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1M. W. Carroll ; D. A. Matthews ; J. A. Hiscox ; M. J. Elmore ; G. Pollakis ; A. Rambaut ; R. Hewson ; I. Garcia-Dorival ; J. A. Bore ; R. Koundouno ; S. Abdellati ; B. Afrough ; J. Aiyepada ; P. Akhilomen ; D. Asogun ; B. Atkinson ; M. Badusche ; A. Bah ; S. Bate ; J. Baumann ; D. Becker ; B. Becker-Ziaja ; A. Bocquin ; B. Borremans ; A. Bosworth ; J. P. Boettcher ; A. Cannas ; F. Carletti ; C. Castilletti ; S. Clark ; F. Colavita ; S. Diederich ; A. Donatus ; S. Duraffour ; D. Ehichioya ; H. Ellerbrok ; M. D. Fernandez-Garcia ; A. Fizet ; E. Fleischmann ; S. Gryseels ; A. Hermelink ; J. Hinzmann ; U. Hopf-Guevara ; Y. Ighodalo ; L. Jameson ; A. Kelterbaum ; Z. Kis ; S. Kloth ; C. Kohl ; M. Korva ; A. Kraus ; E. Kuisma ; A. Kurth ; B. Liedigk ; C. H. Logue ; A. Ludtke ; P. Maes ; J. McCowen ; S. Mely ; M. Mertens ; S. Meschi ; B. Meyer ; J. Michel ; P. Molkenthin ; C. Munoz-Fontela ; D. Muth ; E. N. Newman ; D. Ngabo ; L. Oestereich ; J. Okosun ; T. Olokor ; R. Omiunu ; E. Omomoh ; E. Pallasch ; B. Palyi ; J. Portmann ; T. Pottage ; C. Pratt ; S. Priesnitz ; S. Quartu ; J. Rappe ; J. Repits ; M. Richter ; M. Rudolf ; A. Sachse ; K. M. Schmidt ; G. Schudt ; T. Strecker ; R. Thom ; S. Thomas ; E. Tobin ; H. Tolley ; J. Trautner ; T. Vermoesen ; I. Vitoriano ; M. Wagner ; S. Wolff ; C. Yue ; M. R. Capobianchi ; B. Kretschmer ; Y. Hall ; J. G. Kenny ; N. Y. Rickett ; G. Dudas ; C. E. Coltart ; R. Kerber ; D. Steer ; C. Wright ; F. Senyah ; S. Keita ; P. Drury ; B. Diallo ; H. de Clerck ; M. Van Herp ; A. Sprecher ; A. Traore ; M. Diakite ; M. K. Konde ; L. Koivogui ; N. Magassouba ; T. Avsic-Zupanc ; A. Nitsche ; M. Strasser ; G. Ippolito ; S. Becker ; K. Stoecker ; M. Gabriel ; H. Raoul ; A. Di Caro ; R. Wolfel ; P. Formenty ; S. Gunther
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-18Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2P. Ruibal ; L. Oestereich ; A. Ludtke ; B. Becker-Ziaja ; D. M. Wozniak ; R. Kerber ; M. Korva ; M. Cabeza-Cabrerizo ; J. A. Bore ; F. R. Koundouno ; S. Duraffour ; R. Weller ; A. Thorenz ; E. Cimini ; D. Viola ; C. Agrati ; J. Repits ; B. Afrough ; L. A. Cowley ; D. Ngabo ; J. Hinzmann ; M. Mertens ; I. Vitoriano ; C. H. Logue ; J. P. Boettcher ; E. Pallasch ; A. Sachse ; A. Bah ; K. Nitzsche ; E. Kuisma ; J. Michel ; T. Holm ; E. G. Zekeng ; I. Garcia-Dorival ; R. Wolfel ; K. Stoecker ; E. Fleischmann ; T. Strecker ; A. Di Caro ; T. Avsic-Zupanc ; A. Kurth ; S. Meschi ; S. Mely ; E. Newman ; A. Bocquin ; Z. Kis ; A. Kelterbaum ; P. Molkenthin ; F. Carletti ; J. Portmann ; S. Wolff ; C. Castilletti ; G. Schudt ; A. Fizet ; L. J. Ottowell ; E. Herker ; T. Jacobs ; B. Kretschmer ; E. Severi ; N. Ouedraogo ; M. Lago ; A. Negredo ; L. Franco ; P. Anda ; S. Schmiedel ; B. Kreuels ; D. Wichmann ; M. M. Addo ; A. W. Lohse ; H. De Clerck ; C. Nanclares ; S. Jonckheere ; M. Van Herp ; A. Sprecher ; G. Xiaojiang ; M. Carrington ; O. Miranda ; C. M. Castro ; M. Gabriel ; P. Drury ; P. Formenty ; B. Diallo ; L. Koivogui ; N. Magassouba ; M. W. Carroll ; S. Gunther ; C. Munoz-Fontela
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: CTLA-4 Antigen/metabolism ; Ebolavirus/*immunology ; Female ; Flow Cytometry ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/*immunology/mortality/*physiopathology ; Humans ; Inflammation Mediators/immunology ; Longitudinal Studies ; Lymphocyte Activation ; Male ; Patient Discharge ; Programmed Cell Death 1 Receptor/metabolism ; Survivors ; T-Lymphocytes/*immunology/metabolism ; Viral LoadPublished by: -
3M. Woolhouse ; P. Drury ; C. Dye
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-12-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Communicable Disease Control ; Epidemics/*prevention & control ; Epidemiological Monitoring ; *Global Health ; Hemorrhagic Fever, Ebola/epidemiology/physiopathology/prevention & control ; Humans ; Interdisciplinary Communication ; *International Agencies ; *International CooperationPublished by: -
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ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A case is presented in which unexpected and persistent postoperative respiratory problems led to the finding of bilateral abductor vocal cord paralysis and confirmed the diagnosis of the Shy-Drager syndrome. Anaesthetists should be aware that vocal cord paralysis may be a feature of this uncommon condition, and should consider the possibility of glottic obstruction as a cause of ventilatory difficulties.Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0307-4412Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
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ISSN: 1432-0428Keywords: Type 1 diabetes ; angiotensin II ; blood pressure ; vasopressorSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The blood pressure response to infused angiotensin II (0.3 to 3 ng · kg−1 · min −1) was investigated in six normotensive patients with Type 1 (insulin-dependent) diabetes free of complications and in six healthy subjects matched for age, sex and weight. Basal blood pressures (111/68 and 114/72 mmHg) and basal plasma angiotensin II levels (18.0±5.2 and 14.1±2.4 pmol/l; mean + SD) were similar in the diabetic and control groups as were 24 h urinary excretions of sodium (157±88 and 154±84 mmol/24h). Equal increments in plasma angiotensin II were produced during the infusions in the two groups. Increases in both diastolic and systolic blood pressure were significantly greater in the diabetic patients throughout the infusion. Mean diastolic increments were: 6.7 versus 1.3 mmHg (0.3 ng dose), 11.0 versus 6.9 mmHg (1 ng dose) and 16.7 versus 12.3 mmHg (3 ng dose) (p〈0.001). Corresponding figures for systolic pressure were: 8.7 versus 1.3mmHg, 10.3 versus 3.7mmHg and 15.3 versus 8.7mmHg (p〈0.001). Vasopressor responsiveness to angiotensin II is thus increased in Type 1 diabetic patients without complications; it may, therefore, be a consequence of the diabetes rather than of the presence of microvascular disease or hypertension.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0428Keywords: Blood pressure ; Type 1 (insulin-dependent) diabetes ; nephropathy ; albumin excretion ; hereditary factorsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Blood pressure has been measured by a single observer using a standardised technique in 163 Type 1 (insulin-dependent) diabetic patients aged 4 to 32 years, 232 of their non-diabetic siblings in the same age range and in 292 of their natural parents. Results for each sex were examined separately by analysis of variance. Systolic pressures were not significantly different overall nor in any single 4-year age band. In contrast, phase IV diastolic pressure was slightly but significantly higher in the diabetic males than in their sibling group overall (increment= +2.8 mmHg; p〈0.03), a difference also shown individually within the 16–20 year age band (81.3 versus 76.5 mmHg, p〈0.025). There were no significant differences in diastolic pressure between the female groups, and no effect of duration of diabetes on blood pressure was shown in either sex. Eighteen of 97 male diabetic patients (19%) had mean blood pressures above the 90th centile for age, derived from the sibling data, compared with 12 of 137 siblings (9%, p=0.05). The higher blood pressures among the diabetic males could not be explained solely by early nephropathy; familial factors appeared to be important in the determination of elevated blood pressure in this group as well as in the siblings. Alone, these small differences in blood pressure are unlikely to make a major contribution to the incidence of diabetic vascular disease, but the isolated increase in diastolic pressure may indicate altered vascular regulation in Type 1 diabetes.Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-0428Keywords: Type 1 diabetes ; Type 2 diabetes ; hypertension ; epidemiology ; obesity ; diabetic complications ; nephropathy ; retinopathy ; sodium ; renin ; catecholamines ; peripheral vascular disease ; antihypertensive drugsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The epidemiology, pathogenesis, significance and management of hypertension in diabetic subjects are discussed. In Type 1 diabetes the presence of diastolic hypertension is closely related to the presence of diabetic nephropathy, from the stage of persistent proteinuria onwards. There may also be some elevation of systolic pressure. The apparent increased prevalence of hypertension in Type 2 diabetes is largely explicable, directly or indirectly, by obesity but there may be an excess of systolic hypertension among elderly patients. Hypertension in the diabetic population is associated with an increased incidence of both microvascular and macrovascular complications, but whether the high blood pressure is causal is not clear. The possible roles of sodium and insulin, the renin-angiotensin system, catecholamines and physical factors are explored. All current antihypertensive agents have additional limitations and disadvantages when used in diabetic patients: diuretics and beta-blockers are probably the initial drugs of choice. Only in the case of diabetic nephropathy is there yet reasonable evidence of antihypertensive treatment reducing the rate of progression of the disease.Type of Medium: Electronic ResourceURL: