Search Results - (Author, Cooperation:P. D. Nguyen)

2016-05-21

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

2014-08-15

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Aorta/cytology/embryology ; Biomarkers/analysis ; Cell Movement ; Chemokine CXCL12/analysis/metabolism ; Chick Embryo ; Endothelial Cells/*cytology/metabolism ; Hematopoietic Stem Cells/*cytology/metabolism ; Homeodomain Proteins/analysis/genetics/*metabolism ; Humans ; Mice ; Muscles/cytology/metabolism ; Mutation/genetics ; Somites/*cytology/metabolism ; Transcription Factors/analysis/genetics/*metabolism ; Wnt Proteins/analysis/metabolism ; Zebrafish/embryology/metabolism ; Zebrafish Proteins/analysis/genetics/*metabolism

2018-04-14

The Company of Biologists

0950-1991

1477-9129

Biology

Stem cells & regeneration

1432-2072

Key words Acquisition ; Drug self-administration ; Oral phencyclidine ; PCP ; Rhesus monkey ; Sex

Springer Online Journal Archives 1860-2000

Medicine

Abstract  Rationale: There are increasing reports of sex differences in the etiology of drug abuse in humans. A nonhuman primate model is useful for examining sex as a variable in drug abuse. Objectives: To determine whether there are sex differences in the acquisition of oral phencyclidine (PCP) self-administration and to compare the effect of altered feeding conditions on drug self-administration in male and female monkeys. Methods: Acquisition of orally delivered PCP was studied using 7 female and 11 male adult rhesus monkeys. Initially, the monkeys were not food restricted, and they were given access to water under concurrent fixed-ratio (FR) 1 schedules during daily 3-h sessions. Each lip-contact response on a drinking spout resulted in a 0.3 ml liquid delivery. After baseline levels of water intake were obtained for 5 days, water was replaced with PCP (0.125 mg/ml) at both drinking spouts. Body weights were then reduced to 85% of free-feeding weights, and the monkeys were fed 30 min before the session began. The FR value was increased from 1 to 2, 4, and 8, at both drinking spouts. As a final step in the procedure, water and PCP were concurrently available at the two spouts under FR 8 schedules. Acquisition of PCP-reinforced behavior was considered to have occurred if PCP intake was consistently greater than water intake. Results: Lip-contact responses and liquid deliveries were not significantly different between the females and males throughout the acquisition period, but there was a significant increase in responding and decrease in liquid intake as FR increased, and a significant increase in PCP consumption due to food restriction that did not differ in males and females. On a milligram per kilogram basis, female monkeys consumed nearly twice as much PCP as the males; however, this effect was not significant. The females showed significantly higher PCP than water intake while the males consumed approximately equal amounts of PCP and water. Of the seven females, 100% met the acquisition criterion of significantly greater PCP than water intake, while only 36.4% of the males met the criterion. Conclusion: These results concur with previous rat studies and indicate that female monkeys are more likely than males to acquire drug-reinforced behavior.

Electronic Resource