Search Results - (Author, Cooperation:P. Gordon)

2018-01-03

Rockefeller University Press

0022-1007

1540-9538

Medicine

Metabolism

2018-06-27

National Academy of Sciences

0027-8424

1091-6490

Biology

Medicine

Natural Sciences in General

2011-11-19

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antimalarials/chemistry/pharmacokinetics/*pharmacology/therapeutic use ; Cell Line, Tumor ; *Drug Discovery ; Drug Evaluation, Preclinical ; Drug Resistance ; Erythrocytes/parasitology ; Humans ; Imidazoles/chemistry/pharmacokinetics/*pharmacology/therapeutic use ; Liver/*parasitology ; Malaria/*drug therapy/parasitology/prevention & control ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Piperazines/chemistry/pharmacokinetics/*pharmacology/therapeutic use ; Plasmodium/cytology/*drug effects/growth & development/physiology ; Plasmodium berghei/cytology/drug effects/growth & development/physiology ; Plasmodium falciparum/cytology/drug effects/growth & development/physiology ; Plasmodium yoelii/cytology/drug effects/growth & development/physiology ; Polymorphism, Single Nucleotide ; Protozoan Proteins/chemistry/genetics/metabolism ; Random Allocation ; Small Molecule Libraries ; Sporozoites/drug effects/growth & development

2018-12-14

American Chemical Society (ACS)

0002-7863

1520-5126

Chemistry and Pharmacology

book

2023

Entwicklungspsychologie ; Jugendpsychologie ; Persönlichkeitsentwicklung ; Rollenspiel ; Soziale Beziehung ; Jugend ; Jugendsoziologie ; Digitale Medien ; Medien ; Medienethik ; Mediennutzung ; Medienpsychologie ; Mediensoziologie ; Medienwirkung ; Jugendschutz ; Mobbing ; Soziale Software ; Suchtgefährdung ; Cyberspace ; Jugendgefährdung ; Diskussion ; Risiko ; Jugendlicher

English

article

2009

Organisationswandel ; Didaktik ; Lehrplan ; Nachhaltige Entwicklung ; Ausbildung ; Studium ; Betriebswirtschaftslehre ; Führungskraft

Journal of management education, Bd. 33 (2009) H. 3, S. 296-322, 1052-5629

English

1550-7408

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Tritrichomonas foetus, Pentatrichomonas gallinarum, and nasal and fecal forms of Trichomonas suis grew well in NIH Thioglycollate Broth with 1% beef serum, and produced acid end-products. Succinic acid was the major acid produced by T. foetus P. gallinarum, and the nasal T. suis, accounting for over 50% of the total acid for each. The fecal T. suis produced more lactic than succinic acid; about 45% of the total acid was not accounted for. Pyruvic acid was found in small amounts in all cultures. The lactic/pyruvic ratio was about 2.5 for the two swine forms, and about 1.0 for the other two. The nasal form of T. suis produced much more total acid than the others.O2 uptake, CO2 production, H2 evolution, and anaerobic acid formation varied with age of organism. Respiratory activity was highest at 12 hours but varied considerably thereafter. The nature of the buffer used in manometric experiments also affected the results.Glucose, mannose, fructose and galactose most stimulated respiration. Disaccharides were slowly utilized (lactose and sucrose were not used by P. gallinarum). In a few cases lactate, pyruvate, formate, and malate stimulated O2 uptake.Evidence was obtained for hexokinase, phosphohexoisomer-ase, phosphofructokinase, aldolase, and glucose-6-phcsphate dehydrogenase in all 4 organisms. Phosphoglucomutase was demonstrated in T. foetus and the fecal T. suis. T. foetus and P. gallinarum showed evidence of phosphoglyceromutase and enolase. T. suis (fecal) and P. gallinarum had malic dehydrogenase, and P. gallinarum gave evidence of “malic enzyme” activity. Formic dehydrogenase activity was marked in all and presumptive evidence for a formic hydrogenlyase system was obtained for T. foetus and P. gallinarum.Study of reactions involving pyruvate and malate (with a possible linkage to a hexose monophosphate shunt) might perhaps provide a key to a better understanding of trichmonad metabolism.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Details are given of a new organic electro-optic crystal, 3-(1,1-dicyanoethenyl)-1-phenyl-4,5-dihydro-1H-pyrazole, having a reduced half-wave voltage of 370 V (approximately 8 times lower than lithium niobate). The molecular design, synthesis, and molecular characterization of this compound are outlined and a description is given of growth of 1-cm dimension crystals. These crystals have been characterized in terms of their structure, linear optical properties (refractive index, orientation of optical axes, absorption spectra), and also of their linear electro-optic (Pockels) effect. The compound crystallizes in the noncentrosymmetric space group Cc, with the molecules showing a high degree of parallelism. This structure is discussed in terms of the applicability of the crystals to different nonlinear optical effects. Calculated molecular hyperpolarizabilities are used, in conjunction with the determined crystal structure, to estimate the coefficients of the crystalline χ(2) tensor, which is dominated by the single coefficient χ333. The related dominant electro-optic coefficient, r333, is measured to be 8.7×10−11 m/V.

Electronic Resource

1471-0528

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1600-0536

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1467-9639

Blackwell Publishing Journal Backfiles 1879-2005

Mathematics

All introductory statistics students must master certain basic descriptive statistics, including means, standard deviations and correlations. Students must also gain insight into such complex concepts as the central limit theorem and standard error. This article introduces and describes the Friendly Introductory Statistics Help (FISH) computer program, which is free and easy-to-use software designed to help students learn such introductory statistical concepts.

Electronic Resource

1095-9270

Blackwell Publishing Journal Backfiles 1879-2005

Archaeology

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1745-9125

Blackwell Publishing Journal Backfiles 1879-2005

Law

This study examines the relationship between assessments of the risk of punishment and self-reported involvement in three illegal behaviors in a sample of college-aged respondents. It is found that those respondents who had not yet committed a particular offense were more likely to perceive a greater certainty of punishment than those with experience in committing the offense. For two of three offenses the effect of becoming involved in offending had a more substantial impact on the perceptions of those respondents with both experience in offending and high perceived certainty of punishment than on those who had experience and less pessimistic estimates of risk Finally, a multivariate analysis of the relationship between behavioral and perceptual change reveals that each variable affects the other even when other sources of change are controlled. The importance of the findings for the deterrence doctrine are discussed.

Electronic Resource

1745-9125

Blackwell Publishing Journal Backfiles 1879-2005

Law

Electronic Resource

1745-9125

Blackwell Publishing Journal Backfiles 1879-2005

Law

Electronic Resource

1600-0625

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Contact dermatitis (CD) is a frequent dermatological disease with a high socioeconomical impact characterized by acute to chronic inflammation of the skin, often leading to therapy-resistent eczema. Proteinase-activated receptor-2 (PAR-2), a G-protein-coupled receptor for certain serine proteases, is localized on keratinocytes, endothelial cells, and nerve fibers and has been demonstrated to play a role during inflammation of several tissues. However, the precise role of PAR-2 and the underlying mechanism of PAR-2-induced regulation of inflammation are still fragmentary. Therefore, we were interested in whether or not PAR-2 is involved in cutaneous inflammation using a model of experimentally induced allergic (ACD) and irritant (ICD) contact dermatitis. In wild-type (PAR-2+/+) mice, PAR-2 agonists induced an increased intradermal edema and enhanced plasma extravasation with a maximum between 3 and 24 h. These inflammatory responses were significantly diminished in PAR-2-deficient (PAR2–/–) mice and controls (vehicle). Morphological analysis revealed a dramatic increase of spongiosis and intradermal edema along with enhanced infiltration of neutrophils and monocytes in PAR-2+/+ mice as compared with PAR-2–/– mice. Interestingly, nitric oxide (NOS) inhibitors significantly diminished these effects, indicating a role of NO in PAR-2-induced inflammatory responses of the skin. Functional studies at the RNA and protein level further revealed PAR-2-induced upregulation of the cell adhesion molecules ICAM-1 and E-selectin by dermal microvascular endothelial cells during inflammation, suggesting that PAR-2 directly regulates cell adhesion molecule function during skin inflammation. PAR-2 agonists also stimulated upregulation of mediators involved in cutaneous inflammatory responses such as IL-6 and NO in murine and human (dermal) endothelial cells. Together, these results strongly suggest a proinflammatory role of PAR-2 during CD and probably other inflammatory dermatoses, especially during the early phase characterized by edema, plasma extravasation, and recruitment of inflammatory cells to the site of inflammation. Thus, PAR-2 antagonists may be therapeutic tools for the treatment of inflammatory skin disorders such as contact dermatitis and atopic eczema.

Electronic Resource

1365-2958

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Medicine

The nucleotide sequence of region 2 of the Escherichia coli K5 capsule gene cluster has been determined. This region, essential for the biosynthesis of the K5 poly-saccharide, contained four genes, termed kfiA-D. The G+C ratio was 33.4%, which was lower than the typical G+C ratio for E. coli and that of the flanking regions 1 and 3 in the K5 capsule gene cluster. Three major RNA transcripts were detected within region 2 by Northern blotting and three promoters located by transcript mapping. Promoter activity was confirmed by promoter-probe analysis. The predicted amino acid sequence of KfiC had homology to a number of glycosyl transferase enzymes and overexpression of the kfiC gene resulted in increased K5 transferase activity. The predicted amino acid sequence of KfiD had homology to a number of NAD-dependent dehydrogenase enzymes and was demonstrated to be a UDP-glucose dehydrogenase that catalyses the formation of UDP-glucuronic acid from UDP-glucose.

Electronic Resource

1600-0765

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

y-seven children, aged 13 yr, were asked to brush their teeth in school and were unaware that their toolhbrushing was being recorded on tape. Plaque levels [Plaque Index] were recorded after brushing. By repealed viewing of the tapes on a monitor, the total brushing time and the number of brushing strokes used in each of 12 areas of the dentition were obtained. The mean total brushing time (±SD) was 51.1 s (±15.4). The number of brushing strokes used in each of the 12 areas of the mouth varied widely, both within and between areas, and correlated poorly with plaque levels after brushing. In only one area (maxillary right posterior buccal) was a statistically significant negative correlation observed, and less plaque (p〈0.05) found in subjects who brushed this area with 〉 10 strokes compared with subjects who brushed with 〈 10 strokes. This study emphasises the need for proper toodibrushing instruction in schoolage children.

Electronic Resource