn, R. A. ; Genco, R. J. ; Evans, R. T.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1978
    Staff View
    ISSN:
    1600-0765
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Several cationic, mixed and amphoteric surfactants were tested for their antimicrobial activity and ability to inhibit the formation of in vitro plaque by oral microorganisms. All had antimicrobial activity against Actinomyces viscosus. Actinomyces naeslundii and Streptococcus mutans. Cationic surfactants were comparable to chlorhexidine in antimicrobial activity but were less effective in inhibiting plaque formation. Amphoteric surfactants were less effective than other detergents in antibacterial activity and had very limited capacity for the inhibition of plaque formation. Comparison of drug structure provides evidence that surfactant substantivity to saliva-coated enamel is a cation active process. Saliva was found to have an antagonistic effect on the activity of cetylpyridinium chloride but not on Triburon.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0765.1978.tb00200.x

    Articles: DFG German National Licenses
  8. 8
    Baker, P. J. ; Amsbaugh, Diana F. ; Prescott, B. ; Stashak, P. W.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1976
    Staff View
    ISSN:
    1744-313X
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Medicine
    Notes:
    Recombinant-inbred strains of mice, as well as the progenitor strains from which they were derived, were evaluated with respect to the capacity of B cells to respond to an optimally immunogenic dose of Type III pneumococcal polysaccharide (SSS-III) and the amount of suppressor and amplifier T cell activity present. None of these functional activities was found to be linked to genes within the major histocompatibility (H-2) or the IgCH allotype complex, and several autosomal genes appeared to govern the expression of each of these characteristics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1744-313X.1976.tb00584.x

    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1476-5535
    Keywords:
    Keywords: echinocandin B deacylase; substrate specificity; evolution/technology; antifungal agent
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Aspergillus nidulans produces echinocandin B, a neutral lipopeptide. A deacylase from Actinoplanes utahensis catalyzes cleavage of the linoleoyl group from echinocandin B, a key step in generating a potential antifungal agent. Virtually all (99.8%) deacylase activity was cell-associated. The deacylase was salt-solubilized, heat-treated and purified to apparent homogeneity by a 3-step chromatographic procedure. The enzyme was a heterodimer consisting of 63- and 18-to-20-kDa subunit, optimally active at pH 6.0, and at 60°C with salt. The K m of the deacylase for echinocandin B was 50 μM and its V max was 14.6 μmol cyclic hexapeptide min−1 mg−1protein. The substrate specificity of the enzyme was broad with respect to both acyl and cyclic peptide analogues of echinocandin B. The two deacylase subunit genes were cloned and over-expressed in Streptomyces lividans. The recombinant deacylase was purified from the culture filtrate to apparent homogeneity by a 1-step chromatographic procedure. Using the recombinant deacylase, an enzymatic deacylation of immobilized echinocandin B resulted in the generation of cyclic hexapeptide at gram-level. Journal of Industrial Microbiology & Biotechnology (2000) 24, 173–180.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/sj.jim.2900796

    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1476-5535
    Keywords:
    Keywords: raloxifene; glucuronidation; Streptomyces sp NRRL 21489
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Process Engineering, Biotechnology, Nutrition Technology
    Notes:
    Raloxifene, also known as Evista®, has recently been approved for the prevention of osteoporosis. Three glucuronidated compounds: raloxifene-6-glucuronide, raloxifene-27-glucuronide, and raloxifene-6,27-diglucuronide are known metabolites of raloxifene in man. Reference standards of the three glucuronides were needed for clinical trials. Although chemical routes exist to make the two mono-glucuronides, these routes were unable to provide material to meet the needs of clinical trial standards. No chemical route existed to synthesize the di-glucuronide. A bioconversion process using the microorganism Streptomyces sp NRRL 21489 was identified and scaled up. The biotranformation products were prepared in a tank fermentation, purified, and characterized by UV, LC/MS and NMR spectroscopy.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/sj.jim.2900716

    Articles: DFG German National Licenses